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Volumn 54, Issue 8, 2006, Pages 3126-3131

Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation

Author keywords

Free radicals; Ischemia; Neuronal damage; Nitric oxide; Phytoestrogen

Indexed keywords

NEUROPROTECTIVE AGENT; RESVERATROL; SCAVENGER; STILBENE DERIVATIVE; SUPEROXIDE DISMUTASE;

EID: 33646526704     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf053011q     Document Type: Article
Times cited : (95)

References (51)
  • 1
    • 0037070370 scopus 로고    scopus 로고
    • Peanut roots as a source of resveratrol
    • Chen, R. S.; Wu, P. L.; Chiou, R. Y. Y. Peanut roots as a source of resveratrol. J. Agric. Food Chem. 2002, 50, 1665-1667.
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 1665-1667
    • Chen, R.S.1    Wu, P.L.2    Chiou, R.Y.Y.3
  • 2
    • 0030760030 scopus 로고    scopus 로고
    • Wine as a biological fluid: History, production, and role in disease prevention
    • Soleas, G. J.; Diamandis, E. P.; Goldberg, D. M. Wine as a biological fluid: history, production, and role in disease prevention. J. Clin. Lab. Anal. 1997, 11, 287-313.
    • (1997) J. Clin. Lab. Anal. , vol.11 , pp. 287-313
    • Soleas, G.J.1    Diamandis, E.P.2    Goldberg, D.M.3
  • 3
    • 0031444281 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor
    • Gehm, B. D.; McAndrews, J. M.; Chien, P. Y.; Jameson, J. L. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 14138-43.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 14138-14143
    • Gehm, B.D.1    McAndrews, J.M.2    Chien, P.Y.3    Jameson, J.L.4
  • 4
    • 0027396786 scopus 로고
    • Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine
    • Frankel, E. N.; Kanner, J.; German, J. B.; Parks, E.; Kinsella, J. E. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 1993, 341, 454-457.
    • (1993) Lancet , vol.341 , pp. 454-457
    • Frankel, E.N.1    Kanner, J.2    German, J.B.3    Parks, E.4    Kinsella, J.E.5
  • 7
    • 0030661964 scopus 로고    scopus 로고
    • Comparative study of radical scavenger and antioxidant properties of phenolic compounds from vinifera cell cultures using in vitro tests
    • Fauconnau, B.; Waffo-Teguo, P.; Hughet, F.; Barrier, L.; Decendit, A.; Merillon, J. M. Comparative study of radical scavenger and antioxidant properties of phenolic compounds from vinifera cell cultures using in vitro tests. Life Sci. 1997, 61, 2103-2110.
    • (1997) Life Sci. , vol.61 , pp. 2103-2110
    • Fauconnau, B.1    Waffo-Teguo, P.2    Hughet, F.3    Barrier, L.4    Decendit, A.5    Merillon, J.M.6
  • 8
    • 0032536359 scopus 로고    scopus 로고
    • Oxidized lipoprotein activate NF-κB binding activity and apoptosis in PC12 cells
    • Draczynska-Lusiak, B.; Chen, Y. M.; Sun, A. Y. Oxidized lipoprotein activate NF-κB binding activity and apoptosis in PC12 cells. Neuroreport 1998, 9, 527-532.
    • (1998) Neuroreport , vol.9 , pp. 527-532
    • Draczynska-Lusiak, B.1    Chen, Y.M.2    Sun, A.Y.3
  • 9
    • 0025881551 scopus 로고
    • Selective vulnerability of the hippocampus in brain ischemia
    • Schmidt-Kastner, R.; Freund, T. F. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 1991, 40, 599-636.
    • (1991) Neuroscience , vol.40 , pp. 599-636
    • Schmidt-Kastner, R.1    Freund, T.F.2
  • 11
    • 0032739003 scopus 로고    scopus 로고
    • Functional changes of N-methyl-D-aspartic acid and α-amino-3- hydroxy-5-methyl-4-isoxazolepropionate channels in gerbil hippocampal CA1, in relation to postischemic enhancement of glutamate receptor-mediated responses
    • Ikemune, K.; Mitani, A.; Namba, S.; Kataoka, K.; Arai, T. Functional changes of N-methyl-D-aspartic acid and α-amino-3-hydroxy-5-methyl-4- isoxazolepropionate channels in gerbil hippocampal CA1, in relation to postischemic enhancement of glutamate receptor-mediated responses. Neurosci. Lett. 1999, 275, 125-128.
    • (1999) Neurosci. Lett. , vol.275 , pp. 125-128
    • Ikemune, K.1    Mitani, A.2    Namba, S.3    Kataoka, K.4    Arai, T.5
  • 13
    • 0026008909 scopus 로고
    • Oxygen radical mechanisms of brain injury following ischemia and reperfusion
    • Traystman, R. J.; Kirsch, J. R.; Koehler, R. C. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 1991, 71, 1185-1195.
    • (1991) J. Appl. Physiol. , vol.71 , pp. 1185-1195
    • Traystman, R.J.1    Kirsch, J.R.2    Koehler, R.C.3
  • 14
    • 0029981730 scopus 로고    scopus 로고
    • Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta
    • Chen, C. K.; Pace-Asciak, C. R. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen. Pharmacol. 1996, 27, 363-366.
    • (1996) Gen. Pharmacol. , vol.27 , pp. 363-366
    • Chen, C.K.1    Pace-Asciak, C.R.2
  • 15
    • 0034682983 scopus 로고    scopus 로고
    • Cardioprotective effects of resveratrol, a natural antioxidant from grapes
    • Hung, L. M.; Chen, J. K.; Huang, S. S.; Lee, R. S.; Su, M. J. Cardioprotective effects of resveratrol, a natural antioxidant from grapes. Cardiovasc. Res. 2000, 47, 549-555.
    • (2000) Cardiovasc. Res. , vol.47 , pp. 549-555
    • Hung, L.M.1    Chen, J.K.2    Huang, S.S.3    Lee, R.S.4    Su, M.J.5
  • 16
    • 0033023541 scopus 로고    scopus 로고
    • Suppression of nitric oxide synthase and the downregulation of the activation of NFκB in macrophages by resveratrol
    • Tsai, S. H.; Lin-Shiao, S. Y.; Lin, J. K. Suppression of nitric oxide synthase and the downregulation of the activation of NFκB in macrophages by resveratrol. Br. J. Pharmacol. 1999, 126, 673-680.
    • (1999) Br. J. Pharmacol. , vol.126 , pp. 673-680
    • Tsai, S.H.1    Lin-Shiao, S.Y.2    Lin, J.K.3
  • 17
    • 0034670172 scopus 로고    scopus 로고
    • Synergy between ethanol and grape polyphenols, quercetin, and resveratrol in the inhibition of the inducible nitric oxide synthase pathway
    • Chan, M. Y.; Mattiacci, J. A.; Hwang, H. S.; Shah, A.; Fong, D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol in the inhibition of the inducible nitric oxide synthase pathway. Biochem. Pharmacol. 2000, 60, 1539-1548.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1539-1548
    • Chan, M.Y.1    Mattiacci, J.A.2    Hwang, H.S.3    Shah, A.4    Fong, D.5
  • 18
    • 0037189154 scopus 로고    scopus 로고
    • Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats
    • Sinha, K.; Chaudhary, G.; Gupta, Y. K. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci. 2002, 71, 655-665.
    • (2002) Life Sci. , vol.71 , pp. 655-665
    • Sinha, K.1    Chaudhary, G.2    Gupta, Y.K.3
  • 19
    • 0032801975 scopus 로고    scopus 로고
    • The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury
    • Ray, P. S.; Maulik, G.; Cordis, G. A.; Bertelli, A. A. E.; Bertelli, A.; Das, D. K. The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury. Free Radical Biol. Med. 1999, 27, 160-169.
    • (1999) Free Radical Biol. Med. , vol.27 , pp. 160-169
    • Ray, P.S.1    Maulik, G.2    Cordis, G.A.3    Bertelli, A.A.E.4    Bertelli, A.5    Das, D.K.6
  • 21
    • 0028677294 scopus 로고
    • Evidence for formation of hydroxyl radicals during reperfusion after global cerebral ischemia in rats using salicylate trapping and microdialysis
    • Christensen, T.; Bruhn, T.; Balchen, T.; Diemer, N. H. Evidence for formation of hydroxyl radicals during reperfusion after global cerebral ischemia in rats using salicylate trapping and microdialysis. Neurobiol. Dis. 1982, 1, 131-138.
    • (1982) Neurobiol. Dis. , vol.1 , pp. 131-138
    • Christensen, T.1    Bruhn, T.2    Balchen, T.3    Diemer, N.H.4
  • 23
    • 0020067965 scopus 로고
    • Temporal profile of neuronal damage in a model of transient forebrain ischemia
    • Pulsinelli, W. A.; Brierley, J. B.; Plum, F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 1982, 11, 491-498.
    • (1982) Ann. Neurol. , vol.11 , pp. 491-498
    • Pulsinelli, W.A.1    Brierley, J.B.2    Plum, F.3
  • 24
    • 0030599172 scopus 로고    scopus 로고
    • Brain nitrite production during global ischemia and reperfusion: An in vivo microdialysis study
    • Shibata, M.; Araki, N.; Hamada, J.; Sasaki, T.; Shimazu, K.; Fukuuchi, Y. Brain nitrite production during global ischemia and reperfusion: an in vivo microdialysis study. Brain Res. 1996, 734, 86-90.
    • (1996) Brain Res. , vol.734 , pp. 86-90
    • Shibata, M.1    Araki, N.2    Hamada, J.3    Sasaki, T.4    Shimazu, K.5    Fukuuchi, Y.6
  • 25
  • 26
    • 2142715917 scopus 로고    scopus 로고
    • FK506 abrogates delayed neuronal death via suppression of nitric oxide production in rats
    • Sasaki, T.; Hamada, J.; Shibata, M.; Gotoh, H.; Araki, N.; Fukuuchi, Y. FK506 abrogates delayed neuronal death via suppression of nitric oxide production in rats. Brain Res. 2004, 1009, 34-39.
    • (2004) Brain Res. , vol.1009 , pp. 34-39
    • Sasaki, T.1    Hamada, J.2    Shibata, M.3    Gotoh, H.4    Araki, N.5    Fukuuchi, Y.6
  • 27
    • 0017410626 scopus 로고
    • Superoxide dismutase: "positive" spectrophotometric assays
    • Misra, H. P.; Fridovich, I. Superoxide dismutase: "positive" spectrophotometric assays. Anal. Biochem. 1977, 70, 553-560.
    • (1977) Anal. Biochem. , vol.70 , pp. 553-560
    • Misra, H.P.1    Fridovich, I.2
  • 28
    • 0026651085 scopus 로고
    • Wine, alcohol, platelets, and the French paradox for coronary heart disease
    • Renaud, S.; DeLorgeril, M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992, 339, 1523-1526.
    • (1992) Lancet , vol.339 , pp. 1523-1526
    • Renaud, S.1    DeLorgeril, M.2
  • 29
    • 0033993607 scopus 로고    scopus 로고
    • Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agents, trans-resveratrol in rats
    • Virgil, M.; Contestabile, A. Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agents, trans-resveratrol in rats. Neurosci. Lett. 2000, 281, 123-126.
    • (2000) Neurosci. Lett. , vol.281 , pp. 123-126
    • Virgil, M.1    Contestabile, A.2
  • 30
    • 0031928451 scopus 로고    scopus 로고
    • Evaluation of kinetics parameters of naturally phytoalexin in resveratrol orally administered in wine to rats
    • Bertelli, A. A.; Giovannini, L.; Stradi, R.; Urien, S.; Tillement, J. P.; Bertelli, A. Evaluation of kinetics parameters of naturally phytoalexin in resveratrol orally administered in wine to rats. Drugs Exp. Clin. Res. 1998, 24, 51-55.
    • (1998) Drugs Exp. Clin. Res. , vol.24 , pp. 51-55
    • Bertelli, A.A.1    Giovannini, L.2    Stradi, R.3    Urien, S.4    Tillement, J.P.5    Bertelli, A.6
  • 31
    • 0023947826 scopus 로고
    • Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger
    • Abe, K.; Yuki, S.; Kogure, K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 1988, 19, 480-485.
    • (1988) Stroke , vol.19 , pp. 480-485
    • Abe, K.1    Yuki, S.2    Kogure, K.3
  • 32
    • 0026782517 scopus 로고
    • Pathophysiology and treatment of focal cerebral ischemia
    • Siesjö, B. K. Pathophysiology and treatment of focal cerebral ischemia. J. Neurosurg. 1992, 77, 337-354.
    • (1992) J. Neurosurg. , vol.77 , pp. 337-354
    • Siesjö, B.K.1
  • 33
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemia brain
    • Chan, P. H. Reactive oxygen radicals in signaling and damage in the ischemia brain. J. Cereb. Blood Flow Metab. 2001, 21, 2-14.
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 34
    • 0035175365 scopus 로고    scopus 로고
    • Protective effective of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats
    • Mizutani, K.; Ikeda, K.; Kawai, Y.; Yamori, Y. Protective effective of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 2001, 28, 55-59.
    • (2001) Clin. Exp. Pharmacol. Physiol. , vol.28 , pp. 55-59
    • Mizutani, K.1    Ikeda, K.2    Kawai, Y.3    Yamori, Y.4
  • 37
    • 0027251608 scopus 로고
    • Oxidative stress induced by glutamate receptor agonists
    • Bondy, S. C.; Lee, D. K. Oxidative stress induced by glutamate receptor agonists. Brain Res. 1993, 610, 229-233.
    • (1993) Brain Res. , vol.610 , pp. 229-233
    • Bondy, S.C.1    Lee, D.K.2
  • 38
    • 0027221998 scopus 로고
    • NMDA dependent superoxide production and neurotoxicity
    • Lafon-Cazal, M.; Pietri, S.; Culeasi, M.; Bockaert, J. NMDA dependent superoxide production and neurotoxicity. Nature 1993, 535-537.
    • (1993) Nature , pp. 535-537
    • Lafon-Cazal, M.1    Pietri, S.2    Culeasi, M.3    Bockaert, J.4
  • 39
    • 0343245712 scopus 로고
    • Interrelationship of excitotoxic and free radical mechanism
    • Krieglstein, J., Oberpichler-Schwenk, H., Eds.; Wissenschartliche Verlagsgesellschaft: Stuttgart, Germany
    • Boisvert, D. P. J.; Schreiber, C. Interrelationship of excitotoxic and free radical mechanism. In Pharmacology of Cerebral Ischemia; Krieglstein, J., Oberpichler-Schwenk, H., Eds.; Wissenschartliche Verlagsgesellschaft: Stuttgart, Germany, 1991; pp 311-320.
    • (1991) Pharmacology of Cerebral Ischemia , pp. 311-320
    • Boisvert, D.P.J.1    Schreiber, C.2
  • 40
    • 0027364979 scopus 로고
    • NMDA receptors increase OH radicals in vivo by using nitric oxide synthase and protein kinase C
    • Hammer, B.; Parker, W. D.; Bennett, J. P. NMDA receptors increase OH radicals in vivo by using nitric oxide synthase and protein kinase C. Neuroreport 1993, 5, 72-74.
    • (1993) Neuroreport , vol.5 , pp. 72-74
    • Hammer, B.1    Parker, W.D.2    Bennett, J.P.3
  • 41
    • 0026034352 scopus 로고
    • NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway
    • Dumuis, A.; Sebben, M.; Haynes, L.; Pin, J. P.; Bockaert, J. NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway. Neurosci. Lett. 1991, 123, 17-19.
    • (1991) Neurosci. Lett. , vol.123 , pp. 17-19
    • Dumuis, A.1    Sebben, M.2    Haynes, L.3    Pin, J.P.4    Bockaert, J.5
  • 42
    • 0027505884 scopus 로고
    • Hydroxyl radical production and lipid peroxidation parallels selective post-ischemic vulnerability in gerbil brain
    • Hall, E. D.; Andrus, P. K.; Althaus, J. S.; Von Voigtlander, P. F. Hydroxyl radical production and lipid peroxidation parallels selective post-ischemic vulnerability in gerbil brain. J. Neurosci. Res. 1993, 34, 107-112.
    • (1993) J. Neurosci. Res. , vol.34 , pp. 107-112
    • Hall, E.D.1    Andrus, P.K.2    Althaus, J.S.3    Von Voigtlander, P.F.4
  • 43
    • 0026034352 scopus 로고
    • NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway
    • East, S. J.; Garthwaite, J. NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway. Neurosci. Lett. 1991, 123, 17-19.
    • (1991) Neurosci. Lett. , vol.123 , pp. 17-19
    • East, S.J.1    Garthwaite, J.2
  • 44
    • 0034073967 scopus 로고    scopus 로고
    • Neuroprotection by 2-h postischemia administration of two free radical scavengers, α-phenyl-n-tert-butyl-nitrone (PBN) and N-teri-butyl-(2- sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia
    • Yang, Y.; Li, Q.; Shuaib, A. Neuroprotection by 2-h postischemia administration of two free radical scavengers, α-phenyl-n-tert-butyl- nitrone (PBN) and N-teri-butyl-(2-sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia. Exp. Neurol. 2000, 163, 39-45.
    • (2000) Exp. Neurol. , vol.163 , pp. 39-45
    • Yang, Y.1    Li, Q.2    Shuaib, A.3
  • 45
    • 0035235476 scopus 로고    scopus 로고
    • Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide related toxicity in cultured hippocampal neurons
    • Bastianetto, S.; Zheng, W. H.; Quirion, R. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide related toxicity in cultured hippocampal neurons. Br. J. Pharmacol. 2000, 31, 711-720.
    • (2000) Br. J. Pharmacol. , vol.31 , pp. 711-720
    • Bastianetto, S.1    Zheng, W.H.2    Quirion, R.3
  • 47
    • 0029841018 scopus 로고    scopus 로고
    • Measurement of nitric oxide and peroxynitrite generation in the postischemic heart: Evidence for peroxynitrite-mediated reperfusion injury
    • Wang, P.; Zweier, J. L. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart: evidence for peroxynitrite-mediated reperfusion injury. J. Biol. Chem. 1996, 271, 29223-29230.
    • (1996) J. Biol. Chem. , vol.271 , pp. 29223-29230
    • Wang, P.1    Zweier, J.L.2
  • 49
    • 0037072618 scopus 로고    scopus 로고
    • Effects of resveratrol-related hydroxystilbenes on the nitric oxide production in macrophage cells: Structural requirements and mechanisms of action
    • Cho, D. I.; Koo, N. Y.; Chung, W. J.; Kim, T. S.; Ryu, S. Y.; Im, S. Y.; Kim, K. M. Effects of resveratrol-related hydroxystilbenes on the nitric oxide production in macrophage cells: structural requirements and mechanisms of action. Life Sci. 2002, 71, 2071-2082.
    • (2002) Life Sci. , vol.71 , pp. 2071-2082
    • Cho, D.I.1    Koo, N.Y.2    Chung, W.J.3    Kim, T.S.4    Ryu, S.Y.5    Im, S.Y.6    Kim, K.M.7
  • 51
    • 0036086657 scopus 로고    scopus 로고
    • Pharmacological preconditioning with resveratrol: Role of nitric oxide
    • Hattori, R.; Otani, H.; Maulin, N.; Das, D. K. Pharmacological preconditioning with resveratrol: role of nitric oxide. Am. J. Physiol. 2002, 282, H1988-H1995.
    • (2002) Am. J. Physiol. , vol.282
    • Hattori, R.1    Otani, H.2    Maulin, N.3    Das, D.K.4


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