Development of dimeric modulators for anti-apoptotic Bcl-2 proteins

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 236-240

  Wang, Liangyou ^a   Kong, Fansen ^a   Kokoski, Candis L ^b   Andrews, David W ^b   Xing, Chengguo ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Antagonist; Apoptosis; Bcl 2; BH3I 1; Dimeric; Modulator; Monomeric; Potency

Indexed keywords

APOPTOSIS INHIBITOR; CYTOCHROME C; FUNCTIONAL GROUP; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; RHODANINE;

ARTICLE; BINDING AFFINITY; DIMERIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME RELEASE; MITOCHONDRION; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; BCL-X PROTEIN; DIMERIZATION; KINETICS; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 37549071875     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.088     Document Type: Article

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