Raf plus TGFΒ-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin

Oncogene

Volumn 25, Issue 54, 2006, Pages 7117-7130

  Janda, E ^a   Nevolo, M ^a   Lehmann, K ^b   Downward, J ^b   Beug, H ^c   Grieco, M ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

E cadherin; EMT; Endocytosis; Monoubiquitination; Raf; TGFbeta

Indexed keywords

4 HYDROXYTAMOXIFEN; CATHEPSIN D; CHLOROQUINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MONENSIN; RAF PROTEIN; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; CADHERIN; HYBRID PROTEIN;

ANIMAL CELL; ARTICLE; CELL LYSATE; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; GENE INDUCTION; GENE LOSS; LYSOSOME MEMBRANE; MEMBRANE VESICLE; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; UPREGULATION; ANIMAL; CELL TRANSFORMATION; CONFOCAL MICROSCOPY; EPITHELIUM CELL; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOPRECIPITATION; LYSOSOME; METABOLISM; NORTHERN BLOTTING; PATHOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CADHERINS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; ENDOCYTOSIS; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOPRECIPITATION; LYSOSOMES; MICE; MICROSCOPY, CONFOCAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; RAF KINASES; RECOMBINANT FUSION PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 33751087736     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209701     Document Type: Article

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