Identification and characterization of an intermediate taxol binding site within microtubule nanopores and a mechanism for tubulin isotype binding selectivity

Journal of Chemical Information and Modeling

Volumn 49, Issue 2, 2009, Pages 424-436

  Freedman, Holly ^a   Huzil, J Torin ^a   Luchko, Tyler ^a   Ludueña, Richard F ^b   Tuszynski, Jack A ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMOTHERAPY; DISEASES; HYDROGEN BONDS; MOLECULAR DYNAMICS; MOLECULES;

ANTICANCER DRUG; BINDING SELECTIVITY; CANCER CHEMOTHERAPY; HETERO DIMERS; HYDROGEN BOND INTERACTION; KINETIC EFFECT; SMALL MOLECULES; TARGETED MOLECULAR DYNAMICS;

NANOPORES;

ANTINEOPLASTIC AGENT; PACLITAXEL;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MICROTUBULE;

ANTINEOPLASTIC AGENTS; BINDING SITES; MICROTUBULES; MODELS, MOLECULAR; PACLITAXEL;

EID: 65249157992     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci8003336     Document Type: Article

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