Smads and chromatin modulation

Cytokine and Growth Factor Reviews

Volumn 16, Issue 4-5, 2005, Pages 495-512

  Van Grunsven, Leo A ^a   Verstappen, Griet ^a   Huylebroeck, Danny ^a   Verschueren, Kristin ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Bone morphogenetic protein; Histones; Remodeling; Signal transduction; Smad

Indexed keywords

HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; METHYL CPG BINDING PROTEIN 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN; PROTEIN P300; PROTEIN P53; PROTEIN SWI; SLOAN KETTERING INSTITUTE PROTEIN; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; SUCROSE NON FERMENTING PROTEIN; SUMO PROTEIN; TRANSCRIPTION FACTOR SIN3A; TRANSCRIPTION FACTOR YY1; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; CELL NUCLEUS; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; ECOTROPIC VIRUS; ENZYME MODIFICATION; ENZYME SUBUNIT; HUMAN; METHYLATION; MODULATION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; VIRUS DNA CELL DNA INTERACTION;

ANIMALS; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA-BINDING PROTEINS; HISTONES; HUMANS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 22644433391     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2005.05.006     Document Type: Review

References (182)

1. P.T. Dijke, and C.S. Hill New insights into TGF-[beta]-Smad signalling Trends Biochem Sci 29 2004 265 273
2. V.C. Foletta, M.A. Lim, and J. Soosairajah Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1 J Cell Biol 162 2003 1089 1098
3. L. Vardouli, A. Moustakas, and C. Stournaras LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta J Biol Chem 280 2005 11448 11457
4. B. Ozdamar, R. Bose, M. Barrios-Rodiles, H.R. Wang, Y. Zhang, and J.L. Wrana Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity Science 307 2005 1603 1609
5. A. Zwijsen, K. Verschueren, and D. Huylebroeck New intracellular components of bone morphogenetic protein/Smad signaling cascades FEBS Lett 546 2003 133 139
6. A. Alevizopoulos, Y. Dusserre, M. Tsai-Pflugfelder, T. von der Weid, W. Wahli, and N. Mermod A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3 Genes Dev 9 1995 3051 3066
7. J. Yan, Y. Fang, and L. Ding Regulation of large-scale chromatin unfolding by Smad4 Biochem Biophys Res Commun 315 2004 330 335
8. K. Luger Structure and dynamic behavior of nucleosomes Curr Opin Genet Dev 13 2003 127 135
9. R. Margueron, P. Trojer, and D. Reinberg The key to development: interpreting the histone code? Curr Opin Genet Dev 15 2005 163 176
10. T. Jenuwein, and C.D. Allis Translating the histone code Science 293 2001 1074 1080
11. B.D. Strahl, and C.D. Allis The language of covalent histone modifications Nature 403 2000 41 45
12. X. de la Cruz, S. Lois, S. Sanchez-Molina, and M.A. Martinez-Balbas Do protein motifs read the histone code? Bioessays 27 2005 164 175
13. P.B. Becker, and W. Horz ATP-dependent nucleosome remodeling Annu Rev Biochem 71 2002 247 273
14. G.J. Narlikar, H.Y. Fan, and R.E. Kingston Cooperation between complexes that regulate chromatin structure and transcription Cell 108 2002 475 487
15. G. Langst, and P.B. Becker Nucleosome remodeling: one mechanism, many phenomena? Biochim Biophys Acta 1677 2004 58 63
16. L. Mohrmann, and C.P. Verrijzer Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes Biochim Biophys Acta 1681 2005 59 73
17. J.A. Eisen, K.S. Sweder, and P.C. Hanawalt Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions Nucleic Acids Res 23 1995 2715 2723
18. A. Lusser, and J.T. Kadonaga Chromatin remodeling by ATP-dependent molecular machines Bioessays 25 2003 1192 1200
19. T. Tsukiyama The in vivo functions of ATP-dependent chromatin-remodelling factors Nat Rev Mol Cell Biol 3 2002 422 429
20. A. Eberharter, and P.B. Becker ATP-dependent nucleosome remodelling: factors and functions J Cell Sci 117 2004 3707 3711
21. S. Sif ATP-dependent nucleosome remodeling complexes: enzymes tailored to deal with chromatin J Cell Biochem 91 2004 1087 1098
22. S.S. Dirscherl, and J.E. Krebs Functional diversity of ISWI complexes Biochem Cell Biol 82 2004 482 489
23. O. Barak, M.A. Lazzaro, W.S. Lane, D.W. Speicher, D.J. Picketts, and R. Shiekhattar Isolation of human NURF: a regulator of Engrailed gene expression Embo J 22 2003 6089 6100
24. N.J. Bowen, N. Fujita, M. Kajita, and P.A. Wade Mi-2/NuRD: multiple complexes for many purposes Biochim Biophys Acta (BBA) Gene Structure and Expression 1677 2004 52 57
25. Q. Feng, R. Cao, L. Xia, H. Erdjument-Bromage, P. Tempst, and Y. Zhang Identification and functional characterization of the p66/p68 components of the MeCP1 complex Mol Cell Biol 22 2002 536 546
26. Y. Zhang, G. LeRoy, H.P. Seelig, W.S. Lane, and D. Reinberg The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities Cell 95 1998 279 289
27. W. Fischle, Y. Wang, and C.D. Allis Histone and chromatin cross-talk Curr Opin Cell Biol 15 2003 172 183
28. J.H. Waterborg Dynamics of histone acetylation in vivo. A function for acetylation turnover? Biochem Cell Biol 80 2002 363 378
29. E.C. Forsberg, and E.H. Bresnick Histone acetylation beyond promoters: long-range acetylation patterns in the chromatin world Bioessays 23 2001 820 830
30. S.Y. Roth, J.M. Denu, and C.D. Allis Histone acetyltransferases Annu Rev Biochem 70 2001 81 120
31. S.L. Berger Histone modifications in transcriptional regulation Curr Opin Genet Dev 12 2002 142 148
32. T. Agalioti, G. Chen, and D. Thanos Deciphering the transcriptional histone acetylation code for a human gene Cell 111 2002 381 392
33. X.J. Yang Lysine acetylation and the bromodomain: a new partnership for signaling Bioessays 26 2004 1076 1087
34. Y. Doyon, and J. Cote The highly conserved and multifunctional NuA4 HAT complex Curr Opin Genet Dev 14 2004 147 154
35. Y. Cai, J. Jin, and L. Florens The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes J Biol Chem 280 2005 13665 13670
36. T. Ikura, V.V. Ogryzko, and M. Grigoriev Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis Cell 102 2000 463 473
37. M.J. Carrozza, R.T. Utley, J.L. Workman, and J. Cote The diverse functions of histone acetyltransferase complexes Trends Genet 19 2003 321 329
38. E. Kalkhoven CBP and p300: HATs for different occasions Biochem Pharmacol 68 2004 1145 1155
39. P.A. Marks, T. Miller, and V.M. Richon Histone deacetylases Curr Opin Pharmacol 3 2003 344 351
40. J. Ahringer NuRD and SIN3: histone deacetylase complexes in development Trends Genet 16 2000 351 356
41. G.W. Humphrey, Y. Wang, and V.R. Russanova Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 J Biol Chem 276 2001 6817 6824
42. A. You, J.K. Tong, C.M. Grozinger, and S.L. Schreiber CoREST is an integral component of the CoREST-human histone deacetylase complex Proc Natl Acad Sci USA 98 2001 1454 1458
43. M.G. Guenther, W.S. Lane, W. Fischle, E. Verdin, M.A. Lazar, and R. Shiekhattar A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness Genes Dev 14 2000 1048 1057
44. Y.D. Wen, V. Perissi, and L.M. Staszewski The histone deacetylase-3 complex contains nuclear receptor corepressors Proc Natl Acad Sci USA 97 2000 7202 7207
45. J. Li, J. Wang, Z. Nawaz, J.M. Liu, J. Qin, and J. Wong Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 Embo J 19 2000 4342 4350
46. Y. Shi, J. Sawada, and G. Sui Coordinated histone modifications mediated by a CtBP co-repressor complex Nature 422 2003 735 738
47. G. Chen, J. Fernandez, S. Mische, and A.J. Courey A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development Genes Dev 13 1999 2218 2230
48. C.Y. Choi, Y.H. Kim, H.J. Kwon, and Y. Kim The homeodomain protein NK-3 recruits groucho and a histone deacetylase complex to repress transcription J Biol Chem 274 1999 33194 33197
49. N. Schreiber-Agus, and R.A. DePinho Repression by the Mad(Mxi1)-Sin3 complex Bioessays 20 1998 808 818
50. D.C. Schultz, J.R. Friedman, and F.J. Rauscher 3rd Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD Genes Dev 15 2001 428 443
51. H.-G. Yoon, Y. Choi, P.A. Cole, and J. Wong Reading and function of a histone code involved in targeting corepressor complexes for repression Mol Cell Biol 25 2005 324 335
52. M. Vermeulen, M.J. Carrozza, E. Lasonder, J.L. Workman, C. Logie, and H.G. Stunnenberg In vitro targeting reveals intrinsic histone tail specificity of the Sin3/histone deacetylase and N-CoR/SMRT corepressor complexes Mol Cell Biol 24 2004 2364 2372
53. T. Kouzarides Histone methylation in transcriptional control Curr Opin Genet Dev 12 2002 198 209
54. A.H. Peters, and D. Schubeler Methylation of histones: playing memory with DNA Curr Opin Cell Biol 17 2005 230 238
55. R. Schneider, A.J. Bannister, and T. Kouzarides Unsafe SETs: histone lysine methyltransferases and cancer Trends Biochem Sci 27 2002 396 402
56. Y. Shi, F. Lan, and C. Matson Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 Cell 119 2004 941 953
57. Y. Wang, J. Wysocka, and J. Sayegh Human PAD4 regulates histone arginine methylation levels via demethylimination Science 306 2004 279 283
58. Y. Zhang Transcriptional regulation by histone ubiquitination and deubiquitination Genes Dev 17 2003 2733 2740
59. R.T. Hay SUMO: a history of modification Mol Cell 18 2005 1 12
60. Y. Shiio, and R.N. Eisenman Histone sumoylation is associated with transcriptional repression Proc Natl Acad Sci USA 100 2003 13225 13230
61. V. Anest, J.L. Hanson, P.C. Cogswell, K.A. Steinbrecher, B.D. Strahl, and A.S. Baldwin A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression Nature 423 2003 659 663
62. K.L. Dunn, P.S. Espino, B. Drobic, S. He, and J.R. Davie The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling Biochem Cell Biol 83 2005 1 14
63. M.Y. Kim, S. Mauro, N. Gevry, J.T. Lis, and W.L. Kraus NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1 Cell 119 2004 803 814
64. M.L. Meyer-Ficca, R.G. Meyer, E.L. Jacobson, and M.K. Jacobson Poly(ADP-ribose) polymerases: managing genome stability Int J Biochem Cell Biol 37 2005 920 926
65. S. Yamagoe, T. Kanno, and Y. Kanno Interaction of histone acetylases and deacetylases in vivo Mol Cell Biol 23 2003 1025 1033
66. K.N. Harikrishnan, M.Z. Chow, and E.K. Baker Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing Nat Genet 37 2005 254 264
67. S. Pal, S.N. Vishwanath, H. Erdjument-Bromage, P. Tempst, and S. Sif Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes Mol Cell Biol 24 2004 9630 9645
68. S. Sif, A.J. Saurin, A.N. Imbalzano, and R.E. Kingston Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes Genes Dev 15 2001 603 618
69. T. Nakamura, T. Mori, and S. Tada ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation Mol Cell 10 2002 1119 1128
70. C. Pouponnot, L. Jayaraman, and J. Massague Physical and Functional Interaction of SMADs and p300/CBP J Biol Chem 273 1998 22865 22868
71. X.H. Feng, Y. Zhang, R.Y. Wu, and R. Derynck The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are co-activators for Smad3 in TGF-beta-induced transcriptional activation Genes Dev 12 1998 2153 2163
72. R. Janknecht, N.J. Wells, and T. Hunter TGF-beta-stimulated cooperation of Smad proteins with the co-activators CBP/p300 Genes Dev 12 1998 2114 2119
73. J.N. Topper, M.R. DiChiara, and J.D. Brown CREB binding protein is a required co-activator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells PNAS 95 1998 9506 9511
74. A. Nishihara, J.-I. Hanai, T. Imamura, K. Miyazono, and M. Kawabata E1A Inhibits Transforming Growth Factor-beta Signaling through Binding to Smad Proteins J Biol Chem 274 1999 28716 28723
75. E. Gronroos, U. Hellman, C.-H. Heldin, and J. Ericsson Control of Smad7 stability by competition between acetylation and ubiquitination Mol Cell 10 2002 483 493
76. R.H. Kim, D. Wang, and M. Tsang A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction Genes Dev 14 2000 1605 1616
77. S. Akiyoshi, H. Inoue, and J. Hanai c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with Smads J Biol Chem 274 1999 35269 35277
78. D. Wotton, R.S. Lo, S. Lee, and J. Massague A Smad transcriptional corepressor Cell 97 1999 29 39
79. C. Caron, E. Col, and S. Khochbin The viral control of cellular acetylation signaling Bioessays 25 2003 58 65
80. U. Schaeper, J.M. Boyd, S. Verma, E. Uhlmann, T. Subramanian, and G. Chinnadurai Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation Proc Natl Acad Sci USA 92 1995 10467 10471
81. J.L. Reid, A.J. Bannister, P. Zegerman, M.A. Martinez-Balbas, and T. Kouzarides E1A directly binds and regulates the P/CAF acetyltransferase Embo J 17 1998 4469 4477
82. K. Kahata, M. Hayashi, and M. Asaka Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional co-activator GCN5 Genes Cells 9 2004 143 151
83. S. Itoh, J. Ericsson, J. Nishikawa, C.H. Heldin, and P. ten Dijke The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling Nucleic Acids Res 28 2000 4291 4298
84. P. Frontelo, J.E. Leader, and N. Yoo Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression Oncogene 23 2004 5242 5251
85. A.M. Naar, B.D. Lemon, and R. Tjian Transcriptional co-activator complexes Ann Rev Biochem 70 2001 475 501
86. H.-M. Bourbon, A. Aguilera, and A.Z. Ansari A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II Mol Cell 14 2004 553 557
87. Y. Lorch, J. Beve, C.M. Gustafsson, L.C. Myers, and R.D. Kornberg Mediator-nucleosome interaction Mol Cell 6 2000 197 201
88. G. Wang, M.A. Balamotis, J.L. Stevens, Y. Yamaguchi, H. Handa, and A.J. Berk Mediator requirement for both recruitment and postrecruitment steps in transcription initiation Mol Cell 17 2005 683 694
89. D.J. Taatjes, M.T. Marr, and R. Tjian Regulatory diversity among metazoan co-activator complexes Nat Rev Mol Cell Biol 5 2004 403 410
90. T. Imamura, M. Takase, and A. Nishihara Smad6 inhibits signalling by the TGF-beta superfamily Nature 389 1997 622 626
91. A. Hata, G. Lagna, J. Massague, and A. Hemmati-Brivanlou Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor Genes Dev 12 1998 186 197
92. S. Bai, X. Shi, X. Yang, and X. Cao Smad6 as a transcriptional corepressor J Biol Chem 275 2000 8267 8270
93. S. Bai, and X. Cao A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling J Biol Chem 277 2002 4176 4182
94. X. Lin, Y.Y. Liang, and B. Sun Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription Mol Cell Biol 23 2003 9081 9093
95. E. Bertolino, B. Reimund, D. Wildt-Perinic, and R.G. Clerc A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif J Biol Chem 270 1995 31178 31188
96. J. Overhauser, H.F. Mitchell, E.H. Zackai, D.B. Tick, K. Rojas, and M. Muenke Physical mapping of the holoprosencephaly critical region in 18p11.3 Am J Hum Genet 57 1995 1080 1085
97. D. Wotton, P.S. Knoepfler, C.D. Laherty, R.N. Eisenman, and J. Massague The Smad transcriptional corepressor TGIF recruits mSin3 Cell Growth Differ 12 2001 457 463
98. D. Wotton, R.S. Lo, L.A. Swaby, and J. Massague Multiple modes of repression by the Smad transcriptional corepressor TGIF J Biol Chem 274 1999 37105 37110
99. T.A. Melhuish, and D. Wotton The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF J Biol Chem 275 2000 39762 39766
100. X. Liu, Y. Sun, R.A. Weinberg, and H.F. Lodish Ski/Sno and TGF-[beta] signaling Cytokine Growth Factor Rev 12 2001 1 8
101. K. Luo Ski and SnoN: negative regulators of TGF-[beta] signaling Curr Opin Genet Develop 14 2004 65 70
102. Y. Sun, X. Liu, E.N. Eaton, W.S. Lane, H.F. Lodish, and R.A. Weinberg Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling Mol Cell 4 1999 499 509
103. W. Wang, F.V. Mariani, R.M. Harland, and K. Luo Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells PNAS 97 2000 14394 14399
104. K. Luo, S.L. Stroschein, and W. Wang The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling Genes Dev 13 1999 2196 2206
105. N. Ueki, and M.J. Hayman Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling J Biol Chem 278 2003 32489 32492
106. J.W. Wu, A.R. Krawitz, and J. Chai Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling Cell 111 2002 357 367
107. B.Y. Qin, S.S. Lam, J.J. Correia, and K. Lin Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control Genes Dev 16 2002 1950 1963
108. T. Nomura, M.M. Khan, and S.C. Kaul Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor Genes Dev 13 1999 412 423
109. G.M. Leong, N. Subramaniam, and J. Figueroa Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta- dependent transcription J Biol Chem 276 2001 18243 18248
110. S. Zhou, M. Fujimuro, J.J. Hsieh, L. Chen, and S.D. Hayward A role for SKIP in EBNA2 activation of CBF1-repressed promoters J Virol 74 2000 1939 1947
111. G.M. Leong, N. Subramaniam, and L.L. Issa Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300 Biochem Biophys Res Commun 315 2004 1070 1076
112. N. Ueki, and M.J. Hayman Signal-dependent N-CoR requirement for repression by the Ski oncoprotein J Biol Chem 278 2003 24858 24864
113. J. Harada, K. Kokura, and C. Kanei-Ishii Requirement of the co-repressor homeodomain-interacting protein kinase 2 for Ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation J Biol Chem 278 2003 38998 39005
114. Hofmann TG, Moller A, Sirma H, et al. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. 2002;4:1-10.
115. D'Orazi G, Cecchinelli B, Bruno T, et al. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. 2002;4:11-19.
116. K. Kokura, S.C. Kaul, and R. Wadhwa The Ski protein family is required for MeCP2-mediated transcriptional repression J Biol Chem 276 2001 34115 34121
117. Z. Kozmik, P. Pfeffer, and J. Kralova Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene Dev Genes Evol 209 1999 537 545
118. K. Wu, Y. Yang, and C. Wang DACH1 inhibits transforming growth factor-beta signaling through binding Smad4 J Biol Chem 278 2003 51673 51684
119. X. Li, V. Perissi, F. Liu, D.W. Rose, and M.G. Rosenfeld Tissue-specific regulation of retinal and pituitary precursor cell proliferation Science 297 2002 1180 1183
120. Y. Kida, Y. Maeda, T. Shiraishi, T. Suzuki, and T. Ogura Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis Development 131 2004 4179 4187
121. E.R. Cameron, and J.C. Neil The Runx genes: lineage-specific oncogenes and tumor suppressors Oncogene 23 2004 4308 4314
122. Y. Zhang, and R. Derynck Transcriptional regulation of the transforming growth factor-beta-inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members J Biol Chem 275 2000 16979 16985
123. K.S. Lee, H.J. Kim, and Q.L. Li Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12 Mol Cell Biol 20 2000 8783 8792
124. R. Coffman, D. Lebman, and B. Shrader Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes J Exp Med 170 1989 1039 1044
125. M.-J. Shi, and J. Stavnezer CBF{alpha}3 (AML2) Is Induced by TGF-{beta}1 to Bind and Activate the Mouse Germline Ig {alpha} Promoter J Immunol 161 1998 6751 6760
126. J.-i. Hanai, L.F. Chen, and T. Kanno Interaction and Functional Cooperation of PEBP2/CBF with Smads. synergistic induction of the immunoglobulin germline calpha promoter J Biol Chem 274 1999 31577 31582
127. E. Pardali, X.-Q. Xie, and P. Tsapogas Smad and AML Proteins Synergistically Confer Transforming Growth Factor beta 1 Responsiveness to Human Germ-line IgA Genes J Biol Chem 275 2000 3552 3560
128. S.K. Zaidi, A.J. Sullivan, A.J. van Wijnen, J.L. Stein, G.S. Stein, and J.B. Lian Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites Proc Natl Acad Sci USA 99 2002 8048 8053
129. K. Miyazono, S. Maeda, and T. Imamura Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins Oncogene 23 2004 4232 4237
130. I. Kitabayashi, A. Yokoyama, K. Shimizu, and M. Ohki Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation Embo J 17 1998 2994 3004
131. A. Jakubowiak, C. Pouponnot, and F. Berguido Inhibition of the Transforming Growth Factor beta 1 Signaling Pathway by the AML1/ETO Leukemia-associated Fusion Protein J Biol Chem 275 2000 40282 40287
132. Y. Yamaguchi, M. Kurokawa, and Y. Imai AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues J Biol Chem 279 2004 15630 15638
133. B. Aronson, A. Fisher, K. Blechman, M. Caudy, and J. Gergen Groucho-dependent and -independent repression activities of Runt domain proteins Mol Cell Biol 17 1997 5581 5587
134. Y. Imai, M. Kurokawa, and K. Tanaka TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation Biochem Biophys Res Commun 252 1998 582 589
135. B. Lutterbach, J.J. Westendorf, B. Linggi, S. Isaac, E. Seto, and S.W. Hiebert A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia J Biol Chem 275 2000 651 656
136. A. Javed, B. Guo, and S. Hiebert Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription J Cell Sci 113 2000 2221 2231
137. K.L. Durst, and S.W. Hiebert Role of RUNX family members in transcriptional repression and gene silencing Oncogene 23 2004 4220 4224
138. K.L. Durst, B. Lutterbach, T. Kummalue, A.D. Friedman, and S.W. Hiebert The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain Mol Cell Biol 23 2003 607 619
139. J.J. Westendorf, S.K. Zaidi, and J.E. Cascino Runx2 (Cbfa1, AML-3) Interacts with Histone Deacetylase 6 and Represses the p21CIP1/WAF1 Promoter Mol Cell Biol 22 2002 7982 7992
140. S. Liu, T. Shen, and L. Huynh Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia Cancer Res 65 2005 1277 1284
141. S. Chakraborty, K.K. Sinha, V. Senyuk, and G. Nucifora SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo Oncogene 22 2003 5229 5237
142. J. Jolkowska, and M. Witt The EVI-1 gene: its role in pathogenesis of human leukemias Leuk Res 24 2000 553 558
143. M. Ohta, J.S. Greenberger, P. Anklesaria, A. Bassols, and J. Massague Two forms of transforming growth factor-beta distinguished by multipotential haematopoietic progenitor cells Nature 329 1987 539 541
144. W. Piacibello, A. Severino, A. Stacchini, and M. Aglietta Differential effect of transforming growth factor beta 1 on the proliferation of human lymphoid and myeloid leukemia cells Haematologica 76 1991 460 466
145. M. Kurokawa, K. Mitani, and K. Irie The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3 Nature 394 1998 92 96
146. S. Palmer, J.P. Brouillet, and A. Kilbey Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins J Biol Chem 276 2001 25834 25840
147. K. Izutsu, M. Kurokawa, Y. Imai, K. Maki, K. Mitani, and H. Hirai The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling Blood 97 2001 2815 2822
148. S. Chakraborty, V. Senyuk, S. Sitailo, Y. Chi, and G. Nucifora Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles J Biol Chem 276 2001 44936 44943
149. U. Vinatzer, J. Taplick, C. Seiser, C. Fonatsch, and R. Wieser The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase Br J Haematol 114 2001 566 573
150. T. Alliston, T.C. Ko, and Y. Cao Repression of BMP and activin-inducible transcription by Evi-1 J Biol Chem 2005 M414305200
151. V. Senyuk, K.K. Sinha, S. Chakraborty, S. Buonamici, and G. Nucifora P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein Biochem Biophys Res Commun 307 2003 980 986
152. Y. Chi, V. Senyuk, S. Chakraborty, and G. Nucifora EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity J Biol Chem 278 2003 49806 49811
153. S. Sengupta, and C.C. Harris p53: traffic cop at the crossroads of DNA repair and recombination Nat Rev Mol Cell Biol 6 2005 44 55
154. D. Lee, J.W. Kim, T. Seo, S.G. Hwang, E.-J. Choi, and J. Choe SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription J Biol Chem 277 2002 22330 22337
155. D.M. Scolnick, N.H. Chehab, and E.S. Stavridi CREB-binding protein and p300/CBP-associated factor are transcriptional co-activators of the p53 tumor suppressor protein Cancer Res 57 1997 3693 3696
156. J.M. Espinosa, and B.M. Emerson Transcriptional regulation by p53 through Intrinsic DNA/chromatin binding and site-directed cofactor recruitment Mol Cell 8 2001 57 69
157. N.A. Barlev, L. Liu, and N.H. Chehab Acetylation of p53 activates transcription through recruitment of co-activators/histone acetyltransferases Mol Cell 8 2001 1243 1254
158. C.L. Brooks, and W. Gu Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation Curr Opin Cell Biol 15 2003 164 171
159. A.M. Bode, and Z. Dong Post-translational modification of p53 in tumorigenesis Nat Rev Cancer 4 2004 793 805
160. Y. Xu Regulation of p53 responses by post-translational modifications Cell Death Differ 10 2003 400 403
161. M. Cordenonsi, S. Dupont, S. Maretto, A. Insinga, C. Imbriano, and S. Piccolo Links between tumor suppressors: p53 is required for TGF-[beta] gene responses by cooperating with Smads Cell 113 2003 301 314
162. K. Takebayashi-Suzuki, J. Funami, and D. Tokumori Interplay between the tumor suppressor p53 and TGF{beta} signaling shapes embryonic body axes in Xenopus Development 130 2003 3929 3939
163. S. Dupont, L. Zacchigna, and M. Adorno Convergence of p53 and TGF-beta signaling networks Cancer Lett 213 2004 129 138
164. D.S. Wilkinson, S.K. Ogden, and S.A. Stratton A direct intersection between p53 and transforming growth factor {beta} pathways targets chromatin modification and transcription repression of the {alpha}-fetoprotein gene Mol Cell Biol 25 2005 1200 1212
165. K. Kurisaki, A. Kurisaki, and U. Valcourt Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation Mol Cell Biol 23 2003 4494 4510
166. Y. Shi, E. Seto, L.S. Chang, and T. Shenk Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein Cell 67 1991 377 388
167. E. Seto, Y. Shi, and T. Shenk YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro Nature 354 1991 241 245
168. M.J. Thomas, and E. Seto Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? Gene 236 1999 197 208
169. J.S. Lee, K.M. Galvin, and R.H. See Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300 Genes Dev 9 1995 1188 1198
170. W.-M. Yang, C. Inouye, Y. Zeng, D. Bearss, and E. Seto Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3 PNAS 93 1996 12845 12850
171. W.-M. Yang, Y.-L. Yao, J.-M. Sun, J.R. Davie, and E. Seto Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family J Biol Chem 272 1997 28001 28007
172. Y.-L. Yao, W.-M. Yang, and E. Seto Regulation of transcription factor YY1 by acetylation and deacetylation Mol Cell Biol 21 2001 5979 5991
173. N. Rezai-Zadeh, X. Zhang, and F. Namour Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1 Genes Dev 17 2003 1019 1029
174. Y.-L. Yao, and W.-M. Yang The Metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity J Biol Chem 278 2003 42560 42568
175. S.L. Oei, and Y. Shi Poly(ADP-Ribosyl)ation of Transcription Factor Yin Yang 1 under Conditions of DNA Damage Biochem Biophys Res Commun 285 2001 27 31
176. H. Mendoza-Alvarez, and R. Alvarez-Gonzalez Regulation of p53 sequence-specific DNA-binding by covalent poly(ADP-ribosyl)ation J Biol Chem 276 2001 36425 36430
177. M.-C. Ku, S. Stewart, and A. Hata Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes Biochem Biophys Res Commun 311 2003 702 707
178. K.-H. Lee, S. Evans, T.Y. Ruan, and A.B. Lassar SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer Development 131 2004 4709 4723
179. Y. Kato, R. Habas, Y. Katsuyama, A.M. Naar, and X. He A component of the ARC/Mediator complex required for TGF[beta]/Nodal signalling Nature 418 2002 641 646
180. A. Hata, J. Seoane, G. Lagna, E. Montalvo, A. Hemmati-Brivanlou, and J. Massague OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP- Smad and Olf signaling pathways Cell 100 2000 229 240
181. M. Murphy, J. Ahn, and K.K. Walker Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a Genes Dev 13 1999 2490 2501
182. T.A. Melhuish, C.M. Gallo, and D. Wotton TGIF2 interacts with histone deacetylase 1 and represses transcription J Biol Chem 276 2001 32109 32114