-
1
-
-
4344572092
-
Microtubule structure and its stabilisation
-
Amos, L. A. Microtubule structure and its stabilisation. Org. Biomol. Chem., 2004, 2, 2153-2160
-
(2004)
Org. Biomol. Chem.
, vol.2
, pp. 2153-2160
-
-
Amos, L.A.1
-
2
-
-
20044379059
-
Review: Tubulin function, action of antitubulin drugs, and new drug development
-
Pellegrini, F.; Budman, D. R. Review: tubulin function, action of antitubulin drugs, and new drug development. Cancer Invest., 2005, 23, 264-273
-
(2005)
Cancer Invest.
, vol.23
, pp. 264-273
-
-
Pellegrini, F.1
Budman, D.R.2
-
3
-
-
0842311621
-
Vascular Targeting Agents As Cancer Therapeutics
-
DOI 10.1158/1078-0432.CCR-0642-03
-
Thorpe, P. E. Vascular targeting agents as cancer therapeutics. Clin. Cancer Res., 2004, 10, 415-427 (Pubitemid 38173977)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.2
, pp. 415-427
-
-
Thorpe, P.E.1
-
4
-
-
0020081554
-
Endothelial cell proliferation as a novel approach to targeting tumor therapy
-
Denekamp, J. Endothelial cell proliferation as a novel approach to targeting tumour therapy. Br. J. Cancer, 1982, 45, 136-139 (Pubitemid 12207761)
-
(1982)
British Journal of Cancer
, vol.45
, Issue.1
, pp. 136-139
-
-
Denekamp, J.1
-
5
-
-
0025093973
-
Vascular attack as a therapeutic strategy for cancer
-
Denekamp, J. Vascular attack as a therapeutic strategy for cancer. Cancer Metastasis Rev., 1990, 9, 267-282 (Pubitemid 20380383)
-
(1990)
Cancer and Metastasis Reviews
, vol.9
, Issue.3
, pp. 267-282
-
-
Denekamp, J.1
-
6
-
-
0020449692
-
Endothelial-cell proliferation in experimental tumours
-
Denekamp, J.; Hobson, B. Endothelial-cell proliferation in experimental tumours. Br. J. Cancer, 1982, 46, 711-720
-
(1982)
Br. J. Cancer
, vol.46
, pp. 711-720
-
-
Denekamp, J.1
Hobson, B.2
-
7
-
-
0032758736
-
In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
-
Grosios, K.; Holwell, S. E.; McGown, A. T.; Pettit, G. R.; Bibby, M. C. In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug. Br. J. Cancer, 1999, 81, 1318-1327
-
(1999)
Br. J. Cancer
, vol.81
, pp. 1318-1327
-
-
Grosios, K.1
Holwell, S.E.2
McGown, A.T.3
Pettit, G.R.4
Bibby, M.C.5
-
8
-
-
0035064594
-
Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo
-
Galbraith, S. M.; Chaplin, D. J.; Lee, F.; Stratford, M. R.; Locke, R. J.; Vojnovic, B.; Tozer, G. M. Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo. Anticancer Res., 2001, 21, 93-102.
-
(2001)
Anticancer Res.
, vol.21
, pp. 93-102
-
-
Galbraith, S.M.1
Chaplin, D.J.2
Lee, F.3
Stratford, M.R.4
Locke, R.J.5
Vojnovic, B.6
Tozer, G.M.7
-
9
-
-
0037085753
-
The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
-
Kanthou, C.; Tozer, G. M. The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells. Blood, 2002, 99, 2060-2069
-
(2002)
Blood
, vol.99
, pp. 2060-2069
-
-
Kanthou, C.1
Tozer, G.M.2
-
10
-
-
0034518173
-
Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics
-
Downing, K. H. Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Annu. Rev. Cell. Dev. Biol., 2000, 16, 89-111.
-
(2000)
Annu. Rev. Cell. Dev. Biol.
, vol.16
, pp. 89-111
-
-
Downing, K.H.1
-
11
-
-
0022453641
-
Identification of a distinct class of vinblastine binding sites on microtubules
-
Jordan, M. A.; Margolis, R. L.; Himes, R. H.; Wilson, L. Identification of a distinct class of vinblastine binding sites on microtubules. J. Mol. Biol., 1986, 187, 61-73. (Pubitemid 16065316)
-
(1986)
Journal of Molecular Biology
, vol.187
, Issue.1
, pp. 61-73
-
-
Jordan, M.A.1
Margolis, R.L.2
Himes, R.H.3
Wilson, L.4
-
12
-
-
17544366715
-
Localization of the vinblastine-binding site on beta-tubulin
-
Rai, S. S.; Wolff, J. Localization of the vinblastine-binding site on beta-tubulin. J. Biol. Chem., 1996, 271, 14707-14711
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 14707-14711
-
-
Rai, S.S.1
Wolff, J.2
-
13
-
-
19544393159
-
Structural basis for the regulation of tubulin by vinblastine
-
DOI 10.1038/nature03566
-
Gigant, B.; Wang, C.; Ravelli, R.; Roussi, F.; Steinmetz, M.; Curmi, P.; Sobel, A.; Knossow, M. Structural basis for the regulation of tubulin by vinblastine. Nature, 2005, 435, 519-522. (Pubitemid 40734250)
-
(2005)
Nature
, vol.435
, Issue.7041
, pp. 519-522
-
-
Gigant, B.1
Wang, C.2
Ravelli, R.B.G.3
Roussi, F.4
Steinmetz, M.O.5
Curmi, P.A.6
Sobel, A.7
Knossow, M.8
-
14
-
-
0032495513
-
Structure of the alpha beta tubulin dimer by electron crystallography
-
Nogales, E.; Wolf, S. G.; Downing, K. H. Structure of the alpha beta tubulin dimer by electron crystallography. Nature, 1998, 391, 199-203.
-
(1998)
Nature
, vol.391
, pp. 199-203
-
-
Nogales, E.1
Wolf, S.G.2
Downing, K.H.3
-
15
-
-
0033621479
-
Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol
-
Rao, S.; He, L.; Chakravarty, S.; Ojima, I.; Orr, G. A.; Horwitz, S. B. Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol. J. Biol. Chem., 1999, 274, 37990-37994
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37990-37994
-
-
Rao, S.1
He, L.2
Chakravarty, S.3
Ojima, I.4
Orr, G.A.5
Horwitz, S.B.6
-
16
-
-
0028169689
-
3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin
-
Rao, S.; Krauss, N. E.; Heerding, J. M.; Swindell, C. S.; Ringel, I.; Orr, G. A.; Horwitz, S. B. 3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin. J. Biol. Chem., 1994, 269, 3132-3134 (Pubitemid 2044957)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.5
, pp. 3132-3134
-
-
Rao, S.1
Krauss, N.E.2
Heerding, J.M.3
Swindell, C.S.4
Ringel, I.5
Orr, G.A.6
Horwitz, S.B.7
-
17
-
-
0028861177
-
Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin
-
Rao, S.; Orr, G. A.; Chaudhary, A. G.; Kingston, D. G.; Horwitz, S. B. Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin. J. Biol. Chem., 1995, 270, 20235-20238
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 20235-20238
-
-
Rao, S.1
Orr, G.A.2
Chaudhary, A.G.3
Kingston, D.G.4
Horwitz, S.B.5
-
18
-
-
0035942226
-
The binding conformation of Taxol in beta-tubulin: A model based on electron crystallographic density
-
DOI 10.1073/pnas.051309398
-
Snyder, J. P.; Nettles, J. H.; Cornett, B.; Downing, K. H.; Nogales, E. The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density. Proc. Natl. Acad. Sci. U.S.A., 2001, 98, 5312-5316 (Pubitemid 32397125)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.9
, pp. 5312-5316
-
-
Snyder, J.P.1
Nettles, J.H.2
Cornett, B.3
Downing, K.H.4
Nogales, E.5
-
19
-
-
15844426797
-
Identification of cysteine 354 of beta-tubulin as part of the binding site for the a ring of colchicine
-
DOI 10.1074/jbc.271.21.12639
-
Bai, R.; Pei, X. F.; Boye, O.; Getahun, Z.; Grover, S.; Bekisz, J.; Nguyen, N. Y.; Brossi, A.; Hamel, E. Identification of cysteine 354 of beta-tubulin as part of the binding site for the A ring of colchicine. J. Biol. Chem., 1996, 271, 12639-12645 (Pubitemid 26160939)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.21
, pp. 12639-12645
-
-
Bai, R.1
Pei, X.-F.2
Boyw, O.3
Getahun, Z.4
Grover, S.5
Bekisz, J.6
Nguyen, N.Y.7
Brossi, A.8
Hamel, E.9
-
20
-
-
1642401199
-
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
-
DOI 10.1038/nature02393
-
Ravelli, R. B.; Gigant, B.; Curmi, P. A.; Jourdain, I.; Lachkar, S.; Sobel, A.; Knossow, M. Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature, 2004, 428, 198-202. (Pubitemid 38374318)
-
(2004)
Nature
, vol.428
, Issue.6979
, pp. 198-202
-
-
Ravelli, R.B.G.1
Gigant, B.2
Curmi, P.A.3
Jourdain, I.4
Lachkar, S.5
Sobel, A.6
Knossow, M.7
-
21
-
-
0027140153
-
Localization of the colchicine-binding site of tubulin
-
Uppuluri, S.; Knipling, L.; Sackett, D. L.; Wolff, J. Localization of the colchicine-binding site of tubulin. Proc. Natl. Acad. Sci. U S A, 1993, 90, 11598-11602
-
(1993)
Proc. Natl. Acad. Sci. U S A
, vol.90
, pp. 11598-11602
-
-
Uppuluri, S.1
Knipling, L.2
Sackett, D.L.3
Wolff, J.4
-
22
-
-
57449091909
-
Benomyl and colchicine synergistically inhibit cell proliferation and mitosis: Evidence of distinct binding sites for these agents in tubulin
-
Clement, M. J.; Rathinasamy, K.; Adjadj, E.; Toma, F.; Curmi, P. A.; Panda, D. Benomyl and colchicine synergistically inhibit cell proliferation and mitosis: evidence of distinct binding sites for these agents in tubulin. Biochemistry, 2008, 47, 13016-13025
-
(2008)
Biochemistry
, vol.47
, pp. 13016-13025
-
-
Clement, M.J.1
Rathinasamy, K.2
Adjadj, E.3
Toma, F.4
Curmi, P.A.5
Panda, D.6
-
23
-
-
2542603198
-
Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin
-
DOI 10.1021/bi036112v
-
Gupta, K.; Bishop, J.; Peck, A.; Brown, J.; Wilson, L.; Panda, D. Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin. Biochem., 2004, 43, 6645-6655 (Pubitemid 38697564)
-
(2004)
Biochemistry
, vol.43
, Issue.21
, pp. 6645-6655
-
-
Gupta, K.1
Bishop, J.2
Peck, A.3
Brown, J.4
Wilson, L.5
Panda, D.6
-
24
-
-
6944245215
-
Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum
-
MacDonald, L. M.; Armson, A.; Thompson, A. R.; Reynoldson, J. A. Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum. Mol. Biochem. Parasitol., 2004, 138, 89-96.
-
(2004)
Mol. Biochem. Parasitol.
, vol.138
, pp. 89-96
-
-
MacDonald, L.M.1
Armson, A.2
Thompson, A.R.3
Reynoldson, J.A.4
-
25
-
-
59649117610
-
Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics
-
Yenjerla, M.; Cox, C.; Wilson, L.; Jordan, M. A. Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics. J. Pharmacol. Exp. Ther., 2009, 328, 390-398
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.328
, pp. 390-398
-
-
Yenjerla, M.1
Cox, C.2
Wilson, L.3
Jordan, M.A.4
-
26
-
-
65349169465
-
Caulerpenyne binding to tubulin: Structural modifications by a non conventional pharmacological agent
-
Bourdron, J.; Barbier, P.; Allegro, D.; Villard, C.; Lafitte, D.; Commeiras, L.; Parrain, J. L.; Peyrot, V. Caulerpenyne binding to tubulin: structural modifications by a non conventional pharmacological agent. Med. Chem., 2009, 5, 182-190
-
(2009)
Med. Chem.
, vol.5
, pp. 182-190
-
-
Bourdron, J.1
Barbier, P.2
Allegro, D.3
Villard, C.4
Lafitte, D.5
Commeiras, L.6
Parrain, J.L.7
Peyrot, V.8
-
27
-
-
1642546217
-
Dinitroanilines bind alpha-tubulin to disrupt microtubules
-
Morrissette, N. S.; Mitra, A.; Sept, D.; Sibley, L. D. Dinitroanilines bind alpha-tubulin to disrupt microtubules. Mol. Biol. Cell, 2004, 15, 1960-1968
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 1960-1968
-
-
Morrissette, N.S.1
Mitra, A.2
Sept, D.3
Sibley, L.D.4
-
28
-
-
0026069885
-
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data
-
Bai, R. L.; Paull, K. D.; Herald, C. L.; Malspeis, L.; Pettit, G. R.; Hamel, E. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J. Biol. Chem., 1991, 266, 15882-15889
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 15882-15889
-
-
Bai, R.L.1
Paull, K.D.2
Herald, C.L.3
Malspeis, L.4
Pettit, G.R.5
Hamel, E.6
-
29
-
-
34249308550
-
In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent
-
Liu, J.; Towle, M. J.; Cheng, H.; Saxton, P.; Reardon, C.; Wu, J.; Murphy, E. A.; Kuznetsov, G.; Johannes, C. W.; Tremblay, M. R.; Zhao, H.; Pesant, M.; Fang, F. G.; Vermeulen, M. W.; Gallagher, B. M., Jr.; Littlefield, B. A. In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent. Anticancer Res., 2007, 27, 1509-1518
-
(2007)
Anticancer Res.
, vol.27
, pp. 1509-1518
-
-
Liu, J.1
Towle, M.J.2
Cheng, H.3
Saxton, P.4
Reardon, C.5
Wu, J.6
Murphy, E.A.7
Kuznetsov, G.8
Johannes, C.W.9
Tremblay, M.R.10
Zhao, H.11
Pesant, M.12
Fang, F.G.13
Vermeulen, M.W.14
Gallagher Jr., B.M.15
Littlefield, B.A.16
-
30
-
-
0033672861
-
20th-century advances in drug therapy in oncology - Part. II
-
Dutcher, J. P.; Novik, Y.; O'Boyle, K.; Marcoullis, G.; Secco, C.; Wiernik, P. H. 20th-century advances in drug therapy in oncology - Part. II. J. Clin. Pharmacol., 2000, 40, 1079-1092.
-
(2000)
J. Clin. Pharmacol.
, vol.40
, pp. 1079-1092
-
-
Dutcher, J.P.1
Novik, Y.2
O'Boyle, K.3
Marcoullis, G.4
Secco, C.5
Wiernik, P.H.6
-
31
-
-
0021848573
-
Early resection of residual tumor during cisplatin, vinblastine, bleomycin combination chemotherapy in stage III and bulky stage II nonseminomatous testicular cancer
-
Pizzocaro, G.; Salvioni, R.; Pasi, M.; Zanoni, F.; Milani, A.; Pilotti, S.; Monfardini, S. Early resection of residual tumor during cisplatin, vinblastine, bleomycin combination chemotherapy in stage III and bulky stage II nonseminomatous testicular cancer. Cancer, 1985, 56.
-
(1985)
Cancer
, vol.56
-
-
Pizzocaro, G.1
Salvioni, R.2
Pasi, M.3
Zanoni, F.4
Milani, A.5
Pilotti, S.6
Monfardini, S.7
-
32
-
-
0029549655
-
The comparative clinical pharmacology of vincristine and vindesine: Does vindesine offer any advantage in clinical use?
-
DOI 10.1016/0305-7372(95)90015-2
-
Joel, S. The comparative clinical pharmacology of vincristine and vindesine: Does vindesine offer any advantage in clinical use? Cancer Treat. Rev., 1995, 21, 513-525. (Pubitemid 26128923)
-
(1995)
Cancer Treatment Reviews
, vol.21
, Issue.6
, pp. 513-525
-
-
Joel, S.1
-
33
-
-
34249823330
-
+ etanidazole nanoparticles on hypoxic human tumor cells in vitro
-
+ etanidazole nanoparticles on hypoxic human tumor cells in vitro. Biomaterials, 2007, 28, 3724-3730.
-
(2007)
Biomaterials
, vol.28
, pp. 3724-3730
-
-
Jin, C.1
Bai, L.2
Wu, H.3
Tian, F.4
Guo, G.5
-
34
-
-
32944482677
-
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
-
DOI 10.1200/JCO.2005.04.937
-
Gradishar, W. J.; Tjulandin, S.; Davidson, N.; Shaw, H.; Desai, N.; Bhar, P.; Hawkins, M.; O'Shaughnessy, J. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J. Clin. Oncol., 2005, 23, 7794-7803 (Pubitemid 46657376)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.31
, pp. 7794-7803
-
-
Gradishar, W.J.1
Tjulandin, S.2
Davidson, N.3
Shaw, H.4
Desai, N.5
Bhar, P.6
Hawkins, M.7
O'Shaughnessy, J.8
-
35
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
-
Bollag, D. M.; McQueney, P. A.; Zhu, J.; Hensens, O.; Koupal, L.; Liesch, J.; Goetz, M.; Lazarides, E.; Woods, C. M. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res., 1995, 55, 2325-2333
-
(1995)
Cancer Res.
, vol.55
, pp. 2325-2333
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
Hensens, O.4
Koupal, L.5
Liesch, J.6
Goetz, M.7
Lazarides, E.8
Woods, C.M.9
-
36
-
-
0013682470
-
Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines
-
Greenberger, L. M.; Lothstein, L.; Williams, S. S.; Horwitz, S. B. Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines. Proc. Natl. Acad. Sci. U.S.A., 1988, 85, 3762-3766
-
(1988)
Proc. Natl. Acad. Sci. U.S.A.
, vol.85
, pp. 3762-3766
-
-
Greenberger, L.M.1
Lothstein, L.2
Williams, S.S.3
Horwitz, S.B.4
-
37
-
-
65249157992
-
Identification and characterization of an intermediate taxol binding site within microtubule nanopores and a mechanism for tubulin isotype binding selectivity
-
Freedman, H.; Huzil, J.; Luchko, T.; Luduen a, R.; Tuszynski, J. Identification and characterization of an intermediate taxol binding site within microtubule nanopores and a mechanism for tubulin isotype binding selectivity. J. Chem. Inf. Model, 2009, 49, 424-436.
-
(2009)
J. Chem. Inf. Model
, vol.49
, pp. 424-436
-
-
Freedman, H.1
Huzil, J.2
Luchko, T.3
Luduena, R.4
Tuszynski, J.5
-
39
-
-
0028105831
-
Sequencing and schedule effects of cisplatin plus etoposide in small-cell lung cancer: Results of a North Central Cancer Treatment Group randomized clinical trial
-
Maksymiuk, A. W.; Jett, J. R.; Earle, J. D.; Su, J. Q.; Diegert, F. A.; Mailliard, J. A.; Kardinal, C. G.; Krook, J. E.; Veeder, M. H.; Wiesenfeld, M. Sequencing and schedule effects of cisplatin plus etoposide in small-cell lung cancer: results of a North Central Cancer Treatment Group randomized clinical trial. J. Clin. Oncol., 1994, 12, 70.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 70
-
-
Maksymiuk, A.W.1
Jett, J.R.2
Earle, J.D.3
Su, J.Q.4
Diegert, F.A.5
Mailliard, J.A.6
Kardinal, C.G.7
Krook, J.E.8
Veeder, M.H.9
Wiesenfeld, M.10
-
40
-
-
0027285520
-
Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo
-
Shirasaka, T.; Shimamoto, Y.; Ohshimo, H.; Saito, H.; Fukushima, M. Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo. Cancer chemo. Pharmacol., 1993, 32, 167-172. (Pubitemid 23146807)
-
(1993)
Cancer Chemotherapy and Pharmacology
, vol.32
, Issue.3
, pp. 167-172
-
-
Shirasaka, T.1
Shimamoto, Y.2
Ohshimo, H.3
Saito, H.4
Fukushima, M.5
-
41
-
-
0027848781
-
Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer
-
Fox, S. B.; Gatter, K. C.; Bicknell, R.; Going, J. J.; Stanton, P.; Cooke, T. G.; Harris, A. L. Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer. Cancer Res., 1993, 53, 4161-4163 (Pubitemid 24146759)
-
(1993)
Cancer Research
, vol.53
, Issue.18
, pp. 4161-4163
-
-
Fox, S.B.1
Gatter, K.C.2
Bicknell, R.3
Going, J.J.4
Stanton, P.5
Cooke, T.G.6
Harris, A.L.7
-
42
-
-
2642571660
-
Vascular-targeting therapies for treatment of malignant disease
-
DOI 10.1002/cncr.20299
-
Siemann, D. W.; Chaplin, D. J.; Horsman, M. R. Vascular-targeting therapies for treatment of malignant disease. Cancer, 2004, 100, 2491-2499 (Pubitemid 38715753)
-
(2004)
Cancer
, vol.100
, Issue.12
, pp. 2491-2499
-
-
Siemann, D.W.1
Chaplin, D.J.2
Horsman, M.R.3
-
43
-
-
20344379950
-
Disrupting tumour blood vessels
-
Tozer, G. M.; Kanthou, C.; Baguley, B. C. Disrupting tumour blood vessels. Nat Rev Cancer, 2005, 5, 423-435
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 423-435
-
-
Tozer, G.M.1
Kanthou, C.2
Baguley, B.C.3
-
44
-
-
33749005405
-
Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
-
DOI 10.1126/science.1127592
-
Shaked, Y.; Ciarrocchi, A.; Franco, M.; Lee, C. R.; Man, S.; Cheung, A. M.; Hicklin, D. J.; Chaplin, D.; Foster, F. S.; Benezra, R.; Kerbel, R. S. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science, 2006, 313, 1785-1787 (Pubitemid 44454154)
-
(2006)
Science
, vol.313
, Issue.5794
, pp. 1785-1787
-
-
Shaked, Y.1
Ciarrocchi, A.2
Franco, M.3
Lee, C.R.4
Man, S.5
Cheung, A.M.6
Hicklin, D.J.7
Chaplin, D.8
Foster, F.S.9
Benezra, R.10
Kerbel, R.S.11
-
45
-
-
0036568457
-
Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
-
Siemann, D. W.; Mercer, E.; Lepler, S.; Rojiani, A. M. Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy. Int. J. Cancer, 2002, 99, 1-6.
-
(2002)
Int. J. Cancer
, vol.99
, pp. 1-6
-
-
Siemann, D.W.1
Mercer, E.2
Lepler, S.3
Rojiani, A.M.4
-
46
-
-
65549151898
-
Novel classes of dimer antitumour drug candidates
-
Chow, L. M.; Chan, T. H. Novel classes of dimer antitumour drug candidates. Curr. Pharm. Des., 2009, 15, 659-674
-
(2009)
Curr. Pharm. Des.
, vol.15
, pp. 659-674
-
-
Chow, L.M.1
Chan, T.H.2
-
47
-
-
0032476812
-
Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
-
Mammen, M.; Choi, S. K.; Whitesides, G. M. Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors. Angew. Chem.. Int. Ed., 1998, 37, 2755-2794.
-
(1998)
Angew. Chem.. Int. Ed.
, vol.37
, pp. 2755-2794
-
-
Mammen, M.1
Choi, S.K.2
Whitesides, G.M.3
-
48
-
-
16644385119
-
Tumor targeting by doxorubicin-RGD-4C peptide conjugate in an orthotopic mouse hepatoma model
-
Kim, J. W.; Lee, H. S. Tumor targeting by doxorubicin-RGD-4C peptide conjugate in an orthotopic mouse hepatoma model. Int. J. Mol. Med., 2004, 14, 529-535
-
(2004)
Int. J. Mol. Med.
, vol.14
, pp. 529-535
-
-
Kim, J.W.1
Lee, H.S.2
-
49
-
-
38949103712
-
Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature
-
Mukhopadhyay, S.; Barnes, C. M.; Haskel, A.; Short, S. M.; Barnes, K. R.; Lippard, S. J. Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature. Bioconjug. Chem., 2008, 19, 39-49.
-
(2008)
Bioconjug. Chem.
, vol.19
, pp. 39-49
-
-
Mukhopadhyay, S.1
Barnes, C.M.2
Haskel, A.3
Short, S.M.4
Barnes, K.R.5
Lippard, S.J.6
-
50
-
-
38949104405
-
Design of a tumor-homing cell-penetrating peptide
-
Myrberg, H.; Zhang, L.; Mae, M.; Langel, U. Design of a tumor-homing cell-penetrating peptide. Bioconjug. Chem., 2008, 19, 70-75
-
(2008)
Bioconjug. Chem.
, vol.19
, pp. 70-75
-
-
Myrberg, H.1
Zhang, L.2
Mae, M.3
Langel, U.4
-
51
-
-
33845200360
-
Evaluation of RGD-targeted albumin carriers for specific delivery of auristatin e to tumor blood vessels
-
Temming, K.; Meyer, D. L.; Zabinski, R.; Dijkers, E. C.; Poelstra, K.; Molema, G.; Kok, R. J. Evaluation of RGD-targeted albumin carriers for specific delivery of auristatin E to tumor blood vessels. Bioconjug. Chem., 2006, 17, 1385-1394
-
(2006)
Bioconjug. Chem.
, vol.17
, pp. 1385-1394
-
-
Temming, K.1
Meyer, D.L.2
Zabinski, R.3
Dijkers, E.C.4
Poelstra, K.5
Molema, G.6
Kok, R.J.7
-
52
-
-
0028335032
-
Pharmacology and toxicology of Cremophor EL diluent
-
Dorr, R. T. Pharmacology and toxicology of Cremophor EL diluent. Ann. Pharmacother., 1994, 28, S11-4.
-
(1994)
Ann. Pharmacother.
, vol.28
-
-
Dorr, R.T.1
-
53
-
-
0030970184
-
Activity of paclitaxel liposome formulations against human ovarian tumor xenografts
-
Sharma, A.; Mayhew, E.; Bolcsak, L.; Cavanaugh, C.; Harmon, P.; Janoff, A.; Bernacki, R. J. Activity of paclitaxel liposome formulations against human ovarian tumor xenografts. Int. J. Cancer, 1997, 71, 103-107
-
(1997)
Int. J. Cancer
, vol.71
, pp. 103-107
-
-
Sharma, A.1
Mayhew, E.2
Bolcsak, L.3
Cavanaugh, C.4
Harmon, P.5
Janoff, A.6
Bernacki, R.J.7
-
54
-
-
0033118955
-
Cremophor EL-mediated alteration of paclitaxel distribution in human blood: Clinical pharmacokinetic implications
-
Sparreboom, A.; van Zuylen, L.; Brouwer, E.; Loos, W. J.; de Bruijn, P.; Gelderblom, H.; Pillay, M.; Nooter, K.; Stoter, G.; Verweij, J. Cremophor EL-mediated alteration of paclitaxel distribution in human blood: clinical pharmacokinetic implications. Cancer Res., 1999, 59, 1454-1457 (Pubitemid 29160110)
-
(1999)
Cancer Research
, vol.59
, Issue.7
, pp. 1454-1457
-
-
Sparreboom, A.1
Van Zuylen, L.2
Brouwer, E.3
Loos, W.J.4
De Bruijn, P.5
Gelderblom, H.6
Pillay, M.7
Nooter, K.8
Stoter, G.9
Verweij, J.10
-
55
-
-
33644990998
-
Update on tubulin-binding agents
-
Attard, G.; Greystoke, A.; Kaye, S.; De Bono, J. Update on tubulin-binding agents. Pathol. Biol. (Paris), 2006, 54, 72-84.
-
(2006)
Pathol. Biol. (Paris)
, vol.54
, pp. 72-84
-
-
Attard, G.1
Greystoke, A.2
Kaye, S.3
De Bono, J.4
-
56
-
-
34548626932
-
Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer-drug conjugate
-
Chipman, S. D.; Oldham, F. B.; Pezzoni, G.; Singer, J. W. Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer-drug conjugate. Int. J. Nanomed., 2006, 1, 375-383
-
(2006)
Int. J. Nanomed.
, vol.1
, pp. 375-383
-
-
Chipman, S.D.1
Oldham, F.B.2
Pezzoni, G.3
Singer, J.W.4
-
57
-
-
0030958485
-
Structure of a DNA-bisdaunomycin complex
-
Hu, G. G.; Shui, X.; Leng, F.; Priebe, W.; Chaires, J. B.; Williams, L. D. Structure of a DNA-bisdaunomycin complex. Biochem., 1997, 36, 5940-5946
-
(1997)
Biochem.
, vol.36
, pp. 5940-5946
-
-
Hu, G.G.1
Shui, X.2
Leng, F.3
Priebe, W.4
Chaires, J.B.5
Williams, L.D.6
-
58
-
-
0034615062
-
Synthesis and evaluation of daunorubicin-paclitaxel dimers
-
Kar, A. K.; Braun, P. D.; Wandless, T. J. Synthesis and evaluation of daunorubicin-paclitaxel dimers. Bioorg. Med. Chem. Lett., 2000, 10, 261-264
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 261-264
-
-
Kar, A.K.1
Braun, P.D.2
Wandless, T.J.3
-
59
-
-
0030479686
-
Fluorescent taxoids
-
Guy, R.; Scott, Z.; Sloboda, R.; Nicolaou, K. Fluorescent taxoids. Chem. Biol., 1996, 3, 1021-1031
-
(1996)
Chem. Biol.
, vol.3
, pp. 1021-1031
-
-
Guy, R.1
Scott, Z.2
Sloboda, R.3
Nicolaou, K.4
-
60
-
-
0016640250
-
DNA complexing antibiotics: Daunomycin, adriamycin and their derivatives
-
Marco, A.; Arcamone, F. DNA complexing antibiotics: daunomycin, adriamycin and their derivatives. Arzneimittelforschung, 1975, 25, 368-74.
-
(1975)
Arzneimittelforschung
, vol.25
, pp. 368-374
-
-
Marco, A.1
Arcamone, F.2
-
61
-
-
0025270869
-
The clinical use of somatostatin analogues in the treatment of cancer
-
Lamberts, S. W.; Krenning, E. P.; Klijn, J. G.; Reubi, J. C. The clinical use of somatostatin analogues in the treatment of cancer. Baillieres Clin. Endocrinol. Metab., 1990, 4, 29-49.
-
(1990)
Baillieres Clin. Endocrinol. Metab.
, vol.4
, pp. 29-49
-
-
Lamberts, S.W.1
Krenning, E.P.2
Klijn, J.G.3
Reubi, J.C.4
-
62
-
-
0037080274
-
A randomized, multicenter prospective trial assessing long-acting release octreotide pamoate plus tamoxifen as a first line therapy for advanced breast carcinoma
-
DOI 10.1002/cncr.10239
-
Bajetta, E.; Procopio, G.; Ferrari, L.; Martinetti, A.; Zilembo, N.; Catena, L.; Alu, M.; Della, T. S.; Alberti, D.; Buzzoni, R. A randomized, multicenter prospective trial assessing long-acting release octreotide pamoate plus tamoxifen as a first line therapy for advanced breast carcinoma. Cancer, 2002, 94, 299-304. (Pubitemid 34081357)
-
(2002)
Cancer
, vol.94
, Issue.2
, pp. 299-304
-
-
Bajetta, E.1
Procopio, G.2
Ferrari, L.3
Martinetti, A.4
Zilembo, N.5
Catena, L.6
Alu, M.7
Della Torre, S.8
Alberti, D.9
Buzzoni, R.10
-
63
-
-
42249099996
-
Neuroendocrine tumors of the small intestine and the appendix - Management guidelines (recommended by the Polish Network of Neuroendocrine Tumors)
-
Bolanowski, M.; Jarzab, B.; Handkiewicz-Junak, D.; Jeziorski, A.; Kos-Kudla, B.; Zajecki, W. [Neuroendocrine tumors of the small intestine and the appendix - management guidelines (recommended by The Polish Network of Neuroendocrine Tumors)]. Endokrynol. Pol., 2008, 59, 87-96.
-
(2008)
Endokrynol. Pol.
, vol.59
, pp. 87-96
-
-
Bolanowski, M.1
Jarzab, B.2
Handkiewicz-Junak, D.3
Jeziorski, A.4
Kos-Kudla, B.5
Zajecki, W.6
-
64
-
-
0031964609
-
Feasibility, endocrine and anti-tumour effects of a triple endocrine therapy with tamoxifen, a somatostatin analogue and an antiprolactin in post-menopausal metastatic breast cancer: A randomized study with long-term follow-up
-
Bontenbal, M.; Foekens, J. A.; Lamberts, S. W.; de Jong, F. H.; van Putten, W. L.; Braun, H. J.; Burghouts, J. T.; van der Linden, G. H.; Klijn, J. G. Feasibility, endocrine and anti-tumour effects of a triple endocrine therapy with tamoxifen, a somatostatin analogue and an antiprolactin in post-menopausal metastatic breast cancer: a randomized study with long-term follow-up. Br. J. Cancer, 1998, 77, 115-122
-
(1998)
Br. J. Cancer
, vol.77
, pp. 115-122
-
-
Bontenbal, M.1
Foekens, J.A.2
Lamberts, S.W.3
De Jong, F.H.4
Van Putten, W.L.5
Braun, H.J.6
Burghouts, J.T.7
Van Der Linden, G.H.8
Klijn, J.G.9
-
65
-
-
0035069931
-
Treatment of metastatic breast cancer with somatostatin analogues - A meta-analysis
-
Dolan, J. T.; Miltenburg, D. M.; Granchi, T. S.; Miller, C. C., 3rd; Brunicardi, F. C. Treatment of metastatic breast cancer with somatostatin analogues - a meta-analysis. Ann. Surg. Oncol., 2001, 8, 227-233
-
(2001)
Ann. Surg. Oncol.
, vol.8
, pp. 227-233
-
-
Dolan, J.T.1
Miltenburg, D.M.2
Granchi, T.S.3
Miller III, C.C.4
Brunicardi, F.C.5
-
66
-
-
0029818962
-
Octreotide as first-line treatment for women with metastatic breast cancer
-
Ingle, J. N.; Kardinal, C. G.; Suman, V. J.; Krook, J. E.; Hatfield, A. K. Octreotide as first-line treatment for women with metastatic breast cancer. Invest. New Drugs, 1996, 14, 235-237 (Pubitemid 26340695)
-
(1996)
Investigational New Drugs
, vol.14
, Issue.2
, pp. 235-237
-
-
Ingle, J.N.1
Kardinal, C.G.2
Suman, V.J.3
Krook, J.E.4
Hatfield, A.K.5
-
67
-
-
0028131557
-
Octreotide treatment of carcinoid hypertensive crisis
-
Warner, R. R.; Mani, S.; Profeta, J.; Grunstein, E. Octreotide treatment of carcinoid hypertensive crisis. Mt. Sinai J. Med., 1994, 61, 349-355 (Pubitemid 24311064)
-
(1994)
Mount Sinai Journal of Medicine
, vol.61
, Issue.4
, pp. 349-355
-
-
Warner, R.R.P.1
Mani, S.2
Profeta, J.3
Grunstein, E.4
-
68
-
-
38449106056
-
Malignant pancreatic carcinoid tumour
-
Zarina, A. L.; Hamidah, A.; Zulkifli, S. Z.; Zulfiqar, M. A.; Jamal, R. Malignant pancreatic carcinoid tumour. Singapore Med. J., 2007, 48, e320-2.
-
(2007)
Singapore Med. J.
, vol.48
-
-
Zarina, A.L.1
Hamidah, A.2
Zulkifli, S.Z.3
Zulfiqar, M.A.4
Jamal, R.5
-
69
-
-
0026041670
-
The role of somatostatin and its analogs in the diagnosis and treatment of tumors
-
Lamberts, S. W.; Krenning, E. P.; Reubi, J. C. The role of somatostatin and its analogs in the diagnosis and treatment of tumors. Endocr. Rev., 1991, 12, 450-482
-
(1991)
Endocr. Rev.
, vol.12
, pp. 450-482
-
-
Lamberts, S.W.1
Krenning, E.P.2
Reubi, J.C.3
-
70
-
-
0027946389
-
Somatostatin and the concept of peptide receptor scintigraphy in oncology
-
Lamberts, S. W.; Reubi, J. C.; Krenning, E. P. Somatostatin and the concept of peptide receptor scintigraphy in oncology. Semin. Oncol., 1994, 21, 1-5. (Pubitemid 24378898)
-
(1994)
Seminars in Oncology
, vol.21
, Issue.5 SUPPL. 13
, pp. 1-5
-
-
Lamberts, S.W.J.1
Reubi, J.C.2
Krenning, E.P.3
-
71
-
-
0029945532
-
Potentiation of the anti-proliferative effects of anti-cancer drugs by octreotide in vitro and in vivo
-
Weckbecker, G.; Raulf, F.; Tolcsvai, L.; Bruns, C. Potentiation of the anti-proliferative effects of anti-cancer drugs by octreotide in vitro and in vivo. Digestion, 1996, 57 Suppl. 1, 22-28 (Pubitemid 26183914)
-
(1996)
Digestion
, vol.57
, Issue.SUPPL. 1
, pp. 22-28
-
-
Weckbecker, G.1
Raulf, F.2
Tolcsvai, L.3
Bruns, C.4
-
72
-
-
0033927859
-
Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis
-
Huang, C. M.; Wu, Y. T.; Chen, S. T. Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis. Chem. Biol., 2000, 7, 453-461
-
(2000)
Chem. Biol.
, vol.7
, pp. 453-461
-
-
Huang, C.M.1
Wu, Y.T.2
Chen, S.T.3
-
73
-
-
0035953070
-
Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids
-
DOI 10.1016/S0960-894X(01)00067-1, PII S0960894X01000671
-
Wittman, M. D.; Kadow, J. F.; Vyas, D. M.; Lee, F. L.; Rose, W. C.; Long, B. H.; Fairchild, C.; Johnston, K. Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids. Bioorg. Med. Chem. Lett., 2001, 11, 811-814. (Pubitemid 32230686)
-
(2001)
Bioorganic and Medicinal Chemistry Letters
, vol.11
, Issue.6
, pp. 811-814
-
-
Wittman, M.D.1
Kadow, J.F.2
Vyas, D.M.3
Lee, F.L.4
Rose, W.C.5
Long, B.H.6
Fairchild, C.7
Johnston, K.8
-
74
-
-
0035813468
-
Antitumor agents 210. synthesis and evaluation of taxoid- epipodophyllotoxin conjugates as novel cytotoxic agents
-
DOI 10.1016/S0968-0896(01)00206-1, PII S0968089601002061
-
Shi, Q.; Wang, H. K.; Bastow, K. F.; Tachibana, Y.; Chen, K.; Lee, F. Y.; Lee, K. H. Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents. Bioorg. Med. Chem., 2001, 9, 2999-3004. (Pubitemid 32904545)
-
(2001)
Bioorganic and Medicinal Chemistry
, vol.9
, Issue.11
, pp. 2999-3004
-
-
Shi, Q.1
Wang, H.-K.2
Bastow, K.F.3
Tachibana, Y.4
Chen, K.5
Lee, F.-Y.6
Lee, K.-H.7
-
75
-
-
0037377327
-
Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents
-
DOI 10.1016/S0968-0896(03)00040-3
-
Ohtsu, H.; Nakanishi, Y.; Bastow, K. F.; Lee, F. Y.; Lee, K. H. Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents. Bioorg. Med. Chem., 2003, 11, 1851-1857 (Pubitemid 36349166)
-
(2003)
Bioorganic and Medicinal Chemistry
, vol.11
, Issue.8
, pp. 1851-1857
-
-
Ohtsu, H.1
Nakanishi, Y.2
Bastow, K.F.3
Lee, F.-Y.4
Lee, K.-H.5
-
76
-
-
0028685454
-
Synthesis of novel water-soluble 7-(aminoacylhydrazono)-formyl camptothecins with potent inhibition of DNA topoisomerase I
-
Wang, H. K.; Liu, S. Y.; Hwang, K. M.; Taylor, G.; Lee, K. H. Synthesis of novel water-soluble 7-(aminoacylhydrazono)-formyl camptothecins with potent inhibition of DNA topoisomerase I. Bioorg. Med. Chem., 1994, 2, 1397-1402
-
(1994)
Bioorg. Med. Chem.
, vol.2
, pp. 1397-1402
-
-
Wang, H.K.1
Liu, S.Y.2
Hwang, K.M.3
Taylor, G.4
Lee, K.H.5
-
77
-
-
34247494714
-
Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: Evaluation of novel conjugates as cytotoxic agents
-
DOI 10.1016/j.bmcl.2007.02.051, PII S0960894X0700248X
-
Nakagawa-Goto, K.; Nakamura, S.; Bastow, K. F.; Nyarko, A.; Peng, C.-Y.; Lee, F.-Y.; Lee, F.-C.; Lee, K.-H. Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: Evaluation of novel conjugates as cytotoxic agents. Bioorg. Med. Chem. Lett., 2007, 17, 2894-2898. (Pubitemid 46656458)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.10
, pp. 2894-2898
-
-
Nakagawa-Goto, K.1
Nakamura, S.2
Bastow, K.F.3
Nyarko, A.4
Peng, C.-Y.5
Lee, F.-Y.6
Lee, F.-C.7
Lee, K.-H.8
-
78
-
-
34447520330
-
Anticancer carrier-linked prodrugs in clinical trials
-
DOI 10.1517/13543784.16.7.1037
-
Kratz, F.; Abu Ajaj, K.; Warnecke, A. Anticancer carrier-linked prodrugs in clinical trials. Expert Opin. Investig. Drugs, 2007, 16, 1037-1058 (Pubitemid 47074159)
-
(2007)
Expert Opinion on Investigational Drugs
, vol.16
, Issue.7
, pp. 1037-1058
-
-
Kratz, F.1
Ajaj, K.A.2
Warnecke, A.3
-
79
-
-
39349084237
-
Prodrug strategies in anticancer chemotherapy
-
Kratz, F.; Muller, I. A.; Ryppa, C.; Warnecke, A. Prodrug strategies in anticancer chemotherapy. ChemMedChem., 2008, 3, 20-53.
-
(2008)
ChemMedChem.
, vol.3
, pp. 20-53
-
-
Kratz, F.1
Muller, I.A.2
Ryppa, C.3
Warnecke, A.4
-
80
-
-
0141615976
-
Recent trends in the use of polysaccharides for improved delivery of therapeutic agents: Pharmacokinetic and pharmacodynamic perspectives
-
DOI 10.2174/1389201033489685
-
Mehvar, R. Recent trends in the use of polysaccharides for improved delivery of therapeutic agents: pharmacokinetic and pharmacodynamic perspectives. Curr. Pharm. Biotechnol., 2003, 4, 283-302. (Pubitemid 37220861)
-
(2003)
Current Pharmaceutical Biotechnology
, vol.4
, Issue.5
, pp. 283-302
-
-
Mehvar, R.1
-
81
-
-
1942438684
-
Polymeric anticancer drugs with pH-controlled activation
-
DOI 10.1016/j.addr.2003.10.040, PII S0169409X03002837
-
Ulbrich, K.; Subr, V. Polymeric anticancer drugs with pH-controlled activation. Adv. Drug Deliv. Rev., 2004, 56, 1023-1050 (Pubitemid 38520207)
-
(2004)
Advanced Drug Delivery Reviews
, vol.56
, Issue.7
, pp. 1023-1050
-
-
Ulbrich, K.1
Subr, V.2
-
82
-
-
0342314489
-
A novel macromolecular prodrug concept exploiting endogenous serum albumin as a drug carrier for cancer chemotherapy [2]
-
DOI 10.1021/jm9905864
-
Kratz, F.; Muller-Driver, R.; Hofmann, I.; Drevs, J.; Unger, C. A novel macromolecular prodrug concept exploiting endogenous serum albumin as a drug carrier for cancer chemotherapy. J. Med. Chem., 2000, 43, 1253-1256 (Pubitemid 30212566)
-
(2000)
Journal of Medicinal Chemistry
, vol.43
, Issue.7
, pp. 1253-1256
-
-
Kratz, F.1
Muller-Driver, R.2
Hofmann, I.3
Drevs, J.4
Unger, C.5
-
83
-
-
0037028050
-
Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound
-
DOI 10.1021/jm020276c
-
Kratz, F.; Warnecke, A.; Scheuermann, K.; Stockmar, C.; Schwab, J.; Lazar, P.; Druckes, P.; Esser, N.; Drevs, J.; Rognan, D.; Bissantz, C.; Hinderling, C.; Folkers, G.; Fichtner, I.; Unger, C. Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound. J. Med. Chem., 2002, 45, 5523-5533 (Pubitemid 35424970)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.25
, pp. 5523-5533
-
-
Kratz, F.1
Warnecke, A.2
Scheuermann, K.3
Stockmar, C.4
Schwab, J.5
Lazar, P.6
Druckes, P.7
Esser, N.8
Drevs, J.9
Rognan, D.10
Bissantz, C.11
Hinderling, C.12
Folkers, G.13
Fichtner, I.14
Unger, C.15
-
84
-
-
0034000453
-
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
-
DOI 10.1016/S0168-3659(99)00248-5, PII S0168365999002485
-
Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Control Release, 2000, 65, 271-284 (Pubitemid 30122932)
-
(2000)
Journal of Controlled Release
, vol.65
, Issue.1-2
, pp. 271-284
-
-
Maeda, H.1
Wu, J.2
Sawa, T.3
Matsumura, Y.4
Hori, K.5
-
85
-
-
33646872893
-
A phase I study of paclitaxel/doxorubicin/thalidomide in patients with androgen-independent prostate cancer
-
Amato, R. J.; Sarao, H. A phase I study of paclitaxel/doxorubicin/ thalidomide in patients with androgen- independent prostate cancer. Clin. Genitourin. Cancer, 2006, 4, 281-286 (Pubitemid 43779886)
-
(2006)
Clinical Genitourinary Cancer
, vol.4
, Issue.4
, pp. 281-286
-
-
Amato, R.J.1
Sarao, H.2
-
86
-
-
2142708274
-
Gemcitabine, anthracycline, and taxane combinations for advanced breast cancer
-
Zielinski, C. C. Gemcitabine, anthracycline, and taxane combinations for advanced breast cancer. Oncology (Williston Park), 2003, 17, 36-40.
-
(2003)
Oncology (Williston Park)
, vol.17
, pp. 36-40
-
-
Zielinski, C.C.1
-
87
-
-
33846813876
-
Phase I trial of paclitaxel, doxorubicin, and carboplatin (TAC) for the treatment of endometrial cancer
-
DOI 10.1111/j.1525-1438.2007.00801.x
-
Shimada, M.; Kigawa, J.; Terakawa, N.; Yoshizaki, A.; Shoji, T.; Suzuki, M.; Hatae, M.; Tsuda, H.; Ohwada, M.; Sugiyama, T. Phase I trial of paclitaxel, doxorubicin, and carboplatin (TAC) for the treatment of endometrial cancer. Int. J. Gynecol. Cancer, 2007, 17, 210-214 (Pubitemid 46213992)
-
(2007)
International Journal of Gynecological Cancer
, vol.17
, Issue.1
, pp. 210-214
-
-
Shimada, M.1
Kigawa, J.2
Terakawa, N.3
Yoshizaki, A.4
Shoji, T.5
Suzuki, M.6
Hatae, M.7
Tsuda, H.8
Ohwada, M.9
Sugiyama, T.10
-
88
-
-
62549144354
-
Development of protein-binding bifunctional linkers for a new generation of dual-acting prodrugs
-
Ajaj, K. A.; Biniossek, M. L.; Kratz, F. Development of protein-binding bifunctional linkers for a new generation of dual-acting prodrugs. Bioconjug. Chem., 2009, 20, 390-396
-
(2009)
Bioconjug. Chem.
, vol.20
, pp. 390-396
-
-
Ajaj, K.A.1
Biniossek, M.L.2
Kratz, F.3
-
89
-
-
34347354414
-
Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-Linker that are cleaved by cathepsin B: Synthesis and antitumor efficacy
-
DOI 10.1021/bc0602735
-
Schmid, B.; Chung, D. E.; Warnecke, A.; Fichtner, I.; Kratz, F. Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy. Bioconjug. Chem., 2007, 18, 702-716 (Pubitemid 47010789)
-
(2007)
Bioconjugate Chemistry
, vol.18
, Issue.3
, pp. 702-716
-
-
Schmid, B.1
Chung, D.-E.2
Warnecke, A.3
Fichtner, I.4
Kratz, F.5
-
90
-
-
0036074253
-
Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: Model studies of enzymatic drug release and antigen-specific in vitro anticancer activity
-
Dubowchik, G. M.; Firestone, R. A.; Padilla, L.; Willner, D.; Hofstead, S. J.; Mosure, K.; Knipe, J. O.; Lasch, S. J.; Trail, P. A. Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity. Bioconjug. Chem., 2002, 13, 855-869
-
(2002)
Bioconjug. Chem.
, vol.13
, pp. 855-869
-
-
Dubowchik, G.M.1
Firestone, R.A.2
Padilla, L.3
Willner, D.4
Hofstead, S.J.5
Mosure, K.6
Knipe, J.O.7
Lasch, S.J.8
Trail, P.A.9
-
91
-
-
0025326011
-
Differential cytotoxicity of Combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines
-
McGown, A. T.; Fox, B. W. Differential cytotoxicity of combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines. Cancer Chemother. Pharmacol., 1990, 26, 79-81. (Pubitemid 20122896)
-
(1990)
Cancer Chemotherapy and Pharmacology
, vol.26
, Issue.1
, pp. 79-81
-
-
McGown, A.T.1
Fox, B.W.2
-
92
-
-
21744462039
-
Synthesis and biological activity of mustard derivatives of combretastatins
-
DOI 10.1016/j.bmcl.2005.05.052, PII S0960894X05006773
-
Coggiola, B.; Pagliai, F.; Allegrone, G.; Genazzani, A. A.; Tron, G. C. Synthesis and biological activity of mustard derivatives of combretastatins. Bioorg. Med. Chem. Lett., 2005, 15, 3551-3554 (Pubitemid 40942053)
-
(2005)
Bioorganic and Medicinal Chemistry Letters
, vol.15
, Issue.15
, pp. 3551-3554
-
-
Coggiola, B.1
Pagliai, F.2
Allegrone, G.3
Genazzani, A.A.4
Tron, G.C.5
-
93
-
-
0036282385
-
The biology of the combretastatins as tumour vascular targeting agents
-
DOI 10.1046/j.1365-2613.2002.00211.x
-
Tozer, G. M.; Kanthou, C.; Parkins, C. S.; Hill, S. A. The biology of the combretastatins as tumour vascular targeting agents. Int. J. Exp. Pathol., 2002, 83, 21-38. (Pubitemid 34638944)
-
(2002)
International Journal of Experimental Pathology
, vol.83
, Issue.1
, pp. 21-38
-
-
Tozer, G.M.1
Kanthou, C.2
Parkins, C.S.3
Hill, S.A.4
-
94
-
-
11144225831
-
Evidence for glucocorticoid receptor transport on microtubules by dynein
-
Harrell, J. M.; Murphy, P. J.; Morishima, Y.; Chen, H.; Mansfield, J. F.; Galigniana, M. D.; Pratt, W. B. Evidence for glucocorticoid receptor transport on microtubules by dynein. J. Biol. Chem., 2004, 279, 54647-54654
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 54647-54654
-
-
Harrell, J.M.1
Murphy, P.J.2
Morishima, Y.3
Chen, H.4
Mansfield, J.F.5
Galigniana, M.D.6
Pratt, W.B.7
-
95
-
-
34548076585
-
A bifunctional colchicinoid that binds to the androgen receptor
-
DOI 10.1158/1535-7163.MCT-07-0163
-
Sharifi, N.; Hamel, E.; Lill, M. A.; Risbood, P.; Kane, C. T., Jr.; Hossain, M. T.; Jones, A.; Dalton, J. T.; Farrar, W. L. A bifunctional colchicinoid that binds to the androgen receptor. Mol. Cancer Ther., 2007, 6, 2328-2336 (Pubitemid 47294761)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.8
, pp. 2328-2336
-
-
Sharifi, N.1
Hame, E.2
Lill, M.A.3
Risbood, P.4
Kane Jr., C.T.5
Hossain, Md.T.6
Jones, A.7
Dalton, J.T.8
Farrar, W.L.9
-
96
-
-
20044394709
-
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor
-
Estebanez-Perpina, E.; Moore, J. M.; Mar, E.; Delgado-Rodrigues, E.; Nguyen, P.; Baxter, J. D.; Buehrer, B. M.; Webb, P.; Fletterick, R. J.; Guy, R. K. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J. Biol. Chem., 2005, 280, 8060-8068
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 8060-8068
-
-
Estebanez-Perpina, E.1
Moore, J.M.2
Mar, E.3
Delgado-Rodrigues, E.4
Nguyen, P.5
Baxter, J.D.6
Buehrer, B.M.7
Webb, P.8
Fletterick, R.J.9
Guy, R.K.10
-
97
-
-
0025967083
-
Stereochemistry of colchicinoids. Enantiomeric stability and binding to tubulin of desacetamidocolchicine and desacetamidoisocolchicine
-
Berg, U.; Deinum, J.; Lincoln, P.; Kvassman, J. Stereochemistry of colchicinoids. Enantiomeric stability and binding to tubulin of desacetamidocolchicine and desacetamidoisocolchicine. Bioorg. Chem., 1991, 19, 53-65.
-
(1991)
Bioorg. Chem.
, vol.19
, pp. 53-65
-
-
Berg, U.1
Deinum, J.2
Lincoln, P.3
Kvassman, J.4
-
98
-
-
0242658820
-
Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin- formaldehyde conjugate
-
Cogan, P. S.; Koch, T. H. Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. J. Med. Chem., 2003, 46, 5258-5270
-
(2003)
J. Med. Chem.
, vol.46
, pp. 5258-5270
-
-
Cogan, P.S.1
Koch, T.H.2
-
99
-
-
0025281843
-
Antiandrogenic steroidal sulfonylpyrazoles
-
Christiansen, R. G.; Bell, M. R.; D'Ambra, T. E.; Mallamo, J. P.; Herrmann, J. L.; Ackerman, J. H.; Opalka, C. J.; Kullnig, R. K.; Winneker, R. C.; Snyder, B. W.; et al. Antiandrogenic steroidal sulfonylpyrazoles. J. Med. Chem., 1990, 33, 2094-2100
-
(1990)
J. Med. Chem.
, vol.33
, pp. 2094-2100
-
-
Christiansen, R.G.1
Bell, M.R.2
D'Ambra, T.E.3
Mallamo, J.P.4
Herrmann, J.L.5
Ackerman, J.H.6
Opalka, C.J.7
Kullnig, R.K.8
Winneker, R.C.9
Snyder, B.W.10
-
100
-
-
0032481002
-
Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization
-
Gastpar, R.; Goldbrunner, M.; Marko, D.; von Angerer, E. Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization. J. Med. Chem., 1998, 41, 4965-4972
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4965-4972
-
-
Gastpar, R.1
Goldbrunner, M.2
Marko, D.3
Von Angerer, E.4
-
101
-
-
34249944413
-
Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells
-
DOI 10.1016/j.bmc.2007.05.030, PII S0968089607004476
-
Kaufmann, D.; Pojarová, M.; Vogel, S.; Liebl, R.; Gastpar, R.; Gross, D.; Nishino, T.; Pfaller, T.; von Angerer, E. Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells. Bioorg. Med. Chem., 2007, 15, 5122-5136. (Pubitemid 46880379)
-
(2007)
Bioorganic and Medicinal Chemistry
, vol.15
, Issue.15
, pp. 5122-5136
-
-
Kaufmann, D.1
Pojarova, M.2
Vogel, S.3
Liebl, R.4
Gastpar, R.5
Gross, D.6
Nishino, T.7
Pfaller, T.8
Von Angerer, E.9
-
102
-
-
44649170403
-
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents
-
Vogel, S.; Kaufmann, D.; Pojarova, M.; Muller, C.; Pfaller, T.; Kuhne, S.; Bednarski, P. J.; von Angerer, E. Aroyl hydrazones of 2-phenylindole-3- carbaldehydes as novel antimitotic agents. Bioorg. Med. Chem., 2008, 16, 6436-6447
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 6436-6447
-
-
Vogel, S.1
Kaufmann, D.2
Pojarova, M.3
Muller, C.4
Pfaller, T.5
Kuhne, S.6
Bednarski, P.J.7
Von Angerer, E.8
-
103
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley, L. C. The phosphoinositide 3-kinase pathway. Science, 2002, 296, 1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
104
-
-
51049112961
-
Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- And drug-induced apoptosis
-
Opel, D.; Westhoff, M. A.; Bender, A.; Braun, V.; Debatin, K. M.; Fulda, S. Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis. Cancer Res., 2008, 68, 6271-6280
-
(2008)
Cancer Res.
, vol.68
, pp. 6271-6280
-
-
Opel, D.1
Westhoff, M.A.2
Bender, A.3
Braun, V.4
Debatin, K.M.5
Fulda, S.6
-
105
-
-
0018077292
-
Antitumor agents XXX: Evaluation of alpha-methylene-gamma-lactone- containing agents for inhibition of tumor growth, respiration, and nucleic acid synthesis
-
Hall, I. H.; Lee, K. H.; Starnes, C. O.; Eigebaly, S. A.; Ibuka, T.; Wu, Y. S.; Kimura, T.; Haruna, M. Antitumor agents XXX: Evaluation of alpha-methylene-gamma-lactone-containing agents for inhibition of tumor growth, respiration, and nucleic acid synthesis. J. Pharm. Sci., 1978, 67, 1235-1239
-
(1978)
J. Pharm. Sci.
, vol.67
, pp. 1235-1239
-
-
Hall, I.H.1
Lee, K.H.2
Starnes, C.O.3
Eigebaly, S.A.4
Ibuka, T.5
Wu, Y.S.6
Kimura, T.7
Haruna, M.8
-
106
-
-
18444367100
-
Anti-cancer potential of sesquiterpene lactones: Bioactivity and molecular mechanisms
-
Zhang, S.; Won, Y. K.; Ong, C. N.; Shen, H. M. Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms. Curr. Med. Chem. Anticancer Agents, 2005, 5, 239-249
-
(2005)
Curr. Med. Chem. Anticancer Agents
, vol.5
, pp. 239-249
-
-
Zhang, S.1
Won, Y.K.2
Ong, C.N.3
Shen, H.M.4
-
107
-
-
62849122450
-
S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton
-
Zhang, C.; Yang, N.; Yang, C. H.; Ding, H. S.; Luo, C.; Zhang, Y.; Wu, M. J.; Zhang, X. W.; Shen, X.; Jiang, H. L.; Meng, L. H.; Ding, J. S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton. PLoS ONE, 2009, 4, 4881.
-
(2009)
PLoS ONE
, vol.4
, pp. 4881
-
-
Zhang, C.1
Yang, N.2
Yang, C.H.3
Ding, H.S.4
Luo, C.5
Zhang, Y.6
Wu, M.J.7
Zhang, X.W.8
Shen, X.9
Jiang, H.L.10
Meng, L.H.11
Ding, J.12
-
108
-
-
33645504486
-
Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids
-
Danieli, B.; Giardini, A.; Lesma, G.; Passarella, D.; Silvani, A.; Appendino, G.; Noncovich, A.; Fontana, G.; Bombardelli, E.; Sterner, O. Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids. Chem. Biodivers., 2004, 1, 327-345
-
(2004)
Chem. Biodivers.
, vol.1
, pp. 327-345
-
-
Danieli, B.1
Giardini, A.2
Lesma, G.3
Passarella, D.4
Silvani, A.5
Appendino, G.6
Noncovich, A.7
Fontana, G.8
Bombardelli, E.9
Sterner, O.10
-
109
-
-
0037233673
-
Docetaxel and vinorelbine: An effective regimen in recurrent squamous cell esophageal carcinoma
-
DOI 10.1385/MO:20:1:19
-
Airoldi, M.; Cortesina, G.; Giordano, C.; Pedani, F.; Bumma, C.; Gabriele, P. Docetaxel and vinorelbine: an effective regimen in recurrent squamous cell esophageal carcinoma. Med. Oncol., 2003, 20, 19-24. (Pubitemid 36344021)
-
(2003)
Medical Oncology
, vol.20
, Issue.1
, pp. 19-24
-
-
Airoldi, M.1
Cortesina, G.2
Giordano, C.3
Pedani, F.4
Bumma, C.5
Gabriele, P.6
-
110
-
-
8444226440
-
Weekly docetaxel and vinorelbine (VIN-DOX) as first line treatment in patients with hormone refractory prostate cancer
-
DOI 10.1016/j.eururo.2004.08.022, PII S0302283804004518
-
Di Lorenzo, G.; Pizza, C.; Autorino, R.; De Laurentiis, M.; Marano, O.; D'Alessio, A.; Cancello, G.; Altieri, V.; Tortora, G.; Perdona, S.; Bianco, A. R.; De Placido, S. Weekly docetaxel and vinorelbine (VIN-DOX) as first line treatment in patients with hormone refractory prostate cancer. Eur. Urol., 2004, 46, 712-716 (Pubitemid 39488399)
-
(2004)
European Urology
, vol.46
, Issue.6
, pp. 712-716
-
-
Di Lorenzo, G.1
Pizza, C.2
Autorino, R.3
De Laurentiis, M.4
Marano, O.5
D'Alessio, A.6
Cancello, G.7
Altieri, V.8
Tortora, G.9
Perdona, S.10
Bianco, A.R.11
De Placido, S.12
-
111
-
-
0029832490
-
Taxoids in combination chemotherapy for metastatic breast cancer
-
Dieras, V.; Fumoleau, P.; Bourgeois, H.; Misset, J. L.; Azli, N.; Pouillart, P. Taxoids in combination chemotherapy for metastatic breast cancer. Anticancer Drugs, 1996, 7 Suppl. 2, 47-52. (Pubitemid 26275624)
-
(1996)
Anti-Cancer Drugs
, vol.7
, Issue.SUPPL. 2
, pp. 47-52
-
-
Dieras, V.1
Fumoleau, P.2
Bourgeois, H.3
Misset, J.L.4
Azli, N.5
Pouillart, P.6
-
112
-
-
3543109138
-
Biweekly docetaxel and vinorelbine as first-line chemotherapy in metastatic breast cancer
-
Mayordomo, J. I.; Milla, A.; Morales, S.; Yubero, A.; Lorenzo, A.; Baena, J. M.; Modolell, A.; Sanz, J.; Illarramendi, J.; Garcia, M. J.; Machengs, I.; Burrilo, M. A.; Tres, A. Biweekly docetaxel and vinorelbine as first-line chemotherapy in metastatic breast cancer. Clin. Breast Cancer, 2004, 5, 131-135 (Pubitemid 39029205)
-
(2004)
Clinical Breast Cancer
, vol.5
, Issue.2
, pp. 131-135
-
-
Mayordomo, J.I.1
Milla, A.2
Morales, S.3
Yubero, A.4
Lorenzo, A.5
Baena, J.M.6
Modolell, A.7
Sanz, J.8
Illarramendi, J.9
Garcia, M.J.10
Machengs, I.11
Burillo, M.A.12
Tres, A.13
-
113
-
-
0032484528
-
Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: Characterization of a synergistic schedule
-
DOI 10.1002/(SICI)1097-0215(19980105)75:1<57::AID-IJC10>3.0.CO;2-A
-
Giannakakou, P.; Villalba, L.; Li, H.; Poruchynsky, M.; Fojo, T. Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: characterization of a synergistic schedule. Int. J. Cancer, 1998, 75, 57-63. (Pubitemid 28113978)
-
(1998)
International Journal of Cancer
, vol.75
, Issue.1
, pp. 57-63
-
-
Giannakakou, P.1
Villalba, L.2
Li, H.3
Poruchynsky, M.4
Fojo, T.5
-
114
-
-
17644395253
-
Potential antagonism of tubulin-binding anticancer agents in combination therapies
-
DOI 10.1158/1078-0432.CCR-04-1616
-
Taraboletti, G.; Micheletti, G.; Dossi, R.; Borsotti, P.; Martinelli, M.; Fiordaliso, F.; Ryan, A. J.; Giavazzi, R. Potential antagonism of tubulin-binding anticancer agents in combination therapies. Clin. Cancer Res., 2005, 11, 2720-2726 (Pubitemid 40569474)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.7
, pp. 2720-2726
-
-
Taraboletti, G.1
Micheletti, G.2
Dossi, R.3
Borsotti, P.4
Martinelli, M.5
Fiordaliso, F.6
Ryan, A.J.7
Giavazzi, R.8
-
115
-
-
33748699986
-
Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel
-
Bombuwala, K.; Kinstle, T.; Popik, V.; Uppal, S. O.; Olesen, J. B.; Vina, J.; Heckman, C. A. Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel. Beilstein J. Org. Chem., 2006, 2, 13.
-
(2006)
Beilstein J. Org. Chem.
, vol.2
, pp. 13
-
-
Bombuwala, K.1
Kinstle, T.2
Popik, V.3
Uppal, S.O.4
Olesen, J.B.5
Vina, J.6
Heckman, C.A.7
-
116
-
-
51349133964
-
Design, synthesis, and bioactivity of putative tubulin ligands with adamantane core
-
Zefirova, O. N.; Nurieva, E. V.; Lemcke, H.; Ivanov, A. A.; Shishov, D. V.; Weiss, D. G.; Kuznetsov, S. A.; Zefirov, N. S. Design, synthesis, and bioactivity of putative tubulin ligands with adamantane core. Bioorg. Med. Chem. Lett., 2008, 18, 5091-5094.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 5091-5094
-
-
Zefirova, O.N.1
Nurieva, E.V.2
Lemcke, H.3
Ivanov, A.A.4
Shishov, D.V.5
Weiss, D.G.6
Kuznetsov, S.A.7
Zefirov, N.S.8
-
117
-
-
33645509492
-
Thiocolchicine-podophyllotoxin conjugates: Dynamic libraries based on disulfide exchange reaction
-
Danieli, B.; Giardini, A.; Lesma, G.; Passarella, D.; Peretto, B.; Sacchetti, A.; Silvani, A.; Pratesi, G.; Zunino, F. Thiocolchicine- podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction. J. Org. Chem., 2006, 71, 2848-2853
-
(2006)
J. Org. Chem.
, vol.71
, pp. 2848-2853
-
-
Danieli, B.1
Giardini, A.2
Lesma, G.3
Passarella, D.4
Peretto, B.5
Sacchetti, A.6
Silvani, A.7
Pratesi, G.8
Zunino, F.9
-
118
-
-
44449108627
-
Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III
-
DOI 10.1016/j.bmc.2008.04.025, PII S0968089608003532
-
Passarella, D.; Giardini, A.; Peretto, B.; Fontana, G.; Sacchetti, A.; Silvani, A.; Ronchi, C.; Cappelletti, G.; Cartelli, D.; Borlak, J.; Danieli, B. Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III. Bioorg. Med. Chem., 2008, 16, 6269-6285 (Pubitemid 351758817)
-
(2008)
Bioorganic and Medicinal Chemistry
, vol.16
, Issue.11
, pp. 6269-6285
-
-
Passarella, D.1
Giardini, A.2
Peretto, B.3
Fontana, G.4
Sacchetti, A.5
Silvani, A.6
Ronchi, C.7
Cappelletti, G.8
Cartelli, D.9
Borlak, J.10
Danieli, B.11
-
119
-
-
0027317232
-
Taxamycins: A new enediyne family constructed from versatile disilyl-substituted building blocks
-
Lu, Y. F.; Harwig, C. W.; Fallis, A. G. Taxamycins: a new enediyne family constructed from versatile disilyl-substituted building blocks. J. Org. Chem., 1993, 58, 4202-4204.
-
(1993)
J. Org. Chem.
, vol.58
, pp. 4202-4204
-
-
Lu, Y.F.1
Harwig, C.W.2
Fallis, A.G.3
-
120
-
-
0029552452
-
Taxamycins: A new enediyne family with synthetic and biological potential
-
Lu, Y. F.; Harwig, C. W.; Fallis, A. G. Taxamycins: a new enediyne family with synthetic and biological potential. Can. J. Chem., 1995, 73, 2253-2262.
-
(1995)
Can. J. Chem.
, vol.73
, pp. 2253-2262
-
-
Lu, Y.F.1
Harwig, C.W.2
Fallis, A.G.3
-
121
-
-
0032552099
-
Taxamycin studies: Synthesis of taxoid-calicheamicin hybrids
-
Py, S.; Harwig, C. W.; Banerjee, S.; Brown, D. L.; Fallis, A. G. Taxamycin studies: Synthesis of taxoid-calicheamicin hybrids. Tetrahedron Lett., 1998, 39, 6139-6142.
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 6139-6142
-
-
Py, S.1
Harwig, C.W.2
Banerjee, S.3
Brown, D.L.4
Fallis, A.G.5
-
122
-
-
0033551046
-
A common pharmacophore for cytotoxic natural products that stabilize microtubules
-
Ojima, I.; Chakravarty, S.; Inoue, T.; Lin, S.; He, L.; Horwitz, S. B.; Kuduk, S. D.; Danishefsky, S. J. A common pharmacophore for cytotoxic natural products that stabilize microtubules. Proc. Natl. Acad. Sci. U S A, 1999, 96, 4256-4261
-
(1999)
Proc. Natl. Acad. Sci. U S A
, vol.96
, pp. 4256-4261
-
-
Ojima, I.1
Chakravarty, S.2
Inoue, T.3
Lin, S.4
He, L.5
Horwitz, S.B.6
Kuduk, S.D.7
Danishefsky, S.J.8
-
123
-
-
0034616754
-
Macrocycle formation by ring-closing metathesis. Application to the syntheses of novel macrocyclic taxoids
-
Ojima, I.; Lin, S.; Inoue, T.; Miller, M. L.; Borella, C. P.; Geng, X.; Walsh, J. J. Macrocycle formation by ring-closing metathesis. Application to the syntheses of novel macrocyclic taxoids. J. Am. Chem. Soc., 2000, 122, 5343-5353.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 5343-5353
-
-
Ojima, I.1
Lin, S.2
Inoue, T.3
Miller, M.L.4
Borella, C.P.5
Geng, X.6
Walsh, J.J.7
-
124
-
-
0036009887
-
Synthesis and antimicrotubule activity of combretatropone derivatives
-
And references cited
-
Janik, M. E.; Bane, S. L. Synthesis and antimicrotubule activity of combretatropone derivatives. Bioorg. Med. Chem., 2002, 10, 1895-1903 And references cited.
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 1895-1903
-
-
Janik, M.E.1
Bane, S.L.2
-
125
-
-
0029876863
-
Structural analysis of the substoichiometric and stoichiometric microtubule-inhibiting biphenyl analogues of colchicine
-
DOI 10.1021/bi950524p
-
Rossi, M.; Gorbunoff, M. J.; Caruso, F.; Wing, B.; Perez-Ramirez, B.; Timasheff, S. N. Structural analysis of the substoichiometric and stoichiometric microtuble-inhibiting biphenyl analogues of colchicine. Biochemistry, 1996, 35, 3286-3289 (Pubitemid 26082257)
-
(1996)
Biochemistry
, vol.35
, Issue.10
, pp. 3286-3289
-
-
Rossi, M.1
Gorbunoff, M.J.2
Caruso, F.3
Wing, B.4
Perez-Ramirez, B.5
Timasheff, S.N.6
-
126
-
-
0027522753
-
Synthesis and tubulin binding of novel C-10 analogues of colchicine
-
Staretz, M. E.; Hastie, S. B. Synthesis and tubulin binding of novel C-10 analogues of colchicine. J. Med. Chem., 1993, 36, 758-764
-
(1993)
J. Med. Chem.
, vol.36
, pp. 758-764
-
-
Staretz, M.E.1
Hastie, S.B.2
-
127
-
-
0025951280
-
Structural requirements for the binding of colchicine analogs to tubulin: The role of the C-10 substituent
-
Hahn, K. M.; Humphreys, W. G.; Helms, A. M.; Hastie, S. B.; Macdonald, T. L. Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent. Bioorg. Med. Chem. Lett., 1991, 1, 471-476.
-
(1991)
Bioorg. Med. Chem. Lett.
, vol.1
, pp. 471-476
-
-
Hahn, K.M.1
Humphreys, W.G.2
Helms, A.M.3
Hastie, S.B.4
Macdonald, T.L.5
-
128
-
-
0024423981
-
A thermodynamic study of the interaction of tubulin with colchicine site ligands
-
Menendez, M.; Laynez, J.; Medrano, F. J.; Andreu, J. M. A thermodynamic study of the interaction of tubulin with colchicine site ligands. J. Biol. Chem., 1989, 264, 16367-16371
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 16367-16371
-
-
Menendez, M.1
Laynez, J.2
Medrano, F.J.3
Andreu, J.M.4
-
129
-
-
0035861845
-
Caulerpenyne from Caulerpa taxifolia has an antiproliferative activity on tumor cell line SK-N-SH and modifies the microtubule network
-
DOI 10.1016/S0024-3205(01)01396-0, PII S0024320501013960
-
Barbier, P.; Guise, S.; Huitorel, P.; Amade, P.; Pesando, D.; Briand, C.; Peyrot, V. Caulerpenyne from Caulerpa taxifolia has an antiproliferative activity on tumor cell line SK-N-SH and modifies the microtubule network. Life Sci., 2001, 70, 415-429. (Pubitemid 34017536)
-
(2001)
Life Sciences
, vol.70
, Issue.4
, pp. 415-429
-
-
Barbier, P.1
Guise, S.2
Huitorel, P.3
Amade, P.4
Pesando, D.5
Briand, C.6
Peyrot, V.7
-
130
-
-
30944460862
-
Total Synthesis of Terpenoids Isolated from Caulerpale Algae and Their Inhibition of Tubulin Assembly
-
Commeiras, L.; Bourdron, J.; Douillard, S.; Barbier, P.; Vanthuyne, N.; Peyrot, V.; Parrain, J. Total Synthesis of Terpenoids Isolated from Caulerpale Algae and Their Inhibition of Tubulin Assembly. Synthesis, 2006, 1, 166.
-
(2006)
Synthesis
, vol.1
, pp. 166
-
-
Commeiras, L.1
Bourdron, J.2
Douillard, S.3
Barbier, P.4
Vanthuyne, N.5
Peyrot, V.6
Parrain, J.7
-
131
-
-
33745713018
-
Caulerpenyne-colchicine hybrid: Synthesis and biological evaluation
-
DOI 10.1016/j.bmc.2006.04.024, PII S0968089606003051
-
Bourdron, J.; Commeiras, L.; Barbier, P.; Bourgarel-Rey, V.; Pasquier, E.; Vanthuyne, N.; Hubaud, J. C.; Peyrot, V.; Parrain, J. L. Caulerpenyne-colchicine hybrid: synthesis and biological evaluation. Bioorg. Med. Chem., 2006, 14, 5540-5548 (Pubitemid 43996987)
-
(2006)
Bioorganic and Medicinal Chemistry
, vol.14
, Issue.16
, pp. 5540-5548
-
-
Bourdron, J.1
Commeiras, L.2
Barbier, P.3
Bourgarel-Rey, V.4
Pasquier, E.5
Vanthuyne, N.6
Hubaud, J.-C.7
Peyrot, V.8
Parrain, J.-L.9
-
132
-
-
3142764930
-
Lamellarins, from A to Z: A family of anticancer marine pyrrole alkaloids
-
Bailly, C. Lamellarins, from A to Z: a family of anticancer marine pyrrole alkaloids. Curr. Med. Chem. Anti-Cancer Agents, 2004, 4, 363.
-
(2004)
Curr. Med. Chem. Anti-Cancer Agents
, vol.4
, pp. 363
-
-
Bailly, C.1
-
133
-
-
33646750713
-
4, 5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents
-
Banwell, M. G.; Hamel, E.; Hockless, D. C. R.; Verdier-Pinard, P.; Willis, A. C.; Wong, D. J. 4, 5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents. Bioorg. Med. Chem., 2006, 14, 4627-4638.
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 4627-4638
-
-
Banwell, M.G.1
Hamel, E.2
Hockless, D.C.R.3
Verdier-Pinard, P.4
Willis, A.C.5
Wong, D.J.6
-
134
-
-
18744409805
-
The chemistry and biology of antimitotic chalcones and related enone systems
-
Lawrence, N. J.; McGown, A. T. The chemistry and biology of antimitotic chalcones and related enone systems. Curr. Pharm. Des., 2005, 11, 1679-1693
-
(2005)
Curr. Pharm. Des.
, vol.11
, pp. 1679-1693
-
-
Lawrence, N.J.1
McGown, A.T.2
-
135
-
-
34447545619
-
Combretastatin-chalcone hybrids: Synthesis and cytotoxicity
-
Nam, N. H.; Byung-Zun, A. Combretastatin-chalcone hybrids: synthesis and cytotoxicity. Med. Chem., 2007, 3, 373-377
-
(2007)
Med. Chem.
, vol.3
, pp. 373-377
-
-
Nam, N.H.1
Byung-Zun, A.2
-
136
-
-
55549135317
-
Structural insight into the inhibition of tubulin by vinca domain peptide ligands
-
Cormier, A.; Marchand, M.; Ravelli, R. B.; Knossow, M.; Gigant, B. Structural insight into the inhibition of tubulin by vinca domain peptide ligands. EMBO Rep., 2008, 9, 1101-1106
-
(2008)
EMBO Rep.
, vol.9
, pp. 1101-1106
-
-
Cormier, A.1
Marchand, M.2
Ravelli, R.B.3
Knossow, M.4
Gigant, B.5
-
137
-
-
59449089370
-
Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids
-
Ngo, Q. A.; Roussi, F.; Cormier, A.; Thoret, S.; Knossow, M.; Guenard, D.; Gueritte, F. Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids. J. Med. Chem., 2009, 52, 134-142
-
(2009)
J. Med. Chem.
, vol.52
, pp. 134-142
-
-
Ngo, Q.A.1
Roussi, F.2
Cormier, A.3
Thoret, S.4
Knossow, M.5
Guenard, D.6
Gueritte, F.7
-
138
-
-
0029564203
-
Interaction of cryptophycin 1 with tubulin and microtubules
-
Kerksiek, K.; Mejillano, M. R.; Schwartz, R. E.; Georg, G. I.; Himes, R. H. Interaction of cryptophycin 1 with tubulin and microtubules. FEBS Lett., 1995, 377, 59-61.
-
(1995)
FEBS Lett.
, vol.377
, pp. 59-61
-
-
Kerksiek, K.1
Mejillano, M.R.2
Schwartz, R.E.3
Georg, G.I.4
Himes, R.H.5
-
139
-
-
33748940418
-
Synthesis of cryptothilone 1, the first cryptophycin-epothilone hybrid
-
DOI 10.1021/ol0614020
-
White, J. D.; Smits, H.; Hamel, E. Synthesis of cryptothilone 1, the first cryptophycin-epothilone hybrid. Org. Lett., 2006, 8, 3947-3950 (Pubitemid 44432827)
-
(2006)
Organic Letters
, vol.8
, Issue.18
, pp. 3947-3950
-
-
White, J.D.1
Smits, H.2
Hamel, E.3
-
140
-
-
1842431809
-
Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp
-
Paterson, I.; Britton, R.; Delgado, O.; Wright, A. E. Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp. Chem. Commun. (Camb.), 2004, 632-633
-
(2004)
Chem. Commun. (Camb.)
, pp. 632-633
-
-
Paterson, I.1
Britton, R.2
Delgado, O.3
Wright, A.E.4
-
141
-
-
28844499921
-
Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicity
-
Buey, R. M.; Barasoain, I.; Jackson, E.; Meyer, A.; Giannakakou, P.; Paterson, I.; Mooberry, S.; Andreu, J. M.; Diaz, J. F. Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity. Chem. Biol., 2005, 12, 1269-1279
-
(2005)
Chem. Biol.
, vol.12
, pp. 1269-1279
-
-
Buey, R.M.1
Barasoain, I.2
Jackson, E.3
Meyer, A.4
Giannakakou, P.5
Paterson, I.6
Mooberry, S.7
Andreu, J.M.8
Diaz, J.F.9
-
142
-
-
0038005594
-
Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin
-
Isbrucker, R. A.; Cummins, J.; Pomponi, S. A.; Longley, R. E.; Wright, A. E. Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin. Biochem. Pharmacol., 2003, 66, 75-82.
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 75-82
-
-
Isbrucker, R.A.1
Cummins, J.2
Pomponi, S.A.3
Longley, R.E.4
Wright, A.E.5
-
143
-
-
0030039669
-
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
-
ter Haar, E.; Kowalski, R. J.; Hamel, E.; Lin, C. M.; Longley, R. E.; Gunasekera, S. P.; Rosenkranz, H. S.; Day, B. W. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry, 1996, 35, 243-250
-
(1996)
Biochemistry
, vol.35
, pp. 243-250
-
-
Ter Haar, E.1
Kowalski, R.J.2
Hamel, E.3
Lin, C.M.4
Longley, R.E.5
Gunasekera, S.P.6
Rosenkranz, H.S.7
Day, B.W.8
-
144
-
-
0037069732
-
Discodermolide/Dictyostatin hybrids: Synthesis and biological evaluation
-
Shin, Y.; Choy, N.; Turner, T. R.; Balachandran, R.; Madiraju, C.; Day, B. W.; Curran, D. P. Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation. Org. Lett., 2002, 4, 4443-4446
-
(2002)
Org. Lett.
, vol.4
, pp. 4443-4446
-
-
Shin, Y.1
Choy, N.2
Turner, T.R.3
Balachandran, R.4
Madiraju, C.5
Day, B.W.6
Curran, D.P.7
-
145
-
-
33845503870
-
Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid
-
DOI 10.1039/b615122a
-
Paterson, I.; Gardner, N. M. Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid. Chem. Commun. (Camb.), 2007, 49-51. (Pubitemid 44913083)
-
(2007)
Chemical Communications
, Issue.1
, pp. 49-51
-
-
Paterson, I.1
Gardner, N.M.2
-
146
-
-
52649167707
-
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide
-
Paterson, I.; Naylor, G. J.; Wright, A. E. Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide. Chem. Commun. (Camb.), 2008, 4628-4630
-
(2008)
Chem. Commun. (Camb.)
, pp. 4628-4630
-
-
Paterson, I.1
Naylor, G.J.2
Wright, A.E.3
-
147
-
-
0037447174
-
HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo
-
Loganzo, F.; Discafani, C. M.; Annable, T.; Beyer, C.; Musto, S.; Hari, M.; Tan, X.; Hardy, C.; Hernandez, R.; Baxter, M.; Singanallore, T.; Khafizova, G.; Poruchynsky, M. S.; Fojo, T.; Nieman, J. A.; Ayral-Kaloustian, S.; Zask, A.; Andersen, R. J.; Greenberger, L. M. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res., 2003, 63, 1838-1845
-
(2003)
Cancer Res.
, vol.63
, pp. 1838-1845
-
-
Loganzo, F.1
Discafani, C.M.2
Annable, T.3
Beyer, C.4
Musto, S.5
Hari, M.6
Tan, X.7
Hardy, C.8
Hernandez, R.9
Baxter, M.10
Singanallore, T.11
Khafizova, G.12
Poruchynsky, M.S.13
Fojo, T.14
Nieman, J.A.15
Ayral-Kaloustian, S.16
Zask, A.17
Andersen, R.J.18
Greenberger, L.M.19
-
148
-
-
29344454439
-
Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents
-
DOI 10.1021/ja053663v
-
Zask, A.; Kaplan, J.; Musto, S.; Loganzo, F. Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents. J.
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.50
, pp. 17667-17671
-
-
Zask, A.1
Kaplan, J.2
Musto, S.3
Loganzo, F.4
-
149
-
-
62149129314
-
Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation
-
Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Cara, C. L.; Balzarini, J.; Hamel, E.; Canella, A.; Fabbri, E.; Gambari, R.; Basso, G.; Viola, G. Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation. Bioorg. Med. Chem. Lett., 2009, 19, 2022-2028
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 2022-2028
-
-
Romagnoli, R.1
Baraldi, P.G.2
Carrion, M.D.3
Cruz-Lopez, O.4
Cara, C.L.5
Balzarini, J.6
Hamel, E.7
Canella, A.8
Fabbri, E.9
Gambari, R.10
Basso, G.11
Viola, G.12
-
150
-
-
33845302853
-
Tumor selectivity of Hsp90 inhibitors: The explanation remains elusive
-
Chiosis, G.; Neckers, L. Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive. ACS Chem. Biol., 2006, 1, 279-284
-
(2006)
ACS Chem. Biol.
, vol.1
, pp. 279-284
-
-
Chiosis, G.1
Neckers, L.2
-
151
-
-
3042637928
-
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms
-
Wright, L.; Barril, X.; Dymock, B.; Sheridan, L.; Surgenor, A.; Beswick, M.; Drysdale, M.; Collier, A.; Massey, A.; Davies, N.; Fink, A.; Fromont, C.; Aherne, W.; Boxall, K.; Sharp, S.; Workman, P.; Hubbard, R. E. Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms. Chem. Biol., 2004, 11, 775-785
-
(2004)
Chem. Biol.
, vol.11
, pp. 775-785
-
-
Wright, L.1
Barril, X.2
Dymock, B.3
Sheridan, L.4
Surgenor, A.5
Beswick, M.6
Drysdale, M.7
Collier, A.8
Massey, A.9
Davies, N.10
Fink, A.11
Fromont, C.12
Aherne, W.13
Boxall, K.14
Sharp, S.15
Workman, P.16
Hubbard, R.E.17
-
152
-
-
0141518578
-
Structural requirements for the interaction of combretastatins with tubulin: How important is the trimethoxy unit?
-
Gaukroger, K.; Hadfield, J. A.; Lawrence, N. J.; Nolan, S.; McGown, A. T. Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit? Org. Biomol. Chem., 2003, 1, 3033-3037
-
(2003)
Org. Biomol. Chem.
, vol.1
, pp. 3033-3037
-
-
Gaukroger, K.1
Hadfield, J.A.2
Lawrence, N.J.3
Nolan, S.4
McGown, A.T.5
-
153
-
-
65249117573
-
Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin
-
Knox, A. J.; Price, T.; Pawlak, M.; Golfis, G.; Flood, C. T.; Fayne, D.; Williams, D. C.; Meegan, M. J.; Lloyd, D. G. Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin. J. Med. Chem., 2009, 52, 2177-2180
-
(2009)
J. Med. Chem.
, vol.52
, pp. 2177-2180
-
-
Knox, A.J.1
Price, T.2
Pawlak, M.3
Golfis, G.4
Flood, C.T.5
Fayne, D.6
Williams, D.C.7
Meegan, M.J.8
Lloyd, D.G.9
-
154
-
-
15144361344
-
Prodrugs of anthracyclines for use in antibody-directed enzyme prodrug therapy
-
DOI 10.1021/jm970589l
-
Florent, J. C.; Dong, X.; Gaudel, G.; Mitaku, S.; Monneret, C.; Gesson, J. P.; Jacquesy, J. C.; Mondon, M.; Renoux, B.; Andri-anomenjanahary, S.; Michel, S.; Koch, M.; Tillequin, F.; Gerken, M.; Czech, J.; Straub, R.; Bosslet, K. Prodrugs of anthracyclines for use in antibody-directed enzyme prodrug therapy. J. Med. Chem., 1998, 41, 3572-3581 (Pubitemid 28449340)
-
(1998)
Journal of Medicinal Chemistry
, vol.41
, Issue.19
, pp. 3572-3581
-
-
Florent, J.-C.1
Dong, X.2
Gaudel, G.3
Mitaku, S.4
Monneret, C.5
Gesson, J.-P.6
Jacquesy, J.-C.7
Mondon, M.8
Renoux, B.9
Andrianomenjanahary, S.10
Michel, S.11
Koch, M.12
Tillequin, F.13
Gerken, M.14
Czech, J.15
Straub, R.16
Bosslet, K.17
-
155
-
-
0032922077
-
Antineoplastic efficacy of doxorubicin enzymatically assembled on galactose residues of a monoclonal antibody specific for the carcinoembryonic antigen
-
Stan, A. C.; Radu, D. L.; Casares, S.; Bona, C. A.; Brumeanu, T. D. Antineoplastic efficacy of doxorubicin enzymatically assembled on galactose residues of a monoclonal antibody specific for the carcinoembryonic antigen. Cancer Res., 1999, 59, 115-121
-
(1999)
Cancer Res.
, vol.59
, pp. 115-121
-
-
Stan, A.C.1
Radu, D.L.2
Casares, S.3
Bona, C.A.4
Brumeanu, T.D.5
-
156
-
-
22844439645
-
Recent advances in the new generation taxane anticancer agents
-
Geney, R.; Chen, J.; Ojima, I. Recent advances in the new generation taxane anticancer agents. Med. Chem., 2005, 1, 125-139
-
(2005)
Med. Chem.
, vol.1
, pp. 125-139
-
-
Geney, R.1
Chen, J.2
Ojima, I.3
-
157
-
-
58149161759
-
Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker
-
Oflazoglu, E.; Stone, I. J.; Gordon, K.; Wood, C. G.; Repasky, E. A.; Grewal, I. S.; Law, C. L.; Gerber, H. P. Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker. Clin. Cancer Res., 2008, 14, 6171-6180
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6171-6180
-
-
Oflazoglu, E.1
Stone, I.J.2
Gordon, K.3
Wood, C.G.4
Repasky, E.A.5
Grewal, I.S.6
Law, C.L.7
Gerber, H.P.8
-
158
-
-
0035862692
-
Taxane-antibody conjugates afford potent cytotoxicity, enhanced solubility, and tumor target selectivity
-
Guillemard, V.; Saragovi, H. U. Taxane-antibody conjugates afford potent cytotoxicity, enhanced solubility, and tumor target selectivity. Cancer Res., 2001, 61, 694-699
-
(2001)
Cancer Res.
, vol.61
, pp. 694-699
-
-
Guillemard, V.1
Saragovi, H.U.2
-
159
-
-
24344507278
-
Drug-conjugated monoclonal antibodies for the treatment of cancer
-
DOI 10.1016/j.coph.2005.04.017, PII S1471489205001177
-
Lambert, J. M. Drug-conjugated monoclonal antibodies for the treatment of cancer. Curr. Opin. Pharmacol., 2005, 5, 543-549 (Pubitemid 41258574)
-
(2005)
Current Opinion in Pharmacology
, vol.5
, Issue.5 SPEC.ISS
, pp. 543-549
-
-
Lambert, J.M.1
-
160
-
-
0037347183
-
Synthesis and biological evaluation of paclitaxel-C225 conjugate as a model for targeted drug delivery
-
Safavy, A.; Bonner, J. A.; Waksal, H. W.; Buchsbaum, D. J.; Gillespie, G. Y.; Khazaeli, M. B.; Arani, R.; Chen, D. T.; Carpenter, M.; Raisch, K. P. Synthesis and biological evaluation of paclitaxel-C225 conjugate as a model for targeted drug delivery. Bioconjug. Chem., 2003, 14, 302-310
-
(2003)
Bioconjug. Chem.
, vol.14
, pp. 302-310
-
-
Safavy, A.1
Bonner, J.A.2
Waksal, H.W.3
Buchsbaum, D.J.4
Gillespie, G.Y.5
Khazaeli, M.B.6
Arani, R.7
Chen, D.T.8
Carpenter, M.9
Raisch, K.P.10
-
161
-
-
0032727981
-
Paclitaxel derivatives for targeted therapy of cancer: Toward the development of smart taxanes
-
Safavy, A.; Raisch, K. P.; Khazaeli, M. B.; Buchsbaum, D. J.; Bonner, J. A. Paclitaxel derivatives for targeted therapy of cancer: toward the development of smart taxanes. J. Med. Chem., 1999, 42, 4919-4924
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4919-4924
-
-
Safavy, A.1
Raisch, K.P.2
Khazaeli, M.B.3
Buchsbaum, D.J.4
Bonner, J.A.5
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