Glucocorticoid-mediated apoptosis resistance of solid tumors

Results and Problems in Cell Differentiation

Volumn 49, Issue , 2009, Pages 191-218

  Herr, Ingrid ^a   Büchler, Markus W ^a   Mattern, Jürgen ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GLUCOCORTICOID;

ANIMAL; APOPTOSIS; CELL SURVIVAL; DRUG EFFECT; HUMAN; METABOLISM; NEOPLASM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL SURVIVAL; GLUCOCORTICOIDS; HUMANS; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 77649309269     PISSN: 00801844     EISSN: 18610412     Source Type: Book Series    
DOI: 10.1007/400_2008_20     Document Type: Article

References (184)

1. Agosin M, Christen R, Badinez O, Gasic G, Neghme A, Pizarro O, Jarpa A (1952) Cortisone-induced metastases of adenocarcinoma in mice. Proc Soc Exp Biol Med 80:128-131
2. Amsterdam A, Sasson R (2002) The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis. Mol Cell Endocrinol 189:1-9
3. Bailly-Maitre B, de Sousa G, Boulukos K, Gugenheim J, Rahmani R (2001) Dexamethasone inhibits spontaneous apoptosis in primary cultures of human and rat hepatocytes via Bcl-2 and Bcl-xL induction. Cell Death Differ 8:279-288
4. Barkett M, Gilmore TD (1999) Control of apoptosis by Rel/NF-kB transcription factors. Oncogene 18:6910-6924
5. Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A (2003) Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem 278:3897-3902
6. Baserga R, Shubik P (1954) The action of cortisone on transplanted and induced tumors in mice. Cancer Res 14:12-16
7. Baumann S, Dostert A, Novac N, Bauer A, Schmid W, Fas SC, Krueger A, Heinzel T, Kirchhoff S, Schutz G, Krammer PH (2005) Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer. Blood 106:617-625
8. Beato M, Herrlich P, Schutz G (1995 Dec 15) Steroid hormone receptors: many actors in search of a plot. Cell 83:851-857
9. Belova L, Sharma S, Brickley DR, Nicolarsen JR, Patterson C, Conzen SD (2006) Ubiquitin/ proteasome degradation of serum and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP. Biochem J 400(2):235-244
10. Benedetti S, Pirola B, Poliani PL, Cajola L, Pollo B, Bagnati R, Magrassi L, Tunici P, Finocchiaro G (2003) Dexamethasone inhibits the anti-tumor effect of interleukin 4 on rat experimental gliomas. Gene Ther 10:188-192
11. Bergman AM, Pinedo HM, Peters GJ (2001) Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells. Eur J Pharmacol 416:19-24
12. Brady ME, Sartiano GP, Rosenblum SL, Zaglama NE, Bauguess CT (1987) The pharmacokinetics of single high doses of dexamethasone in cancer patients. Eur J Clin Pharmacol 32:593-596
13. Braunschweiger PG, Stragand JJ, Schiffer LM (1978) Effect of methylprednisolone on cell proliferation in C3H/HeJ spontaneous mammary tumors. Cancer Res 38:4510-4514
14. Braunschweiger PG, Ting HL, Schiffer LM (1982) Receptor-dependent antiproliferative effects of corticosteroids in radiation-induced fibrosarcomas and implications for sequential therapy. Cancer Res 42:1686-1691
15. Braunschweiger PG, Ting HL, Schiffer LM (1983) Correlation between glucocorticoid receptor content and the antiproliferative effect of dexamethasone in experimental solid tumors. Cancer Res 43:4757-4761
16. Braunschweiger PG, Ting HL, Schiffer LM (1984) Receptor-mediated antiproliferative effects of corticosteroids in Lewis lung tumors. Eur J Cancer Clin Oncol 20:427-433
17. Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME (2001) Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 21:952-965
18. Brunet CL, Gunby RH, Benson RS, Hickman JA, Watson AJ, Brady G (1998) Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers. Cell Death Differ 5:107-115
19. Buchmann A, Willy C, Buenemann CL, Stroh C, Schmiechen A, Schwarz M (1999) Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity. Cell Death Differ 6:190-200
20. Burgering BM, Medema RH (2003) Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol 73:689-701
21. Buse P, Woo PL, Alexander DB, Cha HH, Reza A, Sirota ND, Firestone GL (1995a) Transforming growth factor-alpha abrogates glucocorticoid-stimulated tight junction formation and growth suppression in rat mammary epithelial tumor cells. J Biol Chem 270:6505-6514
22. Buse P, Woo PL, Alexander DB, Reza A, Firestone GL (1995b) Glucocorticoid-induced functional polarity of growth factor responsiveness regulates tight junction dynamics in transformed mammary epithelial tumor cells. J Biol Chem 270:28223-28227
23. Buttgereit F, Scheffold A (2002) Rapid glucocorticoid effects on immune cells. Steroids 67:529-534
24. Carayol N, Vachier I, Campbell A, Crampette L, Bousquet J, Godard P, Chanez P (2002) Regulation of E-cadherin expression by dexamethasone and tumour necrosis factor-alpha in nasal epithelium. Eur Respir J 20:1430-1436
25. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321
26. Cato AC, Nestl A, Mink S (2002) Rapid actions of steroid receptors in cellular signaling pathways. Sci STKE 2002:RE9
27. Cha HH, Cram EJ, Wang EC, Huang AJ, Kasler HG, Firestone GL (1998) Glucocorticoids stimulate p21 gene expression by targeting multiple transcriptional elements within a steroid responsive region of the p21waf1/cip1 promoter in rat hepatoma cells. J Biol Chem 273:1998-2007
28. Chen YX, Li ZB, Diao F, Cao DM, Fu CC, Lu J (2006) Up-regulation of RhoB by glucocorticoids and its effects on the cell proliferation and NF-kappaB transcriptional activity. J Steroid Biochem Mol Biol 101:179-187
29. Cox AD, Der CJ (2003) The dark side of Ras: regulation of apoptosis. Oncogene 22:8999-9006
30. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789
31. Cui H, Sherr DH, el-Khatib M, Matsui K, Panka DJ, Marshak-Rothstein A, Ju ST (1996) Regulation of T-cell death genes: selective inhibition of FasL- but not Fas-mediated function. Cell Immunol 167:276-284
32. D'Adamio F, Zollo O, Moraca R, Ayroldi E, Bruscoli S, Bartoli A, Cannarile L, Migliorati G, Riccardi C (1997) A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity 7:803-812
33. Das A, Banik NL, Patel SJ, Ray SK (2004) Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities. Mol Cancer 3:36
34. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241
35. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689
36. Desbois-Mouthon C, Cadoret A, Blivet-Van Eggelpoel MJ, Bertrand F, Caron M, Atfi A, Cherqui G, Capeau J (2000) Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitogen-activated protein kinase phosphatase-1-dependent pathway. Endocrinology 141:922-931
37. Dihlmann S, von Knebel Doeberitz M (2005) Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics. Int J Cancer 113:515-524
38. Doble BW, Woodgett JR (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116:1175-1186
39. Drewinko B, Patchen M, Yang LY, Barlogie B (1981) Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells. Cancer Res 41:2328-2333
40. Edinger AL, Thompson CB (2002) Akt maintains cell size and survival by increasing mTORdependent nutrient uptake. Mol Biol Cell 13:2276-2288
41. Embi N, Rylatt DB, Cohen P (1980) Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem 107:519-527
42. Engelbrecht Y, de Wet H, Horsch K, Langeveldt CR, Hough FS, Hulley PA (2003) Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. Endocrinology 144:412-422
43. Evans-Storms RB, Cidlowski JA (2000) Delineation of an antiapoptotic action of glucocorticoids in hepatoma cells: the role of nuclear factor-kappaB. Endocrinology 141:1854-1862
44. Fan W, Sui M, Huang Y (2004) Glucocorticoids selectively inhibit paclitaxel-induced apoptosis: mechanisms and its clinical impact. Curr Med Chem 11:403-411
45. Feng Z, Marti A, Jehn B, Altermatt HJ, Chicaiza G, Jaggi R (1995) Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland. J Cell Biol 131:1095-1103
46. Frame S, Cohen P (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem J 359:1-16
47. Freshney RI, Sherry A, Hassanzadah M, Freshney M, Crilly P, Morgan D (1980) Control of cell proliferation in human glioma by glucocorticoids. Br J Cancer 41:857-866
48. Gascoyne DM, Kypta RM, Vivanco Md (2003) Glucocorticoids inhibit apoptosis during fibrosarcoma developmentby transcriptionally activating Bcl-xL. J Biol Chem 278:18022-18029
49. Gassler N, Zhang C, Schnabel PA, Dienemann H, Debatin K-M, Mattern J, Herr I (2005) Dexamethasone-induced cisplatin and gemcitabine resistance in lung carcinoma samples treated ex vivo. Br J Cancer 92:1084-1088
50. Giles RH, van Es JH, Clevers H (2003) Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653:1-24
51. Glick RD, Medary I, Aronson DC, Scotto KW, Swendeman SL, La Quaglia MP (2000) The effects of serum depletion and dexamethasone on growth and differentiation of human neuroblastoma cell lines. J Pediatr Surg 35:465-472
52. Gorman AM, Hirt UA, Orrenius S, Ceccatelli S (2000) Dexamethasone pre-treatment interferes with apoptotic death in glioma cells. Neuroscience 96:417-425
53. Goya L, Maiyar AC, Ge Y, Firestone GL (1993) Glucocorticoids induce a G1/G0 cell cycle arrest of Con8 rat mammary tumor cells that is synchronously reversed by steroid withdrawal or addition of transforming growth factor-alpha. Mol Endocrinol 7:1121-1132
54. Guan Y, Rubenstein NM, Failor KL, Woo PL, Firestone GL (2004) Glucocorticoids control betacatenin protein expression and localization through distinct pathways that can be uncoupled by disruption of signaling events required for tight junction formation in rat mammary epithelial tumor cells. Mol Endocrinol 18:214-227
55. Gustin JA, Ozes ON, Akca H, Pincheira R, Mayo LD, Li Q, Guzman JR, Korgaonkar CK, Donner DB (2004) Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation. J Biol Chem 279:1615-1620
56. Hafezi-Moghadam A, Simoncini T, Yang Z, Limbourg FP, Plumier JC, Rebsamen MC, Hsieh CM, Chui DS, Thomas KL, Prorock AJ, Laubach VE, Moskowitz MA, French BA, Ley K, Liao JK (2002) Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med 8:473-479
57. Hamdi M, Kool J, Cornelissen-Steijger P, Carlotti F, Popeijus HE, van der Burgt C, Janssen JM, Yasui A, Hoeben RC, Terleth C, Mullenders LH, van Dam H (2005) DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1. Oncogene 24:7135-17134
58. Hammer S, Sauer B, Spika I, Schraut C, Kleuser B, Schafer-Korting M (2004) Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation. J Cell Biochem 91:840-851
59. Harmon JM, Thompson EB (1981) Isolation and characterization of dexamethasone-resistant mutants from human lymphoid cell line CEM-C7. Mol Cell Biol 1:512-521
60. Harwood AJ (2001) Regulation of GSK-3: a cellular multiprocessor. Cell 105:821-824
61. Herr I, Debatin K-M (2001) Cellular stress response and apoptosis in cancer therapy. Blood 98:2603-2614
62. Herr I, Pfitzenmaier J (2006) Glucocorticoid use in prostate cancer and other solid tumors: implications for effectiveness of cytotoxic treatment and metastases. Lancet Oncology 7:425-430
63. Herr I, Ucur E, Herzer K, Okouoyo S, Ridder R, Krammer PH, von Knebel Doeberitz M, Debatin KM (2003) Glucocorticoid co-treatment induces apoptosis resistance toward cancer therapy in carcinomas. Cancer Res 63:3112-3120
64. Herrlich P (2001) Cross-talk between glucocorticoid receptor and AP-1. Oncogene 20:2465-2475
65. Hertweck M, Gobel C, Baumeister R (2004) C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6:577-588
66. Hinoi T, Yamamoto H, Kishida M, Takada S, Kishida S, Kikuchi A (2000) Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 betadependent phosphorylation of beta-catenin and down-regulates beta-catenin. J Biol Chem 275:34399-34406
67. Hofmann J, Kaiser U, Maasberg M, Havemann K (1995) Glucocorticoid receptors and growth inhibitory effects of dexamethasone in human lung cancer cell lines. Eur J Cancer 31A:2053-2058
68. Huang Y, Johnson KR, Norris JS, Fan W (2000) Nuclear factor-kappaB/ IkappaB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res 60:4426-4432
69. Iseki R, Mukai M, Iwata M (1991) Regulation of T lymphocyte apoptosis. Signals for the antagonism between activation- and glucocorticoid-induced death. J Immunol 147:4286-4292
70. Iversen HG (1957) The influence of cortisone on the frequency of tumour metastases. Acta Pathol Microbiol Scand 41:273-280
71. Iversen HG, Hjort GH (1958) The influence of corticoid steroids on the frequency of spleen metastases in patients with breast cancer. Acta Pathol Microbiol Scand 44:205-212
72. Kamradt MC, Mohideen N, Krueger E, Walter S, Vaughan AT (2000) Inhibition of radiation-induced apoptosis by dexamethasone in cervical carcinoma cell lines depends upon increased HPV E6/ E7. Br J Cancer 82:1709-1716
73. Kamradt MC, Walter S, Koudelik J, Shafer L, Weijzen S, Velders M, Vaughan ATM (2001) Steroid-mediated inhibition of radiation-induced apoptosis in C4-1 cervical carcinoma cells is p53-dependent. Eur J Cancer 37:2240-2246
74. Kane LP, Shapiro VS, Stokoe D, Weiss A (1999) Induction of NF-kappaB by the Akt/PKB kinase. Curr Biol 9:601-604
75. Karin M (1999) How NF-kB is activated: The role of the IkB kinase (IKK) complex. Oncogene 18:6867-6874
76. Kaup B, Schindler I, Knupfer H, Schlenzka A, Preiss R, Knupfer MM (2001) Time-dependent inhibition of glioblastoma cell proliferation by dexamethasone. J Neurooncol 51:105-110
77. Kawamura A, Tamaki N, Kokunai T (1998) Effect of dexamethasone on cell proliferation of neuroepithelial tumor cell lines. Neurol Med Chir (Tokyo) 38:633-638; discussion 638-640
78. Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J (1997) Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/ Akt cellular survival pathway. EMBO J 16:2783-2793
79. Kim AH, Khursigara G, Sun X, Franke TF, Chao MV (2001) Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21:893-901
80. Kobayashi T, Deak M, Morrice N, Cohen P (1999) Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J 344(Pt 1):189-197
81. Kofler R, Schmidt S, Kofler A, Ausserlechner MJ (2003) Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia. J Endocrinol 178:19-27
82. Kruit A, Reyes-Moreno C, Newling DW, Geldof A, Koutsilieris M (1999) Response of PC-3 prostate cancer cells to combination therapy using irradiation with glucocorticoids or doxorubicin. Anticancer Res 19:3153-3156
83. Kudawara I, Ueda T, Yoshikawa H, Miyama T, Yamamoto T, Nishizawa Y (2001) In vivo inhibition of tumour growth by dexamethasone in murine osteosarcomas. Eur J Cancer 37:1703-1708
84. Lang F, Cohen P (2001) Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE 2001:RE17
85. Langeveld CH, van Waas MP, Stoof JC, Sutanto W, de Kloet ER, Wolbers JG, Heimans JJ (1992) Implication of glucocorticoid receptors in the stimulation of human glioma cell proliferation by dexamethasone. J Neurosci Res 31:524-531
86. Lauder A, Castellanos A, Weston K (2001) c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-mediated protection from apoptosis. Mol Cell Biol 21:5797-5805
87. Leong ML, Maiyar AC, Kim B, O'Keeffe BA, Firestone GL (2003) Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem 278:5871-5882
88. Letuve S, Druilhe A, Grandsaigne M, Aubier M, Pretolani M (2002) Critical role of mitochondria, but not caspases, during glucocorticosteroid-induced human eosinophil apoptosis. Am J Respir Cell Mol Biol 26:565-571
89. Limbourg FP, Liao JK (2003) Nontranscriptional actions of the glucocorticoid receptor. J Mol Med 81:168-174
90. Loda M, Capodieci P, Mishra R, Yao H, Corless C, Grigioni W, Wang Y, Magi-Galluzzi C, Stork PJ (1996) Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis. Am J Pathol 149:1553-1564
91. Lu YS, Lien HC, Yeh PY, Yeh KH, Kuo ML, Kuo SH, Cheng AL (2005) Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors. World J Gastroenterol 11:6373-6380
92. Lu YS, Lien HC, Yeh PY, Kuo SH, Chang WC, Kuo ML, Cheng AL (2006) Glucocorticoid receptor expression in advanced non-small cell lung cancer: clinicopathological correlation and in vitro effect of glucocorticoid on cell growth and chemosensitivity. Lung Cancer 53:303-310
93. Lund LR, Romer J, Thomasset N, Solberg H, Pyke C, Bissell MJ, Dano K, Werb Z (1996) Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development 122:181-193
94. Machuca C, Mendoza-Milla C, Cordova E, Mejia S, Covarrubias L, Ventura J, Zentella A (2006) Dexamethasone protection from TNF-alpha-induced cell death in MCF-7 cells requires NF-kappaB and is independent from AKT. BMC Cell Biol 7:9
95. Madge LA, Pober JS (2000) A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J Biol Chem 275:15458-15465
96. Magi-Galluzzi C, Mishra R, Fiorentino M, Montironi R, Yao H, Capodieci P, Wishnow K, Kaplan I, Stork PJ, Loda M (1997) Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis. Lab Invest 76:37-51
97. Marini G, Murray S, Goldhirsch A, Gelber RD, Castiglione-Gertsch M, Price KN, Tattersall MH, Rudenstam CM, Collins J, Lindtner J, Cavalli F, Cortes-Funes H, Gudgeon A, Forbes JF, Galligioni E, Coates AS, Senn HJ (1996) The effect of adjuvant prednisone combined with CMF on patterns of relapse and occurrence of second malignancies in patients with breast cancer. International (Ludwig) Breast Cancer Study Group. Ann Oncol 7:245-250
98. Mattern J, Wayss K, Volm M (1984) Effect of five antineoplastic agents on tumor xenografts with different growth rates. J Natl Cancer Inst 72:1335-1339
99. Mattern J, Klinga K, Runnebaum B, Volm M (1985) Influence of hormone therapy on human lung tumors transplanted into nude mice. Oncology 42:388-390
100. Mealey J, Jr, Chen TT, Schanz GP (1971) Effects of dexamethasone and methylprednisolone on cell cultures of human glioblastomas. J Neurosurg 34:324-334
101. Messmer UK, Winkel G, Briner VA, Pfeilschifter J (1999) Glucocorticoids potently block tumour necrosis factor-alpha- and lipopolysaccharide-induced apoptotic cell death in bovine glomerular endothelial cells upstream of caspase 3 activation. Br J Pharmacol 127:1633-1640
102. Messmer UK, Pereda-Fernandez C, Manderscheid M, Pfeilschifter J (2001) Dexamethasone inhibits TNF-alpha-induced apoptosis and IAP protein downregulation in MCF-7 cells. Br J Pharmacol 133:467-476
103. Meyer S, Eden T, Kalirai H (2006) Dexamethasone protects against cisplatin-induced activation of the mitochondrial apoptotic pathway in human osteosarcoma cells. Cancer Biol Ther5
104. Mikosz CA, Brickley DR, Sharkey MS, Moran TW, Conzen SD (2001) Glucocorticoid receptormediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem 276:16649-16654
105. Molomut N, Spain DM, Gault SD, Kreisler L (1952) Preliminary report on the experimental induction of metastases from a heterologous cancer graft in mice. Proc Natl Acad Sci USA 38:991-995
106. Moran TJ, Gray S, Mikosz CA, Conzen SD (2000) The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res 60:867-872
107. Mulholland DJ, Dedhar S, Coetzee GA, Nelson CC (2005) Interaction of nuclear receptors with Wnt/{beta}-catenin/Tcf signalling: Wnt you like to know? Endocr Rev 7:898-915
108. Munstedt K, Borces D, Bohlmann MK, Zygmunt M, von Georgi R (2004) Glucocorticoid administration in antiemetic therapy: is it safe? Cancer 101:1696-1702
109. Murakami N, Fukuchi S, Takeuchi K, Hori T, Shibamoto S, Ito F (1998) Antagonistic regulation of cell migration by epidermal growth factor and glucocorticoid in human gastric carcinoma cells. J Cell Physiol 176:127-137
110. Nakae J, Park BC, Accili D (1999) Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem 274:15982-15985
111. Norgaard P, Poulsen HS (1991) Glucocorticoid receptors in human malignancies: a review. Ann Oncol 2:541-557
112. Novac N, Baus D, Dostert A, Heinzel T (2006) Competition between glucocorticoid receptor and NFkappaB for control of the human FasL promoter. Faseb J 20:1074-1081
113. Oh HY, Namkoong S, Lee SJ, Por E, Kim CK, Billiar TR, Han JA, Ha KS, Chung HT, Kwon YG, Lee H, Kim YM (2006) Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP. Cell Death Differ 13:512-523
114. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85
115. Pang D, Kocherginsky M, Krausz T, Kim SY, Conzen SD (2006) Dexamethasone decreases xenograft response to paclitaxel through inhibition of tumor cell apoptosis. Cancer Biol Ther 5(8):941-942
116. Pap M, Cooper GM (1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 273:19929-19932
117. Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ (2002) Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. J Biol Chem 277:2573-2578
118. Pastorino JG, Tafani M, Farber JL (1999) Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway. J Biol Chem 274:19411-19416
119. Peluso JJ, Pappalardo A, Fernandez G (2001) E-cadherin-mediated cell contact prevents apoptosis of spontaneously immortalized granulosa cells by regulating Akt kinase activity. Biol Reprod 64:1183-1190
120. Polakis P (2000) Wnt signaling and cancer. Genes Dev 14:1837-1851
121. Pomeroy TC (1954) Studies on the mechanism of cortisone-induced metastases of transplantable mouse tumors. Cancer Res 14:201-204
122. Postmus PE, Smit EF, Haaxma-Reiche H, van Zandwijk N, Ardizzoni A, Quoix E, Kirkpatrick A, Sahmoud T, Giaccone G (1995) Teniposide for brain metastases of small-cell lung cancer: a phase II study. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group. J Clin Oncol 13:660-665
123. Ramdas J, Liu W, Harmon JM (1999) Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells. Cancer Res 59:1378-1385
124. Rasmuson T, Ljungberg B, Grankvist K, Jacobsen J, Olsson T (2001) Increased serum cortisol levels are associated with high tumour grade in patients with renal cell carcinoma. Acta Oncol 40:83-87
125. Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB (2003) Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol 23:7315-7328
126. Ray A, Prefontaine KE (1994) Physical association and functional antagonism between the p65 subunit of transcription factor NF-kB and the glucocorticoid receptor. Proc Natl Acad Sci USA 91:752-756
127. Reddy SA, Huang JH, Liao WS (2000) Phosphatidylinositol 3-kinase as a mediator of TNFinduced NF-kappa B activation. J Immunol 164:1355-1363
128. Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schutz G (1998) DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93:531-541
129. Rennebeck G, Martelli M, Kyprianou N (2005) Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis? Cancer Res 65:11230-11235
130. Rieger J, Durka S, Streffer J, Dichgans J, Weller M (1999) Gemcitabine cytotoxicity of human malignant glioma cells: modulation by antioxidants, BCL-2 and dexamethasone. Eur J Pharmacol 365:301-308
131. Runnebaum IB, Bruning A (2005) Glucocorticoids inhibit cell death in ovarian cancer and upregulate caspase inhibitor cIAP2. Clin Cancer Res 11:6325-6332
132. Rutz HP, Herr I (2004) Interference of glucocorticoids with apoptosis signaling and host-tumor interactions. Cancer Biol Ther 3:715-718
133. Rutz HP, Mariotta M, von Knebel Doeberitz M, Mirimanoff RO (1998) Dexamethasone-induced radioresistance occurring independent of human papilloma virus gene expression in cervical carcinoma cells. Strahlenther Onkol 174:71-74
134. Sanchez I, Goya L, Vallerga AK, Firestone GL (1993) Glucocorticoids reversibly arrest rat hepatoma cell growth by inducing an early G1 block in cell cycle progression. Cell Growth Differ 4:215-225
135. Sasson R, Amsterdam A (2003) Pleiotropic anti-apoptotic activity of glucocorticoids in ovarian follicular cells. Biochem Pharmacol 66:1393-1401
136. Sasson R, Tajima K, Amsterdam A (2001) Glucocorticoids protect against apoptosis induced by serum deprivation, cyclic adenosine 3¢,5¢- monophosphate and p53 activation in immortalized human granulosa cells: involvement of Bcl-2. Endocrinology 142:802-811
137. Sasson R, Shinder V, Dantes A, Land A, Amsterdam A (2003) Activation of multiple signal transduction pathways by glucocorticoids: protection of ovarian follicular cells against apoptosis. Biochem Biophys Res Commun 311:1047-1056
138. Schmidt S, Rainer J, Ploner C, Presul E, Riml S, Kofler R (2004) Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance. Cell Death Differ 11(Suppl 1):S45-S55
139. Sengupta S, Vonesch JL, Waltzinger C, Zheng H, Wasylyk B (2000) Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells. EMBO J 19:6051-6064
140. Shackney SE, McCormack GW, Cuchural GJ, Jr (1978) Growth rate patterns of solid tumors and their relation to responsiveness to therapy: an analytical review. Ann Intern Med 89:107-121
141. Sherlock P, Hartmann WH (1962) Adrenal steroids and the pattern of metastases of breast cancer. Jama 181:313-317
142. Sinclair WK (1968) Cyclic x-ray responses in mammalian cells in vitro. Radiat Res 33:620-643
143. Song G, Ouyang G, Bao S (2005) The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9:59-71
144. Sorensen HT, Mellemkjaer L, Nielsen GL, Baron JA, Olsen JH, Karagas MR (2004) Skin cancers and non-hodgkin lymphoma among users of systemic glucocorticoids: a population-based cohort study. J Natl Cancer Inst 96:709-711
145. Srikanth S, Franklin CC, Duke RC, Kraft RS (1999) Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis. Mol Cell Biochem 199:169-178
146. Steinmetz R, Wagoner HA, Zeng P, Hammond JR, Hannon TS, Meyers JL, Pescovitz OH (2004) Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation. Mol Endocrinol 18:2570-2582
147. Stevenson BR, Siliciano JD, Mooseker MS, Goodenough DA (1986) Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol 103:755-766
148. Sui M, Chen F, Fan W (2006) Glucocorticoids interfere with therapeutic efficacy of paclitaxel against human breast and ovarian xenograft tumors. Int J Cancer 119:712-717
149. Tao YS, Edwards RA, Tubb B, Wang S, Bryan J, McCrea PD (1996) beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. J Cell Biol 134:1271-1281
150. Teicher BA, Herman TS, Holden SA, Wang YY, Pfeffer MR, Crawford JW, Frei EIIIrd, (1990) Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science 247:1457-1461
151. Terasima T, Tolmach LJ (1961) Changes in x-ray sensitivity of HeLa cells during the division cycle. Nature 190:1210-1211
152. Topper YJ, Freeman CS (1980) Multiple hormone interactions in the developmental biology of the mammary gland. Physiol Rev 60:1049-1106
153. Tormey DC, Gray R, Gilchrist K, Grage T, Carbone PP, Wolter J, Woll JE, Cummings FJ (1990) Adjuvant chemohormonal therapy with cyclophosphamide, methotrexate, 5-fluorouracil, and prednisone (CMFP) or CMFP plus tamoxifen compared with CMF for premenopausal breast cancer patients. An Eastern Cooperative Oncology Group trial. Cancer 65:200-206
154. Valeriote F, van Putten L (1975) Proliferation-dependent cytotoxicity of anticancer agents: a review. Cancer Res 35:2619-2630
155. van Noort M, Meeldijk J, van der Zee R, Destree O, Clevers H (2002) Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem 277:17901-17905
156. Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB (2001) Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol 21:5899-5912
157. Wang JM, Chao JR, Chen W, Kuo ML, Yen JJ, Yang-Yen HF (1999) The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol 19:6195-6206
158. Wang R, Zhang L, Zhang X, Moreno J, Luo X, Tondravi M, Shi Y (2001) Differential regulation of the expression of CD95 ligand, receptor activator of nuclear factor-kappa B ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-alpha during T cell activation. J Immunol 166:1983-1990
159. Webster JC, Huber RM, Hanson RL, Collier PM, Haws TF, Mills JK, Burn TC, Allegretto EA (2002) Dexamethasone and tumor necrosis factor-alpha act together to induce the cellular inhibitor of apoptosis-2 gene and prevent apoptosis in a variety of cell types. Endocrinology 143:3866-3874
160. Wellington JS, Moon HD (1961) Effect of hydrocortisone on human cells in tissue culture. Proc Soc Exp Biol Med 107:556-559
161. Wen LP, Madani K, Fahrni JA, Duncan SR, Rosen GD (1997) Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN- gamma and Fas. Am J Physiol 273:L921-L929
162. Wolf J, Spear P, Yesner R, Patno ME (1960) Nitrogen mustard and the steroid hormones in the treatment of inoperable bronchogenic carcinoma. Am J Med 29:1008-1016
163. Wolff JE, Jurgens H (1994) Dexamethasone induced partial resistance to methotrexate in C6-glioma cells. Anticancer Res 14:1585-1588
164. Wolff JE, Denecke J, Jurgens H (1996) Dexamethasone induces partial resistance to cisplatinum in C6 glioma cells. Anticancer Res 16:805-809
165. Wong V, Ching D, McCrea PD, Firestone GL (1999) Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. J Biol Chem 274:5443-5453
166. Woo PL, Cha HH, Singer KL, Firestone GL (1996) Antagonistic regulation of tight junction dynamics by glucocorticoids and transforming growth factor-beta in mouse mammary epithelial cells. J Biol Chem 271:404-412
167. Woodgett JR (1990) Molecular cloning and expression of glycogen synthase kinase-3/factor A. Embo J 9:2431-2438
168. Wu W, Chaudhuri S, Brickley DR, Pang D, Karrison T, Conzen SD (2004) Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res 64:1757-1764
169. Wu W, Pew T, Zou M, Pang D, Conzen SD (2005) Glucocorticoid receptor-induced MKP-1 expression inhibits paclitaxel-associated MAP kinase activation and contributes to breast cancer cell survival. J Biol Chem 280:4117-4124
170. Wu W, Zou M, Brickley DR, Pew T, Conzen SD (2006) Glucocorticoid receptor activation signals through FOXO3a in breast cancer cells. Mol Endocrinol 20(10):2304-2314
171. Yamamoto M, Fukuda K, Miura N, Suzuki R, Kido T, Komatsu Y (1998) Inhibition by dexamethasone of transforming growth factor beta1-induced apoptosis in rat hepatoma cells: a possible association with Bcl-xL induction. Hepatology 27:959-966
172. Yamamoto T, Nishiguchi M, Inoue N, Goto HG, Kudawara I, Ueda T, Yoshikawa H, Tanigaki Y, Nishizawa Y (2002) Inhibition of murine osteosarcoma cell proliferation by glucocorticoid. Anticancer Res 22:4151-4156
173. Yang Y, Mercep M, Ware CF, Ashwell JD (1995) Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids. J Exp Med 181:1673-1682
174. Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD (2000) Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288:874-877
175. Yerramasetti R, Gollapudi S, Gupta S (2002) Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol 22:37-47
176. Zettl KS, Sjaastad MD, Riskin PM, Parry G, Machen TE, Firestone GL (1992) Glucocorticoidinduced formation of tight junctions in mouse mammary epithelial cells in vitro. Proc Natl Acad Sci U S A 89:9069-9073
177. Zhang C, Kolb A, Mattern J, Gassler N, Wenger T, Herzer K, Debatin KM, Buchler M, Friess H, Rittgen W, Edler L, Herr I (2005) Dexamethasone desensitizes hepatocellular and colorectal tumours toward cytotoxic therapy. Cancer Lett 242(1):104-111
178. Zhang C, Beckermann B, Kallifatidis G, Liu Z, Rittgen W, Edler L, Büchler P, Debatin K-M, Büchler MW, Friess H, Herr I (2006a) Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma. Int J Oncol 29(5):1295-1301
179. Zhang C, Kolb A, Buechler P, Cato ACB, Mattern J, Rittgen W, Edler L, Debatin K-M, Buechler M, Friess H, Herr I (2006b) Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer. BMC Cancer 6:61
180. Zhang C, Marme A, Wenger T, Gutwein P, Edler L, Rittgen W, Debatin K-M, Altevogt P, Mattern J, Herr I (2006c) Glucocorticoid-mediated inhibition of chemotherapy in ovarian carcinomas. Int J Oncology 2:551-557
181. Zhang C, Mattern J, Haferkamp A, Pfitzenmaier J, Hohenfellner M, Rittgen W, Edler L, Debatin KM, Groene E, Herr I (2006d) Corticosteroid-induced chemotherapy resistance in urological cancers. Cancer Biol Ther 5:59-64
182. Zhang C, Wenger T, Mattern J, Ilea S, Frey C, Gutwein P, Altevogt P, Bodenmuller W, Gassler N, Schnabel PA, Dienemann H, Marme A, Hohenfellner M, Haferkamp A, Pfitzenmaier J, Grone HJ, Kolb A, Buchler P, Buchler M, Friess H, Rittgen W, Edler L, Debatin KM, Krammer PH, Rutz HP, Herr I (2007) Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors. Cancer Biol Ther 6:278-287
183. Zibera C, Gibelli N, Butti G, Pedrazzoli P, Carbone M, Magrassi L, Robustelli della Cuna G (1992) Proliferative effect of dexamethasone on a human glioblastoma cell line (HU 197) is mediated by glucocorticoid receptors. Anticancer Res 12:1571-1574
184. Zipp F, Wendling U, Beyer M, Grieger U, Waiczies S, Wagenknecht B, Haas J, Weller M (2000) Dual effect of glucocorticoids on apoptosis of human autoreactive and foreign antigen-specific T cells. J Neuroimmunol 110:214-222