Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin

Biochemistry

Volumn 43, Issue 21, 2004, Pages 6645-6655

  Gupta, Kamlesh ^a   Bishop, Jamie ^b   Peck, Austin ^b   Brown, Julie ^b   Wilson, Leslie ^b   Panda, Dulal ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; DISEASE CONTROL; DRUG PRODUCTS; ENZYME INHIBITION; FUNGI; POLYMERIZATION; TUMORS;

ANTIFUNGAL AGENTS; BENOMYL; BRAIN TUBULIN;

BIOCHEMISTRY;

5,5' DITHIOBIS(2 NITROBENZOIC ACID); 8 ANILINO 1 NAPHTHALENESULFONIC ACID; ANTIFUNGAL AGENT; ANTIMITOTIC AGENT; BENOMYL; COLCHICINE; CYSTEINE; TUBULIN; VINBLASTINE;

ARTICLE; BRAIN; CANCER ADJUVANT THERAPY; CANCER CELL; CELL PROLIFERATION; CHROMOSOME STRUCTURE; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; HELA CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; MAMMAL; MICROTUBULE ASSEMBLY; MITOSIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; BENOMYL; BINDING SITES; BRAIN; CELL DIVISION; COLCHICINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MAMMALS; MICROTUBULES; MITOSIS; PROTEIN CONFORMATION; TUBULIN; TUMOR CELLS, CULTURED;

FUNGI; MAMMALIA;

EID: 2542603198     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036112v     Document Type: Article

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