Glutathione deficiency potentiates manganese toxicity in rat striatum and brainstem and in PC12 cells

Pharmacological Research

Volumn 36, Issue 4, 1997, Pages 285-292

  Desole, Maria S ^a   Esposito, Giovanni ^a   Migheli, Rossana ^a   Sircana, Sara ^a   Delogu, Maria R ^a   Fresu, Luigia ^a   Miele, Maddalena ^a   De Natale, Guglielmo ^a   Miele, Egidio ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

Brainstem; Glutathione synthesis inhibition; Manganese neurotoxicity; Oxidative stress; PC12 cells; Striatum

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; DEHYDROASCORBIC ACID; DIHYDROXYPHENYLACETIC ACID; DOPAMINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HOMOVANILLIC ACID; MANGANESE; MANGANESE CHLORIDE; NORADRENALIN; URIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CELL LOSS; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; LONG TERM EXPOSURE; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TISSUE LEVEL;

EID: 0031257743     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1997.0197     Document Type: Article

References (33)

1. 1. Donaldson J, Barbeau A. Manganese neurotoxicity: possible clue to the ethiology of human brain disorders. In: Gabay S. Harris H. Ho BT. eds. Metal Ions in Neurology and Psychiatry. New York: R Liss, 1985: 259-85.
2. 2. Seth PK, Chandra SV. Neurotransmitters and neurotransmitter receptors in developping and adult rats during manganese poisoning. Neurotoxicology 1984; 5: 67-76.
3. 3. Desole MS, Esposito G, Migheli R, Fresu L, Sircana S, Zangani D, Miele M, Miele E. Cellular defence mechanisms in the striatum and of young and aged rats subchronically exposed to manganese. Neuropharmacology 1995b; 34: 298-305.
4. 4. Archibald FS, Tyree C. Manganese poisoning and the attack of trivalent manganese upon catecholamines. Arch Biochem Biophys 1987; 256: 638-50.
5. 5. Graham DG. Oxidative pathways of catecholamine in the genesis of neuromelanine and cytotoxic quinones. Mol Pharmacol 1978; 14: 633-5.
6. 6. Graham DG. Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinsons's disease. Neurotoxicology 1984; 5: 113-18.
7. 7. Hastings TG, Lewis DA, Zigmond MJ. Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections. Proc Natl Acad Sci 1996; 93: 1956-61.
8. 8. Spina MB, Cohen G. Dopamine turnover and glutathione oxidation: implication for Parkinsons's disease. Proc Natl Acad Sci 1989; 87: 1398-400.
9. 9. Sun AY, Yang WL, Kim HD. Free radical and lipid peroxidation in manganese-induced neuronal cell injury. Ann NY Acad Sci 1993; 679: 358-63.
10. 10. Maker HS, Weiss C, Silides D, Cohen G. Coupling of dopamine oxidation (monoamine oxidase activity) to glutathione oxidation via the generation of hydrogen peroxide in rat brain homogenates. J Neurochem 1981; 36: 589-93.
11. 11. Martenson J, Meister A. Glutathione deficiency decrease tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects. Proc Natl Acad Sci 1991; 88: 4656-60.
12. 12. Donaldson J. The physiopathological significance of manganese in brain: Its relation to schizophrenia and neurodegenerative disorders. Neurotoxicology 1987; 8: 451-62.
13. 13. Liccione JJ, Maines MD. Selective vulnerability of glutathione metabolism and cellular defence mechanism in rat striatum to manganese. J Pharmacol Exp Ther 1988; 247: 156-61.
14. 14. Roginsky VA, Barsukova TK, Bruchelt G, Stegmann HB. Interaction of catecholamines and 6-hydroxy-dopamine with ascorbate during autoxidation. Pharmacol Res 1995; 31S: 141.
15. 15. Desole MS, Miele M, Esposito G, Migheli R, Fresu L, De Natale G, Miele E. Dopaminergic system activity and cellular defence mechanisms in the striatum and striatal synaptosomes of the rat subchronically exposed to manganese. Arch Toxicol 1994; 68: 566-70.
16. 16. Desole MS, Esposito G, Migheli R, Fresu L, Sircana S, Miele M, De Natale G, Miele, E. Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat. Neurosci Lett 1995; 192: 73-6.
17. 17. Jain A, Martenson J, Stole E, Auld PAM, Meister A. Glutathione deficiency leads to mitochondrial damage in Proc Natl Acad Sci 1991; 88: 1913-17.
18. 18. Anderson ME. Determination of glutathione and glutathione disulfide in biological samples. Meth Enzymol 1985; 113: 348-55.
19. 19. Hughes RE. The use of homocysteine in the estimation of dehydroascorbate. Biochem J 1956; 64: 203-8.
20. 20. Mosman T. Rapid colourimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Meth 1983; 65: 55-63.
21. 21. Becker BB. Towards the physiological function of uric acid. Free Rad Biol Med 1993; 14: 615-31.
22. 22. Sasame, HA, Boyd MR. Paradoxical effects of cobaltous chloride and salts of other divalent metals on tissue levels of reduced glutathione and microsomal mixed-function oxidase components. J Pharmacol Exp Ther 1978; 250: 718-24.
23. 23. Desole MS, Miele M, Esposito G, Migheli R, Fresu L, Zangani D, Sircana S, Grella G, Miele E. The response of neuronal antioxidant system to MPTP induced oxidative stress in the striatum and brainstem of the rat. Pharmacol Biochem Behav 1995; 51: 581-92.
24. 24. Niki E. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. Am J Clin Netr 1991; 54: 1119S-24S.
25. 25. Rice ME, Pérez-Pinzòn A, Lee EJK. Ascorbic acid, but not glutathione, is taken up by brain slices and preserves cell morphology. J Neurophysiol 1994; 71: 1591-6.
26. 26. Diliberto EJ, Allen PM. Mechanism of dopamine-á-hydroxylation. J Biol Chem 1981; 256: 3385-93.
27. 27. Olanow CW. A radical hypothes for neurodegeneration. Trends Neurosci 1993; 16: 439-44.
28. 28. Buttke T, Sandstrom PA. Oxidative stress as mediator of apoptosis. Immunol Today 1994; 15: 7-10.
29. 29. Sandstrom PA, Mannie MD, Buttke TM. Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J Leucocyte Biol 1994; 55: 221-6.
30. 30. Ziv I, Melamed E, Nardi N, Luria D, Achiron A, Offen D, Barzilai A. Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons-a possible novel pathogenetic mechanism in Parkinson's desease. Neurosci Lett 1994; 170: 136-40.
31. 31. Desole MS, Sciola L, Delogu MR, Sircana S, Migheli R. Manganese and l-methyl-4-(2′-ethylphenyl)-1,2,3,6-tetrahydropyridine induce apoptosis in PC12 cells. Neurosci Lett 1996; 209: 193-6.
32. 2+ sequestration by mitochondria and inhibition of oxidative phosphorylation. Toxicol Appl Pharmacol 1992; 115: 1-5.
33. 33. Bondy SC, LeBel CP. The relationship between excitoxicity and oxidative stress in the central nervous system. Free Rad Biol Med 1993; 14: 633-42.