Role of dietary polyphenols in attenuating brain edema and cell swelling in cerebral ischemia

Recent Patents on CNS Drug Discovery

Volumn 5, Issue 2, 2010, Pages 99-108

  Panickar, Kiran S ^a   Anderson, Richard A ^a  

^a BELTSVILLE HUMAN NUTRITION RESEARCH CENTER   (United States)

Author keywords

Cinnamon; Edema; Ischemia; Mitochondria; Obesity; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; BLUEBERRY EXTRACT; CATECHIN; CINNAMON EXTRACT; CYCLOSPORIN A; EPIGALLOCATECHIN GALLATE; GREEN TEA EXTRACT; PLACEBO; POLYPHENOL; QUERCETIN; RESVERATROL; TACROLIMUS; TANNIN DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN EDEMA; BRAIN ISCHEMIA; CELL SWELLING; CLINICAL FEATURE; COGNITIVE DEFECT; DIETARY INTAKE; DRUG MECHANISM; HUMAN; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; FLAVONOIDS; HUMANS; NEUROGLIA; NEURONS; PHENOLS; PLANT PREPARATIONS;

EID: 77953818051     PISSN: 15748898     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488910791213149     Document Type: Article

References (132)

1. Bravo L. Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 1998; 56(11): 317-333
2. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: Food sources and bioavailability. Am J Clin Nutr 2004; 79(5): 727-747
3. Ross JA, Kasum CM. Dietary flavonoids: Bioavailability, metabolic effects, and safety. Annu Rev Nutr 2002; 22: 19-34.
4. Hendrich AB. Flavonoid-membrane interactions: Possible consequences for biological effects of some polyphenolic compounds. Acta Pharmacol Sin 2006; 27(1): 27-40.
5. Han X, Shen T, Lou H. Dietary polyphenols and their biological significance. Int J Mol Sci 2007; 8: 950-88.
6. Panickar KS, Norenberg MD.Astrocytes in cerebral ischemic injury: Morphological and general considerations. Glia 2005; 50(4): 287-298.
7. Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA.Flavonoids: A review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001; 74(4): 418-25.
8. Myhill, P.R., Driscoll,W.J.Methods for enhancing antioxidant enzyme activity and reducing c-reactive protein levels. US7579026 (2009)
9. Inanami O, Watanabe Y, Syuto B, Nakano M, Tsuji M, Kuwabara M. Oral administration of (-)catechin protects against ischemia-reperfusion-induced neuronal death in the gerbil. Free Radic Res 1998; 29(4): 359-65.
10. Sutherland BA, Rahman RM, Appleton I.Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration.J Nutr Biochem 2006; 17(5): 291-306.
11. Lee H, Bae JH, Lee SR. Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils. J Neurosci Res 2004; 77(6): 892-900.
12. Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Yun YP, et al. Protective effect of green tea extract on ischemia/reperfusion-induced brain injury in Mongolian gerbils. Brain Res 2001; 888: 11-8.
13. Sinha K, Chaudhary G, Gupta YK.Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci 2002; 71(6): 655-65.
14. Wang Q, Xu J, Rottinghaus GE, Simonyi A, Lubahn D, Sun GY, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res 2002; 958(2): 439-47.
15. Caplan LR, Schmahmann JD, Kase CS, Feldmann E, Baquis G, Greenberg JP, et al. Caudate infarcts. Arch Neurol 1990; 47(2): 133-43.
16. Phipps L. Assessment of neurologic deficits in stroke: Acute-care and rehabilitation implications. Nurs Clin North Am 1991; 26: 957-70.
17. Markgraf CG, Green EJ, Hurwitz BE, Morikawa E, Dietrich WD, McCabe PM, et al. Sensorimotor and cognitive conse-quences of middle cerebral artery occlusion in rats. Brain Res 1992; 575(2): 238-46.
18. Cain DP, Boon F. Detailed behavioral analysis reveals both task strategies and spatial memory impairments in rats given bilateral middle cerebral artery stroke. Brain Res 2003; 972(1-2): 64-74.
19. Deschamps V, Barberger-Gateau P, Peuchant E, Orgogozo JM.Nutritional factors in cerebral aging and dementia: Epidemiological arguments for a role of oxidative stress. Neuroepidemiology 2001; 20(1): 7-15.
20. Joseph JA, Denisova NA, Bielinski D, Fisher DR, Shukitt-Hale B. Oxidative stress protection and vulnerability in aging: Putative nutritional implications for intervention. Mech Ageing Dev 2000; 116(2-3): 141-53.
21. Youdim KA, Joseph JA.A possible emerging role of phyto-chemicals in improving age-related neurological dysfunctions: A multiplicity of effects. Free Radic Biol Med 2001; 30(6): 583-94.
22. Pu F, Mishima K, Egashira N, Iwasaki K, Kaneko T, Uchida T, Protective effect of buckwheat polyphenols against long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia. J Pharmacol Sci 2004; 94(4): 393-402.
23. Wang Q, Sun AY, Simonyi A, Miller DK, Smith RE, Luchtefeld RG, et al. Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: Comparison of pre-and post-ischemic administration. J Nutr Biochem 2008; 20(5): 369-77.
24. Huh JW, Widing AG, Raghupathi R. Midline brain injury in the immature rat induces sustained cognitive deficits, bihemispheric axonal injury and neurodegeneration. Exp Neurol 2008; 213(1): 84-92.
25. Klatzo I.Pathophysiological aspects of brain edema.Acta Neuropathol 1987; 72(3): 236-39.
26. Katzman R, Clasen R, Klatzo I, Meyer JS, Pappius HM, Waltz AG.Report of Joint Committee for Stroke Resources. IV. Brain edema in stroke. Stroke 1977; 8(4): 512-40.
27. Kimelberg HK.Current concepts of brain edema.Review of laboratory investigations.J Neurosurg 1995; 83(6): 1051-9.
28. Garcia JH, Kalimo H, Kamijyo Y, Trump BF. Cellular events during partial cerebral ischemia.I. Electron microscopy of feline cerebral cortex after middle-cerebral-artery occlusion. Virchows Arch B Cell Pathol 1977; 25(3): 191-206.
29. Petito CK, Pulsinelli WA, Jacobson G, Plum F. Edema and vascular permeability in cerebral ischemia: Comparison between ischemic neuronal damage and infarction. J Neuropathol Exp Neurol 1982; 41(4): 423-36.
30. Klatzo I.Pathophysiological aspects of brain edema.Acta Neuropathol 1987; 72(3): 236-9.
31. Ito U, Ohno K, Nakamura R, Suganuma F, Inaba Y. Brain edema during ischemia and after restoration of blood flow.Measurement of water, sodium, potassium content and plasma protein permeability. Stroke 1979; 10(5): 542-7.
32. Brott T, Bogousslavsky J. Treatment of acute ischemic stroke.N Engl J Med 2000; 343(10): 710-22.
33. Garcia JH, Liu KF, Ho KL.Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex. Stroke 1995; 26(4): 636-42.
34. Zhang K, Lindsberg PJ, Tatlisumak T, Kaste M, Olsen HS, Andersson LC. Stanniocalcin: A molecular guard of neurons during cerebral ischemia. Proc Natl Acad Sci USA 2000; 97(7): 3637-42.
35. Dewar D, Underhill SM, Goldberg MP.Oligodendrocytes and ischemic brain injury.J Cereb Blood Flow Metab 2003; 23(3): 263-74.
36. Lee JH, Song DK, Jung CH, Shin DH, Park J, Kwon TK, et al. (-)-Epigallocatechin gallate attenuates glutamate-induced cytotoxicity via intracellular Ca modulation in PC12 cells. Clin Exp Pharmacol Physiol 2004; 31(8): 530-6.
37. Panickar KS, Polansky MM, Anderson RA.Green tea polyphenols attenuate glial swelling and mitochondrial dysfunction following oxygen-glucose deprivation in cultures.Nutr Neurosci 2009; 12(3): 105-13.
38. Panickar KS, Polansky MM, Anderson RA.Cinnamon polyphenols attenuate cell swelling and mitochondrial dysfunction following oxygen-glucose deprivation in glial cells. Exp Neurol 2009; 216(2): 420-7.
39. Kuroiwa T, Shibutani M, Okeda R. Nonhyperemic blood flow restoration and brain edema in experimental focal cerebral ischemia. J Neurosurg 1989; 70(1): 73-80.
40. Nakagawa Y, Fujimoto N, Matsumoto K, Cervós-Navarro. Morphological changes in acute cerebral ischemia after occlusion and reperfusion in the rat. Adv Neurol 1990; 52: 21-7
41. Utepbergenov DI, Fanning AS, Anderson JM.Dimerization of the scaffolding protein ZO-1 through the second PDZ domain.J Biol Chem 2006; 281(34): 24671-7.
42. Ito U, Go KG, Walker JT, Jr, Spatz M, Klatzo I. Experimental cerebral ischemia in Mongolian gerbils III. Behaviour of the blood-brain barrier.Acta Neuropathol 1976; 34(1): 1-6.
43. Kuroiwa T, Ueki M, Chen Q, Suemasu H, Taniguchi I, Okeda R. Biomechanical characteristics of brain edema: The difference between vasogenic-type and cytotoxic-type edema.Acta Neurochir Suppl (Wien) 1994; 60: 158-61.
44. Tan WK, Williams CE, During MJ, Mallard CE, Gunning MI, Gunn AJ, et al. Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep. Pediatr Res 1996; 39(5): 791-7.
45. Albers GW.Diffusion-weighted MRI for evaluation of acute stroke.Neurology 1998; 51(3 Suppl 3): S47-9.
46. Siesjö BK.Cerebral circulation and metabolism.J Neurosurg 1984; 60(5): 883-908.
47. Vexler ZS, Roberts TP, Bollen AW, Derugin N, Arieff AI.Transient cerebral ischemia. Association of apoptosis induction with hypoperfusion.J Clin Invest 1997; 99(6): 1453-9
48. Mellergård P, Bengtsson F, Smith ML, Riesenfeld V, Siesjö BK. Time course of early brain edema following reversible forebrain ischemia in rats. Stroke 1989; 20(11): 1565-70.
49. Ayata C, Ropper AH.Ischaemic brain oedema.J Clin Neurosci 2002; 9(2): 113-24.
50. 2+.Glia 1990; 3(5): 405-12.
51. Rutledge EM, Kimelberg HK.Release of [3H]-D-aspartate from primary astrocyte cultures in response to raised external potassium. J Neurosci 1996; 16(24): 7803-11.
52. Kimelberg HK.Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy.Glia 2005; 50(4): 389-97.
53. MacGregor DG, Avshalumov MV, Rice ME.Brain edema induced by in vitro ischemia: Causal factors and neuroprotection. J Neurochem 2003; 85(6): 1402-11.
54. Rao RKV, Chen M, Simard JM, Norenberg M. Suppression of ammonia-induced astrocyte swelling by cyclosporin A. J Neurosci Res 2003; 74(6): 891-7.
55. Panickar KS, Jayakumar AR, Norenberg MD.The mitochondrial permeability transition and MAP kinase phosphorylation in the mechanism of astrocyte swelling following in vitro trauma.Soc Neurosci Abstr 2006; 180: 14.
56. Jayakumar AR, Rao KV, Panickar KS, Moriyama M, Reddy PV, Norenberg MD. Trauma-induced cell swelling in cultured astrocytes. J Neuropathol Exp Neurol 2008; 67(5): 417-27.
57. Zoratti M, Szabò I.The mitochondrial permeability transition. Biochim Biophys Acta 1995; 1241(2): 139-76.
58. Bernardi P, Krauskopf A, Basso E, Petronilli V, Blachly-Dyson E, Di Lisa F, et al. The mitochondrial permeability transition from in vitro artifact to disease target.FEBS J 2006; 273(10): 2077-99.
59. Gunter TE, Pfeiffer DR. Mechanisms by which mitochondria transport calcium.Am J Physiol 1990; 258(5 Pt 1): C755-C86
60. Zamzami N, Hirsch T, Dallaporta B, Petit PX, Kroemer G. Mitochondrial implication in accidental and programmed cell death: Apoptosis and necrosis. J Bioenerg Biomembr 1997; 29(2): 185-93.
61. 2+ release to cyclosporine A and related compounds. Biochem Pharmacol 1993; 45(3): 641-6.
62. Connern CP, Halestrap AP. Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel.Biochem J 1994; 302 (Pt 2): 321-4.
63. Haas M.The Na-K-Cl cotransporters.Am J Physiol 1994; 267(4 Pt 1): C869-85
64. Chen H, Sun D.The role of Na-K-Cl co-transporter in cerebral ischemia.Neurol Res 2005; 27(3): 280-6.
65. Yan Y, Dempsey RJ, Flemmer A, Forbush B, Sun D. Inhibition of Na(+)-K(+)-Cl(-) cotransporter during focal cerebral ischemia decreases edema and neuronal damage. Brain Res 2003; 961(1): 22-31.
66. DiPolo R, Beaugé L. Sodium/calcium exchanger: Influence of metabolic regulation on ion carrier interactions. Physiol Rev 2006; 86(1): 155-203.
67. 2+ exchanger for the treatment of optic neuropathy associated with glaucoma and ischemic optic neuropathy. WO2003039573 (2003)
68. Orlowski J, Kandasamy RA, Shull GE.Molecular cloning of putative members of the Na/H exchanger gene family.cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem 1992; 267(13): 9331-9.
69. Pizzonia JH, Ransom BR, Pappas CA. Characterization of Na+/H+ exchange activity in cultured rat hippocampal astrocytes. J Neurosci Res 1996; 144(2): 191-8.
70. Boron WF, Fong P, Hediger MA, Boulpaep EL, Romero MF.The electrogenic Na/HCO3 cotransporter.Wien Klin Wochenschr 1997; 109(12-13): 445-56.
71. Chen M, Dong Y, Simard JM.Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain. J Neurosci 2003; 23(24): 8568-77.
72. Simard JM, Chen M, Tarasov KV, Bhatta S, Ivanova S, Melnitchenko L, et al. Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke. Nat Med 2006; 12(4): 433-40.
73. Chinopoulos C, Tretter L, Rozsa A, Adam-Vizi V. Exacerbated responses to oxidative stress by an Na(+)load in isolated nerve terminals: The role of ATP depletion and rise of [Ca(2+)](i). J Neurosci 2000; 20(6): 2094-103.
74. Haddad GG, Jiang C. Mechanisms of anoxia-induced depolarization in brainstem neurons: in vitro Current and voltage clamp studies in the adult rat. Brain Res 1993; 625(2): 261-8.
75. Calabresi P, Marfia GA, Centonze D, Pisani A, Bernardi G. Sodium influx plays a major role in the membrane depolarization induced by oxygen and glucose deprivation in rat striatal spiny neurons. Stroke 1999; 30(1): 171-9.
76. 2+ release from mitochondria. J Neurosci 1999; 19(9): 3307-15.
77. Agre P.The aquaporin water channels.Proc Am Thorac Soc 2006; 3(1): 5-13.
78. Jensen, P.H., Keller, D.Membrane for filtering of water.US20090120874A1 (2009)
79. Amiry-Moghaddam M, Ottersen OP.The molecular basis of water transport in the brain. Nat Rev Neurosci 2003; 4(12): 991-1001.
80. Nagelhus EA, Horio Y, Inanobe A, Fujita A, Haug FM, Nielsen S, et al. Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia 1999; 26(1): 47-54.
81. Saadoun S, Papadopoulos MC, Krishna S. Water transport becomes uncoupled from K+ siphoning in brain contusion, bacterial meningitis, and brain tumours: Immunohistochemical case review. J Clin Pathol 2003; 56(12): 972-5.
82. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 2000; 6(2): 159-63.
83. Heo JH, Lucero J, Abumiya T, Koziol JA, Copeland BR, del Zoppo G. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia. J Cereb Blood Flow Metab 1999; 19(6): 624-33.
84. Heo JH, Han SW, Lee SK. Free radicals as triggers of brain edema formation after stroke. Free Radic Biol Med 2005; 39(1): 51-70.
85. del Zoppo GJ, Schmid-Schönbein GW, Mori E, Copeland BR, Chang CM. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 1991; 22(10): 1276-83.
86. Urquiaga I, Leighton F.Plant polyphenol antioxidants and oxidative stress.Biol Res 2000; 33(2): 55-64.
87. Halliwell B.Are polyphenols antioxidants or pro-oxidants?What do we learn from cell culture and in vivo studies? Arch Biochem Biophys 2008; 476 (2): 107-12.
88. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, et al.Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem 2004; 52: 65-70.
89. Lee JS, Jeon SM, Park EM, Huh TL, Kwon OS, Lee MK, et al. Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. J Med Food 2003; 6 (3): 183-91.
90. Lin CC, Wu SJ, Chang CH, Ng LT. Antioxidant activity of Cinnamomum cassia. Phytother Res 2003; 17(7): 726-30.
91. Roussel AM, Benaraba R, Ziegenfuss TN, Anderson RA. Antioxidant effects of cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr 2009; 28(1): 16-21.
92. Jayakumar AR, Panickar KS, Murthy Ch.R, Norenberg MD.Oxidative stress and mitogen-activated protein kinase phosphory-lation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. J Neurosci 2006; 26(18): 4774-84.
93. Unterberg AW, Stover J, Kress B, Kiening KL.Edema and brain trauma.Neuroscience 2004; 129(4): 1021-9.
94. Marmarou A. Pathophysiology of traumatic brain edema: Current concepts. Acta Neurochir Suppl 2003; 86: 7-10.
95. Xue D, Slivka A, Buchan AM.Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats. Stroke 1992; 23: 894-9
96. Cherubini A, Ruggiero C, Morand C, Lattanzio F, Dell'aquila G, Zuliani G, et al. Dietary antioxidants as potential pharmacological agents for ischemic stroke. Curr Med Chem 2008; 15(12): 1236-48.
97. Sims NR, Finegan JM, Blass JP.Effects of postdecapitative ischemia on mitochondrial respiration in brain tissue homogenates.J Neurochem 1986; 47(2): 506-11.
98. Sims NR.Selective impairment of respiration in mitochondria isolated from brain subregions following transient forebrain ischemia in the rat. J Neurochem 1991; 56(6): 1836-44.
99. Wallace CH, Baczkó I, Jones L, Fercho M, Light PE.Inhibition of cardiac voltage-gated sodium channels by grape polyphenols. Br J Pharmacol 2006; 149(6): 657-65.
100. Sakagami H, Kuribayashi N, Iida M, Sakagami T, Takeda M, Fukuchi K. Induction of DNA fragmentation by tannin- and lignin-related substances. Anticancer Res 1995; 15(5B): 2121-8.
101. Martin S, Andriambeloson E, Takeda K, Andriantsitohaina R.Red wine polyphenols increase calcium in bovine aortic endothelial cells: A basis to elucidate signalling pathways leading to nitric oxide production. Br J Pharmacol 2002; 135(6): 1579-1587.
102. Wang H, Joseph JA.Structure-activity relationships of quercetin in antagonizing hydrogen peroxide-induced calcium dysregulation in PC12 cells.Free Radic Biol Med 1999; 27(5-6): 683-94.
103. Kanda T, Akiyama H, Yanagida A, Tanabe M, Goda Y, Toyoda M, et al.Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells. Biosci Biotechnol Biochem 1998; 62(7): 1284-9.
104. Cao H, Urban JF, Jr, Anderson RA.Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages. J Nutr 2008; 138: 5: 833-40.
105. Panickar KS, Cao HC, Qin B, Anderson RA.Molecular targets and therapeutic uses of cinnamon.Molecular targets and therapeutic uses of spices: Modern uses for ancient medicine. Monograph of Spices.In: Aggarwal BB, Kunnumakkara AB, Eds. World Scientific Publishing Co., Inc.: NY 2009; 87-115.
106. Fujiki H, Suganuma M, Okabe S, Sueoka E, Suga K, Imai K, et al. Mechanistic findings of green tea as cancer preventive for humans. Proc Soc Exp Biol Med 1999; 220(4): 225-8.
107. Bu SY, Lerner M, Stoecker BJ, Boldrin E, Brackett DJ, Lucas EA, et al. Dried plum polyphenols inhibit osteoclastogenesis by downregulating NFATc1 and inflammatory mediators. Calcif Tissue Int 2008; 82(6): 475-88.
108. Di Paola R, Mazzon E, Muià C, Genovese T, Menegazzi M, Zaffini R, et al. Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice. Respir Res 2005; 6: 66.
109. Subbaramaiah K, Chung WJ, Michaluart P, Telang N, Tanabe T, Inoue H, et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J Biol Chem 1998; 273(34): 21875-82.
110. Li YT, Shen F, Liu BH, Cheng GF.Resveratrol inhibits matrix metalloproteinase-9 transcription in U937 cells. Acta Pharmacol Sin 2003; 24(11): 1167-71.
111. Norenberg MD, Jayakumar AR, Rama RKV, Panickar KS.New concepts in the mechanism of ammonia-induced astrocyte swelling.Metab Brain Dis 2007; 22(3-4): 219-34.
112. Guo S, Yan J, Yang T, Yang X, Bezard E, Zhao B. Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway. Biol Psychiatry 2007; 62(12): 1353-62.
113. Guo S, Bezard E, Zhao B. Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway. Free Radic Biol Med 2005; 39(5): 682-95.
114. Bastianetto S, Zheng WH, Quirion R.Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons.Br J Pharmacol 2000; 131(4): 711-20.
115. Lau FC, Bielinski DF, Joseph JA.Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. J Neurosci Res 2007; 85(5): 1010-7.
116. Jendeková L, Kojsová S, Andriantsitohaina R, Pechánová O. The time-dependent effect of Provinols on brain NO synthase activity in L-NAME-induced hypertension. Physiol Res 2006; 55 (Suppl 1): S31-S7.
117. Lu KT, Chiou RY, Chen LG, Chen MH, Tseng WT, Hsieh HT, et al. Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation. J Agric Food Chem 2006; 54(8): 3126-31.
118. Kiziltepe U, Turan NN, Han U, Ulus AT, Akar F. Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury. J Vasc Surg 2004; 40(1): 138-45.
119. Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, et al. S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death. Science 2002; 297(5584): 1186-90.
120. Gürsoy-Ozdemir Y, Can A, Dalkara T. Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 2004; 35(6): 1449-53.
121. Chi OZ, Liu X, Weiss HR. Effects of cyclic GMP on microvascular permeability of the cerebral cortex. Microvasc Res 1999; 58(1): 35-40.
122. Abbott RD, Behrens GR, Sharp DS, Rodriguez BL, Burchfiel CM, Ross GW, et al. Body mass index and thromboembolic stroke in nonsmoking men in older middle age.The Honolulu Heart Program.Stroke 1994; 25(12): 2370-6.
123. Rexrode KM, Hennekens CH, Willett WC, Colditz GA, Stampfer MJ, Rich-Edwards JW, et al.A prospective study of body mass index, weight change, and risk of stroke in women. JAMA 1997; 277(19): 1539-45.
124. Kurth T, Gaziano JM, Berger K, Kase CS, Rexrode KM, Cook NR, et al. Body mass index and the risk of stroke in men. Arch Intern Med 2002; 162(22): 2557-62.
125. St-Pierre P, Bouffard L, Papirakis ME, Maheux P.Increased extravasation of macromolecules in skeletal muscles of the Zucker rat model. Obesity (Silver Spring) 2006; 14(5): 787-93.
126. Dell'Omo G, Penno G, Pucci L, Mariani M, Del Prato S, Pedrinelli R. Abnormal capillary permeability and endothelial dysfunction in hypertension with comorbid metabolic syndrome. Atherosclerosis 2004; 172(2): 383-9.
127. Terao S, Yilmaz G, Stokes KY, Ishikawa M, Kawase T, Granger DN. Inflammatory and injury responses to ischemic stroke in obese mice. Stroke 2008; 39(3): 943-50.
128. Khan A, Safdar M, Khan AMM, Khattak KN, Anderson RA.Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003; 26(12): 3215-8. [130]
129. Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA.Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr 2006; 3: 45-53.
130. Venables MC, Hulston CJ, Cox HR, Jeukendrup AE.Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr 2008; 87(3): 778-84.
131. Nagasako-Akazome Y, Kanda T, Ohtake Y, Shimasaki H, Kobayashi T. Apple polyphenols influence cholesterol metabolism in healthy subjects with relatively high body mass index. J Oleo Sci 2007; 56(8): 417-28.
132. Alkan A, Sahin I, Keskin L, Cikim A, Karakas H, Sigirci A, et al. Diffusion-weighted imaging features of brain in obesity. Magn Reson Imaging 2008; 26(4): 446-50.