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Volumn 10, Issue 12, 2008, Pages 1444-1458

Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in ras-transformed breast epithelial cells

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN LIGHT CHAIN KINASE; RAC PROTEIN; RAS PROTEIN; UVOMORULIN;

EID: 57349178376     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.08968     Document Type: Article
Times cited : (69)

References (69)
  • 1
    • 23944501378 scopus 로고    scopus 로고
    • Cadherins and the mammary gland
    • Knudsen KA and Wheelock MJ (2005). Cadherins and the mammary gland. J Cell Biochem 95, 488-496.
    • (2005) J Cell Biochem , vol.95 , pp. 488-496
    • Knudsen, K.A.1    Wheelock, M.J.2
  • 3
    • 0035947772 scopus 로고    scopus 로고
    • E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner
    • Gottardi CJ, Wong E, and Gumbiner BM (2001). E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol 153, 1049-1060.
    • (2001) J Cell Biol , vol.153 , pp. 1049-1060
    • Gottardi, C.J.1    Wong, E.2    Gumbiner, B.M.3
  • 5
    • 42249099793 scopus 로고    scopus 로고
    • Heterogeneity of breast cancer metastases: Comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases
    • Wu JM, Fackler MJ, Halushka MK, Molavi DW, Taylor ME, Teo WW, Griffin C, Fetting J, Davidson NE, De Marzo AM, et al. (2008). Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res 14, 1938-1946.
    • (2008) Clin Cancer Res , vol.14 , pp. 1938-1946
    • Wu, J.M.1    Fackler, M.J.2    Halushka, M.K.3    Molavi, D.W.4    Taylor, M.E.5    Teo, W.W.6    Griffin, C.7    Fetting, J.8    Davidson, N.E.9    De Marzo, A.M.10
  • 7
    • 0037086277 scopus 로고    scopus 로고
    • The SLUG zinc-finger protein represses E-cadherin in breast cancer
    • Hajra KM, Chen DY, and Fearon ER (2002). The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res 62, 1613-1618.
    • (2002) Cancer Res , vol.62 , pp. 1613-1618
    • Hajra, K.M.1    Chen, D.Y.2    Fearon, E.R.3
  • 8
    • 0033518130 scopus 로고    scopus 로고
    • Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements
    • Hajra KM, Ji X, and Fearon ER (1999). Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements. Oncogene 18, 7274-7279.
    • (1999) Oncogene , vol.18 , pp. 7274-7279
    • Hajra, K.M.1    Ji, X.2    Fearon, E.R.3
  • 9
    • 0242361298 scopus 로고    scopus 로고
    • Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase
    • Schmidt CR, Washington MK, Gi YJ, Coffey RJ, Beauchamp RD, and Pearson AS (2003). Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase. Am J Surg 186, 426-430.
    • (2003) Am J Surg , vol.186 , pp. 426-430
    • Schmidt, C.R.1    Washington, M.K.2    Gi, Y.J.3    Coffey, R.J.4    Beauchamp, R.D.5    Pearson, A.S.6
  • 10
    • 0035186670 scopus 로고    scopus 로고
    • Immunocytochemical expression of E-cadherin on fine-needle aspirates from breast carcinomas correlate with the cell dissociation pattern seen on smears
    • Sauer T, Boudjema G, Jebsen PW, and Naess O (2001). Immunocytochemical expression of E-cadherin on fine-needle aspirates from breast carcinomas correlate with the cell dissociation pattern seen on smears. Diagn Cytopathol 25, 382-388.
    • (2001) Diagn Cytopathol , vol.25 , pp. 382-388
    • Sauer, T.1    Boudjema, G.2    Jebsen, P.W.3    Naess, O.4
  • 11
    • 35548958302 scopus 로고    scopus 로고
    • Making and breaking contacts: The cellular biology of cadherin regulation
    • Yap AS, Crampton MS, and Hardin J (2007). Making and breaking contacts: the cellular biology of cadherin regulation. Curr Opin Cell Biol 19, 508-514.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 508-514
    • Yap, A.S.1    Crampton, M.S.2    Hardin, J.3
  • 12
    • 14644416543 scopus 로고    scopus 로고
    • Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion
    • Nasarre P, Kusy S, Constantin B, Castellani V, Drabkin HA, Bagnard D, and Roche J (2005). Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion. Neoplasia 7, 180-189.
    • (2005) Neoplasia , vol.7 , pp. 180-189
    • Nasarre, P.1    Kusy, S.2    Constantin, B.3    Castellani, V.4    Drabkin, H.A.5    Bagnard, D.6    Roche, J.7
  • 13
    • 4143146438 scopus 로고    scopus 로고
    • The ins and outs of E-cadherin trafficking
    • Bryant DM and Stow JL (2004). The ins and outs of E-cadherin trafficking. Trends Cell Biol 14, 427-434.
    • (2004) Trends Cell Biol , vol.14 , pp. 427-434
    • Bryant, D.M.1    Stow, J.L.2
  • 14
    • 0030785342 scopus 로고    scopus 로고
    • Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells
    • Zhong C, Kinch MS, and Burridge K (1997). Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells. Mol Biol Cell 8, 2329-2344.
    • (1997) Mol Biol Cell , vol.8 , pp. 2329-2344
    • Zhong, C.1    Kinch, M.S.2    Burridge, K.3
  • 15
    • 0030968177 scopus 로고    scopus 로고
    • The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
    • Braga VM, Machesky LM, Hall A, and Hotchin NA (1997). The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol 137, 1421-1431.
    • (1997) J Cell Biol , vol.137 , pp. 1421-1431
    • Braga, V.M.1    Machesky, L.M.2    Hall, A.3    Hotchin, N.A.4
  • 16
    • 2642615752 scopus 로고    scopus 로고
    • Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells
    • Wojciak-Stothard B, Entwistle A, Garg R, and Ridley AJ (1998). Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells. J Cell Physiol 176, 150-165.
    • (1998) J Cell Physiol , vol.176 , pp. 150-165
    • Wojciak-Stothard, B.1    Entwistle, A.2    Garg, R.3    Ridley, A.J.4
  • 17
    • 19644377230 scopus 로고    scopus 로고
    • Polarized trafficking of E-cadherin is regulated by Rac1 and Cdc42 in Madin-Darby canine kidney cells
    • Wang B, Wylie FG, Teasdale RD, and Stow JL (2005). Polarized trafficking of E-cadherin is regulated by Rac1 and Cdc42 in Madin-Darby canine kidney cells. Am J Physiol Cell Physiol 288, C1411-C1419.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Wang, B.1    Wylie, F.G.2    Teasdale, R.D.3    Stow, J.L.4
  • 18
    • 2542426492 scopus 로고    scopus 로고
    • Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition
    • Avizienyte E, Fincham VJ, Brunton VG, and Frame MC (2004). Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Mol Biol Cell 15, 2794-2803.
    • (2004) Mol Biol Cell , vol.15 , pp. 2794-2803
    • Avizienyte, E.1    Fincham, V.J.2    Brunton, V.G.3    Frame, M.C.4
  • 19
    • 2442552774 scopus 로고    scopus 로고
    • E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases
    • Qian X, Karpova T, Sheppard AM, McNally J, and Lowy DR (2004). E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases. EMBO J 23, 1739-1748.
    • (2004) EMBO J , vol.23 , pp. 1739-1748
    • Qian, X.1    Karpova, T.2    Sheppard, A.M.3    McNally, J.4    Lowy, D.R.5
  • 21
    • 0032502669 scopus 로고    scopus 로고
    • The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton
    • Hazan RB and Norton L (1998). The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. J Biol Chem 273, 9078-9084.
    • (1998) J Biol Chem , vol.273 , pp. 9078-9084
    • Hazan, R.B.1    Norton, L.2
  • 22
    • 0028170977 scopus 로고
    • Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
    • Hoschuetzky H, Aberle H, and Kemler R (1994). Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 127, 1375-1380.
    • (1994) J Cell Biol , vol.127 , pp. 1375-1380
    • Hoschuetzky, H.1    Aberle, H.2    Kemler, R.3
  • 23
    • 0036748514 scopus 로고    scopus 로고
    • Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis
    • Nam JS, Ino Y, Sakamoto M, and Hirohashi S (2002). Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis. Jpn J Cancer Res 93, 1020-1028.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 1020-1028
    • Nam, J.S.1    Ino, Y.2    Sakamoto, M.3    Hirohashi, S.4
  • 24
    • 33847236288 scopus 로고    scopus 로고
    • MEK/ERK regulates adherens junctions and migration through Rac1
    • Ray RM, Vaidya RJ, and Johnson LR (2007). MEK/ERK regulates adherens junctions and migration through Rac1. Cell Motil Cytoskeleton 64, 143-156.
    • (2007) Cell Motil Cytoskeleton , vol.64 , pp. 143-156
    • Ray, R.M.1    Vaidya, R.J.2    Johnson, L.R.3
  • 25
    • 0034658674 scopus 로고    scopus 로고
    • Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition
    • Zondag GC, Evers EE, ten Klooster JP, Janssen L, van der Kammen RA, and Collard JG (2000). Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. J Cell Biol 149, 775-782.
    • (2000) J Cell Biol , vol.149 , pp. 775-782
    • Zondag, G.C.1    Evers, E.E.2    ten Klooster, J.P.3    Janssen, L.4    van der Kammen, R.A.5    Collard, J.G.6
  • 26
    • 24344489479 scopus 로고    scopus 로고
    • E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells
    • Schmidt CR, Gi YJ, Patel TA, Coffey RJ, Beauchamp RD, and Pearson AS (2005). E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Surgery 138, 306-312.
    • (2005) Surgery , vol.138 , pp. 306-312
    • Schmidt, C.R.1    Gi, Y.J.2    Patel, T.A.3    Coffey, R.J.4    Beauchamp, R.D.5    Pearson, A.S.6
  • 27
    • 3843120071 scopus 로고    scopus 로고
    • Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells
    • Schmidt CR, Gi YJ, Coffey RJ, Beauchamp RD, and Pearson AS (2004). Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells. Surgery 136, 303-309.
    • (2004) Surgery , vol.136 , pp. 303-309
    • Schmidt, C.R.1    Gi, Y.J.2    Coffey, R.J.3    Beauchamp, R.D.4    Pearson, A.S.5
  • 29
    • 0025818032 scopus 로고
    • Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
    • Vleminckx K, Vakaet L Jr, Mareel M, Fiers W, and van Roy F (1991). Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66, 107-119.
    • (1991) Cell , vol.66 , pp. 107-119
    • Vleminckx, K.1    Vakaet Jr, L.2    Mareel, M.3    Fiers, W.4    van Roy, F.5
  • 30
    • 0034650586 scopus 로고    scopus 로고
    • H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: A role for MMP-2 in the H-ras-induced invasive phenotype
    • Moon A, Kim MS, Kim TG, Kim SH, Kim HE, Chen YQ, and Kim HR (2000). H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: a role for MMP-2 in the H-ras-induced invasive phenotype. Int J Cancer 85, 176-181.
    • (2000) Int J Cancer , vol.85 , pp. 176-181
    • Moon, A.1    Kim, M.S.2    Kim, T.G.3    Kim, S.H.4    Kim, H.E.5    Chen, Y.Q.6    Kim, H.R.7
  • 31
    • 41649085584 scopus 로고    scopus 로고
    • p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer
    • Li Q, Mullins SR, Sloane BF, and Mattingly RR (2008). p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia 10, 314-329.
    • (2008) Neoplasia , vol.10 , pp. 314-329
    • Li, Q.1    Mullins, S.R.2    Sloane, B.F.3    Mattingly, R.R.4
  • 33
    • 29244466812 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines
    • Mattingly RR, Kraniak JM, Dilworth JT, Mathieu P, Bealmear B, Nowak JE, Benjamins JA, Tainsky MA, and Reiners JJ Jr (2006). The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines. J Pharmacol Exp Ther 316, 456-465.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 456-465
    • Mattingly, R.R.1    Kraniak, J.M.2    Dilworth, J.T.3    Mathieu, P.4    Bealmear, B.5    Nowak, J.E.6    Benjamins, J.A.7    Tainsky, M.A.8    Reiners Jr, J.J.9
  • 34
    • 33745745744 scopus 로고    scopus 로고
    • The Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology
    • Yang H and Mattingly RR (2006). The Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology. Mol Biol Cell 17, 2177-2189.
    • (2006) Mol Biol Cell , vol.17 , pp. 2177-2189
    • Yang, H.1    Mattingly, R.R.2
  • 36
    • 23244467708 scopus 로고    scopus 로고
    • Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis
    • Menard RE, Jovanovski AP, and Mattingly RR (2005). Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis. Neoplasia 7, 638-645.
    • (2005) Neoplasia , vol.7 , pp. 638-645
    • Menard, R.E.1    Jovanovski, A.P.2    Mattingly, R.R.3
  • 38
    • 0030044330 scopus 로고    scopus 로고
    • MCF10AT: A model for the evolution of cancer from proliferative breast disease
    • Dawson PJ, Wolman SR, Tait L, Heppner GH, and Miller FR (1996). MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am J Pathol 148, 313-319.
    • (1996) Am J Pathol , vol.148 , pp. 313-319
    • Dawson, P.J.1    Wolman, S.R.2    Tait, L.3    Heppner, G.H.4    Miller, F.R.5
  • 39
    • 3042742432 scopus 로고    scopus 로고
    • Eckert LB, Repasky GA, Ulku AS, McFall A, Zhou H, Sartor CI, and Der CJ (2004). Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res 64, 4585-4592.
    • Eckert LB, Repasky GA, Ulku AS, McFall A, Zhou H, Sartor CI, and Der CJ (2004). Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res 64, 4585-4592.
  • 40
    • 0037306387 scopus 로고    scopus 로고
    • Inhibiting Ras signaling in the therapy of breast cancer
    • discussion 417-420
    • Li T and Sparano JA (2003). Inhibiting Ras signaling in the therapy of breast cancer. Clin Breast Cancer 3, 405-416discussion 417-420.
    • (2003) Clin Breast Cancer , vol.3 , pp. 405-416
    • Li, T.1    Sparano, J.A.2
  • 42
    • 0034686626 scopus 로고    scopus 로고
    • MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ
    • Miller FR, Santner SJ, Tait L, and Dawson PJ (2000). MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ. J Natl Cancer Inst 92, 1185-1186.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1185-1186
    • Miller, F.R.1    Santner, S.J.2    Tait, L.3    Dawson, P.J.4
  • 45
    • 25844469620 scopus 로고    scopus 로고
    • Inhibition of either phosphatidylinositol 3-kinase/Akt or the mitogen/extracellular-regulated kinase, MEK/ERK, signaling pathways suppress growth of breast cancer cell lines, but MEK/ERK signaling is critical for cell survival
    • Ripple MO, Kalmadi S, and Eastman A (2005). Inhibition of either phosphatidylinositol 3-kinase/Akt or the mitogen/extracellular-regulated kinase, MEK/ERK, signaling pathways suppress growth of breast cancer cell lines, but MEK/ERK signaling is critical for cell survival. Breast Cancer Res Treat 93, 177-188.
    • (2005) Breast Cancer Res Treat , vol.93 , pp. 177-188
    • Ripple, M.O.1    Kalmadi, S.2    Eastman, A.3
  • 46
    • 32844465287 scopus 로고    scopus 로고
    • Regulatory mechanisms controlling human E-cadherin gene expression
    • Liu YN, Lee WW, Wang CY, Chao TH, Chen Y, and Chen JH (2005). Regulatory mechanisms controlling human E-cadherin gene expression. Oncogene 24, 8277-8290.
    • (2005) Oncogene , vol.24 , pp. 8277-8290
    • Liu, Y.N.1    Lee, W.W.2    Wang, C.Y.3    Chao, T.H.4    Chen, Y.5    Chen, J.H.6
  • 47
    • 0345599013 scopus 로고    scopus 로고
    • Autoregulation of E-cadherin expression by cadherin-cadherin interactions: The roles of beta-catenin signaling, Slug, and MAPK
    • Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, and Ben-Ze'ev A (2003). Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol 163, 847-857.
    • (2003) J Cell Biol , vol.163 , pp. 847-857
    • Conacci-Sorrell, M.1    Simcha, I.2    Ben-Yedidia, T.3    Blechman, J.4    Savagner, P.5    Ben-Ze'ev, A.6
  • 48
    • 34347255755 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells
    • Choi J, Park SY, and Joo CK (2007). Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells. Invest Ophthalmol Vis Sci 48, 2708-2718.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 2708-2718
    • Choi, J.1    Park, S.Y.2    Joo, C.K.3
  • 49
    • 0141756144 scopus 로고    scopus 로고
    • Role of Rho-family proteins in cell adhesion and cancer
    • Malliri A and Collard JG (2003). Role of Rho-family proteins in cell adhesion and cancer. Curr Opin Cell Biol 15, 583-589.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 583-589
    • Malliri, A.1    Collard, J.G.2
  • 55
    • 38349023012 scopus 로고    scopus 로고
    • Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    • Vesuna F, van Diest P, Chen JH, and Raman V (2008). Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer. Biochem Biophys Res Commun 367, 235-241.
    • (2008) Biochem Biophys Res Commun , vol.367 , pp. 235-241
    • Vesuna, F.1    van Diest, P.2    Chen, J.H.3    Raman, V.4
  • 58
    • 1442278555 scopus 로고    scopus 로고
    • Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis
    • Ward KR, Zhang KX, Somasiri AM, Roskelley CD, and Schrader JW (2004). Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis. Oncogene 23, 1187-1196.
    • (2004) Oncogene , vol.23 , pp. 1187-1196
    • Ward, K.R.1    Zhang, K.X.2    Somasiri, A.M.3    Roskelley, C.D.4    Schrader, J.W.5
  • 59
    • 0027406396 scopus 로고
    • Different levels of v-Ha-ras p21 expression in primary keratinocytes transformed with Harvey sarcoma virus correlate with benign versus malignant behavior
    • Brissette JL, Missero C, Yuspa SH, and Dotto GP (1993). Different levels of v-Ha-ras p21 expression in primary keratinocytes transformed with Harvey sarcoma virus correlate with benign versus malignant behavior. Mol Carcinog 7, 21-25.
    • (1993) Mol Carcinog , vol.7 , pp. 21-25
    • Brissette, J.L.1    Missero, C.2    Yuspa, S.H.3    Dotto, G.P.4
  • 60
    • 24344491428 scopus 로고    scopus 로고
    • Pathwayand expression level-dependent effects of oncogenic N-Ras: P27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling
    • Kfir S, Ehrlich M, Goldshmid A, Liu X, Kloog Y, and Henis YI (2005). Pathwayand expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling. Mol Cell Biol 25, 8239-8250.
    • (2005) Mol Cell Biol , vol.25 , pp. 8239-8250
    • Kfir, S.1    Ehrlich, M.2    Goldshmid, A.3    Liu, X.4    Kloog, Y.5    Henis, Y.I.6
  • 61
    • 0042349229 scopus 로고    scopus 로고
    • ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
    • Vial E, Sahai E, and Marshall CJ (2003). ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell 4, 67-79.
    • (2003) Cancer Cell , vol.4 , pp. 67-79
    • Vial, E.1    Sahai, E.2    Marshall, C.J.3
  • 62
    • 1442352096 scopus 로고    scopus 로고
    • EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation
    • Jiang K, Delarue FL, and Sebti SM (2004). EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation. Oncogene 23, 1136-1145.
    • (2004) Oncogene , vol.23 , pp. 1136-1145
    • Jiang, K.1    Delarue, F.L.2    Sebti, S.M.3
  • 63
    • 33646188288 scopus 로고    scopus 로고
    • Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells
    • Gu LZ, Hu WY, Antic N, Mehta R, Turner JR, and de Lanerolle P (2006). Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells. Eur J Cancer 42, 948-957.
    • (2006) Eur J Cancer , vol.42 , pp. 948-957
    • Gu, L.Z.1    Hu, W.Y.2    Antic, N.3    Mehta, R.4    Turner, J.R.5    de Lanerolle, P.6
  • 64
    • 0030718609 scopus 로고    scopus 로고
    • Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells
    • Takaishi K, Sasaki T, Kotani H, Nishioka H, and Takai Y (1997). Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol 139, 1047-1059.
    • (1997) J Cell Biol , vol.139 , pp. 1047-1059
    • Takaishi, K.1    Sasaki, T.2    Kotani, H.3    Nishioka, H.4    Takai, Y.5
  • 66
    • 0034808219 scopus 로고    scopus 로고
    • RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells
    • Liu AX, Rane N, Liu JP, and Prendergast GC (2001). RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. Mol Cell Biol 21, 6906-6912.
    • (2001) Mol Cell Biol , vol.21 , pp. 6906-6912
    • Liu, A.X.1    Rane, N.2    Liu, J.P.3    Prendergast, G.C.4
  • 67
    • 0036785434 scopus 로고    scopus 로고
    • Potent suppression of proliferation of a10 vascular smooth muscle cells by combined treatment with lovastatin and 3-allylfarnesol, an inhibitor of protein farnesyltransferase
    • Mattingly RR, Gibbs RA, Menard RE, and Reiners JJ Jr (2002). Potent suppression of proliferation of a10 vascular smooth muscle cells by combined treatment with lovastatin and 3-allylfarnesol, an inhibitor of protein farnesyltransferase. J Pharmacol Exp Ther 303, 74-81.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 74-81
    • Mattingly, R.R.1    Gibbs, R.A.2    Menard, R.E.3    Reiners Jr, J.J.4
  • 69
    • 0242468891 scopus 로고    scopus 로고
    • CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)
    • Allen LF, Sebolt-Leopold J, and Meyer MB (2003). CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol 30, 105-116.
    • (2003) Semin Oncol , vol.30 , pp. 105-116
    • Allen, L.F.1    Sebolt-Leopold, J.2    Meyer, M.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.