Oxidative damage to RNA: Mechanisms, consequences, and diseases

Cellular and Molecular Life Sciences

Volumn 67, Issue 11, 2010, Pages 1817-1829

  Kong, Qiongman ^a   Lin, Chien Liang Glenn ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

ALS; Alzheimer's disease; Free radical; Neurodegeneration; Oxidative damage; Oxidative stress; RNA oxidation

Indexed keywords

ALPHA SYNUCLEIN; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; COPPER ZINC SUPEROXIDE DISMUTASE; MELATONIN; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; RIBOSOME RNA; UBIDECARENONE; FREE RADICAL; NERVE PROTEIN; RNA;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANTIOXIDANT ACTIVITY; DEGENERATIVE DISEASE; EPILEPSY; HUMAN; MOLECULAR BIOLOGY; MOLECULAR MECHANICS; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; REVIEW; RNA ISOLATION; RNA METABOLISM; RNA PROCESSING; RNA STRUCTURE; RNA SYNTHESIS; RNA TRANSLATION; SPINAL CORD INJURY; ANIMAL; ATHEROSCLEROSIS; BIOSYNTHESIS; CHEMISTRY; DISEASE COURSE; METABOLISM; OXIDATION REDUCTION REACTION;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ATHEROSCLEROSIS; DISEASE PROGRESSION; EPILEPSY; FREE RADICALS; HUMANS; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PARKINSON DISEASE; RNA; RNA, MESSENGER; SPINAL CORD INJURIES;

EID: 77952563624     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0277-y     Document Type: Review

References (118)

1. RA Miller BE Britigan 1997 Role of oxidants in microbial pathophysiology Clin Microbiol Rev 10 1 18 1:CAS:528:DyaK2sXotlSqsQ%3D%3D 8993856
2. P Pacher JS Beckman L Liaudet 2007 Nitric oxide and peroxynitrite in health and disease Physiol Rev 87 315 424 1:CAS:528:DC%2BD2sXitVagsr8%3D 17237348
3. FL Muller MS Lustgarten Y Jang A Richardson H Van Remmen 2007 Trends in oxidative aging theories Free Radic Biol Med 43 477 503 1:CAS:528: DC%2BD2sXotVWkur0%3D 17640558
4. IM Fearon SP Faux 2009 Oxidative stress and cardiovascular disease: novel tools give (free) radical insight J Mol Cell Cardiol 47 372 381 1:CAS:528:DC%2BD1MXptVegsbY%3D 19481547
5. AI Cederbaum Y Lu D Wu 2009 Role of oxidative stress in alcohol-induced liver injury Arch Toxicol 83 519 548 1:CAS:528:DC%2BD1MXlvFyiu78%3D 19448996
6. KP Shatwell AW Segal 1996 NADPH oxidase Int J Biochem Cell Biol 28 1191 1195 1:CAS:528:DyaK2sXoslSnug%3D%3D 9022278
7. IN Zelko TJ Mariani RJ Folz 2002 Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression Free Radic Biol Med 33 337 349 1:CAS:528:DC%2BD38Xlt12kur8%3D 12126755
8. P Chelikani I Fita PC Loewen 2004 Diversity of structures and properties among catalases Cell Mol Life Sci 61 192 208 1:CAS:528:DC%2BD2cXjt1yhtL8%3D 14745498
9. GC Mills 1957 Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown J Biol Chem 229 189 197 1:CAS:528:DyaG1cXjsFKltA%3D%3D 13491573
10. H Sies 1993 Strategies of antioxidant defense Eur J Biochem 215 213 219 1:CAS:528:DyaK3sXltlKms7w%3D 7688300
11. E Culotta DE Koshland Jr 1992 NO news is good news Science 258 1862 1865 1:STN:280:DyaK3s7htVegug%3D%3D 1361684
12. JB Hibbs Jr RR Taintor Z Vavrin EM Rachlin 1988 Nitric oxide: a cytotoxic activated macrophage effector molecule Biochem Biophys Res Commun 157 87 94 1:CAS:528:DyaL1MXntlOisw%3D%3D 3196352
13. I Dalle-Donne G Aldini M Carini R Colombo R Rossi A Milzani 2006 Protein carbonylation, cellular dysfunction, and disease progression J Cell Mol Med 10 389 406 1:CAS:528:DC%2BD2sXlvFCltb0%3D 16796807
14. H Ischiropoulos 2009 Protein tyrosine nitration-an update Arch Biochem Biophys 484 117 121 1:CAS:528:DC%2BD1MXltVyqsr0%3D 19007743
15. U Nair H Bartsch J Nair 2007 Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: a review of published adduct types and levels in humans Free Radic Biol Med 43 1109 1120 1:CAS:528:DC%2BD2sXhtVCisLjL 17854706
16. J Cadet T Douki D Gasparutto JL Ravanat 2003 Oxidative damage to DNA: formation, measurement and biochemical features Mutat Res 531 5 23 1:CAS:528:DC%2BD3sXpt1ertrY%3D 14637244
17. J Barciszewski MZ Barciszewska G Siboska SI Rattan BF Clark 1999 Some unusual nucleic acid bases are products of hydroxyl radical oxidation of DNA and RNA Mol Biol Rep 26 231 238 1:CAS:528:DC%2BD3cXktF2gtA%3D%3D 10634505
18. T Abe H Tohgi C Isobe T Murata C Sato 2002 Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease J Neurosci Res 70 447 450 1:CAS:528:DC%2BD38XosVaqu7c%3D 12391605
19. T Abe C Isobe T Murata C Sato H Tohgi 2003 Alteration of 8-hydroxyguanosine concentrations in the cerebrospinal fluid and serum from patients with Parkinson's disease Neurosci Lett 336 105 108 1:CAS:528: DC%2BD38XpslSmsbo%3D 12499051
20. T Hofer AY Seo M Prudencio C Leeuwenburgh 2006 A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration Biol Chem 387 103 111 1:CAS:528:DC%2BD28XhsVKjt7k%3D 16497170
21. EM Park MK Shigenaga P Degan TS Korn JW Kitzler CM Wehr P Kolachana BN Ames 1992 Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column Proc Natl Acad Sci USA 89 3375 3379 1:CAS:528:DyaK38XksVajsbo%3D 1565629
22. B Yin RM Whyatt FP Perera MC Randall TB Cooper RM Santella 1995 Determination of 8-hydroxydeoxyguanosine by an immunoaffinity chromatography-monoclonal antibody-based ELISA Free Radic Biol Med 18 1023 1032 1:CAS:528:DyaK2MXltlOkurw%3D 7628728
23. A Nunomura G Perry MA Pappolla R Wade K Hirai S Chiba MA Smith 1999 RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease J Neurosci 19 1959 1964 1:CAS:528:DyaK1MXhslKnurg%3D 10066249 (Pubitemid 29133374)
24. K Honda MA Smith X Zhu D Baus WC Merrick AM Tartakoff T Hattier PL Harris SL Siedlak H Fujioka Q Liu PI Moreira FP Miller A Nunomura S Shimohama G Perry 2005 Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron J Biol Chem 280 20978 20986 1:CAS:528:DC%2BD2MXks1emurk%3D 15767256
25. J Zhang G Perry MA Smith D Robertson SJ Olson DG Graham TJ Montine 1999 Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons Am J Pathol 154 1423 1429 1:STN:280: DyaK1M3mtlekug%3D%3D 10329595
26. A Kikuchi A Takeda H Onodera T Kimpara K Hisanaga N Sato A Nunomura RJ Castellani G Perry MA Smith Y Itoyama 2002 Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy Neurobiol Dis 9 244 248 1:CAS:528:DC%2BD38XhvVSksrk%3D 11895375
27. A Nunomura G Perry K Hirai G Aliev A Takeda S Chiba MA Smith 1999 Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome Ann N Y Acad Sci 893 362 364 1:CAS:528:DC%2BD3cXms1GktA%3D%3D 10672267 (Pubitemid 30038105)
28. A Nunomura S Chiba K Kosaka A Takeda RJ Castellani MA Smith G Perry 2002 Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies Neuroreport 13 2035 2039 1:CAS:528:DC%2BD38XovVeiurY%3D 12438921
29. M Guentchev SL Siedlak C Jarius F Tagliavini RJ Castellani G Perry MA Smith H Budka 2002 Oxidative damage to nucleic acids in human prion disease Neurobiol Dis 9 275 281 1:CAS:528:DC%2BD38XislSgtLk%3D 11950273
30. MA Lovell WR Markesbery 2008 Oxidatively modified RNA in mild cognitive impairment Neurobiol Dis 29 169 175 1:CAS:528:DC%2BD1cXptlSgsQ%3D%3D 17920285
31. M Hayashi N Arai J Satoh H Suzuki K Katayama K Tamagawa Y Morimatsu 2002 Neurodegenerative mechanisms in subacute sclerosing panencephalitis J Child Neurol 17 725 730 12546425
32. M Hayashi S Araki J Kohyama K Shioda R Fukatsu 2005 Oxidative nucleotide damage and superoxide dismutase expression in the brains of xeroderma pigmentosum group A and Cockayne syndrome Brain Dev 27 34 38 15626539
33. X Shan H Tashiro CL Lin 2003 The identification and characterization of oxidized RNAs in Alzheimer's disease J Neurosci 23 4913 4921 1:CAS:528:DC%2BD3sXltlensbg%3D 12832513
34. Q Ding WR Markesbery V Cecarini JN Keller 2006 Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease Neurochem Res 31 705 710 1:CAS:528:DC%2BD28XlsFCjt7Y%3D 16770743
35. Q Ding E Dimayuga WR Markesbery JN Keller 2004 Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures J Neurochem 91 1211 1218 1:CAS:528:DC%2BD2cXhtFSitr7F 15569264
36. B Gorg N Qvartskhava V Keitel HJ Bidmon O Selbach F Schliess D Haussinger 2008 Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo Hepatology 48 567 579 18506841
37. X Shan CL Lin 2006 Quantification of oxidized RNAs in Alzheimer's disease Neurobiol Aging 27 657 662 1:CAS:528:DC%2BD28Xjs1Wns7g%3D 15979765
38. Y Chang Q Kong X Shan G Tian H Ilieva DW Cleveland JD Rothstein DR Borchelt PC Wong CL Lin 2008 Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS PLoS One 3 e2849 18682740
39. PT Nelson JN Keller 2007 RNA in brain disease: no longer just "the messenger in the middle" J Neuropathol Exp Neurol 66 461 468 1:CAS:528:DC%2BD2sXnsFKmt7o%3D 17549006
40. X Cao G Yeo AR Muotri T Kuwabara FH Gage 2006 Noncoding RNAs in the mammalian central nervous system Annu Rev Neurosci 29 77 103 1:CAS:528:DC%2BD28XosVeisbk%3D 16776580
41. Q Ding WR Markesbery Q Chen F Li JN Keller 2005 Ribosome dysfunction is an early event in Alzheimer's disease J Neurosci 25 9171 9175 1:CAS:528:DC%2BD2MXhtFGktrrM 16207876
42. A Nunomura S Chiba CF Lippa P Cras RN Kalaria A Takeda K Honda MA Smith G Perry 2004 Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease Neurobiol Dis 17 108 113 1:CAS:528:DC%2BD2cXntlaqsr8%3D 15350971
43. A Nunomura G Perry G Aliev K Hirai A Takeda EK Balraj PK Jones H Ghanbari T Wataya S Shimohama S Chiba CS Atwood RB Petersen MA Smith 2001 Oxidative damage is the earliest event in Alzheimer disease J Neuropathol Exp Neurol 60 759 767 1:CAS:528:DC%2BD3MXmtVGmsr0%3D 11487050
44. X Shan Y Chang CL Lin 2007 Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression FASEB J 21 2753 2764 1:CAS:528:DC%2BD2sXhtVehu77I 17496160
45. Q Ding E Dimayuga JN Keller 2007 Oxidative stress alters neuronal RNA-and protein-synthesis: implications for neural viability Free Radic Res 41 903 910 1:CAS:528:DC%2BD2sXotFSjtLo%3D 17654047
46. M Tanaka PB Chock ER Stadtman 2007 Oxidized messenger RNA induces translation errors Proc Natl Acad Sci USA 104 66 71 1:CAS:528: DC%2BD2sXjs1Wmuw%3D%3D 17190801
47. AB Shyu MF Wilkinson A van Hoof 2008 Messenger RNA regulation: to translate or to degrade EMBO J 27 471 481 1:CAS:528:DC%2BD1cXhs1Kgt7Y%3D 18256698
48. H Hayakawa M Kuwano M Sekiguchi 2001 Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein Biochemistry 40 9977 9982 1:CAS:528:DC%2BD3MXltlyht7c%3D 11502194
49. H Hayakawa T Uchiumi T Fukuda M Ashizuka K Kohno M Kuwano M Sekiguchi 2002 Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine Biochemistry 41 12739 12744 12379116
50. PA Aas M Otterlei PO Falnes CB Vagbo F Skorpen M Akbari O Sundheim M Bjoras G Slupphaug E Seeberg HE Krokan 2003 Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA Nature 421 859 863 1:CAS:528:DC%2BD3sXht1Kqt74%3D 12594517
51. G McKhann D Drachman M Folstein R Katzman D Price EM Stadlan 1984 Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 34 939 944 1:STN:280:DyaL2c3ks1altQ%3D%3D 6610841
52. MA Smith PL Harris LM Sayre G Perry 1997 Iron accumulation in Alzheimer disease is a source of redox-generated free radicals Proc Natl Acad Sci USA 94 9866 9868 1:CAS:528:DyaK2sXlvVWjsLo%3D 9275217
53. MA Lovell JD Robertson WJ Teesdale JL Campbell WR Markesbery 1998 Copper, iron and zinc in Alzheimer's disease senile plaques J Neurol Sci 158 47 52 1:CAS:528:DyaK1cXjsVentbo%3D 9667777
54. LM Sayre G Perry PL Harris Y Liu KA Schubert MA Smith 2000 In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals J Neurochem 74 270 279 1:CAS:528:DC%2BD3cXlt12k 10617129
55. JR Connor EA Milward S Moalem M Sampietro P Boyer ME Percy C Vergani RJ Scott M Chorney 2001 Is hemochromatosis a risk factor for Alzheimer's disease? J Alzheimers Dis 3 471 477 1:CAS:528:DC%2BD38XislehtQ%3D%3D 12214033
56. G Casadesus MA Smith X Zhu G Aliev AD Cash K Honda RB Petersen G Perry 2004 Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species J Alzheimers Dis 6 165 169 1:CAS:528: DC%2BD2cXjtFOmurw%3D 15096700
57. K Honda G Casadesus RB Petersen G Perry MA Smith 2004 Oxidative stress and redox-active iron in Alzheimer's disease Ann N Y Acad Sci 1012 179 182 1:CAS:528:DC%2BD2cXjvVOmsrs%3D 15105265 (Pubitemid 38453525)
58. SD Yan SF Yan X Chen J Fu M Chen P Kuppusamy MA Smith G Perry GC Godman P Nawroth JL Zweier D Stern 1995 Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide Nat Med 1 693 699 1:CAS:528: DyaK2MXms1Kgtr8%3D 7585153
59. JT Rogers JD Randall CM Cahill PS Eder X Huang H Gunshin L Leiter J McPhee SS Sarang T Utsuki NH Greig DK Lahiri RE Tanzi AI Bush T Giordano SR Gullans 2002 An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript J Biol Chem 277 45518 45528 1:CAS:528:DC%2BD38Xosl2ks70%3D 12198135
60. E Tamagno M Parola P Bardini A Piccini R Borghi M Guglielmotto G Santoro A Davit O Danni MA Smith G Perry M Tabaton 2005 Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways J Neurochem 92 628 636 1:CAS:528:DC%2BD2MXht12msb8%3D 15659232
61. CS Atwood G Perry H Zeng Y Kato WD Jones KQ Ling X Huang RD Moir D Wang LM Sayre MA Smith SG Chen AI Bush 2004 Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta Biochemistry 43 560 568 1:CAS:528: DC%2BD3sXpvFSju7c%3D 14717612
62. MM Hoehn MD Yahr 1967 Parkinsonism: onset, progression and mortality Neurology 17 427 442 1:STN:280:DyaF2s7jvFSgsg%3D%3D 6067254
63. MS Pollanen DW Dickson C Bergeron 1993 Pathology and biology of the Lewy body J Neuropathol Exp Neurol 52 183 191 1:STN:280:DyaK3s3mtVCrsA%3D%3D 7684074
64. M Parenti L Rusconi V Cappabianca EA Parati A Groppetti 1988 Role of dopamine in manganese neurotoxicity Brain Res 473 236 240 1:CAS:528: DyaL1MXlt1Gltg%3D%3D 2852985
65. E Kienzl L Puchinger K Jellinger W Linert H Stachelberger RF Jameson 1995 The role of transition metals in the pathogenesis of Parkinson's disease J Neurol Sci 134 Suppl 69 78 8847547
66. E Sofic P Riederer H Heinsen H Beckmann GP Reynolds G Hebenstreit MB Youdim 1988 Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain J Neural Transm 74 199 205 1:STN:280:DyaL1M%2FpsVegsQ%3D%3D 3210014
67. J Lotharius P Brundin 2002 Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease Hum Mol Genet 11 2395 2407 1:CAS:528:DC%2BD38XnvVems7s%3D 12351575
68. JJ Liccione MD Maines 1988 Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese J Pharmacol Exp Ther 247 156 161 1:CAS:528:DyaL1cXmt1ChsLc%3D 2902211
69. MS Desole L Sciola MR Delogu S Sircana R Migheli E Miele 1997 Role of oxidative stress in the manganese and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6- tetrahydropyridine-induced apoptosis in PC12 cells Neurochem Int 31 169 176 1:CAS:528:DyaK2sXksFahs7o%3D 9220449
70. MS Desole G Esposito R Migheli S Sircana MR Delogu L Fresu M Miele G de Natale E Miele 1997 Glutathione deficiency potentiates manganese toxicity in rat striatum and brainstem and in PC12 cells Pharmacol Res 36 285 292 1:CAS:528:DyaK1cXjsl2iuw%3D%3D 9425617
71. XM Shen G Dryhurst 1998 Iron-and manganese-catalyzed autoxidation of dopamine in the presence of l-cysteine: possible insights into iron-and manganese-mediated dopaminergic neurotoxicity Chem Res Toxicol 11 824 837 1:CAS:528:DyaK1cXkvVGksb8%3D 9671546
72. S Oikawa I Hirosawa S Tada-Oikawa A Furukawa K Nishiura S Kawanishi 2006 Mechanism for manganese enhancement of dopamine-induced oxidative DNA damage and neuronal cell death Free Radic Biol Med 41 748 756 1:CAS:528: DC%2BD28XotVyqtro%3D 16895795
73. A Yoritaka N Hattori K Uchida M Tanaka ER Stadtman Y Mizuno 1996 Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease Proc Natl Acad Sci USA 93 2696 2701 1:CAS:528:DyaK28XitVCis7Y%3D 8610103
74. ZI Alam A Jenner SE Daniel AJ Lees N Cairns CD Marsden P Jenner B Halliwell 1997 Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra J Neurochem 69 1196 1203 1:CAS:528:DyaK2sXls1Chtbs%3D 9282943
75. ZI Alam SE Daniel AJ Lees DC Marsden P Jenner B Halliwell 1997 A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease J Neurochem 69 1326 1329 1:CAS:528: DyaK2sXls1Chu70%3D 9282961
76. S Boillee C Vande Velde DW Cleveland 2006 ALS: a disease of motor neurons and their nonneuronal neighbors Neuron 52 39 59 1:CAS:528:DC%2BD28XhtFensbfP 17015226
77. JP Julien J Kriz 2006 Transgenic mouse models of amyotrophic lateral sclerosis Biochim Biophys Acta 1762 1013 1024 1:CAS:528:DC%2BD28Xht1CgsLnO 16675207
78. CS Lobsiger DW Cleveland 2007 Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease Nat Neurosci 10 1355 1360 1:CAS:528:DC%2BD2sXht1ajsbfF 17965655
79. MT Carri A Battistoni F Polizio A Desideri G Rotilio 1994 Impaired copper binding by the H46R mutant of human Cu,Zn superoxide dismutase, involved in amyotrophic lateral sclerosis FEBS Lett 356 314 316 1:CAS:528:DyaK2MXis12ns7Y%3D 7805862
80. BJ Turner K Talbot 2008 Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS Prog Neurobiol 85 94 134 1:CAS:528:DC%2BD1cXls1yksbY%3D 18282652
81. RP Bunge WR Puckett JL Becerra A Marcillo RM Quencer 1993 Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination Adv Neurol 59 75 89 1:STN:280:DyaK3s7ivVSjsA%3D%3D 8420126
82. BA Kakulas 1999 A review of the neuropathology of human spinal cord injury with emphasis on special features J Spinal Cord Med 22 119 124 1:STN:280:DC%2BD3c3os1Siuw%3D%3D 10826269
83. JE Springer RD Azbill RJ Mark JG Begley G Waeg MP Mattson 1997 4-hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake J Neurochem 68 2469 2476 1:STN:280:DyaK2szgvFehtA%3D%3D 9166741
84. ED Hall JM Braughler 1986 Role of lipid peroxidation in post-traumatic spinal cord degeneration: a review Cent Nerv Syst Trauma 3 281 294 1:STN:280:DyaL2s3hs1SitQ%3D%3D 3555850
85. AP Amar ML Levy 1999 Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury Neurosurgery 44 1027 1039 1:STN:280:DyaK1M3kslCqtA%3D%3D 10232536 (discussion 1039-1040)
86. ML Leski F Bao L Wu H Qian D Sun D Liu 2001 Protein and DNA oxidation in spinal injury: neurofilaments-an oxidation target Free Radic Biol Med 30 613 624 1:CAS:528:DC%2BD3MXisVWnsbg%3D 11295359
87. M Aksenova DA Butterfield SX Zhang M Underwood JW Geddes 2002 Increased protein oxidation and decreased creatine kinase BB expression and activity after spinal cord contusion injury J Neurotrauma 19 491 502 11990354
88. F Bao Y Chen GA Dekaban LC Weaver 2004 Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats J Neurochem 88 1335 1344 1:CAS:528:DC%2BD2cXivVCit7o%3D 15009633
89. F Bao Y Chen GA Dekaban LC Weaver 2004 An anti-CD11d integrin antibody reduces cyclooxygenase-2 expression and protein and DNA oxidation after spinal cord injury in rats J Neurochem 90 1194 1204 1:CAS:528:DC%2BD2cXns1Sqsro%3D 15312174
90. M Xu GW Yip LT Gan YK Ng 2005 Distinct roles of oxidative stress and antioxidants in the nucleus dorsalis and red nucleus following spinal cord hemisection Brain Res 1055 137 142 1:CAS:528:DC%2BD2MXpvV2ktLc%3D 16095570
91. HS Sharma PO Sjoquist S Mohanty L Wiklund 2006 Post-injury treatment with a new antioxidant compound H-290/51 attenuates spinal cord trauma-induced c-fos expression, motor dysfunction, edema formation, and cell injury in the rat Acta Neurochir Suppl 96 322 328 1:STN:280:DC%2BD283kslKqsQ%3D%3D 16671479
92. VR King WL Huang SC Dyall OE Curran JV Priestley AT Michael-Titus 2006 Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat J Neurosci 26 4672 4680 1:CAS:528:DC%2BD28XksFWqu74%3D 16641248
93. WL Huang VR King OE Curran SC Dyall RE Ward N Lal JV Priestley AT Michael-Titus 2007 A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury Brain 130 3004 3019 1:STN:280:DC%2BD2snjtFaktw%3D%3D 17901087
94. WL Huang KJ George V Ibba MC Liu S Averill M Quartu PJ Hamlyn JV Priestley 2007 The characteristics of neuronal injury in a static compression model of spinal cord injury in adult rats Eur J Neurosci 25 362 372 1:STN:280:DC%2BD2s%2Fos1yqsg%3D%3D 17284176
95. DC Henshall DP Bonislawski SL Skradski JQ Lan R Meller RP Simon 2001 Cleavage of bid may amplify caspase-8-induced neuronal death following focally evoked limbic seizures Neurobiol Dis 8 568 580 1:CAS:528:DC%2BD3MXlslGiurg%3D 11493022
96. DC Henshall T Araki CK Schindler JQ Lan KL Tiekoter W Taki RP Simon 2002 Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death J Neurosci 22 8458 8465 1:CAS:528:DC%2BD38Xns1Cju7s%3D 12351720
97. LL Dugan SL Sensi LM Canzoniero SD Handran SM Rothman TS Lin MP Goldberg DW Choi 1995 Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate J Neurosci 15 6377 6388 1:CAS:528:DyaK2MXovFWhtL0%3D 7472402
98. IJ Reynolds TG Hastings 1995 Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation J Neurosci 15 3318 3327 1:CAS:528:DyaK2MXls1ahtL8%3D 7751912
99. VP Bindokas J Jordan CC Lee RJ Miller 1996 Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine J Neurosci 16 1324 1336 1:CAS:528:DyaK28XhtVWmsb8%3D 8778284
100. M Patel BJ Day JD Crapo I Fridovich JO McNamara 1996 Requirement for superoxide in excitotoxic cell death Neuron 16 345 355 1:CAS:528: DyaK28XhtlGhsLc%3D 8789949
101. JW Olney RC Collins RS Sloviter 1986 Excitotoxic mechanisms of epileptic brain damage Adv Neurol 44 857 877 1:STN:280:DyaL283htFKhsA%3D%3D 3706027
102. DG MacGregor MJ Higgins PA Jones WL Maxwell MW Watson DI Graham TW Stone 1996 Ascorbate attenuates the systemic kainate-induced neurotoxicity in the rat hippocampus Brain Res 727 133 144 1:CAS:528:DyaK28Xkt12lu70%3D 8842391
103. DX Tan LC Manchester RJ Reiter W Qi SJ Kim GH El-Sokkary 1998 Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice J Neurosci Res 54 382 389 1:CAS:528:DyaK1cXntFOgsb0%3D 9819143
104. Y Rong SR Doctrow G Tocco M Baudry 1999 EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology Proc Natl Acad Sci USA 96 9897 9902 1:CAS:528:DyaK1MXlsVymtbY%3D 10449791
105. RC Gupta D Milatovic M Zivin WD Dettbarn 2000 Seizure-induced changes in energy metabolites and effects of N-tert-butyl-alpha-phenylnitrone (PNB) and vitamin E in rats Pflugers Arch 440 R160 R162 1:CAS:528:DC%2BD3cXnsVyhtL4%3D 11005654
106. AJ Bruce M Baudry 1995 Oxygen free radicals in rat limbic structures after kainate-induced seizures Free Radic Biol Med 18 993 1002 1:CAS:528:DyaK2MXltlOktbc%3D 7628735
107. J Lan DC Henshall RP Simon J Chen 2000 Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat J Neurochem 74 302 309 1:CAS:528: DC%2BD3cXltlSi 10617133
108. LJ Roberts JD Morrow 2000 Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo Free Radic Biol Med 28 505 513 1:CAS:528: DC%2BD3cXhslaksLY%3D 10719231
109. AJ Lusis 2000 Atherosclerosis Nature 407 233 241 1:CAS:528: DC%2BD3cXmvVSlsrk%3D 11001066
110. W Martinet MW Knaapen GR De Meyer AG Herman MM Kockx 2001 Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering Circ Res 88 733 739 1:CAS:528:DC%2BD3MXjtlWrsrc%3D 11304497
111. W Martinet MW Knaapen GR De Meyer AG Herman MM Kockx 2002 Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques Circulation 106 927 932 1:CAS:528:DC%2BD38XntlSqs74%3D 12186795
112. W Martinet GR de Meyer AG Herman MM Kockx 2004 Reactive oxygen species induce RNA damage in human atherosclerosis Eur J Clin Invest 34 323 327 1:CAS:528:DC%2BD2cXlsFCrs7c%3D 15147328
113. W Martinet GR De Meyer AG Herman MM Kockx 2005 Amino acid deprivation induces both apoptosis and autophagy in murine C2C12 muscle cells Biotechnol Lett 27 1157 1163 1:CAS:528:DC%2BD2MXpvFOkt7c%3D 16158257
114. RB Petersen SL Siedlak HG Lee YS Kim A Nunomura F Tagliavini B Ghetti P Cras PI Moreira RJ Castellani M Guentchev H Budka JW Ironside P Gambetti MA Smith G Perry 2005 Redox metals and oxidative abnormalities in human prion diseases Acta Neuropathol (Berl) 110 232 238 1:CAS:528:DC%2BD2MXhtVektrjP
115. K Broedbaek HE Poulsen A Weimann GD Kom E Schwedhelm P Nielsen RH Boger 2009 Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis Free Radic Biol Med 47 1230 1233 1:CAS:528: DC%2BD1MXhtFGqsbnK 19686840
116. T Hofer E Marzetti J Xu AY Seo S Gulec MD Knutson C Leeuwenburgh EE Dupont-Versteegden 2008 Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy Exp Gerontol 43 563 570 1:CAS:528:DC%2BD1cXmtlyitbo%3D 18395385
117. M Tateyama A Takeda Y Onodera M Matsuzaki T Hasegawa A Nunomura K Hirai G Perry MA Smith Y Itoyama 2003 Oxidative stress and predominant Abeta42(43) deposition in myopathies with rimmed vacuoles Acta Neuropathol 105 581 585 1:CAS:528:DC%2BD3sXjsVGrsro%3D 12734664
118. G Deslee JC Woods C Moore SH Conradi DS Gierada JJ Atkinson JT Battaile L Liu GA Patterson TL Adair-Kirk MJ Holtzman RA Pierce 2009 Oxidative damage to nucleic acids in severe emphysema Chest 135 4 965 974 1:CAS:528: DC%2BD1MXlsFOgt7o%3D 19118262