Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease

Journal of Neuroscience Research

Volumn 70, Issue 3, 2002, Pages 447-450

  Abe, Takashi ^a   Tohgi, Hideo ^a   Isobe, Chiaki ^a   Murata, Takahiko ^a   Sato, Chigumi ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

8 hydroxyguanosine; Alzheimer's disease; Cerebrospinal fluid; Oxidative stress; RNA

Indexed keywords

8 HYDROXYGUANINE; 8 HYDROXYGUANOSINE; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DNA REPAIR; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL;

AGED; ALZHEIMER DISEASE; BRAIN; FEMALE; GUANOSINE; HUMANS; MALE; MIDDLE AGED; NEURONS; OXIDATIVE STRESS; RNA; UP-REGULATION;

EID: 0037010314     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10349     Document Type: Article

References (31)

1. Akama KT, Albanese C, Pestell RG, VanEldik J. 1998. Amyloid β-protid stimulates nitric oxide production in astrocytes through an NF κ B-dependent mechanism. Proc Natl Acad Sci USA 95:5795-5800.
2. American Psychiatric Association. 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th Edition. Washington, D.C.: APA. p 133-155.
3. Beal MF.1995. Aging, energy, and oxidative stress in neurodegenerative disease. Ann Neurol 38:357-366.
4. Behl C, Davis JB, Lesley R, Schubert D. 1994. Hydrogen peroxide mediates amyloid protein toxicity. Cell 77:817-827.
5. Benzing WC, Mufson EJ. 1995. Increased number of NADPH-d-positive neurons whthin the substantia innominata in Alzheimer's disease. Brain Res 30:351-355.
6. Christen Y. 2000. Oxidative stress and Alzheimer disease (1). Am J Clin Nutr 71:621S-629S.
7. Colton CA, Gilbert DL. 1987. Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett 223:284-288.
8. Dani SU. 1997. Molecular turnover and aging. In: Dani SU, Hori A, Walter GF, editors. Principles of Neural Aging. Amsterdam: Elsevier. p 83-101.
9. Fiala ES, Conaway CC, Mathis JE. 1989. Oxidative DNA and RNA damage in the livers of Sprague Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res 49:5518-5522.
10. Floyd RA. 1999. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 222:236-245.
11. Folstein MF, Folstein SE, McHug PR. 1975. "Mini-Mental State." A practical method of grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
12. Hachinski VC, Ilifj LD, Zilhka E, Du Boulay GH, McAllister VL, Marshall J, Russell RW, Symon L. 1975. Cerebral blood flow in dementia. Arch Neurol 32:632-637.
13. Harman D. 1956. Aging: A theory based on free radical and radiation chentistry. J Gerontol 11:298-300.
14. Lin C-LG, Bristol LA, Jin L, Dykes-Hoberg M, Crawford T, Clawson L, Rothstein JD. 1998. Aberrant RNA processing in a neurodegerative disease: The cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron 20:589-602.
15. Markesbery WP, Carney JM. 1999. Oxidative alterations in Alzheimer's disease. Brain Pathol 9:133-146.
16. Mckhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. 1984. Clinical diagnosis Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34:939-944.
17. Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. 1999a. RNA oxidations is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci 19:1959-1964.
18. Nunomura A, Perry G, Zhang J, Montine TJ, Takeda A, Chiba S, Smith MA. 1999b. RNA oxidation in Alzheimer and Parkinson diseases. J Anti-Aging Med 2:227-230.
19. Nunomura A, Perry G, Pappolla MA, Friedland RP, Hirai K, Chiba S, Smith MA. 2000. Neuronal oxidative stress precedes amyloid-β deposition in Down syndrome. J Neuropath Exp Neurol 59:1011-1017.
20. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. 2001. Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60:759-767.
21. Rhee Y, Valentine MR, Termini J. 1995. Oxidative base damage in RNA detected by reverse transcriptase. Nucleic Acids Res 23:3275-3282.
22. Sayre LM, Perry G, Smith MA. 1999. In situ methods for detection and localization of oxidative stress: Application in neurodegenerative disorders. Methods Enzymol 309:133-152.
23. Shigenaga MK, Gimeno CJ, Ames BN. 1989. Urinary 8-hydroxy-2′-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc Natl Acad Sci USA 86:9697-9701.
24. Smith MA, Harris RP, Sayre LM, Beckman JS, Perry G. 1997. Widespread peroxynitrite-midiated damage in Alzheimer's disease. J Neurosci 17:2653-2657.
25. Smith MA, Hirai K, Nunomura A, Perry G. 1999. Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease. Drug Dev Res 46:26-33.
26. Taddei F, Hayakawa H, Bouton MF, Cirinesi A, Matic I, Sekiguchi M, Radman M. 1997. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science 278:128-130.
27. Tohgi H, Abe T, Yamazaki K, Murata T, Ishizaki E, Isobe C. 1999. Alteration of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. Neurosci Lett 269:52-54.
28. van Leeuwen FW, de Kleijn DPV, van den Hurk HH, Neubauer A, Sonnemans MA, Slluijs JA, Koycu S, Ramdjielal RD, Salehi A, Martens GJ, Grosveld FG, Peter J, Burbach H, Hol EM. 1998. Franmeshift mutants of β amyloid precursor protein and ubiguitin-B in Alzheimer's and Down patients. Science 279:242-247.
29. Wamer WG, Wei RR. 1997. In vitro photooxidation of nucleic acids by ultraviolet A radiation. Photochem Photobiol 65:560-563.
30. Wamer WG, Yin JJ, Wei RR. 1997. Oxidative damage to nucleic acids photosensitized by titanium dioxide. Free Radic Biol Med 23:851-858.
31. Zhang J, Perry G, Smith MA, Robertson D, olson SJ, Graham DJ, Montine TJ. 1999. Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol 154:1423-1429.