Bcl-2 family proteins are essential for platelet survival

Cell Death and Differentiation

Volumn 14, Issue 5, 2007, Pages 943-951

  Zhang, H ^a   Nimmer, P M ^a   Tahir, S K ^a   Chen, J ^a   Fryer, R M ^a   Hahn, K R ^a   Iciek, L A ^a   Morgan, S J ^a   Nasarre, M C ^a   Nelson, R ^a   Preusser, L C ^a   Reinhart, G A ^a   Smith, M L ^a   Rosenberg, S H ^a   Elmore, S W ^a   Tse, C ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; CASPASE 3; CYTOCHROME C; INDIUM 111; PHOSPHATIDYLSERINE; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL LABELING; CONTROLLED STUDY; DOG; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LIVER CLEARANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; RETICULOENDOTHELIAL SYSTEM; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE LIFESPAN; WHOLE BODY SCINTISCANNING;

ANIMALS; APOPTOSIS; BIPHENYL COMPOUNDS; BLOOD PLATELETS; CELL SEPARATION; CELL SURVIVAL; CYTOPLASMIC GRANULES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXOCYTOSIS; FLOW CYTOMETRY; HUMANS; LIVER; MALE; NITROPHENOLS; PHOSPHATIDYLSERINES; PIPERAZINES; PLATELET AGGREGATION; PLATELET COUNT; PROTO-ONCOGENE PROTEINS C-BCL-2; SULFONAMIDES;

CANIS FAMILIARIS;

EID: 33947223337     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4402081     Document Type: Article

References (31)

1. Troy GC. An overview of hemostasis. Vet Clin North Am Small Anim Pract 1988; 18 (1): 5-20.
2. Packham MA. Role of platelets in thrombosis and hemostasis. Can J Physiol Pharmacol 1994; 72 (3): 278-284.
3. Wolf BB, Goldstein JC, Stennicke HR, Beere H, Amarante-Mendes GP, Salvesen GS et al. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood 1999; 94 (5): 1683-1692.
4. Shcherbina A, Remold-O'Donnell E. Role of caspase in a subset of human platelet activation responses. Blood 1999; 93 (12): 4222-4231.
5. Kaluzhny Y, Ravid K. Role of apoptotic processes in platelet biogenesis. Acta Haematol 2004; 111 (1-2): 67-77.
6. Patel SR, Hartwig JH, Italiano Jr JE. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest 2005; 115 (12): 3348-3354.
7. Stuart MJ, Murphy S, Oski FA. A simple nonradioisotope technic for the determination of platelet life-span. N Engl J Med 1975; 292 (25): 1310-1313.
8. Tsan MF. Kinetics and distribution of platelets in man. Am J Hematol 1984; 17 (1): 97-104.
9. Pereira J, Palomo I, Ocqueteau M, Soto M, Aranda E, Mezzano D. Platelet aging in vivo is associated with loss of membrane phospholipid asymmetry. Thromb Haemost 1999; 82 (4): 1318-1321.
10. Pereira J, Soto M, Palomo I, Ocqueteau M, Coetzee LM, Astudillo S et al. Platelet aging in vivo is associated with activation of apoptotic pathways: Studies in a model of suppressed thrombopoiesis in dogs. Thromb Haemost 2002; 87 (5): 905-909.
11. Li J, Xia Y, Bertino AM, Coburn JP, Kuter DJ. The mechanism of apoptosis in human platelets during storage. Transfusion 2000; 40 (11): 1320-1329.
12. Bertino AM, Qi XQ, Li J, Xia Y, Kuter DJ. Apoptotic markers are increased in platelets stored at 37 degrees C. Transfusion 2003; 43 (7): 857-866.
13. Clarke MCH, Savill J, Jones DB, Noble BS, Brown SB. Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death. J Cell Biol 2003; 160 (4): 577-587.
14. Vanags DM, Orrenius S, Aguilar-Santelises M. Alterations in Bcl-2/Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis. Br J Haematol 1997; 99 (4): 824-831.
15. Brown SB, Clarke MC, Magowan L, Sanderson H, Savill J. Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program. J Biol Chem 2000; 275 (8): 5987-5996.
16. Coultas L, Strasser A. The role of the Bcl-2 protein family in cancer. Semin Cancer Biol 2003; 13 (2): 115-123.
17. Gelinas C, White E. BH3-only proteins in control: Specificity regulates MCL-1 and BAK-mediated apoptosis. Genes Dev 2005; 19 (11): 1263-1268.
18. Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435 (7042): 677-681.
19. Kahn ML. Platelet-collagen responses: Molecular basis and therapeutic promise. Semin Thromb Hemost 2004; 30 (4): 419-425.
20. Manoharan A, Gemmell R, Brighton T, Dunkley S, Lopez K, Kyle P. Thrombosis and bleeding in myeloproliferative disorders: Identification of at-risk patients with whole blood platelet aggregation studies. Br J Haematol 1999; 105 (3): 618-625.
21. Rendu F, Brohard-Bohn B. The platelet release reaction: Granules' constituents, secretion and functions. Platelets 2001; 12 (5): 261-273.
22. Kawabata K, Nakai S, Miwa M, Sugiura T, Otsuka Y, Shinzato T et al. Platelet GPIIb/IIIa is activated and platelet-leukocyte coaggregates formed in vivo during hemodialysis. Nephron 2002; 90 (4): 391-400.
23. Jacobson MD, Burne JF, Raff MC. Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J 1994; 13 (8): 1899-1910.
24. Martin SJ, Finucane DM, Amarante-Mendes GP, O'Brien GA, Green DR. Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity. J Biol Chem 1996; 271 (46): 28753-28756.
25. Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 2000; 405 (6782): 85-90.
26. Sanz C, Benet I, Richard C, Badia B, Andreu EJ, Prosper F et al. Antiapoptotic protein Bcl-x(L) is up-regulated during megakaryocytic differentiation of CD34(+) progenitors but is absent from senescent megakaryocytes. Exp Hematol 2001; 29 (6): 728-735.
27. Proimos G. Platelet aggregation inhibition with glycoprotein IIb-IIIa inhibitors. J Thromb Thrombolysis 2001; 11 (2): 99-110.
28. Judge HM, Buckland RJ, Holgate CE, Storey RF. Glycoprotein IIb/IIIa and P2Y12 receptor antagonists yield additive inhibition of platelet aggregation, granule secretion, soluble CD40L release and procoagulant responses. Platelets 2005; 16 (7): 398-407.
29. Lecompte T, Hardy J-F. Antiplatelet agents and perioperative bleeding: [Les inhibiteurs plaquettaires et le saignement perioperatoire]. Can J Anesth 2006; 53 (6 suppl): S103-S112.
30. Fryer RM, Preusser LC, Calzadilla SV, Hu Y, Xu H, Marsh KC et al. (-)-9S)-9-(3-bromo-4-fluorophenyl)-2, 3, 5, 6, 7, 9-hexahydrothieno[3,2-b]quin olin-8(4H)-one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: Hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine. J Cardiovasc Pharmacol 2004; 44 (2): 137-147.
31. Fryer RM, Rakestraw PA, Preusser LC, Brune ME, Carroll WA, Buckner SA et al. Pharmacological characterization of the novel dihydropyridine potassium channel opener, (9R -9-(3-iodo-4-methylphenyl)-5, 9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyri dine-1, 8(4H, 7 H)-dione (A-325100), and the regulation of cardiovascular function in conscious and anesthetized beagle dogs. J Cardiovasc Pharmacol 2005; 46 (2): 232-240.