Magnetic relaxation switches capable of sensing molecular interactions

Nature Biotechnology

Volumn 20, Issue 8, 2002, Pages 816-820

  Perez, J Manuel ^a   Josephson, Lee ^a   O'Loughlin, Terrence ^a   Högemann, Dagmar ^a   Weissleder, Ralph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSENSORS; DATA ACQUISITION; DNA; MAGNETIC RESONANCE IMAGING; PROTEINS;

MAGNETIC RELAXATION SWITCHES (MRS);

BIOTECHNOLOGY;

ARTICLE; BINDING AFFINITY; BIOSENSOR; CELL LYSATE; ENZYME MECHANISM; IMAGE ANALYSIS; MAGNETISM; MEASUREMENT; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SENSITIVITY AND SPECIFICITY; ATOMIC FORCE MICROSCOPY; CELL CULTURE; GENETIC PROCEDURES; HUMAN; INSTRUMENTATION; METABOLISM; METHODOLOGY; NANOTECHNOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEOTIDE SEQUENCE; PROTEIN BINDING;

BASE SEQUENCE; BIOSENSING TECHNIQUES; CASPASES; DNA; HUMAN; LIGANDS; LUMINESCENT PROTEINS; MAGNETIC RESONANCE IMAGING; MAGNETICS; MICROSCOPY, ATOMIC FORCE; NANOTECHNOLOGY; NUCLEIC ACIDS; PROTEIN BINDING; PROTEINS; PROTONS; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; CASPASE 3; GREEN FLUORESCENT PROTEINS; HUMANS;

CASP3 PROTEIN, HUMAN; CASPASE; CASPASE 3; DNA; GREEN FLUORESCENT PROTEIN; LIGAND; MESSENGER RNA; NUCLEIC ACID; PHOTOPROTEIN; PROTEIN; PROTON;

EID: 0036022520     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt720     Document Type: Article

References (31)

1. Semiconductor clusters, nanocrystals and quantum dots
2. A DNA-based method for rationally assembling nanoparticles into macroscopic materials
3. Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles
4. One-pot colorimetric differentiation of polynucleotides with single base imperfections using gold nanoparticles
5. Organization of 'nanocrystal molecules' using DNA
6. Semiconductor nanocrystals as fluorescent biological labels
7. Quantum dot bioconjugates for ultrasensitive nonisotopic detection
8. A biosensor based on magnetoresistance technology
9. Advancements toward magneto immunoassays
10. The BARC biosensor applied to the detection of biological warfare agents
11. Scanometric DNA array detection with nanoparticle probes
12. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules
13. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
14. In vivo magnetic resonance imaging of transgene expression
15. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates
16. Magnetic nanosensors for the detection of oligonucleotide sequences
17. An invasive cleavage assay for direct quantitation of specific RNAs
18. Expression profiling using cDNA microarrays
19. NMR tools for biotechnology
20. Direct-injection NMR (DI-NMR): A flow NMR technique for the analysis of combinatorial chemistry libraries
21. Application of Chemical Shift Imaging for Simultaneous and Fast Acquisition of NMR Spectra on Multiple Samples
22. Analysis of multiple samples using multiplex sample NMR: Selective excitation and chemical shift imaging approaches
23. Magnetic anisotropy of a single cobalt nanocluster
24. Ultrasensitive magnetic biosensor for homogeneous immunoassay
25. Magnetite defines a vertebrate magnetoreceptor
26. Long-circulation iron oxides for MR imaging
27. In vivo molecular target assessment of matrix metalloproteinase inhibition
28. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
29. Tat Peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles
30. High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes
31. Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV- 1 DNA in a bacterial artificial chromosome