-
1
-
-
33846457870
-
Cancer statistics, 2007
-
Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.
-
(2007)
CA Cancer J Clin
, vol.57
, pp. 43-66
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Murray, T.4
Xu, J.5
Thun, M.J.6
-
2
-
-
22144484150
-
Androgen deprivation therapy for prostate cancer
-
Sharifi N, Gulley JL, Dahut WL. Androgen deprivation therapy for prostate cancer. JAMA 2005;294:238-44.
-
(2005)
JAMA
, vol.294
, pp. 238-244
-
-
Sharifi, N.1
Gulley, J.L.2
Dahut, W.L.3
-
3
-
-
33644675811
-
Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgen-receptor signaling axis
-
Scher HI, Sawyers CL. Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol 2005;23:8253-61.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8253-8261
-
-
Scher, H.I.1
Sawyers, C.L.2
-
4
-
-
2342558431
-
Androgen receptor in prostate cancer
-
Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004;25:276-308.
-
(2004)
Endocr Rev
, vol.25
, pp. 276-308
-
-
Heinlein, C.A.1
Chang, C.2
-
5
-
-
1542574202
-
Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance
-
Holzbeierlein J, Lal P, LaTulippe E, et al. Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am J Pathol 2004;164:217-27.
-
(2004)
Am J Pathol
, vol.164
, pp. 217-227
-
-
Holzbeierlein, J.1
Lal, P.2
LaTulippe, E.3
-
6
-
-
33750448008
-
The case for secondary hormonal therapies in the chemotherapy age
-
Small EJ, Ryan CJ. The case for secondary hormonal therapies in the chemotherapy age. J Urol 2006;176:S66-71.
-
(2006)
J Urol
, vol.176
-
-
Small, E.J.1
Ryan, C.J.2
-
7
-
-
33646576828
-
Androgen receptor as a therapeutic target for androgen independent prostate cancer
-
Sharifi N, Farrar WL. Androgen receptor as a therapeutic target for androgen independent prostate cancer. Am J Ther 2006;13:166-70.
-
(2006)
Am J Ther
, vol.13
, pp. 166-170
-
-
Sharifi, N.1
Farrar, W.L.2
-
8
-
-
4744337716
-
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
-
Petrylak DP, Tangen CM, Hussain MH, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004;351:1513-20.
-
(2004)
N Engl J Med
, vol.351
, pp. 1513-1520
-
-
Petrylak, D.P.1
Tangen, C.M.2
Hussain, M.H.3
-
9
-
-
4744366279
-
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
-
Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004;351:1502-12.
-
(2004)
N Engl J Med
, vol.351
, pp. 1502-1512
-
-
Tannock, I.F.1
de Wit, R.2
Berry, W.R.3
-
10
-
-
11144225831
-
Evidence for glucocorticoid receptor transport on microtubules by dynein
-
Harrell JM, Murphy PJ, Morishima Y, et al. Evidence for glucocorticoid receptor transport on microtubules by dynein. J Biol Chem 2004;279:54647-54.
-
(2004)
J Biol Chem
, vol.279
, pp. 54647-54654
-
-
Harrell, J.M.1
Murphy, P.J.2
Morishima, Y.3
-
11
-
-
30444446327
-
Molecular dynamics simulations of ligand dissociation from thyroid hormone receptors: Evidence of the likeliest escape pathway and its implications for the design of novel ligands
-
Martinez L, Webb P, Polikarpov I, Skaf MS. Molecular dynamics simulations of ligand dissociation from thyroid hormone receptors: evidence of the likeliest escape pathway and its implications for the design of novel ligands. J Med Chem 2006;49:23-6.
-
(2006)
J Med Chem
, vol.49
, pp. 23-26
-
-
Martinez, L.1
Webb, P.2
Polikarpov, I.3
Skaf, M.S.4
-
12
-
-
20044394709
-
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor
-
Estebanez-Perpina E, Moore JM, Mar E, et al. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J Biol Chem 2005;280:8060-8.
-
(2005)
J Biol Chem
, vol.280
, pp. 8060-8068
-
-
Estebanez-Perpina, E.1
Moore, J.M.2
Mar, E.3
-
13
-
-
0026328348
-
Interactions of colchicine with tubulin
-
Hastie SB. Interactions of colchicine with tubulin. Pharmacol Ther 1991;51:377-401.
-
(1991)
Pharmacol Ther
, vol.51
, pp. 377-401
-
-
Hastie, S.B.1
-
14
-
-
0025967083
-
Stereochemistry of colchicinoids. Enantiomeric stability and binding to tubulin of desacetamidocolchicine and desacetamidoisocolchicine
-
Berg U, Deinum J, Lincoln P, Kvassman J. Stereochemistry of colchicinoids. Enantiomeric stability and binding to tubulin of desacetamidocolchicine and desacetamidoisocolchicine. Bioorg Chem 1991;19:53-65.
-
(1991)
Bioorg Chem
, vol.19
, pp. 53-65
-
-
Berg, U.1
Deinum, J.2
Lincoln, P.3
Kvassman, J.4
-
15
-
-
0242658820
-
Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate
-
Cogan PS, Koch TH. Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. J Med Chem 2003;46:5258-70.
-
(2003)
J Med Chem
, vol.46
, pp. 5258-5270
-
-
Cogan, P.S.1
Koch, T.H.2
-
16
-
-
10844268815
-
Synthesis and characterization of a cobalamin-colchicine conjugate as a novel tumor-targeted cytotoxin
-
Bagnato JD, Eilers AL, Horton RA, Grissom CB. Synthesis and characterization of a cobalamin-colchicine conjugate as a novel tumor-targeted cytotoxin. J Org Chem 2004;69:8987-96.
-
(2004)
J Org Chem
, vol.69
, pp. 8987-8996
-
-
Bagnato, J.D.1
Eilers, A.L.2
Horton, R.A.3
Grissom, C.B.4
-
17
-
-
27844611242
-
Structural basis for accommodation of nonsteroidal ligands in the androgen receptor
-
Bohl CE, Miller DD, Chen J, Bell CE, Dalton JT. Structural basis for accommodation of nonsteroidal ligands in the androgen receptor. J Biol Chem 2005;280:37747-54.
-
(2005)
J Biol Chem
, vol.280
, pp. 37747-37754
-
-
Bohl, C.E.1
Miller, D.D.2
Chen, J.3
Bell, C.E.4
Dalton, J.T.5
-
18
-
-
33845902528
-
Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator: Potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats
-
Ostrowski J, Kuhns JE, Lupisella JA, et al. Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology 2007;148:4-12.
-
(2007)
Endocrinology
, vol.148
, pp. 4-12
-
-
Ostrowski, J.1
Kuhns, J.E.2
Lupisella, J.A.3
-
19
-
-
0037188507
-
Evaluating conformational free energies: The colony energy and its application to the problem of loop prediction
-
Xiang Z, Soto CS, Honig B. Evaluating conformational free energies: the colony energy and its application to the problem of loop prediction. Proc Natl Acad Sci U S A 2002;99:7432-7.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 7432-7437
-
-
Xiang, Z.1
Soto, C.S.2
Honig, B.3
-
20
-
-
27344454932
-
GROMACS: Fast, flexible, and free
-
Van Der Spoel D, Lindahl E, Hess B, Groenhof G, Mark AE, Berendsen HJ. GROMACS: fast, flexible, and free. J Comput Chem 2005;26:1701-18.
-
(2005)
J Comput Chem
, vol.26
, pp. 1701-1718
-
-
Van Der Spoel, D.1
Lindahl, E.2
Hess, B.3
Groenhof, G.4
Mark, A.E.5
Berendsen, H.J.6
-
21
-
-
7544226311
-
-
Schuettelkopf AW vAD. PRODRG - a tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallographica 2004;D60:1355-63.
-
Schuettelkopf AW vAD. PRODRG - a tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallographica 2004;D60:1355-63.
-
-
-
-
22
-
-
0030987036
-
Molecular dynamics study of unbinding of the avidin-biotin complex
-
Izrailev S, Stepaniants S, Balsera M, Oono Y, Schulten K. Molecular dynamics study of unbinding of the avidin-biotin complex. Biophys J 1997;72:1568-81.
-
(1997)
Biophys J
, vol.72
, pp. 1568-1581
-
-
Izrailev, S.1
Stepaniants, S.2
Balsera, M.3
Oono, Y.4
Schulten, K.5
-
23
-
-
0142036683
-
Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin
-
Hamel E. Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin. Cell Biochem Biophys 2003;38:1-22.
-
(2003)
Cell Biochem Biophys
, vol.38
, pp. 1-22
-
-
Hamel, E.1
-
24
-
-
0031913357
-
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells
-
Verdier-Pinard P, Lai JY, Yoo HD, et al. Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells. Mol Pharmacol 1998;53:62-76.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 62-76
-
-
Verdier-Pinard, P.1
Lai, J.Y.2
Yoo, H.D.3
-
25
-
-
0029863106
-
Enantioselective binding of Casodex to the androgen receptor
-
Mukherjee A, Kirkovsky L, Yao XT, Yates RC, Miller DD, Dalton JT. Enantioselective binding of Casodex to the androgen receptor. Xenobiotica 1996;26:117-22.
-
(1996)
Xenobiotica
, vol.26
, pp. 117-122
-
-
Mukherjee, A.1
Kirkovsky, L.2
Yao, X.T.3
Yates, R.C.4
Miller, D.D.5
Dalton, J.T.6
-
27
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski AM, Pike AC, Dauter Z, et al. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 1997;389:753-8.
-
(1997)
Nature
, vol.389
, pp. 753-758
-
-
Brzozowski, A.M.1
Pike, A.C.2
Dauter, Z.3
-
28
-
-
0029012163
-
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
-
Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 1995;375:377-82.
-
(1995)
Nature
, vol.375
, pp. 377-382
-
-
Bourguet, W.1
Ruff, M.2
Chambon, P.3
Gronemeyer, H.4
Moras, D.5
-
29
-
-
1642401199
-
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
-
Ravelli RB, Gigant B, Curmi PA, et al. Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature 2004;428:198-202.
-
(2004)
Nature
, vol.428
, pp. 198-202
-
-
Ravelli, R.B.1
Gigant, B.2
Curmi, P.A.3
-
30
-
-
0024427745
-
Antimitotic natural products combretastatin A-4 and combretastatin A-2: Studies on the mechanism of their inhibition of the binding of colchicine to tubulin
-
Lin CM, Ho HH, Pettit GR, Hamel E. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. Biochemistry 1989;28:6984-91.
-
(1989)
Biochemistry
, vol.28
, pp. 6984-6991
-
-
Lin, C.M.1
Ho, H.H.2
Pettit, G.R.3
Hamel, E.4
-
31
-
-
0028331925
-
2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site
-
D'Amato RJ, Lin CM, Flynn E, Folkman J, Hamel E. 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc Natl Acad Sci U S A 1994;91:3964-8.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 3964-3968
-
-
D'Amato, R.J.1
Lin, C.M.2
Flynn, E.3
Folkman, J.4
Hamel, E.5
-
32
-
-
0025644325
-
A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens
-
Veldscholte J, Ris-Stalpers C, Kuiper GG, et al. A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. Biochem Biophys Res Commun 1990;173:534-40.
-
(1990)
Biochem Biophys Res Commun
, vol.173
, pp. 534-540
-
-
Veldscholte, J.1
Ris-Stalpers, C.2
Kuiper, G.G.3
-
33
-
-
0036645414
-
Molecular biology of the androgen receptor
-
Gelmann EP. Molecular biology of the androgen receptor. J Clin Oncol 2002;20:3001-15.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3001-3015
-
-
Gelmann, E.P.1
|