Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase

Journal of Biological Chemistry

Volumn 280, Issue 14, 2005, Pages 13229-13240

  Mayr, Georg W ^a   Windhorst, Sabine ^a   Hillemeier, Kirsten ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYME INHIBITION; ENZYMES; METABOLISM; PLANTS (BOTANY);

ANTIPROLIFERATIVE PLANT; CATALYTIC DOMAINS; INOSITOL POLYPHOSPHATE MULTIKINASE (IPMK); POLYPHENOLICS;

PHENOLS;

3',4',7,8 TETRAHYDROXYFLAVONE; ANTHRAQUINONE DERIVATIVE; AURINTRICARBOXYLIC ACID; CALPHOSTIN C; CATECHIN; CHLOROGENIC ACID; DAIDZEIN; DOXORUBICIN; ELLAGIC ACID; EPICATECHIN; EPICATECHIN 3 GALLATE; EPIGALLOCATECHIN GALLATE; FLAVONE DERIVATIVE; FLAVONOL DERIVATIVE; GALLIC ACID; GENISTEIN; GOSSYPOL; HYPERICIN; INOSITOL 1,4,5 TRISPHOSPHATE 3 KINASE DERIVATIVE; INOSITOL POLYPHOSPHATE MULTIKINASE; ISOFLAVONE DERIVATIVE; MYRICETIN; POLYPHENOL DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; PSEUDOHYPERICIN; QUERCETIN; QUINALIZARIN; ROTTLERIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MAMMAL; MUTAGENESIS; PHOSPHORYLATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL PROLIFERATION; FLAVONOIDS; HUMANS; INOSITOL PHOSPHATES; ISOENZYMES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PHENOLS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLANTS; RATS; SECOND MESSENGER SYSTEMS; SEQUENCE ALIGNMENT;

EID: 17144366551     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500545200     Document Type: Article

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