Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer disease

Journal of Neuropathology and Experimental Neurology

Volumn 60, Issue 12, 2001, Pages 1219-1232

  Husseman, Jacob W ^a   Hallows, Janice L ^a   Bregman, David B ^c   Leverenz, James B ^a,b   Nochlin, David ^a   Jin, Lee Way ^a   Vincent, Inez ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer disease; Cdc2; Cell cycle; Neurofibrillary tangles; RNA polymerase II; Tau phosphorylation; Transcription

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN KINASE; RNA; RNA POLYMERASE II;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN TISSUE; MALE; MITOSIS; NERVE CELL DIFFERENTIATION; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; RNA ANALYSIS;

EID: 0035205666     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/60.12.1219     Document Type: Article

References (86)

1. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
2. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
3. Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
4. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
5. Synaptic and neuritic alterations during the progression of Alzheimer's disease
6. Familial and sporadic Alzheimer's disease: Neuropathology cannot exclude a final common pathway
7. Hyperphosphorylation of tau in PHF
8. Tau protein and the neurofibrillary pathology of Alzheimer's disease
9. Flow cytometry of mitotic cells
10. Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology
11. Mitotic mechanisms in Alzheimer's disease?
12. Aberrant expression of mitotic cdc2/cyclin BI kinase in degenerating neurons of Alzheimer's disease brain
13. Localization and expression of cdc2 and cdk4 in Alzheimer brain tissue
14. Cell cycle markers in the hippocampus in Alzheimer's disease
15. Alzheimer's disease neurofibrillary tangles contain mitosis-specific phosphoepitopes
16. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
17. Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y
18. Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells
19. The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: Implications for Alzheimer's disease
20. Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease
21. Expression of cell division markers in the hippocampus in Alzheimer's disease and other neuro-degenerative conditions
22. Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
23. Immunoreactivity of the nuclear antigen p105 is associated with plaques and tangles in Alzheimer's disease
24. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins
25. Presenilin overexpression arrests cells in the G1 phase of the cell cycle: Arrest potentiated by the Alzheimer's disease PS2(N141I)mutant
26. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
27. The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex
28. Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription
29. The interaction of RNA polymerase II with the adenovirus-2 major late promoter is precluded by phosphorylation of the C-terminal domain of subunit IIa
30. RNA polymerases IIA and IIO have distinct roles during transcription from the TATA-less murine dihydrofolate reductase promoter
31. Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: Correlations with gene activity and transcript processing
32. RNA contacts subunits IIo and IIc in HeLa RNA polymerase II transcription complexes
33. Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II
34. Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2
35. Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit
36. The cycling of RNA polymerase II during transcription
37. Phosphorylation of the C-terminal domain of RNA polymerase II
38. Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription
39. Cytophotometric mapping of neuronal Changes in senile dementia
40. Nerve cell protein metabolism and degenerative disease
41. Transcriptional and translational regulatory mechanisms during normal aging of the mammalian brain and in Alzheimer's disease
42. Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease
43. Cytostellin: A novel, highly conserved protein that undergoes continuous redistribution during the cell cycle
44. Mitotic activation: A convergent mechanism for a cohort of neurodegenerative diseases
45. Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease
46. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
47. Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease
48. The natural history of Alzheimer neurofibrillary tangles and amyloid deposits
49. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
50. The brain's microenvironment, early functional loss, and the conversion to Alzheimer's disease
51. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease
52. Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration
53. Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death
54. A protein kinase associated with paired helical filaments in Alzheimer disease
55. Double immunolabeling of neuropeptides in the human hypothalamus as analyzed by confocal laser scanning fluorescence microscopy
56. Cell cycle regulation and RNA polymerase II
57. Proline-directed protein phosphorylation and cell cycle regulation
58. A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease
59. Reversible phosphorylation of the C-terminal domain of RNA polymerase II
60. Cyclins A and B1 in the human cell cycle
61. Neurons and Glia
62. The prolyl isomerase Pinl restores the function of Alzheimer-associated phosphorylated tau protein
63. Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl -terminal domain
64. A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver
65. Enhanced phosphorylation of the C-terminal domain of RNA polymerase II upon serum stimulation of quiescent cells: Possible involvement of MAP kinases
66. Regulation of protein kinase CKII during the cell division cycle
67. Transcriptiondependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains
68. Constitutive Weel and Cdc25B activities in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration
69. The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease
70. Neuronal CDK7 in hippocampus is related to aging and alzheimer disease
71. Neuronal RNA in relation to neuronal loss and neurofibrillary pathology in the hippocampus in Alzheimer's disease
72. Neuronal RNA in relation to Alz-50 immunoreactivity in Alzheimer's disease
73. Genes differentially expressed in Alzheimer's disease brain
74. Expression profiles of multiple genes in single neurons of Alzheimer's disease
75. Gene expression in Alzheimer neocortex as a function of age and pathologic severity
76. Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles
77. A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease
78. DNA damage and chronic neuronal degenerations
79. DNA damage, DNA repair and the genetic basis of Alzheimer's disease
80. Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
81. DNA repair mechanisms in neurological diseases: Facts and hypotheses
82. Studies on DNA repair defects in degenerative brain disease
83. Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture
84. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain
85. Decreased DNA repair capacity in familial, but not in sporadic Alzheimer's disease
86. DNA repair and Alzheimer's disease