Nonspecificity of binding of γ-secretase modulators to the amyloid precursor protein

Biochemistry

Volumn 48, Issue 50, 2009, Pages 11837-11839

  Beel, Andrew J ^a   Barrett, Paul ^a   Schnier, Paul D ^b   Hitchcock, Stephen A ^b   Bagal, Dhanashri ^b   Sanders, Charles R ^a   Jordan, John B ^b  

^a VANDERBILT UNIVERSITY   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEINS; C-TERMINAL DOMAINS; MONODISPERSE; NON-SPECIFICITY; PROTEASE COMPLEX; SECRETASES; SPECIFIC BINDING;

PROTEINS;

GLYCOPROTEINS;

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; HUMANS; MICELLES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 72449208456     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901839d     Document Type: Article

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