Strength of conjugate binding to plasmid DNA affects degradation rate and expression level in vivo

Biochimica et Biophysica Acta - General Subjects

Volumn 1523, Issue 1, 2000, Pages 103-110

  Mullen, Patricia M ^a   Lollo, Charles P ^a   Phan, Quynh Chi ^a   Amini, Arjang ^a   Banaszczyk, Mariusz G ^a   Fabrycki, Joanne M ^a   Wu, Dongpei ^a   Carlo, Alison T ^a   Pezzoli, Patrick ^a   Coffin, Christopher C ^a   Carlo, Dennis J ^a  

^a Orchestra Therapeutics Inc   (United States)

Author keywords

Degradation; DNA; Expression; In vivo; Polyplex

Indexed keywords

MACROGOL; PLASMID DNA; POLYLYSINE;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; DNA DEGRADATION; DNA DETERMINATION; GENE EXPRESSION; HYDROPHOBICITY; PRIORITY JOURNAL;

ANIMAL; DEOXYRIBONUCLEASES; DNA; ELECTROPHORESIS, AGAR GEL; KINETICS; LUCIFERASE; MICE; MICE, INBRED BALB C; PHOSPHORUS RADIOISOTOPES; PLASMIDS; POLYETHYLENE GLYCOLS; POLYLYSINE;

EID: 0034283349     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(00)00104-5     Document Type: Article

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