Thermosensitive polymers as carriers for DNA delivery

Journal of Controlled Release

Volumn 60, Issue 2-3, 1999, Pages 249-259

  Hinrichs, W L J ^a   Schuurmans Nieuwenbroek, N M E ^a   Van De Wetering, P ^a   Hennink, W E ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Cationic polymers; DNA; Thermosensitive polymers; Transfection

Indexed keywords

COPOLYMER; POLYMER; POLYMETHACRYLIC ACID DERIVATIVE;

ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DNA TRANSFECTION; DRUG DEGRADATION; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR WEIGHT; PARTICLE SIZE; PLASMID; PRIORITY JOURNAL; TEMPERATURE; ZETA POTENTIAL;

ACRYLAMIDES; DNA ADDUCTS; DRUG CARRIERS; DRUG STABILITY; HEAT; HUMANS; METHACRYLATES; PARTICLE SIZE; PLASMIDS; POLYMERS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032769434     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00075-9     Document Type: Article

References (30)

1. Middaugh C.R., Evans R.K., Montgomery D.L., Casimiro D.R. Analysis of plasmid DNA from a pharmaceutical perspective. J. Pharm. Sci. 87:1998;130-145.
2. Ledley F.D. Pharmaceutical approach to somatic gene therapy. Pharm. Res. 13:1996;1595-1614.
3. Lehn P., Fabrega S., Oudrhiri N., Navarro J. Gene delivery systems: bridging the gap between recombinant viruses and artificial vectors. Adv. Drug. Delivery Rev. 30:1998;5-11.
4. Lasic D.D., Templeton N.S. Liposomes in gene therapy. Adv. Drug Delivery Rev. 20:1996;221-266.
5. Smith J., Zhang Y., Niven R. Towards development of a non-viral gene therapeutic. Adv. Drug Delivery Rev. 26:1997;135-150.
6. Zauner W., Ogris M., Wagner E. Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv. Drug Delivery Rev. 30:1998;97-113.
7. Hashida M., Takemura S., Nishikawa M., Takakura Y. Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine). J. Control. Release. 53:1998;301-310.
8. Erbacher P., Roche A.C., Monsigny M., Midoux P. The reduction of positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes. Biochim. Biophys. Acta. 1324:1997;27-36.
9. Remy J.-S., Abdallah B., Zanta M.A., Boussif O., Behr J.-P., Demenaix B. Gene transfer with lipospermines and polyethylenimines. Adv. Drug Delivery Rev. 30:1998;85-95.
10. Toncheva V., Wolfert M., Dash P.R., Oupicky D., Ulbrich K., Seymour L.W., Schacht E.H. Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers. Biochim. Biophys. Acta. 1380:1998;354-368.
11. Boussif O., Lezoualch F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., Behr J.-P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo. Proc. Natl. Acad. Sci. USA. 92:1995;7297-7301.
12. Cherng J.-Y., Wetering P.V.d., Talsma H., Crommelin D.J.A., Hennink W.E. Effect of size and serum protein on transfection efficiency of poly ((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharm. Res. 13:1996;1038-1042.
13. P. Van de Wetering, E.E. Moret, N.M. E. Nieuwenbroek, M.J. van Steenbergen, W.E. Hennink, Structure-activity relationship of water-soluble cationic methacrylate/methacrylamide polymers as non-viral gene delivery agents, Gene Ther. (submitted).
14. P. Van de Wetering, N.M. E. Nieuwenbroek, M.J. van Steenbergen, W.E. Hennink, Copolymers of 2-dimethylamino)ethyl methacrylate with ethoxytriethylene glycol methacrylate or N-vinyl-pyrrolidone as gene transfer agents, J. Control. Release (submitted).
15. Van de Wetering P., Cherng J.-Y., Talsma H., Hennink W.E. Relation between transfection efficiency and cytotoxicity of poly(2-(dimethylamino)ethyl methacrylate)/plasmid complexes. J. Control. Release. 49:1997;59-69.
16. Van de Wetering P., Cherng J.-Y., Talsma H., Hennink W.E. 2-(Dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents. J. Control. Release. 53:1998;145-153.
17. Priest J.H., Murray S.L., Nelson R.J., Hoffman A.S. Lower critical solution temperatures of aqueous copolymers of N-isopropylacrylamide and other N-substituted acrylamides. Russo P.S. Reversible Polymeric Gels and Related Systems. 1987;254-264 Am. Chem. Soc, Washington, DC.
18. H. Feil, Thermosensitive polymers and hydrogels based on N-isopropylacrylamide, Ph.D. thesis, University of Twente, The Netherlands (1994).
19. Bae Y.H., Okano T., Hsu R., Kim S.W. Thermo-sensitive polymers as on-off switches for drug release. Makromol. Chem. Rapid Comm. 8:1987;481-485.
20. Takei Y.G., Aoki T., Sanui K., Ogata N., Okano T., Sakurai Y. Temperature-responsive bioconjugates 2. Molecular design for temperature-modulated bioseparations. Bioconj. Chem. 4:1993;341-346.
21. Vakkalanka S.K., Peppas N. Swelling behavior of temperature- and pH-sensitive block terpolymers for drug delivery. Polym. Bull. 36:1996;221-225.
22. Chen G., Hoffman A.S. Graft polymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature. 373:1995;49-52.
23. Bout A., Valerio D., Scholte B.J. In vivo transfer and expression of the LacZ gene in the mouse lung. Exp. Lung Res. 19:1993;193-202.
24. Cole C.-A., S.M.Schreiner J., Priest H., Monji N., Hoffman A.S. N-Isopropylacrylamide and N-acryloxysuccinimide copolymer. Russo P.S. Reversible Polymeric Gels and Related Systems. 1987;245-254 Am. Chem. Soc, Washington, DC.
25. P. Van de Wetering, N.J. Zuidam, M.J. van Steenbergen, O.A. G.J. van de Houwen, W.J.M. Underberg, W.E. Hennink, A mechanistic study of the hydrolytic stability of poly(2-(dimethylamino)ethyl methacrylate), Macromolecules (submitted).
26. Wen S., Stevenson W.T.K. Synthetic sensitive polyampholyte hydrogels: a preliminary study. Colloid Polym. Sci. 271:1993;38-49.
27. Yuk S.H., Cho S.H., Lee S.H. pH/temperature-responsive polymer composed of poly((N,N-dimethylamino)ethyl methacrylate-co-ethylacrylamide). Macromolecules. 30:1997;6856-6859.
28. Cho S.H., Jhon M.S., Yuk S.H., Lee H.B. Temperature-induced phase transition of poly(N,N-dimethylaminoethyl methacrylate-co-acrylamide). J. Polym. Sci. Part B. 35:1997;595-598.
29. Choksakulnimitr S., Masuda S., Tokuda H., Takakura Y., Hashida M. In vitro cytotoxicity of macromolecules in different cell culture systems. J. Control. Release. 34:1995;233-241.
30. Morgan D.M.L., Clover J., Pearsson J.D. Effects of polycations on leucine incorporation, lactate dehydrogenase release, and morphology of human umbilical vein endothelial cells. J. Cell Sci. 91:1988;231-238.