Allosteric modulation of PS1/γ-secretase conformation correlates with amyloid β42/40 ratio

PLoS ONE

Volumn 4, Issue 11, 2009, Pages

  Uemura, Kengo ^a   Lill, Christina M ^a   Li, Xuejing ^a   Peters, Jessica A ^a   Ivanov, Alexander ^a   Fan, Zhanyun ^a   DeStrooper, Bart ^b   Bacskai, Brian J ^a   Hyman, Bradley T ^a   Berezovska, Oksana ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; FENOFIBRATE; GAMMA SECRETASE; PRESENILIN 1; AMYLOID BETA PROTEIN; GREEN FLUORESCENT PROTEIN; PRESENILIN; SECRETASE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME MODIFICATION; ENZYME SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NONHUMAN; ANIMAL; BINDING SITE; CELL LINE; CHEMISTRY; CHO CELL; CRICETULUS; GENETICS; HAMSTER; MOUSE; MUTATION; PROTEIN CONFORMATION;

ALLOSTERIC SITE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GREEN FLUORESCENT PROTEINS; HUMANS; MICE; MUTATION; PRESENILIN-1; PRESENILINS; PROTEIN CONFORMATION;

EID: 70849116652     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007893     Document Type: Article

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