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Volumn 9, Issue 10, 2010, Pages 1934-1941

A novel hypothesis for Alzheimer's disease based on neuronal tetraploidy induced by p75NTR

Author keywords

Alzheimer's disease; ApoE; A ; BDNF; Cell cycle; Endoreduplication; Neuronal hypertrophy; Oxidative stress; proNGF; Tau

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLINE; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR P75; TAU PROTEIN; TRANSCRIPTION FACTOR E2F1;

EID: 77953647392     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.10.11582     Document Type: Review
Times cited : (49)

References (165)
  • 1
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease
    • Goedert M, Spillantini MG. A century of Alzheimer's disease. Science 2006; 314:37-9.
    • (2006) Science , vol.314 , pp. 37-39
    • Goedert, M.1    Spillantini, M.G.2
  • 2
  • 4
    • 48949100108 scopus 로고    scopus 로고
    • Tumorigenesis and neurodegeneration: Two sides of the same coin?
    • Staropoli JF. Tumorigenesis and neurodegeneration: two sides of the same coin? Bioessays 2008; 30:719-27.
    • (2008) Bioessays , vol.30 , pp. 719-727
    • Staropoli, J.F.1
  • 5
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
    • Busser J, Geldmacher DS, Herrup K. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 1998; 18:2801-7. (Pubitemid 28163210)
    • (1998) Journal of Neuroscience , vol.18 , Issue.8 , pp. 2801-2807
    • Busser, J.1    Geldmacher, D.S.2    Herrup, K.3
  • 6
    • 0031685160 scopus 로고    scopus 로고
    • Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease
    • Vincent I, Zheng JH, Dickson DW, Kress Y, Davies P. Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease. Neurobiol Aging 1998; 19:287-96.
    • (1998) Neurobiol Aging , vol.19 , pp. 287-296
    • Vincent, I.1    Zheng, J.H.2    Dickson, D.W.3    Kress, Y.4    Davies, P.5
  • 7
    • 0344241479 scopus 로고    scopus 로고
    • Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    • Yang Y, Mufson EJ, Herrup K. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J Neurosci 2003; 23:2557-63.
    • (2003) J Neurosci , vol.23 , pp. 2557-2563
    • Yang, Y.1    Mufson, E.J.2    Herrup, K.3
  • 8
    • 0028295848 scopus 로고
    • Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein
    • Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J 1994; 13:1114-22. (Pubitemid 24074718)
    • (1994) EMBO Journal , vol.13 , Issue.5 , pp. 1114-1122
    • Suzuki, T.1    Oishi, M.2    Marshak, D.R.3    Czernik, A.J.4    Nairn, A.C.5    Greengard, P.6
  • 9
    • 9244224675 scopus 로고    scopus 로고
    • 2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein
    • 2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein. Neuroscience 2005; 130:51-60.
    • (2005) Neuroscience , vol.130 , pp. 51-60
    • López-Sánchez, N.1    Müller, U.2    Frade, J.M.3
  • 10
    • 0026711059 scopus 로고
    • Fetal-type phosphorylation of the tau in paired helical filaments
    • Kanemaru K, Takio K, Miura R, Titani K, Ihara Y. Fetal-type phosphorylation of the tau in paired helical filaments. J Neurochem 1992; 58:1667-75.
    • (1992) J Neurochem , vol.58 , pp. 1667-1675
    • Kanemaru, K.1    Takio, K.2    Miura, R.3    Titani, K.4    Ihara, Y.5
  • 11
    • 0027217679 scopus 로고
    • The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development
    • Goedert M, Jakes R, Crowther RA, Six J, Lübke U, Vandermeeren M, et al. The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proc Natl Acad Sci USA 1993; 90:5066-70.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5066-5070
    • Goedert, M.1    Jakes, R.2    Crowther, R.A.3    Six, J.4    Lübke, U.5    Vandermeeren, M.6
  • 12
    • 0027178335 scopus 로고
    • Cell death and the cell cycle: A relationship between transformation and neurodegeneration?
    • Heintz N. Cell death and the cell cycle: a relationship between transformation and neurodegeneration? Trends Biochem Sci 1993; 18:157-9.
    • (1993) Trends Biochem Sci , vol.18 , pp. 157-159
    • Heintz, N.1
  • 13
    • 0029070087 scopus 로고
    • Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders
    • Smith TW, Lippa CF. Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders. J Neuropathol Exp Neurol 1995; 54:297-303.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 297-303
    • Smith, T.W.1    Lippa, C.F.2
  • 14
    • 0030062245 scopus 로고    scopus 로고
    • Mitotic mechanisms in Alzheimer's disease?
    • Vincent I, Rosado M, Davies P. Mitotic mechanisms in Alzheimer's disease? J Cell Biol 1996; 132:413-25.
    • (1996) J Cell Biol , vol.132 , pp. 413-425
    • Vincent, I.1    Rosado, M.2    Davies, P.3
  • 15
    • 0031006939 scopus 로고    scopus 로고
    • Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
    • Vincent I, Jicha G, Rosado M, Dickson DW. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J Neurosci 1997; 17:3588-98. (Pubitemid 27200586)
    • (1997) Journal of Neuroscience , vol.17 , Issue.10 , pp. 3588-3598
    • Vincent, I.1    Jicha, G.2    Rosado, M.3    Dickson, D.W.4
  • 16
    • 0033635191 scopus 로고    scopus 로고
    • The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease
    • Ding XL, Husseman J, Tomashevski A, Nochlin D, Jin LW, Vincent I. The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease. Am J Pathol 2000; 157:1983-90.
    • (2000) Am J Pathol , vol.157 , pp. 1983-1990
    • Ding, X.L.1    Husseman, J.2    Tomashevski, A.3    Nochlin, D.4    Jin, L.W.5    Vincent, I.6
  • 17
    • 0034990190 scopus 로고    scopus 로고
    • Constitutive wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration
    • Vincent I, Bu B, Hudson K, Husseman J, Nochlin D, Jin L. Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease. Neuroscience 2001; 105:639-50. (Pubitemid 32566520)
    • (2001) Journal of Alzheimer's Disease , vol.3 , Issue.2 , pp. 195-207
    • Tomashevski, A.1    Husseman, J.2    Jin, L.-W.3    Nochlin, D.4    Vincent, I.5
  • 18
    • 0034990190 scopus 로고    scopus 로고
    • Constitutive wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration
    • Tomashevski A, Husseman J, Jin LW, Nochlin D, Vincent I. Constitutive Wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration. J Alzheimers Dis 2001; 3:195-207. (Pubitemid 32566520)
    • (2001) Journal of Alzheimer's Disease , vol.3 , Issue.2 , pp. 195-207
    • Tomashevski, A.1    Husseman, J.2    Jin, L.-W.3    Nochlin, D.4    Vincent, I.5
  • 20
    • 0036938381 scopus 로고    scopus 로고
    • Upregulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration
    • Pei JJ, Braak H, Gong CX, Grundke-Iqbal I, Iqbal K, Winblad B, et al. Upregulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration. Acta Neuropathol 2002; 104:369-76.
    • (2002) Acta Neuropathol , vol.104 , pp. 369-376
    • Pei, J.J.1    Braak, H.2    Gong, C.X.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6
  • 21
    • 0030742818 scopus 로고    scopus 로고
    • Cell cycle markers in the hippocampus in Alzheimer's disease
    • DOI 10.1007/s004010050665
    • Nagy Z, Esiri MM, Cato AM, Smith AD. Cell cycle markers in the hippocampus in Alzheimer's disease. Acta Neuropathol 1997; 94:6-15. (Pubitemid 27289096)
    • (1997) Acta Neuropathologica , vol.94 , Issue.1 , pp. 6-15
    • Nagy, Zs.1    Esiri, M.M.2    Cato, A.-M.3    Smith, A.D.4
  • 24
    • 34248524501 scopus 로고    scopus 로고
    • The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily
    • Bosco P, Caraci F, Copani A, Spada RS, Sortino MA, Salluzzo R, et al. The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. Neurosci Lett 2007; 419:195-8.
    • (2007) Neurosci Lett , vol.419 , pp. 195-198
    • Bosco, P.1    Caraci, F.2    Copani, A.3    Spada, R.S.4    Sortino, M.A.5    Salluzzo, R.6
  • 26
    • 0035871660 scopus 로고    scopus 로고
    • DNA replication precedes neuronal cell death in Alzheimer's disease
    • Yang Y, Geldmacher DS, Herrup K. DNA replication precedes neuronal cell death in Alzheimer's disease. J Neurosci 2001; 21:2661-8. (Pubitemid 32298208)
    • (2001) Journal of Neuroscience , vol.21 , Issue.8 , pp. 2661-2668
    • Yang, Y.1    Geldmacher, D.S.2    Herrup, K.3
  • 27
    • 77949884756 scopus 로고    scopus 로고
    • Evidence for the Progression through S-phase in the Ectopic Cell Cycle Re-entry of Neurons in Alzheimer Disease
    • Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic VP, et al. Evidence for the Progression through S-phase in the Ectopic Cell Cycle Re-entry of Neurons in Alzheimer Disease. Aging 2009; 1:382-8.
    • (2009) Aging , vol.1 , pp. 382-388
    • Bonda, D.J.1    Evans, T.A.2    Santocanale, C.3    Llosá, J.C.4    Viña, J.5    Bajic, V.P.6
  • 29
    • 60549117879 scopus 로고    scopus 로고
    • Retinoblastoma Protein Phosphorylation at Multiple Sites is Associated with Neurofibrillary Pathology in Alzheimer Disease
    • Thakur A, Siedlak SL, James SL, Bonda DJ, Rao A, Webber KM, et al. Retinoblastoma Protein Phosphorylation at Multiple Sites is Associated with Neurofibrillary Pathology in Alzheimer Disease. Int J Clin Exp Pathol 2008; 1:134-46.
    • (2008) Int J Clin Exp Pathol , vol.1 , pp. 134-146
    • Thakur, A.1    Siedlak, S.L.2    James, S.L.3    Bonda, D.J.4    Rao, A.5    Webber, K.M.6
  • 31
    • 0031043049 scopus 로고    scopus 로고
    • Expression of cell division markers in the hippocampus in Alzheimer's disease and other nenrodegenerative conditions
    • DOI 10.1007/s004010050617
    • Nagy Z, Esiri MM, Smith AD. Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions. Acta Neuropathol 1997; 93:294-300. (Pubitemid 27104426)
    • (1997) Acta Neuropathologica , vol.93 , Issue.3 , pp. 294-300
    • Nagy, Zs.1    Esiri, M.M.2    Smith, A.D.3
  • 33
    • 33947151122 scopus 로고    scopus 로고
    • The cell cycle hypothesis of Alzheimer's disease: Suggestions for drug development
    • Woods J, Snape M, Smith MA. The cell cycle hypothesis of Alzheimer's disease: suggestions for drug development. Biochim Biophys Acta 2007; 1772:503-8.
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 503-508
    • Woods, J.1    Snape, M.2    Smith, M.A.3
  • 35
    • 33947317590 scopus 로고    scopus 로고
    • Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice
    • Park KH, Hallows JL, Chakrabarty P, Davies P, Vincent I. Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice. J Neurosci 2007; 27:2969-78.
    • (2007) J Neurosci , vol.27 , pp. 2969-2978
    • Park, K.H.1    Hallows, J.L.2    Chakrabarty, P.3    Davies, P.4    Vincent, I.5
  • 36
    • 62549114846 scopus 로고    scopus 로고
    • The neuronal expression of Myc causes a neurodegenerative phenotype in a novel transgenic mouse
    • Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, et al. The neuronal expression of Myc causes a neurodegenerative phenotype in a novel transgenic mouse. Am J Pathol 2009; 174:891-7.
    • (2009) Am J Pathol , vol.174 , pp. 891-897
    • Lee, H.G.1    Casadesus, G.2    Nunomura, A.3    Zhu, X.4    Castellani, R.J.5    Richardson, S.L.6
  • 37
    • 32544459388 scopus 로고    scopus 로고
    • Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models
    • Yang Y, Varvel NH, Lamb BT, Herrup K. Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models. J Neurosci 2006; 26:775-84.
    • (2006) J Neurosci , vol.26 , pp. 775-784
    • Yang, Y.1    Varvel, N.H.2    Lamb, B.T.3    Herrup, K.4
  • 38
    • 49349088898 scopus 로고    scopus 로고
    • Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo
    • Ahn KW, Joo Y, Choi Y, Kim M, Lee SH, Cha SH, et al. Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo. J Neurosci Res 2008; 86:2476-87.
    • (2008) J Neurosci Res , vol.86 , pp. 2476-2487
    • Ahn, K.W.1    Joo, Y.2    Choi, Y.3    Kim, M.4    Lee, S.H.5    Cha, S.H.6
  • 39
    • 41849118025 scopus 로고    scopus 로고
    • Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the presenilin-1 Alzheimer's disease brain
    • Malik B, Currais A, Andres A, Towlson C, Pitsi D, Nunes A, et al. Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the presenilin-1 Alzheimer's disease brain. Cell Cycle 2008; 7:637-46.
    • (2008) Cell Cycle , vol.7 , pp. 637-646
    • Malik, B.1    Currais, A.2    Andres, A.3    Towlson, C.4    Pitsi, D.5    Nunes, A.6
  • 40
    • 31944434543 scopus 로고    scopus 로고
    • TOR-mediated cell cycle activation causes neurodegeneration in a Drosophila tauopathy model
    • Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB. TOR-mediated cell cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol 2006; 16:230-41.
    • (2006) Curr Biol , vol.16 , pp. 230-241
    • Khurana, V.1    Lu, Y.2    Steinhilb, M.L.3    Oldham, S.4    Shulman, J.M.5    Feany, M.B.6
  • 41
    • 0026492630 scopus 로고
    • Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice
    • Feddersen RM, Ehlenfeldt R, Yunis WS, Clark HB, Orr HT. Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice. Neuron 1992; 9:955-66.
    • (1992) Neuron , vol.9 , pp. 955-966
    • Feddersen, R.M.1    Ehlenfeldt, R.2    Yunis, W.S.3    Clark, H.B.4    Orr, H.T.5
  • 42
    • 0026557171 scopus 로고
    • Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice
    • Al-Ubaidi MR, Hollyfield JG, Overbeek PA, Baehr W. Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice. Proc Natl Acad Sci USA 1992; 89:1194-8.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1194-1198
    • Al-Ubaidi, M.R.1    Hollyfield, J.G.2    Overbeek, P.A.3    Baehr, W.4
  • 43
    • 0036592637 scopus 로고    scopus 로고
    • Cell cycle proteins in Alzheimer's disease: Plenty of wheels but no cycle
    • Bowser R, Smith MA. Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle. J Alzheimers Dis 2002; 4:249-54.
    • (2002) J Alzheimers Dis , vol.4 , pp. 249-254
    • Bowser, R.1    Smith, M.A.2
  • 44
    • 2342648875 scopus 로고    scopus 로고
    • Analysis of premature centromere division (PCD) of the X chromosome in Alzheimer patients through the cell cycle
    • Spremo-Potparevic B, Zivkovic L, Djelic N, Bajic V. Analysis of premature centromere division (PCD) of the X chromosome in Alzheimer patients through the cell cycle. Exp Gerontol 2004; 39:849-54.
    • (2004) Exp Gerontol , vol.39 , pp. 849-854
    • Spremo-Potparevic, B.1    Zivkovic, L.2    Djelic, N.3    Bajic, V.4
  • 45
    • 64449088956 scopus 로고    scopus 로고
    • Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaning
    • Iourov IY, Vorsanova SG, Liehr T, Yurov YB. Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning. Neurobiol Dis 2009; 34:212-20.
    • (2009) Neurobiol Dis , vol.34 , pp. 212-220
    • Iourov, I.Y.1    Vorsanova, S.G.2    Liehr, T.3    Yurov, Y.B.4
  • 46
    • 34347351340 scopus 로고    scopus 로고
    • Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease
    • Mosch B, Morawski M, Mittag A, Lenz D, Tarnok A, Arendt T. Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease. J Neurosci 2007; 27:6859-67.
    • (2007) J Neurosci , vol.27 , pp. 6859-6867
    • Mosch, B.1    Morawski, M.2    Mittag, A.3    Lenz, D.4    Tarnok, A.5    Arendt, T.6
  • 47
    • 77949422826 scopus 로고    scopus 로고
    • A Reevaluation of Tetraploidy in the Alzheimer's Disease Brain
    • Westra JW, Barral S, Chun J. A Reevaluation of Tetraploidy in the Alzheimer's Disease Brain. Neurodegener Dis 2009; 6:221-9.
    • (2009) Neurodegener Dis , vol.6 , pp. 221-229
    • Westra, J.W.1    Barral, S.2    Chun, J.3
  • 51
    • 0035805201 scopus 로고    scopus 로고
    • Endoreplication cell cycles: More for less
    • Edgar BA, Orr-Weaver TL. Endoreplication cell cycles: more for less. Cell 2001; 105:297-306.
    • (2001) Cell , vol.105 , pp. 297-306
    • Edgar, B.A.1    Orr-Weaver, T.L.2
  • 52
    • 66849143693 scopus 로고    scopus 로고
    • Developmentally programmed endoreduplication in animals
    • Ullah Z, Lee CY, Lilly MA, DePamphilis ML. Developmentally programmed endoreduplication in animals. Cell Cycle 2009; 8:1501-9.
    • (2009) Cell Cycle , vol.8 , pp. 1501-1509
    • Ullah, Z.1    Lee, C.Y.2    Lilly, M.A.3    DePamphilis, M.L.4
  • 53
    • 0030454478 scopus 로고    scopus 로고
    • Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease
    • Arendt T, Rödel L, Gärtner U, Holzer M. Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease. Neuroreport 1996; 7:3047-9.
    • (1996) Neuroreport , vol.7 , pp. 3047-3049
    • Arendt, T.1    Rödel, L.2    Gärtner, U.3    Holzer, M.4
  • 54
    • 0031737550 scopus 로고    scopus 로고
    • Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease
    • Arendt T, Holzer M, Gärtner U. Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease. J Neural Transm 1998; 105:949-60.
    • (1998) J Neural Transm , vol.105 , pp. 949-960
    • Arendt, T.1    Holzer, M.2    Gärtner, U.3
  • 56
    • 0041419869 scopus 로고    scopus 로고
    • Increased p27, an essential component of cell cycle control, in Alzheimer's disease
    • Ogawa O, Lee HG, Zhu X, Raina A, Harris PL, Castellani RJ, et al. Increased p27, an essential component of cell cycle control, in Alzheimer's disease. Aging Cell 2003; 2:105-10.
    • (2003) Aging Cell , vol.2 , pp. 105-110
    • Ogawa, O.1    Lee, H.G.2    Zhu, X.3    Raina, A.4    Harris, P.L.5    Castellani, R.J.6
  • 57
    • 76249123177 scopus 로고    scopus 로고
    • Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor
    • Morillo SM, Escoll P, de la Hera A, Frade JM. Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc Natl Acad Sci USA 2010; 107:109-14.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 109-114
    • Morillo, S.M.1    Escoll, P.2    De La Hera, A.3    Frade, J.M.4
  • 58
    • 0034014639 scopus 로고    scopus 로고
    • Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones
    • Frade JM. Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones. J Cell Sci 2000; 113:1139-48.
    • (2000) J Cell Sci , vol.113 , pp. 1139-1148
    • Frade, J.M.1
  • 59
    • 1542381057 scopus 로고    scopus 로고
    • Cell cycle regulation of neuronal apoptosis in development and disease
    • Becker EB, Bonni A. Cell cycle regulation of neuronal apoptosis in development and disease. Prog Neurobiol 2004; 72:1-25.
    • (2004) Prog Neurobiol , vol.72 , pp. 1-25
    • Becker, E.B.1    Bonni, A.2
  • 60
    • 0029245289 scopus 로고
    • A potential role for apoptosis in neurodegeneration and Alzheimer's disease
    • Cotman CW, Anderson AJ. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol 1995; 10:19-45.
    • (1995) Mol Neurobiol , vol.10 , pp. 19-45
    • Cotman, C.W.1    Anderson, A.J.2
  • 61
    • 33748466130 scopus 로고    scopus 로고
    • Apoptosis in Alzheimer disease: A mathematical improbability
    • Zhu X, Raina AK, Perry G, Smith MA. Apoptosis in Alzheimer disease: a mathematical improbability. Curr Alzheimer Res 2006; 3:393-6.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 393-396
    • Zhu, X.1    Raina, A.K.2    Perry, G.3    Smith, M.A.4
  • 63
    • 0023090436 scopus 로고
    • Effect of tetraploidy on dendritic branching in neurons and glial cells of the frog, Xenopus laevis
    • Szaro BG, Tompkins R. Effect of tetraploidy on dendritic branching in neurons and glial cells of the frog, Xenopus laevis. J Comp Neurol 1987; 258:304-16.
    • (1987) J Comp Neurol , vol.258 , pp. 304-316
    • Szaro, B.G.1    Tompkins, R.2
  • 64
    • 0023038233 scopus 로고
    • Dendritic changes in the basal nucleus of Meynert and in the diagonal band nucleus in Alzheimer's disease. A quantitative Golgi investigation
    • Arendt T, Zvegintseva HG, Leontovich TA. Dendritic changes in the basal nucleus of Meynert and in the diagonal band nucleus in Alzheimer's disease. A quantitative Golgi investigation. Neuroscience 1986; 19:1265-78.
    • (1986) Neuroscience , vol.19 , pp. 1265-1278
    • Arendt, T.1    Zvegintseva, H.G.2    Leontovich, T.A.3
  • 65
    • 0026034181 scopus 로고
    • Cell loss and nuclear hypertrophy in topographical subdivisions of the nucleus basalis of Meynert in Alzheimer's disease
    • Iraizoz I, de Lacalle S, Gonzalo LM. Cell loss and nuclear hypertrophy in topographical subdivisions of the nucleus basalis of Meynert in Alzheimer's disease. Neuroscience 1991; 41:33-40.
    • (1991) Neuroscience , vol.41 , pp. 33-40
    • Iraizoz, I.1    De Lacalle, S.2    Gonzalo, L.M.3
  • 68
    • 0022178992 scopus 로고
    • Morphometric investigation of nerve cells, neuropil and senile plaques in senile dementia of the Alzheimer type
    • Meier-Ruge W, Ulrich J, Stähelin HB. Morphometric investigation of nerve cells, neuropil and senile plaques in senile dementia of the Alzheimer type. Arch Gerontol Geriatr 1985; 4:219-29.
    • (1985) Arch Gerontol Geriatr , vol.4 , pp. 219-229
    • Meier-Ruge, W.1    Ulrich, J.2    Stähelin, H.B.3
  • 69
    • 0035027630 scopus 로고    scopus 로고
    • Size of neocortical neurons in control subjects and in Alzheimer's disease
    • Bundgaard MJ, Regeur L, Gundersen HJ, Pakkenberg B. Size of neocortical neurons in control subjects and in Alzheimer's disease. J Anat 2001; 198:481-9.
    • (2001) J Anat , vol.198 , pp. 481-489
    • Bundgaard, M.J.1    Regeur, L.2    Gundersen, H.J.3    Pakkenberg, B.4
  • 72
    • 85011940326 scopus 로고    scopus 로고
    • Asymptomatic AD is associated with hypertrophy of CA1-hippocampus neurons in the NUN study
    • Iacono D, Pletnikova O, Rudow G, Patel E, Tudor D, Markesbery W, Snowdon D, et al. Asymptomatic AD is associated with hypertrophy of CA1-hippocampus neurons in the NUN study. FASEB J 2008; 22:702-7.
    • (2008) FASEB J , vol.22 , pp. 702-707
    • Iacono, D.1    Pletnikova, O.2    Rudow, G.3    Patel, E.4    Tudor, D.5    Markesbery, W.6    Snowdon, D.7
  • 73
    • 70349336015 scopus 로고    scopus 로고
    • The Nun study: Clinically silent AD, neuronal hypertrophy, and linguistic skills in early life
    • Iacono D, Markesbery WR, Gross M, Pletnikova O, Rudow G, Zandi P, et al. The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life. Neurology 2009; 73:665-73.
    • (2009) Neurology , vol.73 , pp. 665-673
    • Iacono, D.1    Markesbery, W.R.2    Gross, M.3    Pletnikova, O.4    Rudow, G.5    Zandi, P.6
  • 74
    • 35548930820 scopus 로고    scopus 로고
    • Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
    • Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, et al. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci 2007; 10:1449-57.
    • (2007) Nat Neurosci , vol.10 , pp. 1449-1457
    • Jansen, P.1    Giehl, K.2    Nyengaard, J.R.3    Teng, K.4    Lioubinski, O.5    Sjoegaard, S.S.6
  • 75
    • 34447641466 scopus 로고    scopus 로고
    • Intracellular sortilin expression pattern regulates proNGF-induced naturally occurring cell death during development
    • Nakamura K, Namekata K, Harada C, Harada T. Intracellular sortilin expression pattern regulates proNGF-induced naturally occurring cell death during development. Cell Death Differ 2007; 14:1552-4.
    • (2007) Cell Death Differ , vol.14 , pp. 1552-1554
    • Nakamura, K.1    Namekata, K.2    Harada, C.3    Harada, T.4
  • 77
    • 0025857391 scopus 로고
    • The trk proto-oncogene encodes a receptor for nerve growth factor
    • Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 1991; 65:189-97.
    • (1991) Cell , vol.65 , pp. 189-197
    • Klein, R.1    Jing, S.Q.2    Nanduri, V.3    O'Rourke, E.4    Barbacid, M.5
  • 78
    • 2442463255 scopus 로고    scopus 로고
    • NTR is positively promiscuous: Novel partners and new insights
    • NTR is positively promiscuous: novel partners and new insights. Neuron 2004; 42:529-33.
    • (2004) Neuron , vol.42 , pp. 529-533
    • Barker, P.A.1
  • 79
    • 0036790749 scopus 로고    scopus 로고
    • Control of the cell cycle by neurotrophins: Lessons from the p75 neurotrophin receptor
    • López-Sánchez N, Frade JM. Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor. Histol Histopathol 2002; 17:1227-37.
    • (2002) Histol Histopathol , vol.17 , pp. 1227-1237
    • López-Sánchez, N.1    Frade, J.M.2
  • 80
    • 0036830562 scopus 로고    scopus 로고
    • The neurotrophin receptor p75(NTR): Novel functions and implications for diseases of the nervous system
    • Dechant G, Barde YA. The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nat Neurosci 2002; 5:1131-6.
    • (2002) Nat Neurosci , vol.5 , pp. 1131-1136
    • Dechant, G.1    Barde, Y.A.2
  • 81
    • 70449697890 scopus 로고    scopus 로고
    • Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease
    • Diarra A, Geetha T, Potter P, Babu JR. Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease. Biochem Biophys Res Commun 2009; 390:352-6.
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 352-356
    • Diarra, A.1    Geetha, T.2    Potter, P.3    Babu, J.R.4
  • 82
    • 68949124786 scopus 로고    scopus 로고
    • The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease
    • Coulson EJ, May LM, Sykes AM, Hamlin AS. The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease. Neuroscientist 2009; 15:317-23.
    • (2009) Neuroscientist , vol.15 , pp. 317-323
    • Coulson, E.J.1    May, L.M.2    Sykes, A.M.3    Hamlin, A.S.4
  • 83
    • 0023099778 scopus 로고
    • Basal forebrain magnocellular neurons stain for nerve growth factor receptor: Correlation with cholinergic cell bodies and effects of axotomy
    • Springer JE, Koh S, Tayrien MW, Loy R. Basal forebrain magnocellular neurons stain for nerve growth factor receptor: correlation with cholinergic cell bodies and effects of axotomy. J Neurosci Res 1987; 17:111-8.
    • (1987) J Neurosci Res , vol.17 , pp. 111-118
    • Springer, J.E.1    Koh, S.2    Tayrien, M.W.3    Loy, R.4
  • 84
    • 0036445858 scopus 로고    scopus 로고
    • Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients
    • Hu XY, Zhang HY, Qin S, Xu H, Swaab DF, Zhou JN. Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients. Exp Neurol 2002; 178:104-11.
    • (2002) Exp Neurol , vol.178 , pp. 104-111
    • Hu, X.Y.1    Zhang, H.Y.2    Qin, S.3    Xu, H.4    Swaab, D.F.5    Zhou, J.N.6
  • 85
    • 0030723983 scopus 로고    scopus 로고
    • Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease
    • Yaar M, Zhai S, Pilch PF, Doyle SM, Eisenhauer PB, Fine RE, et al. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J Clin Invest 1997; 100:2333-40.
    • (1997) J Clin Invest , vol.100 , pp. 2333-2340
    • Yaar, M.1    Zhai, S.2    Pilch, P.F.3    Doyle, S.M.4    Eisenhauer, P.B.5    Fine, R.E.6
  • 87
    • 69449094771 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo
    • Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, et al. The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci 2009; 29:10627-37.
    • (2009) J Neurosci , vol.29 , pp. 10627-10637
    • Knowles, J.K.1    Rajadas, J.2    Nguyen, T.V.3    Yang, T.4    LeMieux, M.C.5    Vander Griend, L.6
  • 88
    • 24044480687 scopus 로고    scopus 로고
    • Low concentrations of aggregated beta-amyloid induce neurite formation via the neurotrophin receptor p75
    • Susen K, Blöchl A. Low concentrations of aggregated beta-amyloid induce neurite formation via the neurotrophin receptor p75. J Mol Med 2005; 83:720-35.
    • (2005) J Mol Med , vol.83 , pp. 720-735
    • Susen, K.1    Blöchl, A.2
  • 89
    • 0029066704 scopus 로고
    • Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease
    • Arendt T, Holzer M, Grossmann A, Zedlick D, Brückner MK. Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease. Neuroscience 1995; 68:5-18.
    • (1995) Neuroscience , vol.68 , pp. 5-18
    • Arendt, T.1    Holzer, M.2    Grossmann, A.3    Zedlick, D.4    Brückner, M.K.5
  • 91
    • 65249105453 scopus 로고    scopus 로고
    • Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75(NTR) interaction
    • Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen DE. Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Ann Neurol 2009; 65:294-303.
    • (2009) Ann Neurol , vol.65 , pp. 294-303
    • Fombonne, J.1    Rabizadeh, S.2    Banwait, S.3    Mehlen, P.4    Bredesen, D.E.5
  • 93
    • 0035976524 scopus 로고    scopus 로고
    • Regulation of cell survival by secreted proneurotrophins
    • Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science 2001; 294:1945-8.
    • (2001) Science , vol.294 , pp. 1945-1948
    • Lee, R.1    Kermani, P.2    Teng, K.K.3    Hempstead, B.L.4
  • 94
    • 0034848604 scopus 로고    scopus 로고
    • The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease
    • Fahnestock M, Michalski B, Xu B, Coughlin MD. The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol Cell Neurosci 2001; 18:210-20.
    • (2001) Mol Cell Neurosci , vol.18 , pp. 210-220
    • Fahnestock, M.1    Michalski, B.2    Xu, B.3    Coughlin, M.D.4
  • 96
    • 42049088076 scopus 로고    scopus 로고
    • Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system
    • Al-Shawi R, Hafner A, Olsen J, Chun S, Raza S, Thrasivoulou C, et al. Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system. Eur J Neurosci 2008; 27:2103-14.
    • (2008) Eur J Neurosci , vol.27 , pp. 2103-2114
    • Al-Shawi, R.1    Hafner, A.2    Olsen, J.3    Chun, S.4    Raza, S.5    Thrasivoulou, C.6
  • 98
    • 0348110429 scopus 로고    scopus 로고
    • ProNGF: A neurotrophic or an apoptotic molecule?
    • Fahnestock M, Yu G, Coughlin MD. ProNGF: a neurotrophic or an apoptotic molecule? Prog Brain Res 2004; 146:101-10.
    • (2004) Prog Brain Res , vol.146 , pp. 101-110
    • Fahnestock, M.1    Yu, G.2    Coughlin, M.D.3
  • 99
    • 0034087784 scopus 로고    scopus 로고
    • Region-specific neurotrophin imbalances in Alzheimer disease: Decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas
    • Hock C, Heese K, Hulette C, Rosenberg C, Otten U. Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch Neurol 2000; 57:846-51.
    • (2000) Arch Neurol , vol.57 , pp. 846-851
    • Hock, C.1    Heese, K.2    Hulette, C.3    Rosenberg, C.4    Otten, U.5
  • 100
    • 0027197191 scopus 로고
    • Detection of NGF-like activity in human brain tissue increased levels in Alzheimer's disease
    • Crutcher KA, Scott SA, Liang S, Everson WV, Weingartner J. Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease. J Neurosci 1993; 13:2540-50.
    • (1993) J Neurosci , vol.13 , pp. 2540-2550
    • Crutcher, K.A.1    Scott, S.A.2    Liang, S.3    Everson, W.V.4    Weingartner, J.5
  • 102
    • 2942536284 scopus 로고    scopus 로고
    • Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease
    • Peng S, Wuu J, Mufson EJ, Fahnestock M. Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease. J Neuropathol Exp Neurol 2004; 63:641-9.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 641-649
    • Peng, S.1    Wuu, J.2    Mufson, E.J.3    Fahnestock, M.4
  • 103
    • 0030451939 scopus 로고    scopus 로고
    • Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease
    • Narisawa-Saito M, Wakabayashi K, Tsuji S, Takahashi H, Nawa H. Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neuroreport 1996; 7:2925-8.
    • (1996) Neuroreport , vol.7 , pp. 2925-2928
    • Narisawa-Saito, M.1    Wakabayashi, K.2    Tsuji, S.3    Takahashi, H.4    Nawa, H.5
  • 104
    • 0029022112 scopus 로고
    • Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis
    • Scott SA, Mufson EJ, Weingartner JA, Skau KA, Crutcher KA. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J Neurosci 1995; 15:6213-21.
    • (1995) J Neurosci , vol.15 , pp. 6213-6221
    • Scott, S.A.1    Mufson, E.J.2    Weingartner, J.A.3    Skau, K.A.4    Crutcher, K.A.5
  • 107
  • 108
  • 109
    • 0029007478 scopus 로고
    • Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease
    • Smith MA, Rudnicka-Nawrot M, Richey PL, Praprotnik D, Mulvihill P, Miller CA, et al. Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease. J Neurochem 1995; 64:2660-6.
    • (1995) J Neurochem , vol.64 , pp. 2660-2666
    • Smith, M.A.1    Rudnicka-Nawrot, M.2    Richey, P.L.3    Praprotnik, D.4    Mulvihill, P.5    Miller, C.A.6
  • 111
    • 0030989545 scopus 로고    scopus 로고
    • 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
    • Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem 1997; 68:2092-7.
    • (1997) J Neurochem , vol.68 , pp. 2092-2097
    • Sayre, L.M.1    Zelasko, D.A.2    Harris, P.L.3    Perry, G.4    Salomon, R.G.5    Smith, M.A.6
  • 113
    • 73549125459 scopus 로고    scopus 로고
    • Cell death and learning impairment in mice caused by in vitro modified pro-NGF can be related to its increased oxidative modifications in Alzheimer disease
    • Kichev A, Ilieva EV, Piñol-Ripoll G, Podlesniy P, Ferrer I, Portero-Otín M, et al. Cell death and learning impairment in mice caused by in vitro modified pro-NGF can be related to its increased oxidative modifications in Alzheimer disease. Am J Pathol 2009; 175:2574-85.
    • (2009) Am J Pathol , vol.175 , pp. 2574-2585
    • Kichev, A.1    Ilieva, E.V.2    Piñol-Ripoll, G.3    Podlesniy, P.4    Ferrer, I.5    Portero-Otín, M.6
  • 114
    • 0034254808 scopus 로고    scopus 로고
    • p75 neurotrophin receptor signaling: Mechanisms for neurotrophic modulation of cell stress?
    • Dobrowsky RT, Carter BD. p75 neurotrophin receptor signaling: mechanisms for neurotrophic modulation of cell stress? J Neurosci Res 2000; 61:237-43.
    • (2000) J Neurosci Res , vol.61 , pp. 237-243
    • Dobrowsky, R.T.1    Carter, B.D.2
  • 115
    • 27644555712 scopus 로고    scopus 로고
    • Oxidative stress modulates tyrosine kinase receptor A and p75 receptor (low-affinity nerve growth factor receptor) expression in SHSY5Y neuroblastoma cells
    • Olivieri G, Otten U, Meier F, Baysang G, Dimitriades-Schmutz B, Müller-Spahn F, et al. Oxidative stress modulates tyrosine kinase receptor A and p75 receptor (low-affinity nerve growth factor receptor) expression in SHSY5Y neuroblastoma cells. Neurol Clin Neurophysiol 2002; 2002:2-10.
    • (2002) Neurol Clin Neurophysiol , vol.2002 , pp. 2-10
    • Olivieri, G.1    Otten, U.2    Meier, F.3    Baysang, G.4    Dimitriades-Schmutz, B.5    Müller-Spahn, F.6
  • 116
    • 42449100783 scopus 로고    scopus 로고
    • Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes
    • Ali TK, Matragoon S, Pillai BA, Liou GI, El-Remessy AB. Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes. Diabetes 2008; 57:889-98.
    • (2008) Diabetes , vol.57 , pp. 889-898
    • Ali, T.K.1    Matragoon, S.2    Pillai, B.A.3    Liou, G.I.4    El-Remessy, A.B.5
  • 118
    • 79952897537 scopus 로고    scopus 로고
    • Microglia activation mediates fibrillar amyloid-beta toxicity in the aged primate cortex
    • doi: 10.1016/j.neurobiolaging.2009.02.025
    • Leung E, Guo L, Bu J, Maloof M, Khoury JE, Geula C. Microglia activation mediates fibrillar amyloid-beta toxicity in the aged primate cortex. Neurobiol Aging 2009; doi: 10.1016/j.neurobiolaging.2009.02.025.
    • (2009) Neurobiol Aging
    • Leung, E.1    Guo, L.2    Bu, J.3    Maloof, M.4    Khoury, J.E.5    Geula, C.6
  • 119
    • 51349161367 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide protects against beta-amyloid-induced neurodegeneration by inhibiting microglia activation at multiple levels
    • Delgado M, Varela N, Gonzalez-Rey E. Vasoactive intestinal peptide protects against beta-amyloid-induced neurodegeneration by inhibiting microglia activation at multiple levels. Glia 2008; 56:1091-103.
    • (2008) Glia , vol.56 , pp. 1091-1103
    • Delgado, M.1    Varela, N.2    Gonzalez-Rey, E.3
  • 120
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • González-Scarano F, Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 1999; 22:219-40.
    • (1999) Annu Rev Neurosci , vol.22 , pp. 219-240
    • González-Scarano, F.1    Baltuch, G.2
  • 121
    • 0023642584 scopus 로고
    • Production of superoxide anions by a CNS macrophage, the microglia
    • Colton CA, Gilbert DL. Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett 1987; 223:284-8.
    • (1987) FEBS Lett , vol.223 , pp. 284-288
    • Colton, C.A.1    Gilbert, D.L.2
  • 122
    • 0029161781 scopus 로고
    • Glial cytokines in Alzheimer's disease: Review and pathogenic implications
    • Mrak RE, Sheng JG, Griffin WS. Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum Pathol 1995; 26:816-23.
    • (1995) Hum Pathol , vol.26 , pp. 816-823
    • Mrak, R.E.1    Sheng, J.G.2    Griffin, W.S.3
  • 123
    • 0029972857 scopus 로고    scopus 로고
    • Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function
    • Elkabes S, DiCicco-Bloom EM, Black IB. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 1996; 16:2508-21.
    • (1996) J Neurosci , vol.16 , pp. 2508-2521
    • Elkabes, S.1    DiCicco-Bloom, E.M.2    Black, I.B.3
  • 124
    • 0030930287 scopus 로고    scopus 로고
    • Nerve growth factor (NGF) expression in rat microglia is induced by adenosine A2a-receptors
    • Heese K, Fiebich BL, Bauer J, Otten U. Nerve growth factor (NGF) expression in rat microglia is induced by adenosine A2a-receptors. Neurosci Lett 1997; 231:83-6.
    • (1997) Neurosci Lett , vol.231 , pp. 83-86
    • Heese, K.1    Fiebich, B.L.2    Bauer, J.3    Otten, U.4
  • 125
    • 0031934936 scopus 로고    scopus 로고
    • Microglia-derived nerve growth factor causes cell death in the developing retina
    • Frade JM, Barde YA. Microglia-derived nerve growth factor causes cell death in the developing retina. Neuron 1998; 20:35-41.
    • (1998) Neuron , vol.20 , pp. 35-41
    • Frade, J.M.1    Barde, Y.A.2
  • 126
    • 4744370909 scopus 로고    scopus 로고
    • Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor
    • Srinivasan B, Roque CH, Hempstead BL, Al-Ubaidi MR, Roque RS. Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor. J Biol Chem 2004; 279:41839-45.
    • (2004) J Biol Chem , vol.279 , pp. 41839-41845
    • Srinivasan, B.1    Roque, C.H.2    Hempstead, B.L.3    Al-Ubaidi, M.R.4    Roque, R.S.5
  • 127
    • 0031913982 scopus 로고    scopus 로고
    • Inflammatory signals induce neurotrophin expression in human microglial cells
    • Heese K, Hock C, Otten U. Inflammatory signals induce neurotrophin expression in human microglial cells. J Neurochem 1998; 70:699-707.
    • (1998) J Neurochem , vol.70 , pp. 699-707
    • Heese, K.1    Hock, C.2    Otten, U.3
  • 128
    • 0033637884 scopus 로고    scopus 로고
    • Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons
    • Wu Q, Combs C, Cannady SB, Geldmacher DS, Herrup K. Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons. Neurobiol Aging 2000; 21:797-806.
    • (2000) Neurobiol Aging , vol.21 , pp. 797-806
    • Wu, Q.1    Combs, C.2    Cannady, S.B.3    Geldmacher, D.S.4    Herrup, K.5
  • 130
    • 33845192758 scopus 로고    scopus 로고
    • Genome multiplication as adaptation to tissue survival: Evidence from gene expression in mammalian heart and liver
    • Anatskaya OV, Vinogradov AE. Genome multiplication as adaptation to tissue survival: evidence from gene expression in mammalian heart and liver. Genomics 2007; 89:70-80.
    • (2007) Genomics , vol.89 , pp. 70-80
    • Anatskaya, O.V.1    Vinogradov, A.E.2
  • 131
    • 74349090730 scopus 로고    scopus 로고
    • Expression Profiling of Tetraploid Mouse Embryos in the Developmental Stages Using a cDNA Microarray Analysis
    • doi: 10.1262/jrd.09-127A
    • Kawaguchi J, Kano K, Naito K. Expression Profiling of Tetraploid Mouse Embryos in the Developmental Stages Using a cDNA Microarray Analysis. J Reprod Dev 2009; doi: 10.1262/jrd.09-127A.
    • (2009) J Reprod Dev
    • Kawaguchi, J.1    Kano, K.2    Naito, K.3
  • 132
    • 33846658032 scopus 로고    scopus 로고
    • Proteomic analysis of brain tissue from an Alzheimer's disease mouse model by two-dimensional difference gel electrophoresis
    • Sizova D, Charbaut E, Delalande F, Poirier F, High AA, Parker F, et al. Proteomic analysis of brain tissue from an Alzheimer's disease mouse model by two-dimensional difference gel electrophoresis. Neurobiol Aging 2007; 28:357-70.
    • (2007) Neurobiol Aging , vol.28 , pp. 357-370
    • Sizova, D.1    Charbaut, E.2    Delalande, F.3    Poirier, F.4    High, A.A.5    Parker, F.6
  • 133
    • 27144527588 scopus 로고    scopus 로고
    • Comparative proteomic analysis using samples obtained with laser microdissection and saturation dye labelling
    • Wilson KE, Marouga R, Prime JE, Pashby DP, Orange PR, Crosier S, et al. Comparative proteomic analysis using samples obtained with laser microdissection and saturation dye labelling. Proteomics 2005; 5:3851-8.
    • (2005) Proteomics , vol.5 , pp. 3851-3858
    • Wilson, K.E.1    Marouga, R.2    Prime, J.E.3    Pashby, D.P.4    Orange, P.R.5    Crosier, S.6
  • 134
    • 9744239546 scopus 로고    scopus 로고
    • Early dysregulation of hippocampal proteins in transgenic rats with Alzheimer's disease-linked mutations in amyloid precursor protein and presenilin 1
    • Vercauteren FG, Clerens S, Roy L, Hamel N, Arckens L, Vandesande F, et al. Early dysregulation of hippocampal proteins in transgenic rats with Alzheimer's disease-linked mutations in amyloid precursor protein and presenilin 1. Brain Res Mol Brain Res 2004; 132:241-59.
    • (2004) Brain Res Mol Brain Res , vol.132 , pp. 241-259
    • Vercauteren, F.G.1    Clerens, S.2    Roy, L.3    Hamel, N.4    Arckens, L.5    Vandesande, F.6
  • 135
    • 0035205666 scopus 로고    scopus 로고
    • Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer disease
    • Husseman JW, Hallows JL, Bregman DB, Leverenz JB, Nochlin D, Jin LW, et al. Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer disease. J Neuropathol Exp Neurol 2001; 60:1219-32.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 1219-1232
    • Husseman, J.W.1    Hallows, J.L.2    Bregman, D.B.3    Leverenz, J.B.4    Nochlin, D.5    Jin, L.W.6
  • 138
    • 58149220667 scopus 로고    scopus 로고
    • Cholesterol in Alzheimer's disease: Unresolved questions
    • Stefani M, Liguri G. Cholesterol in Alzheimer's disease: unresolved questions. Curr Alzheimer Res 2009; 6:15-29.
    • (2009) Curr Alzheimer Res , vol.6 , pp. 15-29
    • Stefani, M.1    Liguri, G.2
  • 140
    • 50349083801 scopus 로고    scopus 로고
    • Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice
    • Maysinger D, Holmes M, Han X, Epand RM, Pertens E, Foerster A, et al. Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice. J Neurosci 2008; 28:7891-9.
    • (2008) J Neurosci , vol.28 , pp. 7891-7899
    • Maysinger, D.1    Holmes, M.2    Han, X.3    Epand, R.M.4    Pertens, E.5    Foerster, A.6
  • 143
    • 0025279165 scopus 로고
    • Axon sprouting in the rodent and Alzheimer's disease brain: A reactivation of developmental mechanisms?
    • Cotman CW, Geddes JW, Kahle JS. Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms? Prog Brain Res 1990; 83:427-34.
    • (1990) Prog Brain Res , vol.83 , pp. 427-434
    • Cotman, C.W.1    Geddes, J.W.2    Kahle, J.S.3
  • 145
    • 0033215972 scopus 로고    scopus 로고
    • Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice
    • Phinney AL, Deller T, Stalder M, Calhoun ME, Frotscher M, Sommer B, et al. Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice. J Neurosci 1999; 19:8552-9.
    • (1999) J Neurosci , vol.19 , pp. 8552-8559
    • Phinney, A.L.1    Deller, T.2    Stalder, M.3    Calhoun, M.E.4    Frotscher, M.5    Sommer, B.6
  • 146
    • 0035042440 scopus 로고    scopus 로고
    • Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease
    • Arendt T. Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease. Int J Dev Neurosci 2001; 19:231-45.
    • (2001) Int J Dev Neurosci , vol.19 , pp. 231-245
    • Arendt, T.1
  • 147
    • 2442711560 scopus 로고    scopus 로고
    • Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice
    • Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Neurosci 2004; 24:4692-7.
    • (2004) J Neurosci , vol.24 , pp. 4692-4697
    • Chin, J.1    Palop, J.J.2    Yu, G.Q.3    Kojima, N.4    Masliah, E.5    Mucke, L.6
  • 148
    • 34548264782 scopus 로고    scopus 로고
    • Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    • Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 2007; 55:697-711.
    • (2007) Neuron , vol.55 , pp. 697-711
    • Palop, J.J.1    Chin, J.2    Roberson, E.D.3    Wang, J.4    Thwin, M.T.5    Bien-Ly, N.6
  • 150
    • 56349119351 scopus 로고    scopus 로고
    • Linking Abeta and tau in late-onset Alzheimer's disease: A dual pathway hypothesis
    • Small SA, Duff K. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 2008; 60:534-42.
    • (2008) Neuron , vol.60 , pp. 534-542
    • Small, S.A.1    Duff, K.2
  • 151
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991; 82:239-59.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 153
    • 2942572699 scopus 로고    scopus 로고
    • Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: Correlation with the MAP kinase pathway
    • Frasca G, Chiechio S, Vancheri C, Nicoletti F, Copani A, Angela Sortino M. Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: correlation with the MAP kinase pathway. J Mol Neurosci 2004; 22:231-6.
    • (2004) J Mol Neurosci , vol.22 , pp. 231-236
    • Frasca, G.1    Chiechio, S.2    Vancheri, C.3    Nicoletti, F.4    Copani, A.5    Angela Sortino, M.6
  • 154
    • 0032865843 scopus 로고    scopus 로고
    • Molecular mechanisms underlying activity-dependent regulation of BDNF expression
    • Shieh PB, Ghosh A. Molecular mechanisms underlying activity-dependent regulation of BDNF expression. J Neurobiol 1999; 41:127-34.
    • (1999) J Neurobiol , vol.41 , pp. 127-134
    • Shieh, P.B.1    Ghosh, A.2
  • 155
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
    • Murer MG, Yan Q, Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 2001; 63:71-124.
    • (2001) Prog Neurobiol , vol.63 , pp. 71-124
    • Murer, M.G.1    Yan, Q.2    Raisman-Vozari, R.3
  • 156
    • 0033813571 scopus 로고    scopus 로고
    • Neurotrophic factors in Alzheimer's and Parkinson's disease brain
    • Siegel GJ, Chauhan NB. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Brain Res Rev 2000; 33:199-227.
    • (2000) Brain Res Brain Res Rev , vol.33 , pp. 199-227
    • Siegel, G.J.1    Chauhan, N.B.2
  • 157
    • 0032805204 scopus 로고    scopus 로고
    • BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies
    • Ferrer I, Marín C, Rey MJ, Ribalta T, Goutan E, Blanco R, et al. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J. Neuropathol Exp Neurol 1999; 58:729-39.
    • (1999) J. Neuropathol Exp Neurol , vol.58 , pp. 729-739
    • Ferrer, I.1    Marín, C.2    Rey, M.J.3    Ribalta, T.4    Goutan, E.5    Blanco, R.6
  • 158
    • 0033517723 scopus 로고    scopus 로고
    • Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease
    • Allen SJ, Wilcock GK, Dawbarn D. Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease. Biochem Biophys Res Commun 1999; 264:648-51.
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 648-651
    • Allen, S.J.1    Wilcock, G.K.2    Dawbarn, D.3
  • 159
    • 0038388955 scopus 로고    scopus 로고
    • Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: A mitotic catastrophe?
    • Ogawa O, Zhu X, Lee HG, Raina A, Obrenovich ME, Bowser R, et al. Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? Acta Neuropathol 2003; 105:524-8.
    • (2003) Acta Neuropathol , vol.105 , pp. 524-528
    • Ogawa, O.1    Zhu, X.2    Lee, H.G.3    Raina, A.4    Obrenovich, M.E.5    Bowser, R.6
  • 162
    • 0035134990 scopus 로고    scopus 로고
    • A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease
    • Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, et al. A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiatry 2001; 6:83-6.
    • (2001) Mol Psychiatry , vol.6 , pp. 83-86
    • Kunugi, H.1    Ueki, A.2    Otsuka, M.3    Isse, K.4    Hirasawa, H.5    Kato, N.6
  • 163
    • 2942550476 scopus 로고    scopus 로고
    • Lack of association between the brain-derived neurotrophin factor (C-270T) polymorphism and late-onset Alzheimer's disease (LOAD) in Brazilian patients
    • Nishimura AL, Oliveira JR, Mitne-Neto M, Guindalini C, Nitrini R, Bahia VS, et al. Lack of association between the brain-derived neurotrophin factor (C-270T) polymorphism and late-onset Alzheimer's disease (LOAD) in Brazilian patients. J Mol Neurosci 2004; 22:257-60.
    • (2004) J Mol Neurosci , vol.22 , pp. 257-260
    • Nishimura, A.L.1    Oliveira, J.R.2    Mitne-Neto, M.3    Guindalini, C.4    Nitrini, R.5    Bahia, V.S.6
  • 164
    • 1642578180 scopus 로고    scopus 로고
    • Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset
    • Tsai SJ, Hong CJ, Liu HC, Liu TY, Hsu LE, Lin CH. Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology 2004; 49:10-2.
    • (2004) Neuropsychobiology , vol.49 , pp. 10-12
    • Tsai, S.J.1    Hong, C.J.2    Liu, H.C.3    Liu, T.Y.4    Hsu, L.E.5    Lin, C.H.6


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