Lack of association between the brain-derived neurotrophin factor (C-270T) polymorphism and late-onset Alzheimer's disease (LOAD) in Brazilian patients

Journal of Molecular Neuroscience

Volumn 22, Issue 3, 2004, Pages 257-260

  Nishimura, Agnes L ^a   Oliveira, João R M ^b   Mitne Neto, Miguel ^a   Guindalini, Camila ^a   Nitrini, Ricardo ^a   Bahia, Valéria S ^a   De Brito Marques, Paulo R ^c   Otto, Paulo A ^a   Zatz, Mayana ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Behavior Neurology Center   (Brazil)

Author keywords

Alzheimer's disease; BDNF; Polymorphism; Susceptibility locus

Indexed keywords

APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR; APOLIPOPROTEIN E4;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; BRAZIL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENE LOCUS; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PROMOTER REGION; RISK FACTOR; BRAIN; BRAIN LEVEL; CAUCASIAN; ETHNOLOGY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; REPRODUCIBILITY;

AGED; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BRAIN; BRAIN CHEMISTRY; BRAIN-DERIVED NEUROTROPHIC FACTOR; BRAZIL; DNA MUTATIONAL ANALYSIS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); REPRODUCIBILITY OF RESULTS;

EID: 2942550476     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:22:3:257     Document Type: Article

References (18)

1. Ait-Ghezala G., Abdullah L., Crescentini R., Crawford F., Town T., Singh S., et al. (2002) Confirmation of association between D10S583 and Alzheimer's disease in a case-control sample. Neurosci. Lett. 325, 87-90.
2. Bertram L., Blacker D., Mullin K., Keeney D., Jones J., Basu S., et al. (2000) Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 290, 2302-2303.
3. Bertram L. and Tanzi R. E. (2001) Dancing in the dark? The status of late-onset Alzheimer's disease genetics. J. Mol. Neurosci. 2, 127-136. Review.
4. Connor B., Young D., Yan Q., Faull R. L., Synek B., and Dragunow M. (1997) Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res. Mol. Brain Res. 49, 71-81.
5. Ertekin-Taner N., Graff-Radford N., Younkin L. H., Eckman C., Baker M., Adamson J., et al. (2000) Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 290, 2303-2304.
6. Funakoshi H., Risling M., Carlstedt T., Lendahl U., Timmusk T., Metsis M., et al. (1998) Targeted expression of a multifunctional chimeric neurotrophin in the lesioned sciatic nerve accelerates regeneration of sensory and motor axons. Proc. Natl. Acad. Sci. USA 95, 5269-5274.
7. Kunugi H., Hattori M., Kato T., Tatsumi M., Sakai T., Sasaki T., et al. (1997) Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol. Psychiatry 6, 457-462.
8. Kunugi H., Ueki A., Otsuka M., Isse K., Hirasawa H., Kato N., et al. (2001) A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol. Psychiatry 1, 83-86.
9. Majores M., Bagli M., Papassotiropoulos A., Schwab S. G., Jessen F., Rao M. L., et al. (2000) Allelic association between the D10S1423 marker and Alzheimer's disease in a German population. Neurosci. Lett. 289, 224-226.
10. Murer M. G., Yan Q., and Raisman-Vozari R. (2001) Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog. Neurobiol. 63, 71-124. Review.
11. Myers A., Holmans P., Marshall H., Kwon J., Meyer D., Ramic D., et al. (2000) Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290, 2304-2305.
12. Nishimura A. L., Oliveira J. R., Otto P. A., Matioli S. R., Brito-Marques P. R., Bahia V. S., et al. (2001) No evidence of association between the D10S1423 locus and Alzheimer disease in Brazilian patients. J. Neural Transm. 108, 305-310.
13. Nishimura A. L., Oliveira J. R. , Matioli S. R., Brito-Marques P. R., Bahia V. S., Nitrini R., and Zatz M. (2000) Analysis of the disease risk locus DXS1047 polymorphism in Brazilian Alzheimer patients. Mol. Psychiatry 5, 563-566.
14. Oliveira J. R., Gallindo R. M., Maia L. G., Brito-Marques P. R., Otto P. A., Passos-Bueno M. R., et al. (1998) The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease. Mol. Psychiatry 5, 438-441.
15. Oliveira J. R., Lima Filho J. L., Shimokomaki C. M., Okuma M., Passos-Bueno M. R., Zatz M., and Brito-Marques P. R. (1997) The use of apolipoprotein E genotype for preclinical detection of risk's group for Alzheimer's disease. Am. J. Med. Genet. 74, 216-217.
16. Riemenschneider M., Schwarz S., Wagenpfeil S., Diehl J., Muller U., Forstl H., and Kurz A. (2002) A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein Eepsilon4 allele. Mol. Psychiatry 7, 782-785.
17. Tsai S. J. (2003) Brain-derived neurotrophic factor: a bridge between major depression and Alzheimer's disease? Med. Hypotheses 1, 110-113.
18. Zubenko G. S., Hughes H. B., Stiffler J. S., Hurtt M. R., and Kaplan B. B. (1998) A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution. Genomics 50, 121-128.