Structural basis for the regulation of tubulin by vinblastine

Nature

Volumn 435, Issue 7041, 2005, Pages 519-522

  Gigant, Benoît ^a   Wang, Chunguang ^a   Ravelli, Raimond B G ^b   Roussi, Fanny ^c   Steinmetz, Michel O ^d   Curmi, Patrick A ^e,f   Sobel, André ^e   Knossow, Marcel ^a  

^a LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^c CNRS   (France)

^d PAUL SCHERRER INSTITUTE   (Switzerland)

^e INSTITUT DU FER À MOULIN   (France)

^f UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ELECTRON MICROSCOPY; HYDROPHOBICITY; TUMORS; X RAY ANALYSIS;

ANTITUMOR DRUGS; CHEMOTHERAPEUTIC SUCCESSES; TUBULIN; VINBLASTINE;

DRUG PRODUCTS;

ALPHA TUBULIN; ANTINEOPLASTIC AGENT; COLCHICINE; PACLITAXEL; STATHMIN; TUBULIN; VINBLASTINE; VINCA ALKALOID;

BIOCHEMISTRY; MEDICINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOCHEMISTRY; CANCER CHEMOTHERAPY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; ELECTRON MICROSCOPY; HYDROPHOBICITY; MICROTUBULE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; X RAY ANALYSIS;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HYDROPHOBICITY; KINETICS; MICROTUBULE PROTEINS; MODELS, MOLECULAR; PHOSPHOPROTEINS; PROTEIN STRUCTURE, TERTIARY; STATHMIN; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; VINBLASTINE;

VINCA;

EID: 19544393159     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03566     Document Type: Article

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