Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: Model studies of enzymatic drug release and antigen-specific in vitro anticancer activity

Bioconjugate Chemistry

Volumn 13, Issue 4, 2002, Pages 855-869

  Dubowchik, Gene M ^a   Firestone, Raymond A ^a,b   Padilla, Linda ^a   Willner, David ^a   Hofstead, Sandra J ^a   Mosure, Kathleen ^a   Knipe, Jay O ^a   Lasch, Shirley J ^a,c   Trail, Pamela A ^a,c  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; MONOCLONAL ANTIBODIES; PEPTIDES; PLASMA STABILITY; TARGETED DRUG DELIVERY; TUMORS;

ANTICANCER ACTIVITIES; ANTICANCER DRUG; CATHEPSIN B; DI-PEPTIDES; DOXORUBICIN; DRUG RELEASE; IMMUNOCONJUGATE; IN-VITRO; MODELLING STUDIES; SELF-IMMOLATIVE;

ANTIGENS;

BR96 DOXORUBICIN IMMUNOCONJUGATE; BR96-DOXORUBICIN IMMUNOCONJUGATE; CATHEPSIN B; CROSS LINKING REAGENT; DIPEPTIDE; DOXORUBICIN; ENZYME; LEWIS Y ANTIGEN; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

ANIMAL; ARTICLE; BLOOD GROUP LEWIS SYSTEM; CELL CULTURE; CELL DIVISION; CHEMISTRY; DRUG EFFECT; DRUG STABILITY; ENZYMOLOGY; HUMAN; IMMUNOLOGY; KINETICS; LYSOSOME; METABOLISM; RAT; SYNTHESIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CATHEPSIN B; CELL DIVISION; CROSS-LINKING REAGENTS; DIPEPTIDES; DOXORUBICIN; DRUG STABILITY; ENZYMES; HUMANS; KINETICS; LEWIS BLOOD-GROUP SYSTEM; LYSOSOMES; RATS; TUMOR CELLS, CULTURED;

EID: 0036074253     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc025536j     Document Type: Article

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