Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaning

Neurobiology of Disease

Volumn 34, Issue 2, 2009, Pages 212-220

  Iourov, Ivan Y ^a,b   Vorsanova, Svetlana G ^a,b   Liehr, Thomas ^c   Yurov, Yuri B ^a,b  

^a MENTAL HEALTH RESEARCH CENTER   (Russian Federation)

^b N N BLOKHIN NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY   (Russian Federation)

^c Institute of Human Genetics and Anthropology   (Germany)

Author keywords

Alzheimer's disease; Aneuploidy; Ataxia telangiectasia; Cerebral cortex; Fluorescence in situ hybridization (FISH); Human brain; Human chromosomes

Indexed keywords

ADOLESCENT; ADULT; ALZHEIMER DISEASE; ANEUPLOIDY; ARTICLE; ATAXIA TELANGIECTASIA; BRAIN CORTEX; CADAVER; CASE CONTROL STUDY; CHILD; CHROMOSOME 1; CHROMOSOME 11; CHROMOSOME 13; CHROMOSOME 14; CHROMOSOME 17; CHROMOSOME 18; CHROMOSOME 21; CHROMOSOME 7; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA PROBE; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MALE; NERVE CELL; NEUROPATHOLOGY; PRIORITY JOURNAL; SCHOOL CHILD; X CHROMOSOME; Y CHROMOSOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANEUPLOIDY; ATAXIA TELANGIECTASIA; CELL NUCLEUS; CEREBRAL CORTEX; CHILD; CHROMOSOME ABERRATIONS; CHROMOSOME MAPPING; CHROMOSOMES; CHROMOSOMES, HUMAN, PAIR 21; FEMALE; GENETIC MARKERS; HUMANS; MALE; MIDDLE AGED; MOSAICISM; NEURONS; YOUNG ADULT;

EID: 64449088956     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2009.01.003     Document Type: Article

References (36)

1. Allen D.M., Praag van H., Ray J., Weaver Z., Winrow C.J., Carter T.A., Braquet R., Harrington E., Ried T., Brown K.D., Gage F.H., and Barlow C. Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev. 15 (2001) 554-566
2. Arnoldus E.P., Peters A.C., Bots G.T., Raap A.K., and van der Ploeg M. Somatic pairing of chromosome 1 centromeres in interphase nuclei of human cerebellum. Hum. Genet. 83 (1989) 231-234
3. Boeras D.I., Granic A., Padmanabhan J., Crespo N.C., Rojiani A.M., and Potter H. Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy. Neurobiol. Aging 29 (2008) 319-328
4. Duesberg P., and Li R. Multistep carcinogenesis: a chain reaction of aneuploidizations. Cell Cycle 2 (2003) 202-210 (Review)
5. Geller L.N., and Potter H. Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease. Neurobiol. Dis. 6 (1999) 167-179
6. Iourov I.Y., Soloviev I.V., Vorsanova S.G., Monakhov V.V., and Yurov Y.B. An approach for quantitative assessment of fluorescence in situ hybridization signals for applied human molecular cytogenetics. J. Histochem. Cytochem. 53 (2005) 401-408
7. Iourov I.Y., Liehr T., Vorsanova S.G., Kolotii A.D., and Yurov Y.B. Visualization of interphase chromosomes in postmitotic cells of the human brain by multicolor banding. Chromosome Res. 14 (2006) 223-229
8. Iourov I.Y., Vorsanova S.G., Pellestor F., and Yurov Y.B. Brain tissue preparation for chromosomal PRINS labeling. Methods Mol. Biol. 334 (2006) 123-132
9. Iourov I.Y., Vorsanova S.G., and Yurov Y.B. Chromosomal variation in mammalian neuronal cells: known facts and attractive hypotheses. Int. Rev. Cytol. 249 (2006) 143-191 (Review)
10. Iourov I.Y., Liehr T., Vorsanova S.G., and Yurov Y.B. Interphase chromosome-specific multicolor banding (ICS-MCB): a new tool for analysis of interphase chromosomes in their integrity. Biomol. Eng. 24 (2007) 415-417
11. Iourov I.Y., Vorsanova S.G., and Yurov Y.B. Molecular cytogenetics and cytogenomics of brain diseases. Curr. Genomics 9 (2008) 452-465
12. Jin K., Peel A.I., Mao X.O., et al. Increased hippocampal neurogenesis in Alzheimer's disease. Proc. Natl. Acad. Sci USA 101 (2004) 343-347
13. Kingsbury M.A., Friedman B., McConnell M.J., Rehen S.K., Yang A.H., Kaushal D., and Chun J. Aneuploid neurons are functionally active and integrative into brain circuitry. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 6143-6147
14. Kingsbury M.A., Yung Y.C., Peterson S.E., Westra J.W., and Chun J. Aneuploidy in the normal and diseased brain. Cell. Mol. Life Sci. 63 (2006) 2626-2641 (Review)
15. Li J., Xu M., Zhou H., Ma J., and Potter H. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 90 (1997) 917-927
16. Liehr T., Heller A., Starke H., Rubtsov N., Trifonov V., Mrasek K., Weise A., Kuechler A., and Claussen U. Microdissection based high resolution multicolor banding for all 24 human chromosomes. Int. J. Mol. Med. 9 (2002) 335-339
17. Lodish H., Berk A., Ziputsky L., Matsudaria P., Baltimore D., and Darnell J. Molecular Cell Biology. 4th ed (2000), WRH. Freeman Publishers, New York
18. McConnell M.J., Kaushal D., Yang A.H., Kingsbury M.A., Rehen S.K., Treuner K., Helton R., Annas E.G., Chun J., and Barlow C. Failed clearance of aneuploidy embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex. J. Neurosci. 24 (2004) 8090-8096
19. McKinnon P.J. ATM and ataxia telangiectasia. EMBO Rep. 5 (2004) 772-776 (Review)
20. Migliore L., Botto N., Scapato R., Petrozzi L., Cipriani G., and Bonucceli U. Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients. Cytogenet. Cell. Genet. 87 (1999) 41-46
21. Mosch B., Morawski M., Mittag A., Lenz D., Tarnok A., and Arendt T. Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease. J. Neurosci. 27 (2007) 6859-6867
22. Muotri A.R., and Gage F.H. Generation of neuronal variability and complexity. Nature 441 (2006) 903-910 (Review)
23. Rehen S.K., Yung Y.C., McCreight M.P., Kaushal D., Yang A.H., Almeida B.S.V., Kingsbury M.A., Cabral K.M.S., McConell M.J., Anliker B., Fontanoz M., and Chun J. Constitutional aneuploidy in the normal brain. J. Neurosci. 25 (2005) 2176-2180
24. Soloviev I.V., Yurov Y.B., Vorsanova S.G., Fayet F., Roizes G., and Malet P. Prenatal diagnosis of trisomy 21 using interphase fluorescence in situ hybridization of post-replicated cells with site-specific cosmid and cosmid contig probes. Prenat. Diagn. 15 (1995) 237-248
25. Toupin P. Adult neurogenesis in mammals. Curr. Opin. Mol. Ther. 8 (2006) 351-435
26. Vorsanova S.G., Kolotii A.D., Iourov I.Y., Monakhov V.V., Kirillova E.A., Soloviev I.V., and Yurov Y.B. Evidence for high frequency of chromosomal mosaicism in spontaneous abortions revealed by interphase FISH analysis. J. Histochem. Cytochem. 53 (2005) 375-380
27. Westra J.W., Peterson S.E., Yung Y.C., Mutoh T., Barral S., and Chun J. Aneuploid mosaicism in the developing and adult cerebellar cortex. J. Comp. Neurol. 507 (2008) 1944-1951
28. Williams R.W., and Herrup K. The control of neuron number. Annu. Rev. Neurosci. 11 (1988) 423-453
29. Yang Y., and Herrup K. Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism. J. Neurosci. 25 (2005) 2522-2529
30. Yang Y., Geldmacher D.S., and Herrup K. DNA replication precedes neuronal cell death in Alzheimrs disease. J. Neurosci. 21 (2001) 2661-2668
31. Yurov Y.B., Soloviev I.V., Vorsanova S.G., Marcais B., Roizes G., and Lewis R. High resolution fluorescence in situ hybridization using cyanine and fluorescein dyes: ultra-rapid chromosome detection by directly fluorescently labeled alphoid DNA probes. Hum. Genet. 97 (1996) 390-398
32. Yurov Y.B., Vostrikov V.M., Vorsanova S.G., Monakhov V.V., and Iourov I.Y. Multicolor fluorescent in situ hybridization on post mortem brain in schizophrenia as an approach for identification of low-level chromosomal aneuploidy in neuropsychiatric diseases. Brain Dev. 23 (2001) S186-S190
33. Yurov Y.B., Iourov I.Y., Monakhov V.V., Soloviev I.V., Vostrikov V.M., and Vorsanova S.G. The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study. J. Histochem. Cytochem. 53 (2005) 385-390
34. Yurov Y.B., Iourov I.Y., Vorsanova S.G., Liehr T., Kolotii A.D., Kutsev S.I., Pellestor F., Beresheva A.K., Demidova I.A., Kravets V.S., Monakhov V.V., and Soloviev I.V. Aneuploidy and confined chromosomal mosaicism in the developing human brain. PLoS ONE 2 (2007) e558
35. Yurov Y.B., Vorsanova S.G., Iourov I.Y., Demidova I.A., Beresheva A.K., Kravetz V.S., Monakhov V.V., Kolotii A.D., Voinova-Ulas V.Y., and Gorbachevskaya N.L. Unexplained autism is frequently associated with low-level mosaic aneuploidy. J. Med. Genet. 44 8 (2007) 521-535
36. Yurov Y.B., Iourov I.Y., Vorsanova S.G., Demidova I.A., Kravetz V.S., Beresheva A.K., Kolotii A.D., Monakchov V.V., Uranova N.A., Vostrikov V.M., Soloviev I.V., and Liehr T. The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1. Schizophr. Res. 98 (2008) 137-147