Post-injury treatment with a new antioxidant compound H-290/51 attenuates spinal cord trauma-induced c-fos expression, motor dysfunction, edema formation, and cell injury in the rat

Acta Neurochirurgica, Supplementum

Volumn , Issue 96, 2006, Pages 322-328

  Sharma, H S ^a   Sjoquist P O ^b   Mohanty, S ^c   Wiklund, L ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c BANARAS HINDU UNIVERSITY   (India)

Author keywords

antioxidants; blood spinal cord barrier; c fos; edema; gene expression; H 290 51; oxidative stress; Spinal cord injury

Indexed keywords

ANTIOXIDANT; H290 51; H290-51; INDOLE DERIVATIVE; NEUROPROTECTIVE AGENT; PROTEIN C FOS;

ANIMAL; APOPTOSIS; ARTICLE; DRUG EFFECT; EDEMA; MALE; METABOLISM; PARAPLEGIA; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; RAT; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT; TREATMENT OUTCOME;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; EDEMA; INDOLES; MALE; NEUROPROTECTIVE AGENTS; PARAPLEGIA; PERMEABILITY; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TREATMENT OUTCOME;

EID: 85052608674     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/3-211-30714-1_68     Document Type: Article

References (36)

1. Alm P, Sharma HS, Hedlund S, Sjoquist PO, Westman J (1998) Nitric oxide in the pathophysiology of hyperthermic brain injury. Influence of a new anti-oxidant compound H-290/51. A pharmacological study using immunohistochemistry in the rat. Amino Acids 14:95-103
2. Alm P, Sharma HS, Sjoquist PO, Westman J (2000) A new antioxidant compound H-290/51 attenuates nitric oxide synthase and heme oxygenase expression following hyperthermic brain injury. An experimental study using immunohistochemistry in the rat. Amino Acids 19:383-394
3. Bazan NG (2005) Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol 32:89-104
4. Calabrese V, Scapagnini G, Colombrita C, Ravagna A, Pennisi G, Giuffrida Stella AM, Galli F, Butterfield DA (2003) Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: a nutritional approach. Amino Acids 25:437-444
5. Caldwell RB, Bartoli M, Behzadian MA, El-Remessy AE, Al-Shabrawey M, Platt DH, Liou GI, Caldwell RW (2005) Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress. Curr Drug Targets 6:511-524
6. Chan PH (2005) Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke. Ann N Y Acad Sci 1042:203-209
7. Chong ZZ, Li F, Maiese K (2005) Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol 75:207-246
8. Chong ZZ, Li F, Maiese K (2005) Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease. Brain Res Brain Res Rev 49:1-21
9. Kirby J, Halligan E, Baptista MJ, Allen S, Heath PR, Holden H, Barber SC, Loynes CA, Wood-Allum CA, Lunec J, Shaw PJ (2005) Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS. Brain 128:1686-1706
10. Kowaltowski AJ, Fiskum G (2005) Redox mechanisms of cytoprotection by Bcl-2. Antioxid Redox Signal 7:508-514
11. Laplace C, Huet O, Vicaut E, Ract C, Martin L, Benhamou D, Duranteau J (2005) Endothelial oxidative stress induced by serum from patients with severe trauma hemorrhage. Intensive Care Med [Epub ahead of print]
12. Mustafa A, Sharma HS, Olsson Y, Gordh T, Thoren P, Sjoquist PO, Roos P, Adem A, Nyberg F (1995) Vascular permeability to growth hormone in the rat central nervous system after focal spinal cord injury. Influence of a new anti-oxidant H 290/51 and age. Neurosci Res 23:185-194
13. Poulet R, Gentile MT, Vecchione C, Distaso M, Aretini A, Fratta L, Russo G, Echart C, Maffei A, De Simoni MG, Lembo G (2005) Acute hypertension induces oxidative stress in brain tissues. J Cereb Blood Flow Metab [Epub ahead of print]
14. Rodriguez JA, Nespereira B, Perez-Ilzarbe M, Eguinoa E, Paramo JA (2005) Vitamins C and E prevent endothelial VEGF and VEGFR-2 overexpression induced by porcine hypercholesterolemic LDL. Cardiovasc Res 65:665-673
15. Rogerio F, Teixeira SA, de Rezende AC, de Sa RC, de Souza Queiroz L, De Nucci G, Muscara MN, Langone F (2005) Superoxide dismutase isoforms 1 and 2 in lumbar spinal cord of neonatal rats after sciatic nerve transection and melatonin treatment. Brain Res Dev Brain Res 154:217-225
16. Sharma HS (2004) Pathophysiology of the blood-spinal cord barrier in traumatic injury. In: Sharma HS, Westman J (eds) Blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 437-518
17. Sharma HS (2005) Post-traumatic application of brain derived neurotrophic factor and glia derived neurotrophic factor in combination over the traumatized rat spinal cord enhances neuroprotection and improves motor functions. Acta Neurochir [Suppl] 96:359-364
18. Sharma HS (2005) Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr Pharm Des 11:1353-1389
19. Sharma HS (2005) Neuroprotective effects of neurotrophins and melanocortins in spinal cord injury. An experimental study in the rat using pharmacological and morphological approaches. Ann NY Acad Sci 1053:407-421
20. Sharma HS, Sjöquist PO (2002) A new antioxidant compound H-290/51 modulates glutamate and GABA immunoreactivity in the rat spinal cord following trauma. Amino Acids 23:261-272
21. Sharma HS, Winkler T (2002) Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat. Muscle Nerve [Suppl] 11: S83-S91
22. Sharma HS, Westman J, Alm P, Sjoquist PO, Cervos-Navarro J, Nyberg F (1997) Involvement of nitric oxide in the pathophysiology of acute heat stress in the rat. Influence of a new antioxidant compound H-290/51. Ann N Y Acad Sci 813:581-590
23. Sharma HS, Alm P, Sjoquist PO, Westman J (2000) A new antioxidant compound H-290/51 attenuates upregulation of constitutive isoform of heme oxygenase (HO-2) following trauma to the rat spinal cord. Acta Neurochir [Suppl] 76:153-157
24. Sharma HS, Sjöquist PO, Westman J (2001) Pathophysiology of the blood-spinal cord barrier in spinal cord injury. Influence of a new antioxidant compound H-290/51. In: Kobiler D, Lustig S, Shapira S (eds) Blood-brain barrier: drug delivery and brain pathology. Kluwer Academic/Plenum Publishers, New York, pp 401-416
25. Sharma HS, Sjoquist PO, Alm P (2003) A new antioxidant compound H-290/51 attenuates spinal cord injury induced expression of constitutive and inducible isoforms of nitric oxide synthase and edema formation in the rat. Acta Neurochir [Suppl] 86:415-420
26. Sharma HS, Gordh T, Wiklund L, Mohanty S, Sjoquist PO (2005) Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51. An experimental study using light and electron microscopy in the rat. J Neural Transm [in press]
27. Strosznajder RP, Jesko H, Zambrzycka A (2005) Poly (ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury. Mol Neurobiol 31:149-167
28. Svensson L, Borjesson I, Kull B, Sjoquist PO (1993) Automated procedure for measuring TBARS for in vitro comparison of the effect of antioxidants on tissues. Scand J Clin Lab Invest 53:83-85
29. Tariq M, Morais C, Kishore PN, Biary N, Al Deeb S, Al Moutaery K (1998) Neurological recovery in diabetic rats following spinal cord injury. J Neurotrauma 15:239-251
30. Thornwall M, Sharma HS, Gordh T, Sjoquist PO, Nyberg F (1997) Substance P endopeptidase activity in the rat spinal cord following injury: influence of the new anti-oxidant compound H 290/51. Acta Neurochir [Suppl] 70:212-215
31. Tormos C, Javier Chaves F, Garcia MJ, Garrido F, Jover R, O'Connor JE, Iradi A, Oltra A, Oliva MR, Saez GT (2004) Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells. Cancer Lett 208:103-113
32. Valable S, Montaner J, Bellail A, Berezowski V, Brillault J, Cecchelli R, Divoux D, Mackenzie ET, Bernaudin M, Roussel S, Petit E (2005) VEGF-induced BBB permeability is associated with an MMP-9 activity increase in cerebral ischemia: both effects decreased by Ang-1. J Cereb Blood Flow Metab [Epub ahead of print]
33. Westerlund C, Ostlund-Lindqvist AM, Sainsbury M, Shertzer HG, Sjoquist PO (1996) Characterization of novel indenoindoles. Part I. Structure-activity relationships in different model systems of lipid peroxidation. Biochem Pharmacol 51:1397-1402
34. Xu W, Chi L, Xu R, Ke Y, Luo C, Cai J, Qiu M, Gozal D, Liu R (2005) Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury. Spinal Cord 43:204-213
35. Yokoi M, Yamagishi SI, Takeuchi M, Ohgami K, Okamoto T, Saito W, Muramatsu M, Imaizumi T, Ohno S (2005) Elevations of AGE and vascular endothelial growth factor with decreased total antioxidant status in the vitreous fluid of diabetic patients with retinopathy. Br J Ophthalmol 89:673-675
36. Yu F, Sugawara T, Maier CM, Hsieh LB, Chan PH (2005) Akt/Bad signaling and motor neuron survival after spinal cord injury. Neurobiol Dis (Epub ahead of print)