Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas

Cancer Research

Volumn 63, Issue 12, 2003, Pages 3112-3120

  Herr, Ingrid ^a,b   Ucur, Esat ^a,b   Herzer, Kerstin ^a   Okouoyo, Stella ^a,b   Ridder, Rüdiger ^c,d   Krammer, Peter H ^a   Von Knebel Doeberitz, Magnus ^c   Debatin, Klaus Michael ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d MTM Laboratories AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 8; CASPASE 9; CISPLATIN; DEXAMETHASONE; FLICE INHIBITORY PROTEIN; GLUCOCORTICOID; INHIBITOR OF APOPTOSIS PROTEIN; MIFEPRISTONE; PROTEIN BCL 2;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; ENZYME ACTIVITY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CARCINOMA; LYMPHOID CELL; MOUSE; NAUSEA; NONHUMAN; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA; VOMITING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARABIDOPSIS PROTEINS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CASPASE 9; CASPASES; CISPLATIN; DEXAMETHASONE; DRUG RESISTANCE, NEOPLASM; FAS LIGAND PROTEIN; FATTY ACID DESATURASES; FEMALE; GAMMA RAYS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; MEMBRANE GLYCOPROTEINS; MICE; MICE, NUDE; MIFEPRISTONE; MITOCHONDRIA; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0038745821     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Warr, D. Standard treatment of chemotherapy-induced emesis. Support Care Cancer, 5: 12-16, 1997.
2. Kofler, R. The molecular basis of glucocorticoid-induced apoptosis of lymphoblastic leukemia cells. Histochem. Cell. Biol., 114: 1-7, 2000.
3. Planey, S. L., and Litwack, G. Glucocorticoid-induced apoptosis in lymphocytes. Biochem. Biophys. Res. Commun., 279: 307-312, 2000.
4. Evans-Storms, R. B., and Cidlowski, J. A. Delineation of an antiapoptotic action of glucocorticoids in hepatoma cells: the role of nuclear factor-κB. Endocrinology, 141: 1854-1862, 2000.
5. Beato, M., Herrlich, P., and Schulz, G. Steroid hormone receptors: many actors in search of a plot. Cell, 83: 851-857, 1995.
6. Herrlich, P. Cross-talk between glucocorticoid receptor and AP-1. Oncogene 20: 2465-2475, 2001.
7. Heagartner, M. O. The biochemistry of apoptosis. Nature (Lond), 407: 770-776, 2000.
8. Herr, I., and Debatin, K-M. Cellular stress response and apoptosis in cancer therapy. Blood. 98: 2603-2614, 2001.
9. Krammer, P. H. CD95's deadly mission in the immune system. Nature (Lond), 407: 789-795, 2000.
10. Dhein, J., Walczak, H., Bäumler, C., Debatin, K-M., and Krammer, P. H. Autocrine T-cell suicide mediated by APO-1 (Fas/CD95). Nature (Lond.). 373: 438-441, 1995.
11. Herr, I., Wilhelm, D., Boehler, T., Angel, P., and Debatin, K-M. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J., 16: 6200-6208, 1997.
12. Herr, I., Posovszky, C., De Marzio, L., Cifone, M. G., Boehler, T. and Debatin, K-M. Autoamplification of apoptosis following ligation of CD95-L. TRAIL and TNF-α. Oncogene, 19: 4255-4262, 2000.
13. Friesen, C., Herr, I., Krammer, P. H., and Debatin, K-M. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med., 2: 574-577, 1996.
14. Reers, M., Smiley, S. T., Mottola-Hartshorn, C., Chen, A., Lin, M., and Chen, L. B. Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol., 260: 406-417, 1995.
15. Ramdas, J., Liu, W., and Harmon, J. M. Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells. Cancer Res., 59: 1378-1385, 1999.
16. Wolff, J. E., Denecke, J., and Jurgens, H. Dexamethasone induces partial resistance to cisplatinum in C6 glioma cells. Anticancer Res., 16: 805-809, 1996.
17. Chauhan, D., Auclair, D., Robinson, E. K., Hideshima, T., Li, G., Podar, K., Gupta, D., Richardson, P., Schlossman, R. L., Krett, N., Chen, L. B., Munshi, N. C., and Anderson, K. C. Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays. Oncogene, 21: 1346-1358, 2002.
18. Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Ehrhart-Bornstein, M., O'Shea, J. J., Chrousos, G. P., and Bornstein, S. R. Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J., 16: 61-71, 2002.
19. 0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis. FASEB J., 15: 693-699, 2001.
20. Schmidt, M., Luegering, N., Luegering, A., Pauels, H-G., Schulze-Osthoff, K., Domsehke, W., and Kucharzik, T. Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis. J. Immunol., 166: 1344-1351, 2001.
21. Martin, S. J., Lennon, S. V., Bonham, A. M., and Cotter, T. G. Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis. J. Immunol., 145: 1859-1867, 1990.
22. Bailly-Maitre, B., de Sousa, G., Boulukos K., Gugenheim, J., and Rhamani, R. Dexamethasone inhibits spontaneous apoptosis in primary cultures of human and rat hepatocytes via Bcl-2 and Bcl-xL induction. Cell Death. Differ., 8: 279-288, 2001.
23. Gorman, A. M., Hirt, U. A., Orrenius S., and Ceccatelli, S. Dexametasone Pretreatment interferes with apoptotic death in glioma cells. Neuroscience, 96: 417-425, 2000.
24. Messmer, U. K., Winkel, G., Briner, V. A., and Pfeilschifter, J. Suppression of apoptosis by glucocorticoids in glomerular endothelial cells: effects on proapoptotic pathways, Br. J. Pharmacol., 129: 1673-1683, 2000.
25. Kamradt, M. C., Mohideen, N., Krueger, E., Walter, S., and Vaughan, A. T. Inhibition of radiation-induced apoptosis by dexamethasone in cervical carcinoma cell lines depends upon increased HPV E6/E7. Br. J. Cancer, 82: 1709-1716, 2000.
26. Johnstone, R. W., Ruefli, A. A. and Lowe, S. W. Apoptosis: a link between cancer genetics and chemotherapy. Cell, 108: 153-164, 2002.
27. Green, D. R., and Reed, J. C. Mitochondria and apoptosis. Science (Wash. DC), 281: 1309-1312, 1998.
28. Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., Potter, J., Yoshida, R., Kaufman, S. A., Lowe, S. W., Penninger, J. M., and Mak, T. W. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell, 94: 339-352, 1998.
29. Chan, H., Bartos, D. P., and Owen-Schauh, L. B. Activation-dependent transcriptional regulation of the human fas promoter requires NF-κB p50-p65 recruitment. Mol. Cell. Biol., 19: 2098-2108, 1999.
30. Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboudi, A., and Green, D. R. DNA damaging agents induce expression or Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1. Mol. Cell, 1: 543-551, 1998.
31. Li-Weber, M., Laur, O., and Krammer, P. H. Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation. Eur. J. Immunol., 29: 3017-3027, 1999.
32. Srivastava, R. K., Sasaki, C. Y., Hardwick, J. M., and Longo, D. L. Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription. J. Exp. Med., 190: 253-265, 1999.
33. Harmon, J. M., and Thompson, E. B. Isolation and characterization of dexamethasone-resistant mutants from human lymphoid cell line CEM-C7. Mol. Cell. Biol., 1: 512-521, 1981
34. Ray, A. and Prefontaine, K. E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA, 91: 752-756, 1994.
35. Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O. Book, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., and Schutz, G. DNA binding of the glucocorticoid receptor is not essential for survival. Cell, 93: 531-541, 1998.
36. Luyet, C., Burri, P. H., and Schittny, J. C. Suppression of cell proliferation and programmed cell death by dexamethasone during postnatal lung development. Am. J. Physiol. Lung Cell Mol. Physiol., 282: L477-L483, 2002.
37. Song, Y., Mao, B., and Qian, G. Effects of dexamethasone on apoptosis and expression of Fas/FasL system in lung tissues of ALI rats. Zhonghua Jie He He Hu Xi Za Zhi, 23: 23-26, 2000.
38. Newton, C. J., Xie, Y. X., Burgoyne, C. H., Adams, I., Atkin, S. L., Abidia, A., and McCollum, P. T. Fluvastatin induces apoptosis of vascular endothelial cells: blockade by glucocorticoids. Cardiovasc. Surg., 11: 52-60, 2003.
39. Wen, L. P., Madani, K., Fahmi, J. A., Duncan, S. R., and Rosen, G. D. Dexamethasone inhibits lung epithelial cell apoptosis induced hy IFN-γ and Fas. Am. J. Physiol., 273: L921-L929, 1997.
40. Messmer, U. K., Winkel, G., Briner, V. A., and Pfeilschifter, J. Glucocorticoids potently block tumour necrosis factor α- and lipopolysacharide-induced apoptotic cell death in bovine glomerular endothelial cells upstream of caspase 3 activation. Br. J. Pharmacol., 127: 1633-1640, 1999.
41. Feng, Z., Marti, A., Jehn, B., Altermatt, H. J., Chicaiza, G., and Jaggi, R. Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland. J. Cell. Biol., 131: 1095-1103, 1995.
42. Mikosz, C. A., Brickley, D. R., Sharkey, M. S., Moran, T. W., and Conzen, S. D. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J. Biol. Chem., 276: 16649-16654, 2001.
43. Messmer, U. K., Pereda-Fernandez, C., Manderscheid, M., and Pfeilschifter, J. Dexamethasone inhibits TNF-α-induced apoptosis and IAP protein down-regulation in MCF-7 cells. Br. J. Pharmacol., 13: 467-476, 2001.
44. Sasson, R., Winder, N., Kees, S., and Amsterdam, A. Induction of apoptosis in granulosa cells by TNF-α and its attenuation by glucocorticoids involve modulation of Bcl-2. Biochem. Biophys. Res. Commun. 294: 51-59, 2002.
45. Sasson, R., Tajima, K., and Amsterdam, A. Glucocorticoids protect against apoptosis induced by serum deprivation, cyclic adenosine 3′, 5′-monophosphate and p53 activation in immortalized human granulosa cells: involvement of Bcl-2. Endocrinology, 142: 802-811, 2001.
46. Weinstein, R. S., Chen, J. R., Powers, C. C., Stewart, S. A., Landes, R. D., Bellido, T., Jilka, R. L., Parfitt, A. M., and Manolagas, S. C. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J. Clin. Investig., 109: 1041-1048, 2002.
47. Chae, H. J., Chae, S. W., Kang, J. S., Bang, B. G., Cho, S. B., Park, R. K., So, H. S., Kim, Y. K., Kim, H. M., and Kim, H. R. Dexamethasone suppresses tumor necrosis factor α-induced apoptosis in osteoblasts: possible role for ceramide. Endocrinology, 141: 2904-2913, 2000.
48. Robson, H., Anderson, E., Eden, O., Isaksson, O., and Shalet, S. Glucocorticoid pretreatment reduces the cytotoxic effects of a variety of DNA-damaging agents on rat tibial growth-plate chondrocytes in vitro. Cancer Chemother. Pharmacol., 42: 171-176, 1998.
49. Zhang, H. H., Kumar, S., Barnett, A. H., and Eggo, M. C. Dexamethasone inbibits tumor necrosis factor α-induced apoptosis and interleukin-1 β release in human subcutaneous adipocytes and preadipocytes. J. Clin. Endocrinol. Metab., 86: 2817-2825, 2001.
50. Wenzel, A., Grimm, C., Seeliger, M. W., Jaissle, G., Hafezi, F., Kretschmer, R., Zrenner, E., and Reme, C. E. Prevention of photoreceptor apoptosis by activation of the glucocorticoid receptor. Investig. Ophthalmol. Vis. Sci., 42: 1653-1659, 2001.
51. Kruit, A., Reyes-Moreno, C., Newling, D. W., Geldof, A., and Koutsilieris, M. Response of PC-3 prostate cancer cells to combination therapy using irradiation with glucocorticoids or doxorubicin. Anticancer Res., 19: 3153-3156, 1999.
52. Uozumi, J., Koikawa, Y., Yasumasu, T., Tokuda, N., and Kumazawa, J. The protec-tive effect of methylprednisolone against cisplatin-induced nephrotoxicity in patients with urothelial tumors. Int. J. Urol., 3: 343-347, 1996.
53. Yazawa, H., Sasagawa, I., Suzuki, Y., and Nakada, T. Glucocorticoid hormone can suppress apoptosis of rat testicular germ cells induced by testicular ischemia. Fertil. Steril., 75: 980-985, 2001.
54. Friegler, A. B., Bernardo, D., and Verschoor, S. M. Protection of murine bone marrow by dexamethasone during cytotoxic chemotherapy. Blood, 83: 65-71, 1994.
55. Sengupta, S., Vonesch, J. L., Waltzinger, C., Zheng, H., and Wasylyk, B. Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells. EMBO J., 19: 6051-6064, 2000.
56. Macaya, A., Munell, F., Ferrer, I., de Torres, C., and Reventos, J. Cell death and associated c-jun induction in perinatal hypoxia-ischemia. Effect of the neuroprotective drug dexamethasone. Brain Res. Mol. Brain Res., 56: 29-37, 1998.
57. Ekert, P., MacLusky, N., Luo, X. P., Lehotay, D. C., Smith, B., Post, M., Tanswell, A. K. Dexamethasone prevents apoptosisin a neonatal rat model of hypoxic-ischemic encephalopathy (HIE) by a reactive oxygen species-independent mechanism Brain Res., 747: 9-17, 1997.
58. Pearl, J. M., Nelson, D. P., Schwartz, S. M., Wagner, C. J., Bauer, S. M., Setser, E. A., and Duffy, J. Y. Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts. Ann. Thorac. Surg., 74: 830-836; discussion 836-837, 2002.
59. Newton, C. J., Bilko, D., Pappa, S., and Atkin, S. L. Dexamethasone blocks antiostrogen- and oxidant-induced death of pituitary tumour cells. J. Endocrinol., 169: 249-261, 2001.
60. Melcangi, R. C., Cavarretta, I., Magnaghi, V., Ciusani, E., and Salmaggi, A. Corticosteroids protect oligodendrocytes from cytokine-induced cell death. Neuroreport, 11: 3969-3972, 2000.
61. Benedetti, S., Pirola, B., Poliani, P. L., Cajola, L., Pollo, B., Bagnati, R., Magrassi, L., Tunici, P., and Finocchiaro, G. Dexamethasone inhibits the anti-tumor effect of interleukin 4 on rat experimental gliomas. Gene Ther., 10: 188-192, 2003.
62. Zurita, M., Vaquero, J., Oya, S., and Morales, C. Effects of dexamethasone on apoptosis-related cell death after spinal cord injury. J. Neurosurg., 96: 83-89, 2002.
63. Chang, T. C., Hung, M. W., Jiang, S. Y., Chu, J. T., Chu, L. L., and Tsai, L. C. Dexamethasone suppresses apoptosis in a human gastric cancer cell line through modulation of bcl-x gene expression. FEBS Lett., 415: 11-15, 1997.