Protein and DNA oxidation in spinal injury: Neurofilaments - An oxidation target

Free Radical Biology and Medicine

Volumn 30, Issue 6, 2001, Pages 613-624

  Leski, Michael L ^a   Bao, Feng ^a   Wu, Liqin ^a   Qian, Hao ^b   Sun, Dachuan ^a   Liu, Danxia ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

8 hydroxy 2 deoxyguanosine; DNA oxidation; Free radicals; HPLC analysis; Immunohistochemical staining; Mn (III) tetrakis (4 benzoic acid) porphyrin; Neurofilament; Nitro L arginine; Protein carbonyl content; Protein degradation; Protein oxidation; Spinal cord injury

Indexed keywords

2,4 DINITROPHENYLHYDRAZINE; 8 HYDROXY 2 DEOXYGUANOSINE; ARGININE; CARBONYL DERIVATIVE; DEOXYGUANOSINE DERIVATIVE; DNA; FREE RADICAL; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY NF68; NEUROFILAMENT PROTEIN; NEUROFILAMENT PROTEIN 68; NITRIC OXIDE SYNTHASE; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITE; DNA MODIFICATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE FIBER; NEUROFILAMENT; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PERIKARYON; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; RAT; SPINE INJURY; TISSUE LEVEL;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; DNA; FREE RADICAL SCAVENGERS; IMMUNOHISTOCHEMISTRY; MALE; METALLOPORPHYRINS; NEUROFIBRILS; NEUROFILAMENT PROTEINS; NEURONS; NITROARGININE; OXIDATION-REDUCTION; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL INJURIES;

EID: 0035868484     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00500-1     Document Type: Article

References (69)

1. Hypotheses in spinal cord trauma research
2. Session 2: Secondary CNS injury
3. Oxidants and human disease: Some new concepts
4. Oxidants and the central nervous system: Some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke?
5. Superoxide production in experimental brain injury
6. Oxygen-free radicals in traumatic brain edema
7. Oxygen free radical involvement in ischemia and reperfusion injury to brain
8. Hydroxyl radical production and lipid peroxidation parallels selective post-ischemic vulnerability in gerbil brain
9. Roles of nitric oxide in compression injury of rat spinal cord
10. ω-nitro-L-arginine-methylester treatment of mice with traumatic brain injury
11. Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthase in spinal cord injury
12. Superoxide anion may trigger DNA strand breaks in human granulocytes by acting at a membrane target
13. Iron ion-dependent modification of bases in DNA by the superoxide radical-generating system hypoxanthine/xanthine oxidase
14. Hydroxyl free radical mediated formation of 8-hydroxyguanine in isolated DNA
15. DNA damage and oxygen radical toxicity
16. Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivates by metal-catalyzed oxidation reactions
17. Oxidative damage to human plasma proteins by ozone
18. Oxidative stress in neurodegenerative diseases
19. Oxygen free radicals and brain dysfunction
20. Metal-catalyzed oxidatives of proteins
21. Peroxynitrite-mediated oxidation of albumin to the protein-thiyl free radical
22. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
23. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
24. Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite: Evidence for hydroxyl radical production from peroxynitrite
25. The free radical pathology and the microcirculation in the major central nervous system disorders
26. Lipid hydrolysis and peroxidation in injured spinal cord: Partial protection with methylprednisolone or vitamin E and selenium
27. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain
28. Superoxide and nitric oxide cooperation in hypoxia/reoxygenation-induced neuron injury
29. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
30. Traumatically induced reactive change as visualised through the use of monoclonal antibodies targeted to neurofilament subunits
31. Cytoskeletal derangements of cortical neuronal processes three hours after traumatic brain injury in Rats: An immunofluorescence study
32. Increased calpain content and progressive degradation of neurofilament protein in spinal cord injury
33. Cytoskeletal disruption following contusion injury to the rat spinal cord
34. Morphological characterization of the evolving rat spinal cord injury after photochemically induced ischemia
35. Increased calpain I-mediated proteolysis, and preferential loss of dephosphorylated NF200, following traumatic spinal cord injury
36. A calpain inhibitor attentuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat
37. Pretreatment with NMDA receptor antagonist MK801 improves neurophysiological outcome after an acute spinal cord injury
38. Superoxide production after spinal injury detected by microperfusion of cytochrome c
39. Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction
40. The role of reactive nitrogen species in secondary spinal cord injury: Formation of nitric oxide, peroxynitrite, and nitrated protein
41. Generation and detection of hydroxyl radical in vivo in rat spinal cord by microdialysis administration of Fenton's reagents and microdialysis sampling
42. Hydroxyl radicals generated in vivo kill neurons in spinal cord: Electrophysiological, histological, and neurochemical results
43. 2α rises in extracellular fluid in response to hydroxyl radical generated in vivo in rat spinal cord
44. Paraquat - A superoxide generator - Kills neurons in the rat spinal cord
45. The time course of malondialdehyde production following impact injury to rat spinal cord as measured by microdialysis and high pressure liquid chromatography
46. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
47. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock
48. Cell-permeable superoxide dismutase and glutathione peroxidase mimetics afford superior protection against doxorubicin-induced cardiotoxicity: The role of reactive oxygen and nitrogen intermediates
49. Surgery of experimental spinal cord injury equivalent to crush injury of fracture dislocation of spinal column
50. Excitatory amino acids rise to toxic levels upon impact injury to rat spinal cord
51. Methylprednisolone reduces excitatory amino acid release following experimental spinal cord injury
52. N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: Behavioral, anatomic, and neurochemical studies
53. Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography
54. Determination of carbonyl content in oxidatively modified proteins
55. Cleavage of structural proteins during the assembly of the head bacteriophage T4
56. S-100 beta has a neuronal localisation in the rat hindbrain revealed by an antigen retrieval method
57. Conditions influencing yield and analysis of 8-hydroxy-2′-deoxyguanosine in oxidatively damaged DNA
58. In vivo oxidative DNA damage: Measurement of 8-hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection
59. Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo
60. Protein oxidation and aging. I. Difficulties in measuring reactive protein carbonyls in tissues using 2,4-dinitrophenylhydrazine
61. Turnover of bacterial glutamine synthetase: Oxidative inactivation precedes proteolysis
62. Degradation of oxidized proteins in mammalian cells
63. Neurofilament 68 and Neurofilament 200 protein levels decrease after traumatic brain injury
64. Beneficial effect of Mn (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in carrageenan-induced pleurisy
65. Beneficial effect of Mn (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan-induced shock
66. The neuronal cytoskeleton in acute brain injury
67. The protein oxidation product 3,4-dihydroxyphenylalanine (DOPA) mediates oxidative DNA damage
68. Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes
69. Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress