Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells

Advanced Drug Delivery Reviews

Volumn 49, Issue 1-2, 2001, Pages 63-70

  Modica Napolitano, Josephine S ^a   Aprille, June R ^b  

^a MERRIMACK COLLEGE   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Cell killing; Chemotherapeutic agents; Delocalized lipophilic cations; Mitochondria; Tumor

Indexed keywords

CELLS; CHEMOTHERAPY; DNA; PATIENT TREATMENT; POSITIVE IONS; TOXIC MATERIALS; TUMORS;

MITOCHONDRIA;

DRUG THERAPY;

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; ANTIINFECTIVE AGENT; CHALCOGENAPYRYLIUM DYE; DEQUALINIUM; N,N' BIS(2 ETHYL 1,3 DIOXYLENE)KYRPTOCYANINE; PHOTOSENSITIZING AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RHODAMINE 123; THIOPYRYLIUM AA 1; UNCLASSIFIED DRUG; ZIDOVUDINE;

CANCER CELL DESTRUCTION; CANCER COMBINATION CHEMOTHERAPY; CARCINOMA; CARCINOMA CELL; CELLULAR DISTRIBUTION; CYTOTOXICITY; DRUG ACCUMULATION; DRUG EFFICACY; DRUG TARGETING; EPITHELIUM CELL; HUMAN; LIPOPHILICITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PHOTOCHEMOTHERAPY; PHOTOTOXICITY; PRIORITY JOURNAL; REVIEW;

EID: 0035797118     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(01)00125-9     Document Type: Article

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