-
1
-
-
0036674213
-
p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration
-
Bakin AV, Rinehart C, Tomlinson AK, Arteaga CL (2002) p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115: 3193-3206
-
(2002)
J Cell Sci
, vol.115
, pp. 3193-3206
-
-
Bakin, A.V.1
Rinehart, C.2
Tomlinson, A.K.3
Arteaga, C.L.4
-
2
-
-
0034711307
-
Phosphatidylinositol-3 kinase function is required for TGFbeta-mediated epithelial to mesenchymal transition and cell migration
-
Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL (2000) Phosphatidylinositol-3 kinase function is required for TGFbeta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275: 36803-36810
-
(2000)
J Biol Chem
, vol.275
, pp. 36803-36810
-
-
Bakin, A.V.1
Tomlinson, A.K.2
Bhowmick, N.A.3
Moses, H.L.4
Arteaga, C.L.5
-
3
-
-
0035185853
-
Transforming growth factor-betal mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
-
Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL (2001) Transforming growth factor-betal mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 12: 27-36
-
(2001)
Mol Biol Cell
, vol.12
, pp. 27-36
-
-
Bhowmick, N.A.1
Ghiassi, M.2
Bakin, A.3
Aakre, M.4
Lundquist, C.A.5
Engel, M.E.6
Arteaga, C.L.7
Moses, H.L.8
-
4
-
-
0035984434
-
Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis
-
Camenisch TD, Molin DG, Person A, Runyan RB, Gittenberger-De Groot AC, Mcdonald JA, Klewer SE (2002) Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis. Dev Biol 248: 170-181
-
(2002)
Dev Biol
, vol.248
, pp. 170-181
-
-
Camenisch, T.D.1
Molin, D.G.2
Person, A.3
Runyan, R.B.4
Gittenberger-De Groot, A.C.5
Mcdonald, J.A.6
Klewer, S.E.7
-
5
-
-
0033784843
-
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
-
Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, Del Barrio MG, Portillo F, Nieto MA (2000) The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2: 76-83
-
(2000)
Nat Cell Biol
, vol.2
, pp. 76-83
-
-
Cano, A.1
Perez-Moreno, M.A.2
Rodrigo, I.3
Locascio, A.4
Blanco, M.J.5
Del Barrio, M.G.6
Portillo, F.7
Nieto, M.A.8
-
6
-
-
0034964418
-
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
-
Comijn J, Berx G, Vermassen P, Verschueren K, Van Grunsven L, Bruyneel E, Mareel M, Huylebroeck D, Van Roy F (2001) The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 7: 1267-1278
-
(2001)
Mol Cell
, vol.7
, pp. 1267-1278
-
-
Comijn, J.1
Berx, G.2
Vermassen, P.3
Verschueren, K.4
Van Grunsven, L.5
Bruyneel, E.6
Mareel, M.7
Huylebroeck, D.8
Van Roy, F.9
-
7
-
-
0030598681
-
TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
-
Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A, Akhurst RJ (1996) TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86: 531-542
-
(1996)
Cell
, vol.86
, pp. 531-542
-
-
Cui, W.1
Fowlis, D.J.2
Bryson, S.3
Duffie, E.4
Ireland, H.5
Balmain, A.6
Akhurst, R.J.7
-
8
-
-
85047699421
-
Vertebrate hairy and enhancer of split related proteins: Transcriptional repressors regulating cellular differentiation and embryonic patterning
-
Davis RL, Turner DL (2001) Vertebrate hairy and enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning. Oncogene 20: 8342-8357
-
(2001)
Oncogene
, vol.20
, pp. 8342-8357
-
-
Davis, R.L.1
Turner, D.L.2
-
9
-
-
0032101178
-
Direct binding of Smad3 and Smad4 to critical TGFb-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
-
Dennler S, Itoh S, Vivien D, Ten Dijke P, Huet S, Gauthier JM (1998) Direct binding of Smad3 and Smad4 to critical TGFb-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17: 3091-3100
-
(1998)
EMBO J
, vol.17
, pp. 3091-3100
-
-
Dennler, S.1
Itoh, S.2
Vivien, D.3
Ten Dijke, P.4
Huet, S.5
Gauthier, J.M.6
-
10
-
-
0032442852
-
Smads: Transcriptional activators of TGF-beta responses
-
Derynck R, Zhang Y, Feng XH (1998) Smads: transcriptional activators of TGF-beta responses. Cell 95: 737-740
-
(1998)
Cell
, vol.95
, pp. 737-740
-
-
Derynck, R.1
Zhang, Y.2
Feng, X.H.3
-
11
-
-
0037125957
-
Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice
-
Donovan J, Kordylewska A, Jan YN, Utset MF (2002) Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice. Curr Biol 12: 1605-1610
-
(2002)
Curr Biol
, vol.12
, pp. 1605-1610
-
-
Donovan, J.1
Kordylewska, A.2
Jan, Y.N.3
Utset, M.F.4
-
12
-
-
0033386939
-
Progression of the morphogenetic furrow in the Drosophila eye: The roles of Hedgehog, Decapentaplegic and the Raf pathway
-
Greenwood S, Struhl G (1999) Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway. Development 126: 5795-5808
-
(1999)
Development
, vol.126
, pp. 5795-5808
-
-
Greenwood, S.1
Struhl, G.2
-
13
-
-
0029553183
-
An overview of epithelio-mesenchymal transformation
-
Hay ED (1995) An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) 154: 8-20
-
(1995)
Acta Anat (Basel)
, vol.154
, pp. 8-20
-
-
Hay, E.D.1
-
14
-
-
0032765264
-
Patterning of Drosophila leg sensory organs through combinatorial signaling by hedgehog, decapentaplegic and wingless
-
Hays R, Buchanan KT, Neff C, Orenic TV (1999) Patterning of Drosophila leg sensory organs through combinatorial signaling by hedgehog, decapentaplegic and wingless. Development 126: 2891-2899
-
(1999)
Development
, vol.126
, pp. 2891-2899
-
-
Hays, R.1
Buchanan, K.T.2
Neff, C.3
Orenic, T.V.4
-
15
-
-
0031438047
-
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
-
Heldin CH, Miyazono K, Ten Dijke P (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471
-
(1997)
Nature
, vol.390
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
Ten Dijke, P.3
-
16
-
-
0035794134
-
The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation
-
Henderson AM, Wang SJ, Taylor AC, Aitkenhead M, Hughes CC (2001) The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation. J Biol Chem 276: 6169-6176
-
(2001)
J Biol Chem
, vol.276
, pp. 6169-6176
-
-
Henderson, A.M.1
Wang, S.J.2
Taylor, A.C.3
Aitkenhead, M.4
Hughes, C.C.5
-
17
-
-
0030787152
-
Mechanism and function of signaling by the TGF beta superfamily
-
[Review] [160 Refs]
-
Hoodless PA, Wrana JL (1998) Mechanism and function of signaling by the TGF beta superfamily. [Review] [160 Refs]. Curr Top Microbiol Immunol 228: 235-272
-
(1998)
Curr Top Microbiol Immunol
, vol.228
, pp. 235-272
-
-
Hoodless, P.A.1
Wrana, J.L.2
-
18
-
-
0037423374
-
Elucidation of Smad requirement in transforming growth factor-beta Type I receptor-induced responses
-
Itoh S, Thorikay M, Kowanetz M, Moustakas A, Itoh F, Heldin CH, Ten Dijke P (2003) Elucidation of Smad requirement in transforming growth factor-beta Type I receptor-induced responses. J Biol Chem 278: 3751-3761
-
(2003)
J Biol Chem
, vol.278
, pp. 3751-3761
-
-
Itoh, S.1
Thorikay, M.2
Kowanetz, M.3
Moustakas, A.4
Itoh, F.5
Heldin, C.H.6
Ten Dijke, P.7
-
19
-
-
0037148532
-
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
-
Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, Beug H, Grunert S (2002) Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol 156: 299-313
-
(2002)
J Cell Biol
, vol.156
, pp. 299-313
-
-
Janda, E.1
Lehmann, K.2
Killisch, I.3
Jechlinger, M.4
Herzig, M.5
Downward, J.6
Beug, H.7
Grunert, S.8
-
20
-
-
0036799650
-
Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation
-
John GR, Shankar SL, Shafit-Zagardo B, Massimi A, Lee SC, Raine CS, Brosnan CF (2002) Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nat Med 8: 1115-1121
-
(2002)
Nat Med
, vol.8
, pp. 1115-1121
-
-
John, G.R.1
Shankar, S.L.2
Shafit-Zagardo, B.3
Massimi, A.4
Lee, S.C.5
Raine, C.S.6
Brosnan, C.F.7
-
21
-
-
0034726709
-
Comparative analysis of the human and mouse Heyl promoter: Hey genes are new Notch target genes
-
Maier MM, Gessler M (2000) Comparative analysis of the human and mouse Heyl promoter: Hey genes are new Notch target genes. Biochem Biophys Res Commun 275: 652-660
-
(2000)
Biochem Biophys Res Commun
, vol.275
, pp. 652-660
-
-
Maier, M.M.1
Gessler, M.2
-
22
-
-
0034574298
-
How cells read TGF-beta signals
-
Massague J (2000) How cells read TGF-beta signals. Nat Rev Mol Cell Biol 1: 169-178
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, pp. 169-178
-
-
Massague, J.1
-
23
-
-
0028603343
-
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
-
Miettinen PJ, Ebner R, Lopez AR, Derynck R (1994) TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 127: 2021-2036
-
(1994)
J Cell Biol
, vol.127
, pp. 2021-2036
-
-
Miettinen, P.J.1
Ebner, R.2
Lopez, A.R.3
Derynck, R.4
-
24
-
-
0036014932
-
Transforming growth factor-beta induces renal epithelial Jagged-1 expression in fibrotic disease
-
Morrissey J, Guo G, Moridaira K, Fitzgerald M, Mccracken R, Tolley T, Klahr S (2002) Transforming growth factor-beta induces renal epithelial Jagged-1 expression in fibrotic disease. J Am Soc Nephrol 13: 1499-1508
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 1499-1508
-
-
Morrissey, J.1
Guo, G.2
Moridaira, K.3
Fitzgerald, M.4
Mccracken, R.5
Tolley, T.6
Klahr, S.7
-
25
-
-
0034671686
-
Notch signaling: From the outside in
-
Mumm JS, Kopan R (2000) Notch signaling: from the outside in. Dev Biol 228: 151-165
-
(2000)
Dev Biol
, vol.228
, pp. 151-165
-
-
Mumm, J.S.1
Kopan, R.2
-
26
-
-
0034610274
-
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling
-
Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN (2000) Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci USA 97: 13655-13660
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 13655-13660
-
-
Nakagawa, O.1
McFadden, D.G.2
Nakagawa, M.3
Yanagisawa, H.4
Hu, T.5
Srivastava, D.6
Olson, E.N.7
-
27
-
-
0037370310
-
Notchl functions as a tumor suppressor in mouse skin
-
Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, Van Noort M, Hui CC, Clevers H, Dotto GP, Radtke F (2003) Notchl functions as a tumor suppressor in mouse skin. Nat Genet 33: 416-421
-
(2003)
Nat Genet
, vol.33
, pp. 416-421
-
-
Nicolas, M.1
Wolfer, A.2
Raj, K.3
Kummer, J.A.4
Mill, P.5
Van Noort, M.6
Hui, C.C.7
Clevers, H.8
Dotto, G.P.9
Radtke, F.10
-
28
-
-
0036513626
-
The snail superfamily of zinc-finger transcription factors
-
Nieto MA (2002) The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3: 155-166
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 155-166
-
-
Nieto, M.A.1
-
29
-
-
0038756636
-
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
-
Peinado H, Quintanilla M, Cano A (2003) Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278: 21113-21123
-
(2003)
J Biol Chem
, vol.278
, pp. 21113-21123
-
-
Peinado, H.1
Quintanilla, M.2
Cano, A.3
-
30
-
-
0033377867
-
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
-
Piek E, Moustakas A, Kurisaki A, Heldin CH, Ten Dijke P (1999) TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 112 (Part 24): 4557-4568
-
(1999)
J Cell Sci
, vol.112
, Issue.PART 24
, pp. 4557-4568
-
-
Piek, E.1
Moustakas, A.2
Kurisaki, A.3
Heldin, C.H.4
Ten Dijke, P.5
-
31
-
-
0000116653
-
The transforming growth factors-β
-
Sporn MB, Roberts AB (eds)
-
Roberts AB, Sporn MB (1990) The transforming growth factors-β. In Handbook of Experimental Pharmacology. Peptide Growth Factors and their Receptors, Sporn MB, Roberts AB (eds) pp 419-472. Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong: Springer-Verlag
-
(1990)
Handbook of Experimental Pharmacology. Peptide Growth Factors and Their Receptors
, pp. 419-472
-
-
Roberts, A.B.1
Sporn, M.B.2
-
32
-
-
0034235433
-
Slug is an essential target of TGFbeta2 signaling in the developing chicken heart
-
Romano LA, Runyan RB (2000) Slug is an essential target of TGFbeta2 signaling in the developing chicken heart. Dev Biol 223: 91-102
-
(2000)
Dev Biol
, vol.223
, pp. 91-102
-
-
Romano, L.A.1
Runyan, R.B.2
-
33
-
-
0037058935
-
Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2
-
Sakata Y, Kamei CN, Nakagami H, Bronson R, Liao JK, Chin MT (2002) Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci USA 99: 16197-16202
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16197-16202
-
-
Sakata, Y.1
Kamei, C.N.2
Nakagami, H.3
Bronson, R.4
Liao, J.K.5
Chin, M.T.6
-
34
-
-
0030609894
-
TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes
-
Sanford LP, Ormsby I, Gittenberger-De Groot AC, Sariola H, Friedman R, Boivin GP, Cardell EL, Doetschman T (1997) TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 124: 2659-2670
-
(1997)
Development
, vol.124
, pp. 2659-2670
-
-
Sanford, L.P.1
Ormsby, I.2
Gittenberger-De Groot, A.C.3
Sariola, H.4
Friedman, R.5
Boivin, G.P.6
Cardell, E.L.7
Doetschman, T.8
-
35
-
-
0031594269
-
TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro
-
Sun D, Vanderburg CR, Odierna GS, Hay ED (1998) TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro. Development 125: 95-105
-
(1998)
Development
, vol.125
, pp. 95-105
-
-
Sun, D.1
Vanderburg, C.R.2
Odierna, G.S.3
Hay, E.D.4
-
36
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
37
-
-
0034646674
-
Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta
-
Von Gersdorff G, Susztak K, Rezvani F, Bitzer M, Liang D, Böttinger EP (2000) Smad3 And Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta. J Biol Chem 275: 11320-11326
-
(2000)
J Biol Chem
, vol.275
, pp. 11320-11326
-
-
Von Gersdorff, G.1
Susztak, K.2
Rezvani, F.3
Bitzer, M.4
Liang, D.5
Böttinger, E.P.6
-
38
-
-
0036734148
-
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
-
Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A, Osborne BA, Gottipati S, Aster JC, Hahn WC, Rudolf M, Siziopikou K, Kast WM, Miele L (2002) Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med 8: 979-986
-
(2002)
Nat Med
, vol.8
, pp. 979-986
-
-
Weijzen, S.1
Rizzo, P.2
Braid, M.3
Vaishnav, R.4
Jonkheer, S.M.5
Zlobin, A.6
Osborne, B.A.7
Gottipati, S.8
Aster, J.C.9
Hahn, W.C.10
Rudolf, M.11
Siziopikou, K.12
Kast, W.M.13
Miele, L.14
-
39
-
-
0033104503
-
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T Cell responsiveness to TGF-beta
-
Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H, Roberts AB, Deng C (1999) Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T Cell responsiveness to TGF-beta. EMBO J 18: 1280-1291
-
(1999)
EMBO J
, vol.18
, pp. 1280-1291
-
-
Yang, X.1
Letterio, J.J.2
Lechleider, R.J.3
Chen, L.4
Hayman, R.5
Gu, H.6
Roberts, A.B.7
Deng, C.8
-
40
-
-
0041836308
-
Hierarchical model of gene regulation by transforming growth factor beta
-
Yang YC, Piek E, Zavadil J, Liang D, Xie D, Heyer J, Pavlidis P, Kucherlapati R, Roberts AB, Böttinger EP (2003) Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci USA 100: 10269-10274
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10269-10274
-
-
Yang, Y.C.1
Piek, E.2
Zavadil, J.3
Liang, D.4
Xie, D.5
Heyer, J.6
Pavlidis, P.7
Kucherlapati, R.8
Roberts, A.B.9
Böttinger, E.P.10
-
41
-
-
0037099745
-
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
-
Yu L, Hebert MC, Zhang YE (2002) TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J 21: 3749-3759
-
(2002)
EMBO J
, vol.21
, pp. 3749-3759
-
-
Yu, L.1
Hebert, M.C.2
Zhang, Y.E.3
-
42
-
-
0035810944
-
Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta
-
Zavadil J, Bitzer M, Liang D, Yang YC, Massimi A, Kneitz S, Piek E, Böttinger EP (2001) Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc Natl Acad Sci USA 98: 6686-6691
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6686-6691
-
-
Zavadil, J.1
Bitzer, M.2
Liang, D.3
Yang, Y.C.4
Massimi, A.5
Kneitz, S.6
Piek, E.7
Böttinger, E.P.8
|