Roll of oxidative stress in the manganese and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced apoptosis in PC12 cells

Neurochemistry International

Volumn 31, Issue 2, 1997, Pages 169-176

  Desole, M S ^a   Sciola, L ^b   Delogu, M R ^a   Sircana, S ^a   Migheli, R ^a   Miele, E ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b Inst of Gen Physiol and Biochem   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACETYLCYSTEINE; ASCORBIC ACID; DEOXYURIDINE PHOSPHATE; DNA NUCLEOTIDYLEXOTRANSFERASE; MANGANESE; SELEGILINE; 1 METHYL 4 (2' ETHYLPHENYL) 1,2,3,6 TETRAHYDROPYRIDINE; 1-METHYL-4-(2'-ETHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE; ANTIOXIDANT; DRUG DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; CELL VIABILITY; ETIOLOGY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; CELL SURVIVAL; DRUG EFFECT; PHYSIOLOGY;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CELL SURVIVAL; MANGANESE; OXIDATIVE STRESS; PC12 CELLS; RATS;

EID: 0030610502     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(96)00146-5     Document Type: Article

References (37)

1. Adams, J. D. Jr and Odunze, I. N. (1991) Oxygen free radicals and Parkinson's disease. Free Rad. Biol. Med. 10, 161-169.
2. Albina, J. E., Cui, S., Mateo, B. B. and Reichner, S. (1993) Nitric-oxide mediated apoptosis in murine peritoneal macrophages. J. Immun. 150, 5080-5085.
3. Arends, M. J., Morris, R. G. and Willie, A. H. (1990) Apoptosis. The role of the endonuclease. Am. J. Path. 136, 593-608.
4. Basma, A. N., Heikkila, R. E., Nicklas, W. J., Giovanni, A. and Geller, M. H. (1990) 1-Methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine- and 1-methyl-4-(2′-ethyiphenyl)-1,2,3,6-tetra-hydropyridine-induced neurotoxicity in PC12 cells: role of monoamine oxidase A. J. Neurochem. 55, 870-877.
5. Bates, T. E., Heales, S. J. R., Davies, S. E. C., Boakye, P. and Clark, J. B. (1994) Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. J. Neurochem. 63, 640-648.
6. Becket, B. B. (1993) Towards the physiological function of uric acid. Free Rad. Biol. Med. 14, 615-631.
7. Buttke, T. M. and Sandstrom, P. A. (1994) Oxidative stress as a mediator of apoptosis. Immun. Today 15, 6-10.
8. Cleeter, M. W. J., Cooper, J. M. and Schapira, A. H. V. (1992) Irreversible inhibition of mitochondrial compex I by 1-methyl-4-phenyl-pyridinium: evidence for free radical involvement. J. Neurochem. 58, 786-789.
9. Cohen, J. J., (1993) Apoptosis Immun. Today 14, 126-130.
10. Cui, S., Reichner, J. S., Mateo, R. and Albina, J. (1994) Activated murine macrophages induce apoptosis in tumor cell through nitric oxide-dependent or independent mechanisms. Cancer Res. 54, 2462-2467.
11. de la Cruz, C. P., Revilla, E., Steffen, V., Rodriguea-Gomez, J. A., Cano, J. and Machado, A. (1996) Protection of aged substantia nigra of the rat against oxidative damage by (-)-deprenyl. Br. J. Pharmac. 117, 1756-1760.
12. Desole, M. S., Esposito, G., Migheli, R., Fresu, L., Sircana, S., Miele, M., De Natale, G. and Miele, E. (1995) Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat. Neurosci. Lett. 182, 73-76.
13. Desole, M. S., Miele, M., Esposito, G., Fresu, L., Migheli, R., Zangani, D., Sircana, S., Grella, G. and Miele, E. (1995) Neuronai anti-oxidant system and MPTP-induced oxidative stress in the striatum and in brainstem of the rat. Pharmac. Biochem. Behav. 51, 591-592.
14. Desole, M. S., Sciola, L., Delogu, M. R., Sircana, S. and Migheli, R. (1996) Manganese and 1-methyl-4-(2′-ethylphenyl)-1,2,3,6-tetrahydropyridine induce apoptosis in PC12 cells. Neurosci. Lett. 209, 193-196.
15. Dipasquale, B., Marini, M. and Youle, R. J. (1991) Apoptosis and DNA degradation by 1-methyl-4-phenylpyridinium in neurons. Biochem. biophys. Res. Commun. 181, 1442-1448.
16. Garcia, I., Martinou, I., Tsujimoto, Y. and Martinou, J.-C. (1992) Prevention of programmed cell death of sympathetic neurons by bcl-2 proto-oncogene. Science 258, 302-304.
17. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A. (1991) Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J. cell. Biol. 119, 493-501.
18. Graham, D. G. (1984) Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinsons's disease. Neurotoxicology 5, 113-118.
19. Hartley, A., Stone, J. M., Heron, C., Cooper, J. M. and Schapira, A. H. V. (1994) Complex I inhibitors induce dose-depenedent apoptosis in PC12 cells: relevance to Parkinson's disease. J. Neurochem. 63, 1987-1990.
20. Hockenbery, D. M., Oltvai, Z. N., Yin, X.-M., Milliman, C. L. and Korsemeyer, S. J. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241-251.
21. Mah, S. P., Zhong, L. T., Liu, Y., Roghani, A., Edwards, R. and Bredesen, D. E. (1993) The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J. Neurochem. 60, 1183-1186.
22. Mosman, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J. Immun. Meth. 65, 55-63.
23. +) in ventral mesencephalic-striatal co-culture in rat. Neurosci. Lett. 170, 191-194.
24. Oppenheim, R. W. (1991) Cell death during development of the nervous system. A. Rev. Neurosci. 14, 453-501.
25. Ratan, R. R., Murphy, T. H. and Baraban, J. M. (1994) Oxidative stress induces apoptosis in embryonic cortical neurons. J. Neurochem. 62, 376-379.
26. Ratan, R. R., Murphy, T. H. and Baraban, J. M. (1994) Macromolecular synthesis inhibitor prevents oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione. J. Neurosci. 14, 4385-4392.
27. 2+ their relationship to apoptosis and oncogenesis. FEBS 324, 104-107.
28. Roginsky, V. A., Barsukova, T. K., Bruchelt, G. and Stegmann, H. B. (1995) Interaction of catecholamines and 6-hydroxydopamine with ascorbate during autoxidation. Pharmac. Res. 31, 141.
29. Sandstrom, P. A., Manhie, M. D. and Buttke, T. H. (1994) Inhibition of activation-induced death in T cell hybridomas by thiol antioxidant: oxidative stress as a mediator of apoptosis. J. Leucocyte Biol. 55, 221-226.
30. Spina, M. B. and Cohen, G. (1989) Dopamine turnover and glutathione oxidation: implication for Parkinsons's disease. Proc. natn. Acad. Sci. U.S.A. 87, 1398-1400.
31. Sun, A. Y., Yang, W. L. and Kim, H. D. (1993) Free radical and lipid peroxidation in manganese-induced neuronal cell injury. Ann. N. Y. Acad. Sci. 679, 353-358.
32. Tatton, W. G. and Greenwood, C. E. (1991) Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism. J. Neurosci. Res. 30, 394-400.
33. Tatton, W. G., Ju, W., Holland, D. P., Tai, C. and Kwan, J. (1994) (-)-Deprenyl reduces PC12 cell apoptosis by inducing new proteins. J. Neurochem. 63, 1572-1575.
34. Vizuete, M. L., Steffen, V., Ayala, A., Cano, J. and Machado, A. (1993) Protective effect of deprenyl against 1-methyl-4-phenylpyri-dinium neurotoxicity in rat striatum. Neurosci. Lett. 152, 113-116.
35. Whittemore, E. R., Loo, D. T. and Cotman, C. W. (1994) Exposure to hydrogen peroxide induces cell death via apoptosis in coltures of rat cortical neurons. Neuroreport 5, 1485-1488.
36. Youdim, M. R. H., Heldman, E., Pollard, H. B., Fleming, P. and McHugh, E. (1986) Contrasting monoamine oxidase activity and tyramine induced catecholamine release in PC12 cells and chromaffin cells. Neuroscience 19, 1311-1318.
37. Ziv, I., Melamed, E., Nardi, N., Luria, D., Achiron, A., Offen, D. and Barzilai, A. (1994) Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons - a possible novel pathogenetic mechanism in Parkinson's disease. Neurosci. Lett. 170, 136-140.