Induced dimerization of the amyloid precursor protein leads to decreased amyloid-β protein production

Journal of Biological Chemistry

Volumn 284, Issue 42, 2009, Pages 28943-28952

  Eggert, Simone ^a   Midthune, Brea ^a   Cottrell, Barbara ^a   Koo, Edward H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PLAQUES; AMYLOID PRECURSOR PROTEINS; C TERMINUS; FK506-BINDING PROTEINS; HOMODIMERIZATION; HOMODIMERS; N2A CELLS; PROTEIN PRODUCTION; SECRETASES; SYNTHETIC MEMBRANES;

AMINES; DIMERIZATION; GLYCOPROTEINS; OLIGOMERS; PEPTIDES;

PUMPING PLANTS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AP 20187; BETA SECRETASE; CHEMICAL COMPOUND; CYSTEINE; DIMER; FK 506 BINDING PROTEIN; GAMMA SECRETASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; ENZYME DEGRADATION; GENE MUTATION; GENETIC TRANSFECTION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN POLYMERIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CATALYTIC DOMAIN; CELL LINE, TUMOR; DIMERIZATION; GENE EXPRESSION REGULATION; HUMANS; MICE; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

EID: 70350350069     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.038646     Document Type: Article

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