PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice

Bioconjugate Chemistry

Volumn 16, Issue 4, 2005, Pages 785-792

  Merdan, Thomas ^a   Kunath, Klaus ^a   Petersen, Holger ^a   Bakowsky, Udo ^a   Voigt, Karl Heinz ^a   Kopecek, Jindrich ^b   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMIC FORCE MICROSCOPY; BIOMOLECULES; BLOOD; DNA; ETHYLENE; GENE EXPRESSION; MAMMALS; PARTICLE SIZE; PHARMACOKINETICS; RADIOACTIVITY; TOXICITY; ZETA POTENTIAL;

BLOOD LEVELS; CONDITION; IN-VIVO; LOW DOSE; PEGYLATION; PLASMID DNA; POLY(ETHYLENEIMINE); POLYPLEX STABILITY; POLYPLEXES; VIVO TOXICITY;

LIGHT SCATTERING;

IODINE 125; LUCIFERASE; MACROGOL; PHOSPHORUS 32; PLASMID DNA; POLYETHYLENEIMINE;

ANIMAL EXPERIMENT; ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG LIVER LEVEL; DRUG STABILITY; DRUG TISSUE LEVEL; DRUG URINE LEVEL; GENE EXPRESSION; LIGHT SCATTERING; LUNG; MALE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; RADIOACTIVITY; REPORTER GENE; SPLEEN; ZETA POTENTIAL;

EID: 22644444670     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc049743q     Document Type: Article

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