-
1
-
-
0034327411
-
An informatics approach identifying markers of chemosensitivity in human cancer cell lines
-
Amundson SA, Myers TG, Scudiero D, Kitada S, Reed JC, Fornace AJ Jr. 2000. An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 60:6101-6110.
-
(2000)
Cancer Res
, vol.60
, pp. 6101-6110
-
-
Amundson, S.A.1
Myers, T.G.2
Scudiero, D.3
Kitada, S.4
Reed, J.C.5
Fornace Jr., A.J.6
-
3
-
-
9844257587
-
Inhibition of Bax channel-forming activity by Bcl-2
-
DOI 10.1126/science.277.5324.370
-
Antonsson B, Conti F, Ciavatta A, Montessuit S, Lewis S, Martinou I, Bernasconi L, Bernard A, Mermod JJ, Mazzei G, Maundrell K, Gambale F, Sadoul R, Martinou JC. 1997. Inhibition of Bax channel-forming activity by Bcl-2. Science 277:370-372. (Pubitemid 27450709)
-
(1997)
Science
, vol.277
, Issue.5324
, pp. 370-372
-
-
Antonsson, B.1
Conti, F.2
Ciavatta, A.3
Montessuit, S.4
Lewis, S.5
Martinou, I.6
Bernasconi, L.7
Bernard, A.8
Mermod, J.-J.9
Mazzei, G.10
Maundrell, K.11
Gambale, F.12
Sadoul, R.13
Martinou, J.-C.14
-
4
-
-
0021934042
-
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around J(H) on chromosome 14 and near a transcriptional unit on 18
-
Bakhshi A, Jensen JP, Goldman P, Wright JJ, McBride OW, Epstein AL, Korsmeyer SJ. 1985. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41:899-906. (Pubitemid 15243395)
-
(1985)
Cell
, vol.41
, Issue.3
, pp. 899-906
-
-
Bakhshi, A.1
Jensen, J.P.2
Goldman, P.3
-
6
-
-
1942529509
-
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-xL
-
Becattini B, Kitada S, Leone M, Monosov E, Chandler S, Zai D, Kipps TJ, Reed JC, Pellecchia M. 2004. Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-xL. Chem Biol 11:389-395.
-
(2004)
Chem Biol
, vol.11
, pp. 389-395
-
-
Becattini, B.1
Kitada, S.2
Leone, M.3
Monosov, E.4
Chandler, S.5
Zai, D.6
Kipps, T.J.7
Reed, J.C.8
Pellecchia, M.9
-
8
-
-
0023788173
-
In vitro chemical eradication of small cell lung cancer: Application in autologous bone marrow transplantation
-
Benard J, Bettan-Renaud L, Gavoille A, Pico JL, Beaujean F, Lopez M, Riou G. 1988. In vitro chemical eradication of small cell lung cancer: Application in autologous bone marrow transplantation. Eur J Cancer Clin Oncol 24:1561-1566.
-
(1988)
Eur J Cancer Clin Oncol
, vol.24
, pp. 1561-1566
-
-
Benard, J.1
Bettan-Renaud, L.2
Gavoille, A.3
Pico, J.L.4
Beaujean, F.5
Lopez, M.6
Riou, G.7
-
9
-
-
0027474296
-
Metabolic changes in activated T cells: An NMR study of human peripheral blood lymphocytes
-
Bental M, Deutsch C. 1993. Metabolic changes in activated T cells: An NMR study of human peripheral blood lymphocytes. Magn Reson Med 29:317-326. (Pubitemid 23114497)
-
(1993)
Magnetic Resonance in Medicine
, vol.29
, Issue.3
, pp. 317-326
-
-
Bental, M.1
Deutsch, C.2
-
10
-
-
0028302261
-
Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate
-
Bersin RM, Wolfe C, Kwasman M, Lau D, Klinski C, Tanaka K, Khorrami P, Henderson GN, de Marco T, Chatterjee K. 1994. Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate. J Am Coll Cardiol 23:1617-1624. (Pubitemid 24182128)
-
(1994)
Journal of the American College of Cardiology
, vol.23
, Issue.7
, pp. 1617-1624
-
-
Bersin, R.M.1
Wolfe, C.2
Kwasman, M.3
Lau, D.4
Klinski, C.5
Tanaka, K.6
Khorrami, P.7
Henderson, G.N.8
De Marco, T.9
Chatterjee, K.10
-
11
-
-
33846002728
-
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED. 2007. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11:37-51.
-
(2007)
Cancer Cell
, vol.11
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
Lee, C.T.7
Lopaschuk, G.D.8
Puttagunta, L.9
Bonnet, S.10
Harry, G.11
Hashimoto, K.12
Porter, C.J.13
Andrade, M.A.14
Thebaud, B.15
Michelakis, E.D.16
-
12
-
-
33645766204
-
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
-
Bowker SL, Majumdar SR, Veugelers P, Johnson JA. 2006. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29:254-258.
-
(2006)
Diabetes Care
, vol.29
, pp. 254-258
-
-
Bowker, S.L.1
Majumdar, S.R.2
Veugelers, P.3
Johnson, J.A.4
-
13
-
-
46649084593
-
Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates
-
Brown KK, Eriksson SE, Arnér ES, Hampton MB. 2008. Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates. Free Radic Biol Med 45:494-502.
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 494-502
-
-
Brown, K.K.1
Eriksson, S.E.2
Arnér, E.S.3
Hampton, M.B.4
-
14
-
-
0032780442
-
Gossypol treatment of recurrent adult malignant gliomas
-
Bushunow P, Reidenberg MM, Wasenko J, Winfield J, Lorenzo B, Lemke S, Himpler B, Corona R, Coyle T. 1999. Gossypol treatment of recurrent adult malignant gliomas. J Neurooncol 43:79-86.
-
(1999)
J Neurooncol
, vol.43
, pp. 79-86
-
-
Bushunow, P.1
Reidenberg, M.M.2
Wasenko, J.3
Winfield, J.4
Lorenzo, B.5
Lemke, S.6
Himpler, B.7
Corona, R.8
Coyle, T.9
-
15
-
-
34547114031
-
Systemic treatment with the anti-diabetic drug metformin selectively impairs p53-deficient tumor cell growth
-
Buzzai M, Jones RG, Amaravadi RK, Lum JJ, Deberardinis RJ, Zhao F, Viollet B, Thompson CB. 2007. Systemic treatment with the anti-diabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 67:6745-6752.
-
(2007)
Cancer Res
, vol.67
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.J.4
Deberardinis, R.J.5
Zhao, F.6
Viollet, B.7
Thompson, C.B.8
-
16
-
-
0038081194
-
Identification of chelerythrine as an inhibitor of BclXL function
-
Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, Fu NY, Butler MS, Soejarto DD, Buss AD, Yu VC. 2003. Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem 278:20453-20456.
-
(2003)
J Biol Chem
, vol.278
, pp. 20453-20456
-
-
Chan, S.L.1
Lee, M.C.2
Tan, K.O.3
Yang, L.K.4
Lee, A.S.5
Flotow, H.6
Fu, N.Y.7
Butler, M.S.8
Soejarto, D.D.9
Buss, A.D.10
Yu, V.C.11
-
17
-
-
33846674886
-
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
-
Chen S, Dai Y, Harada H, Dent P, Grant S. 2007. Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res 67:782-791.
-
(2007)
Cancer Res
, vol.67
, pp. 782-791
-
-
Chen, S.1
Dai, Y.2
Harada, H.3
Dent, P.4
Grant, S.5
-
18
-
-
0028832667
-
A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions
-
Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G, Lutz RJ. 1995. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J 14:5589-5596.
-
(1995)
EMBO J
, vol.14
, pp. 5589-5596
-
-
Chittenden, T.1
Flemington, C.2
Houghton, A.B.3
Ebb, R.G.4
Gallo, G.J.5
Elangovan, B.6
Chinnadurai, G.7
Lutz, R.J.8
-
19
-
-
0345055662
-
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18
-
Cleary ML, Sklar J. 1985. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci USA 82:7439-7443.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 7439-7443
-
-
Cleary, M.L.1
Sklar, J.2
-
20
-
-
0034642510
-
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis
-
Costantini P, Belzacq AS, Vieira HL, Larochette N, de Pablo MA, Zamzami N, Susin SA, Brenner C, Kroemer G. 2000. Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Oncogene 19:307-314. (Pubitemid 30077228)
-
(2000)
Oncogene
, vol.19
, Issue.2
, pp. 307-314
-
-
Costantini, P.1
Belzacq, A.-S.2
Vieira, H.L.A.3
Larochette, N.4
De Pablo, M.A.5
Zamzami, N.6
Susin, S.A.7
Brenner, C.8
Kroemer, G.9
-
21
-
-
0018221514
-
Dichloroacetate as treatment for congenital lactic acidosis
-
Coude FX, Saudubray JM, DeMaugre F, Marsac C.Leroux JP, Charpentier C. 1978. Dichloroacetate as treatment for congenital lactic acidosis. New Engl J Med 299:1365-1366. (Pubitemid 9106168)
-
(1978)
New England Journal of Medicine
, vol.299
, Issue.24
, pp. 1365-1366
-
-
Coude, F.X.1
Saudubray, J.M.2
Demaugre, F.3
-
22
-
-
70350728803
-
MYC-induced cancer cell energy metabolism and therapeutic opportunities
-
Dang CV. 2009. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res 15:6479-6483.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6479-6483
-
-
Dang, C.V.1
-
23
-
-
0022344345
-
Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells
-
Davis S, Weiss MJ, Wong JR, Lampidis TJ, Chen LB. 1985. Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells. J Biol Chem 260:13844-13850. (Pubitemid 16233244)
-
(1985)
Journal of Biological Chemistry
, vol.260
, Issue.25
, pp. 13844-13850
-
-
Davis, S.1
Weiss, M.J.2
Wong, J.R.3
-
24
-
-
14244265108
-
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands
-
Day CL, Chen L, Richardson SJ, Harrison PJ, Huang DC, Hinds MG. 2005. Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. J Biol Chem 280:4738-4744.
-
(2005)
J Biol Chem
, vol.280
, pp. 4738-4744
-
-
Day, C.L.1
Chen, L.2
Richardson, S.J.3
Harrison, P.J.4
Huang, D.C.5
Hinds, M.G.6
-
25
-
-
0035150803
-
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL
-
Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J. 2001. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol 3:173-182.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 173-182
-
-
Degterev, A.1
Lugovskoy, A.2
Cardone, M.3
Mulley, B.4
Wagner, G.5
Mitchison, T.6
Yuan, J.7
-
26
-
-
33845994359
-
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
-
Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A. 2007. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 117:112-121.
-
(2007)
J Clin Invest
, vol.117
, pp. 112-121
-
-
Del Gaizo Moore, V.1
Brown, J.R.2
Certo, M.3
Love, T.M.4
Novina, C.D.5
Letai, A.6
-
27
-
-
0032491037
-
Reduction in new metastases in breast cancer with adjuvant clodronate treatment
-
Diel IJ, Solomayer EF, Costa SD, Gollan C, Goerner C, Wallwiener D, Kaufmann M, Bastert G. 1998. Reduction in new metastases in breast cancer with adjuvant clodronate treatment. N Engl J Med 339:357-363.
-
(1998)
N Engl J Med
, vol.339
, pp. 357-363
-
-
Diel, I.J.1
Solomayer, E.F.2
Costa, S.D.3
Gollan, C.4
Goerner, C.5
Wallwiener, D.6
Kaufmann, M.7
Bastert, G.8
-
29
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. 2005. Metformin and reduced risk of cancer in diabetic patients. BMJ 330:1304-1305.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
30
-
-
0036654694
-
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth
-
Fantin VR, Berardi MJ, Scorrano L, Korsmeyer SJ, Leder P. 2002. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell 2:29-42.
-
(2002)
Cancer Cell
, vol.2
, pp. 29-42
-
-
Fantin, V.R.1
Berardi, M.J.2
Scorrano, L.3
Korsmeyer, S.J.4
Leder, P.5
-
31
-
-
0038217076
-
BH3-domain mimetic compound BH3I-2′ induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria
-
Feng WY, Liu FT, Patwari Y, Agrawal SG, Newland AC, Jia L. 2003. BH3-domain mimetic compound BH3I-2′ induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria. Br J Haematol 121:332-340.
-
(2003)
Br J Haematol
, vol.121
, pp. 332-340
-
-
Feng, W.Y.1
Liu, F.T.2
Patwari, Y.3
Agrawal, S.G.4
Newland, A.C.5
Jia, L.6
-
32
-
-
0034644508
-
Insights into programmed cell death through structural biology
-
Fesik SW. 2000. Insights into programmed cell death through structural biology. Cell 103:273-282.
-
(2000)
Cell
, vol.103
, pp. 273-282
-
-
Fesik, S.W.1
-
33
-
-
0027460576
-
Oral gossypol in the treatment of metastatic adrenal carcinoma
-
Flack MR, Pyle RG, Mullen NM, Lorenzo B, Wu YW, Knazek RA, Nisula BC, Reidenberg MM. 1993. Oral gossypol in the treatment of metastatic adrenal carcinoma. J Clin Endocrinol Metab 76:1019-1024.
-
(1993)
J Clin Endocrinol Metab
, vol.76
, pp. 1019-1024
-
-
Flack, M.R.1
Pyle, R.G.2
Mullen, N.M.3
Lorenzo, B.4
Wu, Y.W.5
Knazek, R.A.6
Nisula, B.C.7
Reidenberg, M.M.8
-
34
-
-
1442350554
-
Stress-induced apoptosis: Toward a symmetry with receptor-mediated cell death
-
Fumarola C, Guidotti GG. 2004. Stress-induced apoptosis: Toward a symmetry with receptor-mediated cell death. Apoptosis 9:77-82.
-
(2004)
Apoptosis
, vol.9
, pp. 77-82
-
-
Fumarola, C.1
Guidotti, G.G.2
-
35
-
-
54549114986
-
BAX activation is initiated at a novel interaction site
-
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD. 2008. BAX activation is initiated at a novel interaction site. Nature 455:1076-1081.
-
(2008)
Nature
, vol.455
, pp. 1076-1081
-
-
Gavathiotis, E.1
Suzuki, M.2
Davis, M.L.3
Pitter, K.4
Bird, G.H.5
Katz, S.G.6
Tu, H.C.7
Kim, H.8
Cheng, E.H.9
Tjandra, N.10
Walensky, L.D.11
-
36
-
-
0029639183
-
The use of sanguinarine in mouthwashes and toothpaste compared with some other antimicrobial agents
-
Grenby TH. 1995. The use of sanguinarine in mouthwashes and toothpaste compared with some other antimicrobial agents. Br Dent J 178:254-258.
-
(1995)
Br Dent J
, vol.178
, pp. 254-258
-
-
Grenby, T.H.1
-
37
-
-
33646894309
-
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt
-
Han YH, Cao X, Lin B, Lin F, Kolluri SK, Stebbins J, Reed JC, Dawson MI, Zhang XK. 2006. Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. Oncogene 25:2974-2986.
-
(2006)
Oncogene
, vol.25
, pp. 2974-2986
-
-
Han, Y.H.1
Cao, X.2
Lin, B.3
Lin, F.4
Kolluri, S.K.5
Stebbins, J.6
Reed, J.C.7
Dawson, M.I.8
Zhang, X.K.9
-
38
-
-
2442685708
-
Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells
-
Hao JH, Yu M, Liu FT, Newland AC, Jia L. 2004. Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells, Cancer Res 64:3607-3616.
-
(2004)
Cancer Res
, vol.64
, pp. 3607-3616
-
-
Hao, J.H.1
Yu, M.2
Liu, F.T.3
Newland, A.C.4
Jia, L.5
-
39
-
-
0036324142
-
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
-
Hawley SA, Gadalla AE, Olsen GS, Hardie DG. 2002. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 51:2420-2425.
-
(2002)
Diabetes
, vol.51
, pp. 2420-2425
-
-
Hawley, S.A.1
Gadalla, A.E.2
Olsen, G.S.3
Hardie, D.G.4
-
40
-
-
73949112805
-
Critical cystein residues of Kelch-like ECH-associated protein 1 in arsenic-sensing and suppression of nuclear factor erythroid 2-related factor 2
-
He X, Ma Q. 2010. Critical cystein residues of Kelch-like ECH-associated protein 1 in arsenic-sensing and suppression of nuclear factor erythroid 2-related factor 2. J Pharmacol Exp Ther 32:66-75.
-
(2010)
J Pharmacol Exp Ther
, vol.32
, pp. 66-75
-
-
He, X.1
Ma, Q.2
-
41
-
-
0027513548
-
Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity
-
Hennet T, Bertoni G, Richter C, Peterhans E. 1993. Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity. Cancer Res 53:1456-1460. (Pubitemid 23097132)
-
(1993)
Cancer Research
, vol.53
, Issue.6
, pp. 1456-1460
-
-
Hennet, T.1
Bertoni, G.2
Richter, C.3
Peterhans, E.4
-
42
-
-
33845486323
-
Bim, Bad and Bmf: Intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets
-
Hinds MG, Smits C, Fredericks-Short R, Risk JM, Bailey M, Huang DC, Day CL. 2007. Bim, Bad and Bmf: Intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets. Cell Death Differ 14:128-136.
-
(2007)
Cell Death Differ
, vol.14
, pp. 128-136
-
-
Hinds, M.G.1
Smits, C.2
Fredericks-Short, R.3
Risk, J.M.4
Bailey, M.5
Huang, D.C.6
Day, C.L.7
-
43
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. 2009. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69:7507-7511.
-
(2009)
Cancer Res
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
44
-
-
0142135505
-
Early event in the induction of apoptosis in ovarian carcinoma cells by CD437: Activation of the p38 MAP kinase signal pathway
-
Holmes WF, Soprano DR, Soprano KJ. 2003. Early event in the induction of apoptosis in ovarian carcinoma cells by CD437: Activation of the p38 MAP kinase signal pathway. Oncogene 22:6377-6386.
-
(2003)
Oncogene
, vol.22
, pp. 6377-6386
-
-
Holmes, W.F.1
Soprano, D.R.2
Soprano, K.J.3
-
46
-
-
0033635733
-
BH3-Only proteins-essential initiators of apoptotic cell death
-
Huang DC, Strasser A. 2000. BH3-Only proteins-essential initiators of apoptotic cell death. Cell 103:839-842.
-
(2000)
Cell
, vol.103
, pp. 839-842
-
-
Huang, D.C.1
Strasser, A.2
-
47
-
-
67749144226
-
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
-
Jiralerspong S, Palla SL, Giordano SH, Meric-Bernstam F, Liedtke C, Barnett CM, Hsu L, Hung MC, Hortobagyi GN, Gonzalez-Angulo AM. 2009. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol 27:3297-3302.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3297-3302
-
-
Jiralerspong, S.1
Palla, S.L.2
Giordano, S.H.3
Meric-Bernstam, F.4
Liedtke, C.5
Barnett, C.M.6
Hsu, L.7
Hung, M.C.8
Hortobagyi, G.N.9
Gonzalez-Angulo, A.M.10
-
48
-
-
0034786701
-
Identification of enzyme inhibitors from phage-displayed combinatorial peptide libraries
-
Kay BK, Hamilton PT. 2001. Identification of enzyme inhibitors from phage-displayed combinatorial peptide libraries. Comb Chem High Throughput Screen 4:535-543.
-
(2001)
Comb Chem High Throughput Screen
, vol.4
, pp. 535-543
-
-
Kay, B.K.1
Hamilton, P.T.2
-
49
-
-
0035942324
-
Biophysical characterization of recombinant Bcl-2 and its interactions with an inhibitory ligand, antimycin a
-
Kim KM, Giedt CD, Basañez G, O'Neill JW, Hill JJ, Han YH, Tzung SP, Zimmerberg J, Hockenbery DM, Zhang KY. 2001. Biophysical characterization of recombinant Bcl-2 and its interactions with an inhibitory ligand, antimycin A. Biochemistry 40:4911-4922.
-
(2001)
Biochemistry
, vol.40
, pp. 4911-4922
-
-
Kim, K.M.1
Giedt, C.D.2
Basañez, G.3
O'Neill, J.W.4
Hill, J.J.5
Han, Y.H.6
Tzung, S.P.7
Zimmerberg, J.8
Hockenbery, D.M.9
Zhang, K.Y.10
-
50
-
-
0141569444
-
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
-
Kitada S, Leone M, Sareth S, Zhai D, Reed JC, Pellecchia M. 2003. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem 46:4259-4264.
-
(2003)
J Med Chem
, vol.46
, pp. 4259-4264
-
-
Kitada, S.1
Leone, M.2
Sareth, S.3
Zhai, D.4
Reed, J.C.5
Pellecchia, M.6
-
51
-
-
0035829074
-
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: Characterization and targeting hexokinase
-
Ko YH, Pedersen PL, Geschwind JF. 2001. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: Characterization and targeting hexokinase. Cancer Lett 173:83-91.
-
(2001)
Cancer Lett
, vol.173
, pp. 83-91
-
-
Ko, Y.H.1
Pedersen, P.L.2
Geschwind, J.F.3
-
52
-
-
4744341871
-
Advanced cancers: Eradication in all cases using 3-bromopyruvate therapy to deplete ATP
-
Ko YH, Smith BL, Wang Y, Pomper MG, Rini DA, Torbenson MS, Hullihen J, Pedersen PL. 2004. Advanced cancers: Eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem Biophys Res Commun 324:269-275.
-
(2004)
Biochem Biophys Res Commun
, vol.324
, pp. 269-275
-
-
Ko, Y.H.1
Smith, B.L.2
Wang, Y.3
Pomper, M.G.4
Rini, D.A.5
Torbenson, M.S.6
Hullihen, J.7
Pedersen, P.L.8
-
53
-
-
33750628289
-
Mechanisms of apoptosis selectivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, Deng X, Zhai D, Shi YX, Sneed T, Verhaegen M, Soengas M, Ruvolo VR, McQueen T, Schober WD, Watt JC, Jiffar T, Ling X, Marini FC, Harris D, Dietrich M, Estrov Z, McCubrey J, May WS, Reed JC, Andreef M. 2006. Mechanisms of apoptosis selectivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 10:375-388.
-
(2006)
Cancer Cell
, vol.10
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
Samudio, I.4
Ruvolo, P.P.5
Kitada, S.6
Deng, X.7
Zhai, D.8
Shi, Y.X.9
Sneed, T.10
Verhaegen, M.11
Soengas, M.12
Ruvolo, V.R.13
McQueen, T.14
Schober, W.D.15
Watt, J.C.16
Jiffar, T.17
Ling, X.18
Marini, F.C.19
Harris, D.20
Dietrich, M.21
Estrov, Z.22
McCubrey, J.23
May, W.S.24
Reed, J.C.25
Andreef, M.26
more..
-
54
-
-
19444386896
-
Apoptosis in Drosophila: Neither fish nor fowl (nor man, nor worm)
-
Kornbluth S, White K. 2005. Apoptosis in Drosophila: Neither fish nor fowl (nor man, nor worm). J Cell Sci 118:1779-1787.
-
(2005)
J Cell Sci
, vol.118
, pp. 1779-1787
-
-
Kornbluth, S.1
White, K.2
-
55
-
-
13944277343
-
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
-
Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD. 2005. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 17:525-535.
-
(2005)
Mol Cell
, vol.17
, pp. 525-535
-
-
Kuwana, T.1
Bouchier-Hayes, L.2
Chipuk, J.E.3
Bonzon, C.4
Sullivan, B.A.5
Green, D.R.6
Newmeyer, D.D.7
-
56
-
-
0042737939
-
Peripheral-type benzodiazepine receptor: Structure and function of a cholesterol-binding protein in steroid and bile acid synthesis
-
Lacapere JJ, Papadopoulos V. 2003. Peripheral-type benzodiazepine receptor: Structure and function of a cholesterol-binding protein in steroid and bile acid synthesis. Steroids 68:569-585.
-
(2003)
Steroids
, vol.68
, pp. 569-585
-
-
Lacapere, J.J.1
Papadopoulos, V.2
-
57
-
-
34548047900
-
Crystal structure of ABT-737 complexed with Bcl-xL: Implications for selectivity of antagonists of the Bcl-2 family
-
Lee EF, Czabotar PE, Smith BJ, Deshayes K, Zobel K, Colman PM, Fairlie WD. 2007. Crystal structure of ABT-737 complexed with Bcl-xL: Implications for selectivity of antagonists of the Bcl-2 family. Cell Death Differ 14:1711-1713.
-
(2007)
Cell Death Differ
, vol.14
, pp. 1711-1713
-
-
Lee, E.F.1
Czabotar, P.E.2
Smith, B.J.3
Deshayes, K.4
Zobel, K.5
Colman, P.M.6
Fairlie, W.D.7
-
58
-
-
0036238837
-
Further insight into mechanism of action of clodronate: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite
-
Lehenkari PP, Kellinsalmi M, Näpänkangas JP, Ylitalo KV, Mönkkönen J, Rogers MJ, Azhayev A, Väänänen HK, Hassinen IE. 2002. Further insight into mechanism of action of clodronate: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol 61:1255-1262.
-
(2002)
Mol Pharmacol
, vol.61
, pp. 1255-1262
-
-
Lehenkari, P.P.1
Kellinsalmi, M.2
Näpänkangas, J.P.3
Ylitalo, K.V.4
Mönkkönen, J.5
Rogers, M.J.6
Azhayev, A.7
Väänänen, H.K.8
Hassinen, I.E.9
-
59
-
-
33845603436
-
Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformation change in Bcl-2
-
Lei X, Chen Y, Du G, Yu W, Wang X, Qu H, Xia B, He H, Mao J, Zong W, Liao X, Mehrpour M, Hao X, Chen Q. 2006. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformation change in Bcl-2. FASEB J 20:2147-2149.
-
(2006)
FASEB J
, vol.20
, pp. 2147-2149
-
-
Lei, X.1
Chen, Y.2
Du, G.3
Yu, W.4
Wang, X.5
Qu, H.6
Xia, B.7
He, H.8
Mao, J.9
Zong, W.10
Liao, X.11
Mehrpour, M.12
Hao, X.13
Chen, Q.14
-
60
-
-
0024049628
-
In vivo 31P MRS in new antineoplastic agents evaluation on experimental tumor models
-
Le Moyec L, Naruse S, Higuchi T, Hirakawa K, Watari H, de Certaines JD, Roques BP. 1988. In vivo 31P MRS in new antineoplastic agents evaluation on experimental tumor models. Cancer Biochem Biophys 10:31-45.
-
(1988)
Cancer Biochem Biophys
, vol.10
, pp. 31-45
-
-
Le Moyec, L.1
Naruse, S.2
Higuchi, T.3
Hirakawa, K.4
Watari, H.5
De Certaines, J.D.6
Roques, B.P.7
-
61
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ. 2002. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2:183-192.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
-
62
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li H, Zhu H, Xu CJ, Yuan J. 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501. (Pubitemid 28391865)
-
(1998)
Cell
, vol.94
, Issue.4
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.-J.3
Yuan, J.4
-
63
-
-
51449115865
-
PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase
-
Li L, Wang J, Ye RD, Shi G, Jin H, Tang X, Yi J. 2008. PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase. J Cell Physiol 217:486-493.
-
(2008)
J Cell Physiol
, vol.217
, pp. 486-493
-
-
Li, L.1
Wang, J.2
Ye, R.D.3
Shi, G.4
Jin, H.5
Tang, X.6
Yi, J.7
-
64
-
-
69549097703
-
New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
-
Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. 2009. New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes. Diabetes Care 32:1620-1625.
-
(2009)
Diabetes Care
, vol.32
, pp. 1620-1625
-
-
Libby, G.1
Donnelly, L.A.2
Donnan, P.T.3
Alessi, D.R.4
Morris, A.D.5
Evans, J.M.6
-
65
-
-
1342306819
-
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
-
Lin B, Kolluri SK, Lin F, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK. 2004. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell 116:527-540.
-
(2004)
Cell
, vol.116
, pp. 527-540
-
-
Lin, B.1
Kolluri, S.K.2
Lin, F.3
Han, Y.H.4
Cao, X.5
Dawson, M.I.6
Reed, J.C.7
Zhang, X.K.8
-
66
-
-
34249996230
-
'Seed' analysis of off-target siRNAs revelas an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737
-
Lin X, Morgan-Lappe S, Huang X, Li L, Zakula DM, Vernetti LA, Fesik SW, Shen Y. 2007. 'Seed' analysis of off-target siRNAs revelas an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. Oncogene 26:3972-3979.
-
(2007)
Oncogene
, vol.26
, pp. 3972-3979
-
-
Lin, X.1
Morgan-Lappe, S.2
Huang, X.3
Li, L.4
Zakula, D.M.5
Vernetti, L.A.6
Fesik, S.W.7
Shen, Y.8
-
67
-
-
65649130832
-
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer
-
Liu G, Kelly WK, Wilding G, Leopold L, Brill K, Somer B. 2009. An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. Clin Cancer Res 15:3172-3176.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3172-3176
-
-
Liu, G.1
Kelly, W.K.2
Wilding, G.3
Leopold, L.4
Brill, K.5
Somer, B.6
-
68
-
-
42349109916
-
Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program
-
DOI 10.1002/pbc.21433
-
Lock R, Carol H, Houghton PJ, Morton CL, Kolb EA, Gorlick R, Reynolds CP, Maris JM, Keir ST, Wu J, Smith MA. 2008. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer 50:1181-1189. (Pubitemid 351555542)
-
(2008)
Pediatric Blood and Cancer
, vol.50
, Issue.6
, pp. 1181-1189
-
-
Lock, R.1
Carol, H.2
Houghton, P.J.3
Morton, C.L.4
Anders Kolb, E.5
Gorlick, R.6
Patrick Reynolds, C.7
Maris, J.M.8
Keir, S.T.9
Wu, J.10
Smith, M.A.11
-
69
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. 1998. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481-490. (Pubitemid 28391864)
-
(1998)
Cell
, vol.94
, Issue.4
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
70
-
-
33645059697
-
The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death
-
Manero F, Gautier F, Gallenne T, Cauquil N, Gree D, Cartron PF, Geneste O, Gree R, Vallette FM, Juin P. 2006. The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. Cancer Res 66:2757-2764.
-
(2006)
Cancer Res
, vol.66
, pp. 2757-2764
-
-
Manero, F.1
Gautier, F.2
Gallenne, T.3
Cauquil, N.4
Gree, D.5
Cartron, P.F.6
Geneste, O.7
Gree, R.8
Vallette, F.M.9
Juin, P.10
-
71
-
-
0346457100
-
Bcl-XL mutations suppress cellular sensitivity to antimycin a
-
Manion MK, O'Neill JW, Giedt CD, Kim KM, Zhang KY, Hockenbery DM. 2004. Bcl-XL mutations suppress cellular sensitivity to antimycin A. J Biol Chem 279:2159-2165.
-
(2004)
J Biol Chem
, vol.279
, pp. 2159-2165
-
-
Manion, M.K.1
O'Neill, J.W.2
Giedt, C.D.3
Kim, K.M.4
Zhang, K.Y.5
Hockenbery, D.M.6
-
72
-
-
33947227522
-
Programmed anuclear cell death delimits platelet life span
-
Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, Huang DC, Kile BT. 2007. Programmed anuclear cell death delimits platelet life span. Cell 128:1173-1186.
-
(2007)
Cell
, vol.128
, pp. 1173-1186
-
-
Mason, K.D.1
Carpinelli, M.R.2
Fletcher, J.I.3
Collinge, J.E.4
Hilton, A.A.5
Ellis, S.6
Kelly, P.N.7
Ekert, P.G.8
Metcalf, D.9
Roberts, A.W.10
Huang, D.C.11
Kile, B.T.12
-
73
-
-
33746924468
-
Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
-
Mathupala SP, Ko YH, Pedersen PL. 2006. Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25:4777-4786.
-
(2006)
Oncogene
, vol.25
, pp. 4777-4786
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
74
-
-
17144366551
-
Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase
-
Mayr GW, Windhorst S, Hillemeier K. 2005. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. J Biol Chem 280:13229-13240.
-
(2005)
J Biol Chem
, vol.280
, pp. 13229-13240
-
-
Mayr, G.W.1
Windhorst, S.2
Hillemeier, K.3
-
75
-
-
0026053958
-
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18)
-
McDonnell TJ, Korsmeyer SJ. 1991. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature 349:254-256.
-
(1991)
Nature
, vol.349
, pp. 254-256
-
-
McDonnell, T.J.1
Korsmeyer, S.J.2
-
76
-
-
0026591024
-
Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier
-
McEnery MW, Snowman AM, Trifiletti RR, Snyder SH. 1992. Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 89:3170-3174.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 3170-3174
-
-
McEnery, M.W.1
Snowman, A.M.2
Trifiletti, R.R.3
Snyder, S.H.4
-
77
-
-
33744533766
-
The mitochondrial effects of small organic ligands of BCL-2: Sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative
-
Milanesi E, Costantini P, Gambalunga A, Colonna R, Petronilli V, Cabrelle A, Semenzato G, Cesura AM, Pinard E, Bernardi P. 2006. The mitochondrial effects of small organic ligands of BCL-2: Sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative. J Biol Chem 281:10066-10072.
-
(2006)
J Biol Chem
, vol.281
, pp. 10066-10072
-
-
Milanesi, E.1
Costantini, P.2
Gambalunga, A.3
Colonna, R.4
Petronilli, V.5
Cabrelle, A.6
Semenzato, G.7
Cesura, A.M.8
Pinard, E.9
Bernardi, P.10
-
78
-
-
0028982183
-
Expression of bcl-xL can confer a multidrug resistance phenotype
-
Minn AJ, Rudin CM, Boise LH, Thompson CB. 1995. Expression of bcl-xL can confer a multidrug resistance phenotype. Blood 86:1903-1910.
-
(1995)
Blood
, vol.86
, pp. 1903-1910
-
-
Minn, A.J.1
Rudin, C.M.2
Boise, L.H.3
Thompson, C.B.4
-
79
-
-
1842332735
-
Bcl-xL forms an ion channel in synthetic lipid membranes
-
Minn AJ, Vélez P, Schendel SL, Liang H, Muchmore SW, Fesik SW, Fill M, Thompson CB. 1997. Bcl-xL forms an ion channel in synthetic lipid membranes. Nature 385:353-357.
-
(1997)
Nature
, vol.385
, pp. 353-357
-
-
Minn, A.J.1
Vélez, P.2
Schendel, S.L.3
Liang, H.4
Muchmore, S.W.5
Fesik, S.W.6
Fill, M.7
Thompson, C.B.8
-
80
-
-
36849022121
-
Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition
-
Mitsiades CS, Hayden P, Kotoula V, McMillin DW, McMullen C, Negri J, Delmore JE, Poulaki V, Mitsiades N. 2007. Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition, J Clin Endocrinol Metab 92:4845-4852.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 4845-4852
-
-
Mitsiades, C.S.1
Hayden, P.2
Kotoula, V.3
McMillin, D.W.4
McMullen, C.5
Negri, J.6
Delmore, J.E.7
Poulaki, V.8
Mitsiades, N.9
-
81
-
-
0035797118
-
Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
-
Modica-Napolitano JS, Aprille JR. 2001. Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Adv Drug Deliv Rev 49:63-70.
-
(2001)
Adv Drug Deliv Rev
, vol.49
, pp. 63-70
-
-
Modica-Napolitano, J.S.1
Aprille, J.R.2
-
82
-
-
33644539542
-
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
-
Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. 2006. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates. Br J Pharmacol 147:437-445.
-
(2006)
Br J Pharmacol
, vol.147
, pp. 437-445
-
-
Mönkkönen, H.1
Auriola, S.2
Lehenkari, P.3
Kellinsalmi, M.4
Hassinen, I.E.5
Vepsäläinen, J.6
Mönkkönen, J.7
-
83
-
-
67650417891
-
C-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry
-
Morrish F, Isern N, Sadilek M, Jeffrey M, Hockenbery D. 2009. c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry. Oncogene 28:2485-2491.
-
(2009)
Oncogene
, vol.28
, pp. 2485-2491
-
-
Morrish, F.1
Isern, N.2
Sadilek, M.3
Jeffrey, M.4
Hockenbery, D.5
-
84
-
-
5244224827
-
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
-
Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW. 1996. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381:335-341.
-
(1996)
Nature
, vol.381
, pp. 335-341
-
-
Muchmore, S.W.1
Sattler, M.2
Liang, H.3
Meadows, R.P.4
Harlan, J.E.5
Yoon, H.S.6
Nettesheim, D.7
Chang, B.S.8
Thompson, C.B.9
Wong, S.L.10
Ng, S.L.11
Fesik, S.W.12
-
85
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano K, Vousden KH. 2001. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7:683-694.
-
(2001)
Mol Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
86
-
-
0032785021
-
Caspase structure, proteolytic substrates, and function during apoptotic cell death
-
Nicholson DW. 1999. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 6:1028-1042.
-
(1999)
Cell Death Differ
, vol.6
, pp. 1028-1042
-
-
Nicholson, D.W.1
-
87
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR, Goulet D, Viallet J, Bélec L, Billot X, Acoca S, Purisima E, Wiegmans A, Cluse L, Johnstone RW, Beauparlant P, Shore GC. 2007. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci USA 104:19512-19517.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
Marcellus, R.C.2
Roulston, A.3
Watson, M.4
Serfass, L.5
Murthy Madiraju, S.R.6
Goulet, D.7
Viallet, J.8
Bélec, L.9
Billot, X.10
Acoca, S.11
Purisima, E.12
Wiegmans, A.13
Cluse, L.14
Johnstone, R.W.15
Beauparlant, P.16
Shore, G.C.17
-
88
-
-
58849164097
-
Phase I study of obatoclax (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
-
O'Brien SM, Claxton DF, Crump M, Faderl S, Kipps T, Keating MJ, Viallet J, Cheson BD. 2009. Phase I study of obatoclax (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood 113:299-305.
-
(2009)
Blood
, vol.113
, pp. 299-305
-
-
O'Brien, S.M.1
Claxton, D.F.2
Crump, M.3
Faderl, S.4
Kipps, T.5
Keating, M.J.6
Viallet, J.7
Cheson, B.D.8
-
89
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N. 2000. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053-1058.
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
Nemoto, J.4
Shibue, T.5
Yamashita, T.6
Tokino, T.7
Taniguchi, T.8
Tanaka, N.9
-
90
-
-
34248180714
-
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains
-
Olejniczak ET, Van Sant C, Anderson MG, Wang G, Tahir SK, Sauter G, Lesniewski R, Semizarov D. 2007. Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains. Mol Cancer Res 5:331-339.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 331-339
-
-
Olejniczak, E.T.1
Van Sant, C.2
Anderson, M.G.3
Wang, G.4
Tahir, S.K.5
Sauter, G.6
Lesniewski, R.7
Semizarov, D.8
-
91
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH. 2005. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435:677-681.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
Joseph, M.K.11
Kitada, S.12
Korsmeyer, S.J.13
Kunzer, A.R.14
Letai, A.15
Li, C.16
Mitten, M.J.17
Nettesheim, D.G.18
Ng, S.19
Nimmer, P.M.20
O'Connor, J.M.21
Oleksijew, A.22
Petros, A.M.23
Reed, J.C.24
Shen, W.25
Tahir, S.K.26
Thompson, C.B.27
Tomaselli, K.J.28
Wang, B.29
Wendt, M.D.30
Zhang, H.31
Fesik, S.W.32
Rosenberg, S.H.33
more..
-
92
-
-
0027166048
-
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
-
Oltvai ZN, Milliman CL, Korsmeyer SJ. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.
-
(1993)
Cell
, vol.74
, pp. 609-619
-
-
Oltvai, Z.N.1
Milliman, C.L.2
Korsmeyer, S.J.3
-
93
-
-
0034659785
-
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
-
Owen MR, Doran E, Halestrap AP. 2000. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348:607-614.
-
(2000)
Biochem J
, vol.348
, pp. 607-614
-
-
Owen, M.R.1
Doran, E.2
Halestrap, A.P.3
-
94
-
-
21244461186
-
Effect of PK11195, a peripheral benzodiazepine receptor agonist, on insulinoma cell death and insulin secretion
-
Park SY, Cho N, Chang I, Chung JH, Min YK, Lee MK, Kim KW, Kim SJ, Lee MS. 2005. Effect of PK11195, a peripheral benzodiazepine receptor agonist, on insulinoma cell death and insulin secretion. Apoptosis 10:537-544.
-
(2005)
Apoptosis
, vol.10
, pp. 537-544
-
-
Park, S.Y.1
Cho, N.2
Chang, I.3
Chung, J.H.4
Min, Y.K.5
Lee, M.K.6
Kim, K.W.7
Kim, S.J.8
Lee, M.S.9
-
95
-
-
0019294126
-
DNA intercalating compounds as potential antitumor agents. II. Preparation and properties of 7H-pyridocarbazole dimers
-
Pelaprat D, Delbarre A, Le Guen I, Roques BP, Le Pecq JB. 1980. DNA intercalating compounds as potential antitumor agents. II. Preparation and properties of 7H-pyridocarbazole dimers. J Med Chem 23:1336-1343. (Pubitemid 11164101)
-
(1980)
Journal of Medicinal Chemistry
, vol.23
, Issue.12
, pp. 1336-1343
-
-
Pelaprat, D.1
Delbarre, A.2
Le Guen, I.3
-
96
-
-
59849092584
-
Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate
-
Pereira da Silva AP, El-Bacha T, Kyaw N, dos Santos RS, da-Silva WS, Almeida FC, Da Polan AT, Galina A. 2009. Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. Biochem J 417:717-726.
-
(2009)
Biochem J
, vol.417
, pp. 717-726
-
-
Pereira Da Silva, A.P.1
El-Bacha, T.2
Kyaw, N.3
Dos Santos, R.S.4
Da-Silva, W.S.5
Almeida, F.C.6
Da Polan, A.T.7
Galina, A.8
-
97
-
-
1642471824
-
Retinoid targets for apoptosis induction
-
Pfahl M, Piedrafita FJ. 2003. Retinoid targets for apoptosis induction. Oncogene 8:9058-9062.
-
(2003)
Oncogene
, vol.8
, pp. 9058-9062
-
-
Pfahl, M.1
Piedrafita, F.J.2
-
98
-
-
0036682211
-
Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer
-
Powles T, Paterson S, Kanis JA, McCloskey E, Ashley S, Tidy A, Rosenqvist K, Smith I, Ottestad L, Legault S, Pajunen M, Nevantaus A, Männistö E, Suovuori A, Atula S, Nevalainen J, Pylkkänen L. 2002. Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer. J Clin Oncol 20:3219-3224.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3219-3224
-
-
Powles, T.1
Paterson, S.2
Kanis, J.A.3
McCloskey, E.4
Ashley, S.5
Tidy, A.6
Rosenqvist, K.7
Smith, I.8
Ottestad, L.9
Legault, S.10
Pajunen, M.11
Nevantaus, A.12
Männistö, E.13
Suovuori, A.14
Atula, S.15
Nevalainen, J.16
Pylkkänen, L.17
-
99
-
-
34247345833
-
The apoptosome: Signaling platform of cell death
-
Riedl SJ, Salvesen GS. 2007. The apoptosome: Signaling platform of cell death. Nat Rev Mol Cell Biol 462:210-219.
-
(2007)
Nat Rev Mol Cell Biol
, vol.462
, pp. 210-219
-
-
Riedl, S.J.1
Salvesen, G.S.2
-
100
-
-
67649288976
-
Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states
-
Rone MB, Fan J, Papadopoulos V. 2009. Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states. Biochim Biophys Acta 1791:646-658.
-
(2009)
Biochim Biophys Acta
, vol.1791
, pp. 646-658
-
-
Rone, M.B.1
Fan, J.2
Papadopoulos, V.3
-
101
-
-
0034253592
-
BAX-dependent transport of cytochrome c reconstituted in pure liposomes
-
Saito M, Korsmeyer SJ, Schlesinger PH. 2000. BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat Cell Biol 2:553-555.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 553-555
-
-
Saito, M.1
Korsmeyer, S.J.2
Schlesinger, P.H.3
-
103
-
-
0030614915
-
Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
-
Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB, Fesik SW. 1997. Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis. Science 275:983-986.
-
(1997)
Science
, vol.275
, pp. 983-986
-
-
Sattler, M.1
Liang, H.2
Nettesheim, D.3
Meadows, R.P.4
Harlan, J.E.5
Eberstadt, M.6
Yoon, H.S.7
Shuker, S.B.8
Chang, B.S.9
Minn, A.J.10
Thompson, C.B.11
Fesik, S.W.12
-
104
-
-
0031008397
-
Channel formation by antiapoptotic protein Bcl-2
-
DOI 10.1073/pnas.94.10.5113
-
Schendel SL, Xie Z, Montal MO, Matsuyama S, Montal M, Reed JC. 1997. Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci USA 94:5113-5118. (Pubitemid 27214745)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.10
, pp. 5113-5118
-
-
Schendel, S.L.1
Xie, Z.2
Montal, M.O.3
Matsuyama, S.4
Montal, M.5
Reed, J.C.6
-
105
-
-
0017876542
-
Glycolysis in quiescent cultures of 3T3 cells. Addition of serum, epidermal growth factor, and insulin increases the activity of phosphofructokinase in a protein synthesis-independent manner
-
Schneider JA, Diamond I, Rozengurt E. 1978. Glycolysis of quiescent cultures of 3T3 cells. Addition of serum, epidermal growth factor, and insulin increases the activity of phosphofructokinase in a protein synthesis-independent manner. J Biol Chem 253:872-877. (Pubitemid 8271469)
-
(1978)
Journal of Biological Chemistry
, vol.253
, Issue.3
, pp. 872-877
-
-
Schneider, J.A.1
Diamond, I.2
Rozengurt, E.3
-
106
-
-
34447342264
-
2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition
-
Schwartz PS, Manion MK, Emerson CB, Fry JS, Schulz CM, Sweet IR, Hockenbery DM. 2007. 2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition. Mol Cancer Ther 6:2073-2080.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2073-2080
-
-
Schwartz, P.S.1
Manion, M.K.2
Emerson, C.B.3
Fry, J.S.4
Schulz, C.M.5
Sweet, I.R.6
Hockenbery, D.M.7
-
107
-
-
0037427412
-
Mechanisms of cytochrome c release by proapoptotic BCL-2 family members
-
Scorrano L, Korsmeyer SJ. 2003. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 304:437-444.
-
(2003)
Biochem Biophys Res Commun
, vol.304
, pp. 437-444
-
-
Scorrano, L.1
Korsmeyer, S.J.2
-
108
-
-
0023801422
-
Selective loss of mitochondrial DNA after treatment of cells with ditercalinium (NSC 335153), an antitumor bis-intercalating agent
-
Segal-Bendirdjian E, Coulaud D, Roques BP, Le Pecq JB. 1988. Selective loss of mitochondrial DNA after treatment of cells with ditercalinium (NSC 335153), an antitumor bis-intercalating agent. Cancer Res 48:4982-4992.
-
(1988)
Cancer Res
, vol.48
, pp. 4982-4992
-
-
Segal-Bendirdjian, E.1
Coulaud, D.2
Roques, B.P.3
Le Pecq, J.B.4
-
110
-
-
33750627440
-
Mechanical aspects of apoptosome assembly
-
Shi Y. 2006. Mechanical aspects of apoptosome assembly. Curr Opin Cell Biol 18:677-684.
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 677-684
-
-
Shi, Y.1
-
112
-
-
43749120533
-
Anti-apoptotic Bcl-2 family proteins disassemble ceramide channels
-
Siskind LJ, Feinstein L, Yu T, Davis JS, Jones D, Choi J, Zuckerman JE, Tan W, Hill RB, Hardwick JM, Colombini M. 2008. Anti-apoptotic Bcl-2 family proteins disassemble ceramide channels. J Biol Chem 283:6622-6630.
-
(2008)
J Biol Chem
, vol.283
, pp. 6622-6630
-
-
Siskind, L.J.1
Feinstein, L.2
Yu, T.3
Davis, J.S.4
Jones, D.5
Choi, J.6
Zuckerman, J.E.7
Tan, W.8
Hill, R.B.9
Hardwick, J.M.10
Colombini, M.11
-
113
-
-
0026448257
-
A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group
-
Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, Duncan CA, Harman EM, Henderson GN, Jenkinson S, et al. 1992. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. N Engl J Med 327:1564-1569.
-
(1992)
N Engl J Med
, vol.327
, pp. 1564-1569
-
-
Stacpoole, P.W.1
Wright, E.C.2
Baumgartner, T.G.3
Bersin, R.M.4
Buchalter, S.5
Curry, S.H.6
Duncan, C.A.7
Harman, E.M.8
Henderson, G.N.9
Jenkinson, S.10
-
114
-
-
0026687876
-
A preliminary clinical study of gossypol in advanced human cancer
-
Stein RC, Joseph AE, Matlin SA, Cunningham DC, Fort HT, Coombes RC. 1992. A preliminary clinical study of gossypol in advanced human cancer. Cancer Chemother Pharmacol 30:480-482.
-
(1992)
Cancer Chemother Pharmacol
, vol.30
, pp. 480-482
-
-
Stein, R.C.1
Joseph, A.E.2
Matlin, S.A.3
Cunningham, D.C.4
Fort, H.T.5
Coombes, R.C.6
-
115
-
-
33847061737
-
Influence of Bcl-2 family member on the cellular response of small-cell lung cancer cell lines to ABT-737
-
Tahir SK, Yang X, Anderson MG, Morgan-Lappe SE, Sarthy AV, Chen J, Warner RB, Ng SC, Fesik SW, Elmore SW, Rosenberg SH, Tse C. 2007. Influence of Bcl-2 family member on the cellular response of small-cell lung cancer cell lines to ABT-737. Cancer Res 67:1176-1183.
-
(2007)
Cancer Res
, vol.67
, pp. 1176-1183
-
-
Tahir, S.K.1
Yang, X.2
Anderson, M.G.3
Morgan-Lappe, S.E.4
Sarthy, A.V.5
Chen, J.6
Warner, R.B.7
Ng, S.C.8
Fesik, S.W.9
Elmore, S.W.10
Rosenberg, S.H.11
Tse, C.12
-
116
-
-
0028362187
-
Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis
-
Taketani S, Kohno H, Okuda M, Furukawa T, Tokunaga R. 1994. Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis. J Biol Chem 269:7527-7531. (Pubitemid 24217958)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.10
, pp. 7527-7531
-
-
Taketani, S.1
Kohno, H.2
Okuda, M.3
Furukawa, T.4
Tokunaga, R.5
-
117
-
-
55449124298
-
Metformin suppresses intestinal polyp growth in Apc-Min/+ mice
-
Tomimoto A, Endo H, Sugiyama M, Fujisawa T, Hosono K, Takahashi H, Nakajima N, Nagashima Y, Wada K, Nakagama H, Nakajima A. 2008. Metformin suppresses intestinal polyp growth in Apc-Min/+ mice. Cancer Sci 99:2136-2141.
-
(2008)
Cancer Sci
, vol.99
, pp. 2136-2141
-
-
Tomimoto, A.1
Endo, H.2
Sugiyama, M.3
Fujisawa, T.4
Hosono, K.5
Takahashi, H.6
Nakajima, N.7
Nagashima, Y.8
Wada, K.9
Nakagama, H.10
Nakajima, A.11
-
118
-
-
52649153465
-
Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism
-
Trachootham D, Zhang H, Zhang W, Feng L, Du M, Zhou Y, Chen Z, Pelicano H, Plunkett W, Wierda WG, Keating MJ, Huang P. 2008. Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism. Blood 112:1912-1922.
-
(2008)
Blood
, vol.112
, pp. 1912-1922
-
-
Trachootham, D.1
Zhang, H.2
Zhang, W.3
Feng, L.4
Du, M.5
Zhou, Y.6
Chen, Z.7
Pelicano, H.8
Plunkett, W.9
Wierda, W.G.10
Keating, M.J.11
Huang, P.12
-
119
-
-
0021821903
-
Involvement of the bcl-2 gene in human follicular lymphoma
-
Tsujimoto Y, Cossman J, Jaffe E, Croce CM. 1985. Involvement of the bcl-2 gene in human follicular lymphoma. Science 228:1440-1443. (Pubitemid 15041322)
-
(1985)
Science
, vol.228
, Issue.4706
, pp. 1440-1443
-
-
Tsujimoto, Y.1
Cossman, J.2
Jaffe, E.3
Croce, C.M.4
-
120
-
-
0035147650
-
Antimycin a mimics a celldeath-inducing Bcl-2 homology domain 3
-
Tzung SP, Kim KM, Basañez G, Giedt CD, Simon J, Zimmerberg J, Zhang KY, Hockenbery DM. 2001. Antimycin A mimics a celldeath-inducing Bcl-2 homology domain 3. Nat Cell Biol 3:183-191.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 183-191
-
-
Tzung, S.P.1
Kim, K.M.2
Basañez, G.3
Giedt, C.D.4
Simon, J.5
Zimmerberg, J.6
Zhang, K.Y.7
Hockenbery, D.M.8
-
122
-
-
52649158301
-
Targeting of VX2 rabbit liver tumor by selective delivery of 3-bromopyruvate: A biodistribution and survival study
-
Vali M, Vossen JA, Buijs M, Engles JM, Liapi E, Ventura VP, Khwaja A, Acha-Ngwodo O, Shanmugasundaram G, Syed L, Wahl RL, Geschwind JF. 2008. Targeting of VX2 rabbit liver tumor by selective delivery of 3-bromopyruvate: A biodistribution and survival study. J Pharmacol Exp Ther 327:32-37.
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 32-37
-
-
Vali, M.1
Vossen, J.A.2
Buijs, M.3
Engles, J.M.4
Liapi, E.5
Ventura, V.P.6
Khwaja, A.7
Acha-Ngwodo, O.8
Shanmugasundaram, G.9
Syed, L.10
Wahl, R.L.11
Geschwind, J.F.12
-
123
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
Van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC. 2006. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 10:389-399.
-
(2006)
Cancer Cell
, vol.10
, pp. 389-399
-
-
Van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
Vandenberg, C.J.4
Chen, L.5
Czabotar, P.E.6
Willis, S.N.7
Scott, C.L.8
Day, C.L.9
Cory, S.10
Adams, J.M.11
Roberts, A.W.12
Huang, D.C.13
-
124
-
-
0034904776
-
Growth factors can influence cell growth and survival through effects on glucose metabolism
-
Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB. 2001. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol 21:5899-5912.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5899-5912
-
-
Vander Heiden, M.G.1
Plas, D.R.2
Rathmell, J.C.3
Fox, C.J.4
Harris, M.H.5
Thompson, C.B.6
-
125
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. 2009. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
126
-
-
0034922672
-
Oral gossypol in the treatment of patients with refractory metastatic breast cancer: A phase I/II clinical trial
-
Van Poznak C, Seidman AD, Reidenberg MM, Moasser MM, Sklarin N, Van Zee K, Borgen P, Gollub M, Bacotti D, Yao TJ, Bloch R, Ligueros M, Sonenberg M, Norton L, Hudis C. 2001. Oral gossypol in the treatment of patients with refractory metastatic breast cancer: A phase I/II clinical trial. Breast Cancer Res Treat 66:239-248.
-
(2001)
Breast Cancer Res Treat
, vol.66
, pp. 239-248
-
-
Van Poznak, C.1
Seidman, A.D.2
Reidenberg, M.M.3
Moasser, M.M.4
Sklarin, N.5
Van Zee, K.6
Borgen, P.7
Gollub, M.8
Bacotti, D.9
Yao, T.J.10
Bloch, R.11
Ligueros, M.12
Sonenberg, M.13
Norton, L.14
Hudis, C.15
-
127
-
-
0023786047
-
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
-
Vaux DL, Cory S, Adams JM. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442.
-
(1988)
Nature
, vol.335
, pp. 440-442
-
-
Vaux, D.L.1
Cory, S.2
Adams, J.M.3
-
129
-
-
33749660845
-
A stapled BID BH3 helix directly binds and activates BAX
-
Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ. 2006. A stapled BID BH3 helix directly binds and activates BAX. Mol Cell 24:199-210.
-
(2006)
Mol Cell
, vol.24
, pp. 199-210
-
-
Walensky, L.D.1
Pitter, K.2
Morash, J.3
Oh, K.J.4
Barbuto, S.5
Fisher, J.6
Smith, E.7
Verdine, G.L.8
Korsmeyer, S.J.9
-
130
-
-
43749124428
-
Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism
-
Wan KF, Chan SL, Sukumaran SK, Lee MC, Yu VC. 2008. Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism. J Biol Chem 283:8423-8433.
-
(2008)
J Biol Chem
, vol.283
, pp. 8423-8433
-
-
Wan, K.F.1
Chan, S.L.2
Sukumaran, S.K.3
Lee, M.C.4
Yu, V.C.5
-
131
-
-
0029807585
-
BID: A novel BH3 domain-only death agonist
-
Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ. 1996. BID: A novel BH3 domain-only death agonist. Genes Dev 10:2859-2869. (Pubitemid 26394246)
-
(1996)
Genes and Development
, vol.10
, Issue.22
, pp. 2859-2869
-
-
Wang, K.1
Yin, X.-M.2
Chao, D.T.3
Milliman, C.L.4
Korsmeyer, S.J.5
-
132
-
-
0034691130
-
Structure-based discovery of an organic compound that binds bcl-2 protein and induces apoptosis of tumor cells
-
Wang JL, Liu D, Zhang ZJ, Shan S, Han X, Srinivasula SM, Croce CM, Alnemri ES, Huang Z. 2000. Structure-based discovery of an organic compound that binds bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci USA 97:7124-7129.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7124-7129
-
-
Wang, J.L.1
Liu, D.2
Zhang, Z.J.3
Shan, S.4
Han, X.5
Srinivasula, S.M.6
Croce, C.M.7
Alnemri, E.S.8
Huang, Z.9
-
133
-
-
37549071875
-
Development of dimeric modulators for anti-apoptotic Bcl-2 proteins
-
Wang L, Kong F, Kokoski CL, Andrews DW, Xing C. 2008. Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. Bioorg Med Chem Lett 18:236-240.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 236-240
-
-
Wang, L.1
Kong, F.2
Kokoski, C.L.3
Andrews, D.W.4
Xing, C.5
-
134
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. 1956. On the origin of cancer cells. Science 123:309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
135
-
-
0035957653
-
Proapoptotic BAX, BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. 2001. Proapoptotic BAX, BAK: A requisite gateway to mitochondrial dysfunction and death. Science 292:727-730.
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
Roth, K.A.7
MacGregor, G.R.8
Thompson, C.B.9
Korsmeyer, S.J.10
-
136
-
-
32344432986
-
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo
-
Wendt MD, Shen W, Kunzer A, McClellan WJ, Bruncko M, Oost TK, Ding H, Joseph MK, Zhang H, Nimmer PM, Ng SC, Shoemaker AR, Petros AM, Oleksijew A, Marsh K, Bauch J, Oltersdorf T, Belli BA, Martineau D, Fesik SW, Rosenberg SH, Elmore SW. 2006. Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo. J Med Chem 49:1165-1181.
-
(2006)
J Med Chem
, vol.49
, pp. 1165-1181
-
-
Wendt, M.D.1
Shen, W.2
Kunzer, A.3
McClellan, W.J.4
Bruncko, M.5
Oost, T.K.6
Ding, H.7
Joseph, M.K.8
Zhang, H.9
Nimmer, P.M.10
Ng, S.C.11
Shoemaker, A.R.12
Petros, A.M.13
Oleksijew, A.14
Marsh, K.15
Bauch, J.16
Oltersdorf, T.17
Belli, B.A.18
Martineau, D.19
Fesik, S.W.20
Rosenberg, S.H.21
Elmore, S.W.22
more..
-
137
-
-
0016285850
-
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids
-
Whitehouse S, Cooper RH, Randle PJ. 1974. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochem J 141:761-774.
-
(1974)
Biochem J
, vol.141
, pp. 761-774
-
-
Whitehouse, S.1
Cooper, R.H.2
Randle, P.J.3
-
138
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise DR, DeBerardinis, Mancuso A, Sayed N, Zhang X-Y, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB. 2008. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA 105:18782-18787.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
Deberardinis Mancuso, A.2
Sayed, N.3
Zhang, X.-Y.4
Pfeiffer, H.K.5
Nissim, I.6
Daikhin, E.7
Yudkoff, M.8
McMahon, S.B.9
Thompson, C.B.10
-
139
-
-
0035158568
-
Dominant effector genetics in mammalian cells
-
Xu X, Leo C, Jang Y, Chan E, Padilla D, Huang BC, Lin T, Gururaja T, Hitoshi Y, Lorens JB, Anderson DC, Sikic B, Luo Y, Payan DG, Nolan GP. 2001. Dominant effector genetics in mammalian cells. Nat Genet 27:23-29.
-
(2001)
Nat Genet
, vol.27
, pp. 23-29
-
-
Xu, X.1
Leo, C.2
Jang, Y.3
Chan, E.4
Padilla, D.5
Huang, B.C.6
Lin, T.7
Gururaja, T.8
Hitoshi, Y.9
Lorens, J.B.10
Anderson, D.C.11
Sikic, B.12
Luo, Y.13
Payan, D.G.14
Nolan, G.P.15
-
140
-
-
0028206341
-
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
-
Yin XM, Oltvai ZN, Korsmeyer SJ. 1994. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369:321-323.
-
(1994)
Nature
, vol.369
, pp. 321-323
-
-
Yin, X.M.1
Oltvai, Z.N.2
Korsmeyer, S.J.3
-
141
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. 2001. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7:673-682.
-
(2001)
Mol Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Kinzler, K.W.4
Vogelstein, B.5
-
142
-
-
0028203252
-
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
-
Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. 1994. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci USA 91:3147-3150. (Pubitemid 24130192)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.8
, pp. 3147-3150
-
-
Zhang, Y.1
Kensler, T.W.2
Cho, C.-G.3
Posner, G.H.4
Talalay, P.5
-
143
-
-
33750806817
-
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft
-
Zhang YH, Bhunia A, Wan KF, Lee MC, Chan SL, Yu VC, Mok YK. 2006. Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft. J Mol Biol 364:536-549.
-
(2006)
J Mol Biol
, vol.364
, pp. 536-549
-
-
Zhang, Y.H.1
Bhunia, A.2
Wan, K.F.3
Lee, M.C.4
Chan, S.L.5
Yu, V.C.6
Mok, Y.K.7
-
144
-
-
33947223337
-
Bcl-2 family proteins are essential for platelet survival
-
Zhang H, Nimmer PM, Tahir SK, Chen J, Fryer RM, Hahn KR, Iciek LA, Morgan SJ, Nasarre MC, Nelson R, Preusser LC, Reinhart GA, Smith ML, Rosenberg SH, Elmore SW, Tse C. 2007. Bcl-2 family proteins are essential for platelet survival. Cell Death Differ 14:943-951.
-
(2007)
Cell Death Differ
, vol.14
, pp. 943-951
-
-
Zhang, H.1
Nimmer, P.M.2
Tahir, S.K.3
Chen, J.4
Fryer, R.M.5
Hahn, K.R.6
Iciek, L.A.7
Morgan, S.J.8
Nasarre, M.C.9
Nelson, R.10
Preusser, L.C.11
Reinhart, G.A.12
Smith, M.L.13
Rosenberg, S.H.14
Elmore, S.W.15
Tse, C.16
-
145
-
-
1442327526
-
Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide
-
Zheng Y, Shi Y, Tian C, Jiang C, Jin H, Chen J, Almasan A, Tang H, Chen Q. 2004. Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. Oncogene 23:1239-1247.
-
(2004)
Oncogene
, vol.23
, pp. 1239-1247
-
-
Zheng, Y.1
Shi, Y.2
Tian, C.3
Jiang, C.4
Jin, H.5
Chen, J.6
Almasan, A.7
Tang, H.8
Chen, Q.9
-
146
-
-
16744368499
-
Overexpression of Bcl-xL in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion
-
Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS. 2000. Overexpression of Bcl-xL in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am J Physiol Endocrinol Metab 278:E340-E351.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.278
-
-
Zhou, Y.P.1
Pena, J.C.2
Roe, M.W.3
Mittal, A.4
Levisetti, M.5
Baldwin, A.C.6
Pugh, W.7
Ostrega, D.8
Ahmed, N.9
Bindokas, V.P.10
Philipson, L.H.11
Hanahan, D.12
Thompson, C.B.13
Polonsky, K.S.14
-
147
-
-
6344292389
-
Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species
-
Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG IV, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH. 2004. Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem 279:43940-43951.
-
(2004)
J Biol Chem
, vol.279
, pp. 43940-43951
-
-
Zou, M.H.1
Kirkpatrick, S.S.2
Davis, B.J.3
Nelson, J.S.4
Wiles IV, W.G.5
Schlattner, U.6
Neumann, D.7
Brownlee, M.8
Freeman, M.B.9
Goldman, M.H.10
|