메뉴 건너뛰기




Volumn 85, Issue 5, 2007, Pages 1010-1017

Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia

Author keywords

Antioxidants; Cytokines; Microglia; Neuroinflammation

Indexed keywords

BLUEBERRY EXTRACT; CYCLOOXYGENASE 2; CYTOKINE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLANT EXTRACT; POLYPHENOL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 34147196050     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21205     Document Type: Article
Times cited : (213)

References (94)
  • 2
    • 0033963704 scopus 로고    scopus 로고
    • Oxidative stress and gene regulation
    • Allen RG, Tresini M. 2000. Oxidative stress and gene regulation. Free Radic Biol Med 28:463-499.
    • (2000) Free Radic Biol Med , vol.28 , pp. 463-499
    • Allen, R.G.1    Tresini, M.2
  • 3
    • 0031930771 scopus 로고    scopus 로고
    • Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease
    • Banati R, Daniel S, Blunt S. 1998. Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease. Move Disord 13:221-227.
    • (1998) Move Disord , vol.13 , pp. 221-227
    • Banati, R.1    Daniel, S.2    Blunt, S.3
  • 4
    • 0025233694 scopus 로고    scopus 로고
    • Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F. 1990. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 27:229-237.
    • Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F. 1990. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 27:229-237.
  • 6
    • 0029975684 scopus 로고    scopus 로고
    • In vitro anticancer activity of fruit extracts from Vaccinium species
    • Bomser J, Madhavi DL, Singletary K, Smith MA. 1996. In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med 62:212-216.
    • (1996) Planta Med , vol.62 , pp. 212-216
    • Bomser, J.1    Madhavi, D.L.2    Singletary, K.3    Smith, M.A.4
  • 7
    • 0004880564 scopus 로고    scopus 로고
    • Antioxidant capacity of tea and common vegetables
    • Cao G, Sofic E, Prior RL. 1996. Antioxidant capacity of tea and common vegetables. J Agric Food Chem 44:3426-3431.
    • (1996) J Agric Food Chem , vol.44 , pp. 3426-3431
    • Cao, G.1    Sofic, E.2    Prior, R.L.3
  • 8
    • 0035371508 scopus 로고    scopus 로고
    • Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide
    • Chen YC, Shen SC, Chen LG, Lee TJ, Yang LL. 2001. Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem Pharmacol 61:1417-1427.
    • (2001) Biochem Pharmacol , vol.61 , pp. 1417-1427
    • Chen, Y.C.1    Shen, S.C.2    Chen, L.G.3    Lee, T.J.4    Yang, L.L.5
  • 9
    • 21844478809 scopus 로고    scopus 로고
    • Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity
    • Chun W, Lee HJ, Kong PJ, Lee GH, Cheong IY, Park H, Kim SS. 2005. Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity. Arch Pharm Res 28:216-219.
    • (2005) Arch Pharm Res , vol.28 , pp. 216-219
    • Chun, W.1    Lee, H.J.2    Kong, P.J.3    Lee, G.H.4    Cheong, I.Y.5    Park, H.6    Kim, S.S.7
  • 11
    • 0029144638 scopus 로고
    • Nitric oxide and oxygen radicals: A question of balance
    • Darley-Usmar V, Wiseman H, Halliwell B. 1995. Nitric oxide and oxygen radicals: a question of balance. FEBS Lett 369:131-135.
    • (1995) FEBS Lett , vol.369 , pp. 131-135
    • Darley-Usmar, V.1    Wiseman, H.2    Halliwell, B.3
  • 12
    • 0035101295 scopus 로고    scopus 로고
    • Nutritional factors in cerebral aging and dementia: Epidemiological arguments for a role of oxidative stress
    • Deschamps V, Barberger-Gateau P, Peuchant E, Orgogozo JM. 2001. Nutritional factors in cerebral aging and dementia: epidemiological arguments for a role of oxidative stress. Neuroepidemiology 20:7-15.
    • (2001) Neuroepidemiology , vol.20 , pp. 7-15
    • Deschamps, V.1    Barberger-Gateau, P.2    Peuchant, E.3    Orgogozo, J.M.4
  • 13
    • 0032453672 scopus 로고    scopus 로고
    • Microglia in cell culture and in transplantation therapy for central nervous system disease
    • Dobrenis K. 1998. Microglia in cell culture and in transplantation therapy for central nervous system disease. Methods 16:320-344.
    • (1998) Methods , vol.16 , pp. 320-344
    • Dobrenis, K.1
  • 14
    • 0037338145 scopus 로고    scopus 로고
    • Vitamin E (alpha-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia
    • Egger T, Schuligoi R, Wintersperger A, Amann R, Malle E, Sattler W. 2003. Vitamin E (alpha-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia. Biochem J 370:459-467.
    • (2003) Biochem J , vol.370 , pp. 459-467
    • Egger, T.1    Schuligoi, R.2    Wintersperger, A.3    Amann, R.4    Malle, E.5    Sattler, W.6
  • 15
    • 0030250852 scopus 로고    scopus 로고
    • The role of complement and activated microglia in the pathogenesis of Alzheimer's disease
    • Eikelenboom P, Veerhuis R. 1996. The role of complement and activated microglia in the pathogenesis of Alzheimer's disease. Neurobiol Aging 17:673-680.
    • (1996) Neurobiol Aging , vol.17 , pp. 673-680
    • Eikelenboom, P.1    Veerhuis, R.2
  • 16
    • 0032464635 scopus 로고    scopus 로고
    • Pathophysiology of nitric oxide and related species: Free radical reactions and modification of biomolecules
    • Eiserich JP, Patel RP, O'Donnell VB. 1998. Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules. Mol Aspects Med 19:221-357.
    • (1998) Mol Aspects Med , vol.19 , pp. 221-357
    • Eiserich, J.P.1    Patel, R.P.2    O'Donnell, V.B.3
  • 19
    • 0036751978 scopus 로고    scopus 로고
    • A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes
    • Esposito E, Rotilio D, Di Matteo V, Di Giulio C, Cacchio M, Algeri S. 2002. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging 23:719-735.
    • (2002) Neurobiol Aging , vol.23 , pp. 719-735
    • Esposito, E.1    Rotilio, D.2    Di Matteo, V.3    Di Giulio, C.4    Cacchio, M.5    Algeri, S.6
  • 20
    • 0032704101 scopus 로고    scopus 로고
    • Antioxidants, oxidative stress, and degenerative neurological disorders
    • Floyd RA. 1999. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 222:236-245.
    • (1999) Proc Soc Exp Biol Med , vol.222 , pp. 236-245
    • Floyd, R.A.1
  • 21
    • 0028818035 scopus 로고
    • Nitric oxide synthase: Expression and expressional control of the three isoforms
    • Forstermann U, Kleinert H. 1995. Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn Schmiedebergs Arch Pharmacol 352:351-364.
    • (1995) Naunyn Schmiedebergs Arch Pharmacol , vol.352 , pp. 351-364
    • Forstermann, U.1    Kleinert, H.2
  • 22
    • 0031029245 scopus 로고    scopus 로고
    • Alzheimer's, ageing and amyloid: An absurd allegory?
    • Fowler CJ, Cowburn RF, Joseph JA. 1997. Alzheimer's, ageing and amyloid: an absurd allegory? Gerontology 43:132-142.
    • (1997) Gerontology , vol.43 , pp. 132-142
    • Fowler, C.J.1    Cowburn, R.F.2    Joseph, J.A.3
  • 23
    • 29844435927 scopus 로고    scopus 로고
    • Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection
    • Galli RL, Bielinski DF, Szprengiel A, Shukitt-Hale B, Joseph JA. 2006. Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection. Neurobiol Aging 27:344-350.
    • (2006) Neurobiol Aging , vol.27 , pp. 344-350
    • Galli, R.L.1    Bielinski, D.F.2    Szprengiel, A.3    Shukitt-Hale, B.4    Joseph, J.A.5
  • 24
    • 0030722556 scopus 로고    scopus 로고
    • Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat
    • Gordon MN, Schreier WA, Ou X, Holcomb LA, Morgan DG. 1997. Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat. J Comp Neurol 388:106-119.
    • (1997) J Comp Neurol , vol.388 , pp. 106-119
    • Gordon, M.N.1    Schreier, W.A.2    Ou, X.3    Holcomb, L.A.4    Morgan, D.G.5
  • 26
    • 84979132832 scopus 로고
    • Ueber einige azoverbindungen
    • Chem Ber
    • Griess P. 1879. Bemerkungen zu der abhandlung der HH Weselsky und Benedikt. "Ueber einige azoverbindungen." Chem Ber 12:426-428.
    • (1879) , vol.12 , pp. 426-428
    • Griess, P.1
  • 28
    • 16444378016 scopus 로고    scopus 로고
    • Effect of inflammation on central nervous system development and vulnerability
    • Hagberg H, Mallard C. 2005. Effect of inflammation on central nervous system development and vulnerability. Curr Opin Neurol 18:117-123.
    • (2005) Curr Opin Neurol , vol.18 , pp. 117-123
    • Hagberg, H.1    Mallard, C.2
  • 29
    • 0029824431 scopus 로고    scopus 로고
    • Antioxidants in human health and disease
    • Halliwell B. 1996. Antioxidants in human health and disease. Annu Rev Nutr 16:33-50.
    • (1996) Annu Rev Nutr , vol.16 , pp. 33-50
    • Halliwell, B.1
  • 32
    • 0032531735 scopus 로고    scopus 로고
    • Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer bram indicates region-specific accumulation
    • Hensley K, Maidt ML, Yu Z, Sang H, Markesbery WR, Floyd RA. 1998. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer bram indicates region-specific accumulation. J Neurosci 18:8126-8132.
    • (1998) J Neurosci , vol.18 , pp. 8126-8132
    • Hensley, K.1    Maidt, M.L.2    Yu, Z.3    Sang, H.4    Markesbery, W.R.5    Floyd, R.A.6
  • 33
    • 0035922171 scopus 로고    scopus 로고
    • Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells
    • Jang JH, Surh YJ. 2001. Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells. Mutat Res 496:181-190.
    • (2001) Mutat Res , vol.496 , pp. 181-190
    • Jang, J.H.1    Surh, Y.J.2
  • 34
    • 0032189767 scopus 로고    scopus 로고
    • Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits
    • Joseph JA, Shukitt-Hale B, Denisova NA, Prior RL, Cao G, Martin A. Taglialatela G, Bickford PC. 1998. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci 18:8047-8055.
    • (1998) J Neurosci , vol.18 , pp. 8047-8055
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Prior, R.L.4    Cao, G.5    Martin, A.6    Taglialatela, G.7    Bickford, P.C.8
  • 35
    • 0033568849 scopus 로고    scopus 로고
    • Reversals of age-related declines in neuronal signal transduction, cognitive and motor behavioral deficits with blueberry, spinach or strawberry dietary supplementation
    • Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A. McEwen JJ, Bickford PC. 1999. Reversals of age-related declines in neuronal signal transduction, cognitive and motor behavioral deficits with blueberry, spinach or strawberry dietary supplementation. J Neurosci 19:8114-8121.
    • (1999) J Neurosci , vol.19 , pp. 8114-8121
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Bielinski, D.4    Martin, A.5    McEwen, J.J.6    Bickford, P.C.7
  • 36
    • 0037736704 scopus 로고    scopus 로고
    • Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model
    • Joseph JA, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, Morgan D. 2003. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 6:153-162.
    • (2003) Nutr Neurosci , vol.6 , pp. 153-162
    • Joseph, J.A.1    Arendash, G.2    Gordon, M.3    Diamond, D.4    Shukitt-Hale, B.5    Morgan, D.6
  • 38
    • 13844272542 scopus 로고    scopus 로고
    • Reversing the deleterious effects of aging on neuronal communication and behavior: Beneficial properties of fruit polyphenolic compounds
    • Joseph JA, Shukitt-Hale B, Casadesus G. 2005. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr 81(Suppl 1):313S-316S.
    • (2005) Am J Clin Nutr , vol.81 , Issue.SUPPL. 1
    • Joseph, J.A.1    Shukitt-Hale, B.2    Casadesus, G.3
  • 39
    • 33645995425 scopus 로고    scopus 로고
    • Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes
    • Joseph JA, Fisher DR, Bielinski D. 2006. Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes. J Alzheimers Dis 9:35-42.
    • (2006) J Alzheimers Dis , vol.9 , pp. 35-42
    • Joseph, J.A.1    Fisher, D.R.2    Bielinski, D.3
  • 41
    • 10944235044 scopus 로고    scopus 로고
    • Anti-inflammatory plant flavonoids and cellular action mechanisms
    • Kim HP, Son KH, Chang HW, Kang SS. 2004. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci 96:229-245.
    • (2004) J Pharmacol Sci , vol.96 , pp. 229-245
    • Kim, H.P.1    Son, K.H.2    Chang, H.W.3    Kang, S.S.4
  • 42
    • 0037366104 scopus 로고    scopus 로고
    • Oxidative stress, cell cycle, and neurodegeneration
    • Klein JA, Ackerman SL. 2003. Oxidative stress, cell cycle, and neurodegeneration. J Clin Invest 111:785-793.
    • (2003) J Clin Invest , vol.111 , pp. 785-793
    • Klein, J.A.1    Ackerman, S.L.2
  • 44
    • 34147223553 scopus 로고    scopus 로고
    • Lau FC, Shukitt-Hale B, Joseph JA. 2004. Effect of blueberry supplementation on gene expression in the hippocampus of kainic acid-treated and control rats. Soc Neurosci Abstr 30:565.566.
    • Lau FC, Shukitt-Hale B, Joseph JA. 2004. Effect of blueberry supplementation on gene expression in the hippocampus of kainic acid-treated and control rats. Soc Neurosci Abstr 30:565.566.
  • 45
    • 85013577588 scopus 로고    scopus 로고
    • Age-related neuronal and behavioral deficits are improved by polyphenol rich blueberry supplementation
    • Packer L, editor, Boca Raton, FL: CRC Press. p
    • Lau FC, Shukitt-Hale B, Joseph JA. 2005a. Age-related neuronal and behavioral deficits are improved by polyphenol rich blueberry supplementation. In: Packer L, editor. Oxidative stress and age-related neurodegeneration. Boca Raton, FL: CRC Press. p 373-393.
    • (2005) Oxidative stress and age-related neurodegeneration , pp. 373-393
    • Lau, F.C.1    Shukitt-Hale, B.2    Joseph, J.A.3
  • 46
    • 28444463999 scopus 로고    scopus 로고
    • The beneficial effects of fruit polyphenols on brain aging
    • Lau FC, Shukitt-Hale B, Joseph JA. 2005b. The beneficial effects of fruit polyphenols on brain aging. Neurobiol Aging 26(Suppl 1):128-132.
    • (2005) Neurobiol Aging , vol.26 , Issue.SUPPL. 1 , pp. 128-132
    • Lau, F.C.1    Shukitt-Hale, B.2    Joseph, J.A.3
  • 47
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • Lawson LJ, Perry VH, Dri P, Gordon S. 1990. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39:151-170.
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3    Gordon, S.4
  • 48
    • 0032831286 scopus 로고    scopus 로고
    • Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
    • Liang YC, Huang YT, Tsai SH, Lin-Shiau SY, Chen CF, Lin JK. 1999. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 20:1945-1952.
    • (1999) Carcinogenesis , vol.20 , pp. 1945-1952
    • Liang, Y.C.1    Huang, Y.T.2    Tsai, S.H.3    Lin-Shiau, S.Y.4    Chen, C.F.5    Lin, J.K.6
  • 50
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2[-delta delta C(T)] method
    • Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2[-delta delta C(T)] method. Methods 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 52
    • 0031593138 scopus 로고    scopus 로고
    • The sensitivity and specificity of the MTS tetrazolium assay for detecting the in vitro cytotoxicity of 20 chemicals using human cell lines
    • Malich G, Markovic B, Winder C. 1997. The sensitivity and specificity of the MTS tetrazolium assay for detecting the in vitro cytotoxicity of 20 chemicals using human cell lines. Toxicology 124:179-192.
    • (1997) Toxicology , vol.124 , pp. 179-192
    • Malich, G.1    Markovic, B.2    Winder, C.3
  • 53
    • 0036910732 scopus 로고    scopus 로고
    • Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance
    • Martin A, Cherubini A, Andres-Lacueva C, Paniagua M, Joseph J. 2002. Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance. J Nutr Health Aging 6:392-404.
    • (2002) J Nutr Health Aging , vol.6 , pp. 392-404
    • Martin, A.1    Cherubini, A.2    Andres-Lacueva, C.3    Paniagua, M.4    Joseph, J.5
  • 54
    • 1942454250 scopus 로고    scopus 로고
    • Inflammation and neurodegeneration in Parkinson's disease
    • McGeer PL, McGeer EG. 2004a. Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism Rel Disord 10(Suppl 1):S3-S7.
    • (2004) Parkinsonism Rel Disord , vol.10 , Issue.SUPPL. 1
    • McGeer, P.L.1    McGeer, E.G.2
  • 55
    • 14944352071 scopus 로고    scopus 로고
    • Inflammation and the degenerative diseases of aging
    • McGeer PL, McGeer EG. 2004b. Inflammation and the degenerative diseases of aging. Ann N Y Acad Sci 1035:104-116.
    • (2004) Ann N Y Acad Sci , vol.1035 , pp. 104-116
    • McGeer, P.L.1    McGeer, E.G.2
  • 56
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E Jr, Kandaswami C, Theoharides TC. 2000. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton Jr, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 57
    • 0031985513 scopus 로고    scopus 로고
    • Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
    • Minghetti L, Levi G. 1998. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol 54:99-125.
    • (1998) Prog Neurobiol , vol.54 , pp. 99-125
    • Minghetti, L.1    Levi, G.2
  • 58
    • 0032850931 scopus 로고    scopus 로고
    • Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets
    • Mirzoeva S, Koppal T, Petrova TV, Lukas TJ, Watterson DM, Van Eldik LJ. 1999. Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets. Brain Res 844:126-134.
    • (1999) Brain Res , vol.844 , pp. 126-134
    • Mirzoeva, S.1    Koppal, T.2    Petrova, T.V.3    Lukas, T.J.4    Watterson, D.M.5    Van Eldik, L.J.6
  • 59
    • 33646160622 scopus 로고    scopus 로고
    • The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease
    • Moreira PI, Zhu X, Lee HG, Honda K, Smith MA, Perry G. 2006. The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease. Mech Ageing Dev 127:501-506.
    • (2006) Mech Ageing Dev , vol.127 , pp. 501-506
    • Moreira, P.I.1    Zhu, X.2    Lee, H.G.3    Honda, K.4    Smith, M.A.5    Perry, G.6
  • 60
    • 11444256801 scopus 로고    scopus 로고
    • Glia and their cytokines in progression of neurodegeneration
    • Mrak RE, Griffin WS. 2005. Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging 26:349-354.
    • (2005) Neurobiol Aging , vol.26 , pp. 349-354
    • Mrak, R.E.1    Griffin, W.S.2
  • 62
    • 3542996239 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells
    • Murphy GM Jr, Yang L, Cordell B. 1998. Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells. J Biol Chem 273:20967-20971.
    • (1998) J Biol Chem , vol.273 , pp. 20967-20971
    • Murphy Jr, G.M.1    Yang, L.2    Cordell, B.3
  • 63
    • 0036993896 scopus 로고    scopus 로고
    • Parkinson's disease, Parkinsonism and aging
    • Suppl
    • Nicita-Mauro V. 2002. Parkinson's disease, Parkinsonism and aging. Arch Gerontol Geriatr Suppl 35(Suppl):225-238.
    • (2002) Arch Gerontol Geriatr , Issue.SUPPL. 35 , pp. 225-238
    • Nicita-Mauro, V.1
  • 64
    • 0029973611 scopus 로고    scopus 로고
    • Inflammatory mechanisms and anti-inflammatory therapy in Alzheimer's disease
    • O'Banion MK, Finch CE. 1996. Inflammatory mechanisms and anti-inflammatory therapy in Alzheimer's disease. Neurobiol Aging 17:669-671.
    • (1996) Neurobiol Aging , vol.17 , pp. 669-671
    • O'Banion, M.K.1    Finch, C.E.2
  • 65
    • 0036935553 scopus 로고    scopus 로고
    • An inflammatory review of Parkinson's disease
    • Orr CF, Rowe DB, Halliday GM. 2002. An inflammatory review of Parkinson's disease. Prog Neurobiol 68:325-340.
    • (2002) Prog Neurobiol , vol.68 , pp. 325-340
    • Orr, C.F.1    Rowe, D.B.2    Halliday, G.M.3
  • 66
    • 4744370253 scopus 로고    scopus 로고
    • Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
    • Palsson-McDermott EM, O'Neill LA. 2004. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 113:153-162.
    • (2004) Immunology , vol.113 , pp. 153-162
    • Palsson-McDermott, E.M.1    O'Neill, L.A.2
  • 67
    • 0036954496 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intra-neuronal receptor crosstalk?
    • Perry SW, Dewhurst S, Bellizzi MJ, Gelbard HA. 2002. Tumor necrosis factor-alpha in normal and diseased brain: conflicting effects via intra-neuronal receptor crosstalk? J Neurovirol 8:611-624.
    • (2002) J Neurovirol , vol.8 , pp. 611-624
    • Perry, S.W.1    Dewhurst, S.2    Bellizzi, M.J.3    Gelbard, H.A.4
  • 68
    • 0020608713 scopus 로고
    • The estimation of nitrate and nitrite in saliva and urine
    • Phizackerley PJ, Al-Dabbagh SA. 1983. The estimation of nitrate and nitrite in saliva and urine. Anal Biochem 131:242-245.
    • (1983) Anal Biochem , vol.131 , pp. 242-245
    • Phizackerley, P.J.1    Al-Dabbagh, S.A.2
  • 69
    • 0034219727 scopus 로고    scopus 로고
    • Analysis of botanicals and dietary supplements for antioxidant capacity: A review
    • Prior RL, Cao G. 2000. Analysis of botanicals and dietary supplements for antioxidant capacity: a review. J AOAC Int 83:950-956.
    • (2000) J AOAC Int , vol.83 , pp. 950-956
    • Prior, R.L.1    Cao, G.2
  • 71
    • 19644394724 scopus 로고    scopus 로고
    • Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages
    • Rao YK, Fang SH, Tzeng YM. 2005. Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages. Biol Pharm Bull 28:912-915.
    • (2005) Biol Pharm Bull , vol.28 , pp. 912-915
    • Rao, Y.K.1    Fang, S.H.2    Tzeng, Y.M.3
  • 72
    • 0029844446 scopus 로고    scopus 로고
    • Antioxidant activities of flavonoids as bioactive components of food
    • Rice-Evans CA, Miller NJ. 1996. Antioxidant activities of flavonoids as bioactive components of food. Biochem Soc Trans 24:790-794.
    • (1996) Biochem Soc Trans , vol.24 , pp. 790-794
    • Rice-Evans, C.A.1    Miller, N.J.2
  • 73
    • 0023864255 scopus 로고
    • Flavonoids are scavengers of superoxide anions
    • Robak J, Gryglewski RJ. 1988. Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 37:837-841.
    • (1988) Biochem Pharmacol , vol.37 , pp. 837-841
    • Robak, J.1    Gryglewski, R.J.2
  • 75
    • 0028916836 scopus 로고
    • Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging
    • Roth GS, Joseph JA, Mason RP. 1995. Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging. Trends Neurosci 18:203-206.
    • (1995) Trends Neurosci , vol.18 , pp. 203-206
    • Roth, G.S.1    Joseph, J.A.2    Mason, R.P.3
  • 77
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • Krawetz S, Misener S, editors, Totowa, NJ: Humana Press. p
    • Rozen S, Skaletsky HJ. 2000. Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S, editors. Bioinformatics methods and protocols: methods in molecular biology. Totowa, NJ: Humana Press. p 365-386.
    • (2000) Bioinformatics methods and protocols: Methods in molecular biology , pp. 365-386
    • Rozen, S.1    Skaletsky, H.J.2
  • 78
    • 0031960552 scopus 로고    scopus 로고
    • Age-related activation of microglia and astrocytes: In vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation
    • Rozovsky I, Finch CE, Morgan TE. 1998. Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation. Neurobiol Aging 19:97-103.
    • (1998) Neurobiol Aging , vol.19 , pp. 97-103
    • Rozovsky, I.1    Finch, C.E.2    Morgan, T.E.3
  • 80
    • 34147212254 scopus 로고    scopus 로고
    • Shukitt-Hale B, Carey A, Simon LE, Bielinski DF, Lau FC, Galli RL, Spangler EL, Ingram DK, Joseph JA. 2004. Fruit polyphenols prevent inflammatory mediated decrements in cognition. Soc Neurosci Abstr 30:565.565.
    • Shukitt-Hale B, Carey A, Simon LE, Bielinski DF, Lau FC, Galli RL, Spangler EL, Ingram DK, Joseph JA. 2004. Fruit polyphenols prevent inflammatory mediated decrements in cognition. Soc Neurosci Abstr 30:565.565.
  • 81
    • 0032806355 scopus 로고    scopus 로고
    • Increased microglial activation and protein nitration in white matter of the aging monkey
    • Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR. 1999. Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging 20:395-405.
    • (1999) Neurobiol Aging , vol.20 , pp. 395-405
    • Sloane, J.A.1    Hollander, W.2    Moss, M.B.3    Rosene, D.L.4    Abraham, C.R.5
  • 82
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • Streit WJ. 2002. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40:133-139.
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 83
    • 17844404517 scopus 로고    scopus 로고
    • Microglia and neuroprotection: Implications for Alzheimer's disease
    • Streit WJ. 2005. Microglia and neuroprotection: implications for Alzheimer's disease. Brain Res Brain Res Rev 48:234-239.
    • (2005) Brain Res Brain Res Rev , vol.48 , pp. 234-239
    • Streit, W.J.1
  • 85
    • 27744496501 scopus 로고    scopus 로고
    • Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system
    • Stromberg I, Gemma C, Vila J, Bickford PC. 2005. Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system. Exp Neurol 196:298-307.
    • (2005) Exp Neurol , vol.196 , pp. 298-307
    • Stromberg, I.1    Gemma, C.2    Vila, J.3    Bickford, P.C.4
  • 86
    • 0036902931 scopus 로고    scopus 로고
    • Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia-induced brain damage
    • Sweeney MI, Kalt W, MacKinnon SL, Ashby J, Gottschall-Pass KT. 2002. Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia-induced brain damage. Nutr Neurosci 5:427-431.
    • (2002) Nutr Neurosci , vol.5 , pp. 427-431
    • Sweeney, M.I.1    Kalt, W.2    MacKinnon, S.L.3    Ashby, J.4    Gottschall-Pass, K.T.5
  • 89
    • 0035479909 scopus 로고    scopus 로고
    • Effects of ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha
    • Wadsworth TL, McDonald TL, Koop DR. 2001. Effects of ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha. Biochem Pharmacol 62:963-974.
    • (2001) Biochem Pharmacol , vol.62 , pp. 963-974
    • Wadsworth, T.L.1    McDonald, T.L.2    Koop, D.R.3
  • 90
    • 0035783744 scopus 로고    scopus 로고
    • Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia
    • Wong A, Dukic-Stefanovic S, Gasic-Milenkovic J, Schinzel R, Wiesinger H, Riederer P, Munch G. 2001. Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia. Eur J Neurosci 14:1961-1967.
    • (2001) Eur J Neurosci , vol.14 , pp. 1961-1967
    • Wong, A.1    Dukic-Stefanovic, S.2    Gasic-Milenkovic, J.3    Schinzel, R.4    Wiesinger, H.5    Riederer, P.6    Munch, G.7
  • 91
    • 25444490122 scopus 로고    scopus 로고
    • Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis
    • Yi W, Fischer J, Krewer G, Akoh CC. 2005. Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J Agric Food Chem 53:7320-7329.
    • (2005) J Agric Food Chem , vol.53 , pp. 7320-7329
    • Yi, W.1    Fischer, J.2    Krewer, G.3    Akoh, C.C.4
  • 92
    • 0036860951 scopus 로고    scopus 로고
    • Dose effect of oxidative stress on signal transduction in aging
    • Yoon SO, Yun CH, Chung AS. 2002. Dose effect of oxidative stress on signal transduction in aging. Mech Ageing Dev 123:1597-1604.
    • (2002) Mech Ageing Dev , vol.123 , pp. 1597-1604
    • Yoon, S.O.1    Yun, C.H.2    Chung, A.S.3
  • 93
    • 0000863877 scopus 로고    scopus 로고
    • Short-term dietary supplementation of blueberry polyphenolics: Beneficial effects on aging brain performance and peripheral tissue function
    • Youdim KA, Shukitt-Hale B, Martin A, Wang H, Denisova N, Joseph JA. 2000. Short-term dietary supplementation of blueberry polyphenolics: beneficial effects on aging brain performance and peripheral tissue function. Nutr Neurosci 3:383-397.
    • (2000) Nutr Neurosci , vol.3 , pp. 383-397
    • Youdim, K.A.1    Shukitt-Hale, B.2    Martin, A.3    Wang, H.4    Denisova, N.5    Joseph, J.A.6
  • 94
    • 0029760138 scopus 로고    scopus 로고
    • Molecular mechanisms of microglial activation
    • Zielasek J, Hartung HP. 1996. Molecular mechanisms of microglial activation. Adv Neuroimmunol 6:191-122.
    • (1996) Adv Neuroimmunol , vol.6 , pp. 191-122
    • Zielasek, J.1    Hartung, H.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.