APP substitutions V715F and L720P alter PS1 conformation and differentially affect Aβ and AICD generation

Journal of Neurochemistry

Volumn 95, Issue 2, 2005, Pages 446-456

  Tesco, Giuseppina ^a   Ginestroni, Andrea ^a   Hiltunen, Mikko ^a   Kim, Minji ^a   Dolios, Georgia ^b   Hyman, Bradley T ^a   Wang, Rong ^b   Berezovska, Oksana ^a   Tanzi, Rudolph E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

secretase; Amyloid precursor protein; Amyloid precursor protein intracellular domain; Amyloid peptide; Non steroidal anti inflammatory drugs; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-38]; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NONSTEROID ANTIINFLAMMATORY AGENT; PEPTIDE FRAGMENT; PRESENILIN 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; AMYLOID PRECURSOR PROTEIN INTRACELLULAR DOMAIN; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN;

AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CULTURE MEDIA, CONDITIONED; ENERGY METABOLISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MUTAGENESIS, SITE-DIRECTED; PRESENILIN-1; PROTEIN CONFORMATION; RECEPTORS, CELL SURFACE;

EID: 26844552573     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03381.x     Document Type: Article

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