Dexamethasone protects against cisplatin-induced activation of the mitochondrial apoptotic pathway in human osteosarcoma cells

Cancer Biology and Therapy

Volumn 5, Issue 8, 2006, Pages 915-920

  Meyer, Stefan ^a   Eden, Tim ^a   Kalirai, Helen ^a,b  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Apoptosis; Cisplatin; Glucocorticoid; Mitochondria; Osteosarcoma

Indexed keywords

CASPASE; CISPLATIN; CYTOCHROME C; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR ANTAGONIST; MIFEPRISTONE; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRION; OSTEOSARCOMA CELL; UPREGULATION;

EID: 33751190321     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.5.8.2881     Document Type: Article

References (35)

1. Kriegler AB, Bernardo D, Verschoor SM. Protection of murine bone marrow by dexamethasone during cytotoxic chemotherapy. Blood 1994; 83:65-71.
2. Rinehart J, Keville L, Measel J, Spiekerman AM, Burke K. Corticosteroid alteration of carboplatin-induced hematopoietic toxicity in a murine model. Blood 1995; 86:4493-9.
3. Uozumi J, Koikawa Y, Yasumasu T, Tokuda N, Kumazawa J. The protective effect of methylprednisolone against cisplatin-induced nephrotoxicity in patients with urothelial tumors. Int J Urol 1996; 3:343-7.
4. Robson H, Anderson E, Eden O, Isaksson O, Shalet S. Glucocorticoid pretreatment reduces the cytotoxic effects of a variety of DNA-damaging agents on rat tibial growth-plate chondrocytes in vitro. Cancer Chemother Pharmacol 1998; 42:171-6.
5. Evans-Storms RB, Cidlowski JA. Delineation of an antiapoptotic action of glucocorticoids in hepatoma cells: The role of nuclear factor-kappaB. Endocrinology 2000; 141:1854-62.
6. Messmer UK, Pereda-Fernandez C, Manderscheid M, Pfeilschifter J. Dexamethasone inhibits TNF-alpha-induced apoptosis and IAP protein downregulation in MCF-7 cells. Br J Pharmacol 2001; 133:467-76.
7. Mikosz CA, Brickley DR, Sharkey MS, Moran TW, Conzen SD. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem 2001; 276:16649-54.
8. Kamradt MC, Mohideen N, Krueger E, Walter S, Vaughan AT. Inhibition of radiation-induced apoptosis by dexamethasone in cervical carcinoma cell lines depends upon increased HPV E6/E7. Br J Cancer 2000; 82:1709-16.
9. Kruit A, Reyes-Moreno C, Newling DW, Geldof A, Koutsilieris M. Response of PC-3 prostate cancer cells to combination therapy using irradiation with glucocorticoids or doxorubicin. Anticancer Res 1999; 19:3153-6.
10. Gorman AM, Hirt UA, Orrenius S, Ceccatelli S. Dexamethasone pretreatment interferes with apoptotic death in glioma cells. Neuroscience 2000; 96:417-25.
11. Weller M, Schmidt C, Roth W, Dichgans J. Chemotherapy of human malignant glioma: Prevention of efficacy by dexamethasone? Neurology 1997; 48:1704-9.
12. Chang TC, Hung MW, Jiang SY, Chu JT, Chu LL, Tsai LC. Dexamethasone suppresses apoptosis in a human gastric cancer cell line through modulation of bcl-x gene expression. FEBS Lett 1997; 415:11-5.
13. Herr I, Ucur E, Herzer K, et al. Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas. Cancer Res 2003; 63:3112-20.
14. Gascoyne DM, Kypta RM, Vivanco MM. Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-xL. J Biol Chem 2003; 278:18022-9.
15. Naumann U, Durka S, Weller M. Dexamethasone-mediated protection from drug cytotoxicity: Association with p21WAF1/CIP1 protein accumulation? Oncogene. 1998; 17:1567-75.
16. Seki K, Yoshikawa H, Shiiki K, Hamada Y, Akamatsu N, Tasaka K. Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. Cancer Chemother Pharmacol 2000; 45:199-206.
17. Kuwahara D, Tsutsumi K, Kobayashi T, Hasunuma T, Nishioka K. Caspase-9 regulates cisplatin-induced apoptosis in human head and neck squamous cell carcinoma cells. Cancer Lett 2000; 148:65-71.
18. Blanc C, Deveraux QL, Krajewski S, Janicke RU, Porter AG, Reed JC, Jaggi R, Marti A. Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. Cancer Res 2000; 60:4386-90.
19. Dorward AM, Singh G. Energetic characteristics of cisplatin resistant ovarian carcinoma cells. Anticancer Res 1996; 16:443-7.
20. Demonacos CV, Karayanni N, Hatzoglou E, Tsiriyiotis C, Spandidos DA, Sekeris CE. Mitochondrial genes as sites of primary action of steroid hormones. Steroids 1996; 61:226-32.
21. Scheller K, Sekeris CE, Krohne G, Hock R, Hansen IA, Scheer U. Localization of glucocorticoid hormone receptors in mitochondria of human cells [In Process Citation]. Eur J Cell Biol 2000; 79:299-307.
22. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990; 82:1107-12.
23. Sasson R, Shinder V, Dantes A, Land A, Amsterdam A. Activation of multiple signal transduction pathways by glucocorticoids: Protection of ovarian follicular cells against apoptosis. Biochem Biophys Res Commun 2003; 311:1047-56.
24. Blandino G, Levine AJ, Oren M. Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene 1999; 18:477-85.
25. Pestell KE, Hobbs SM, Titley JC, Kelland LR, Walton MI. Effect of p53 status on sensitivity to platinum complexes in a human ovarian cancer cell line. Mol Pharmacol 2000; 57:503-511.
26. Kim JS, Lee JM, Chwae YJ, Kim YH, Lee JH, Kim K, Lee TH, Kim SJ, Park JH. Cisplatin-induced apoptosis in Hep3B cells: Mitochondria-dependent and -independent pathways. Biochem Pharmacol 2004; 67:1459-68.
27. Melendez-Zajgla J, Cruz E, Maldonado V, Espinoza AM. Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin. Biochem Mol Biol Int 1999; 47:765-71.
28. Costantini P, Bruey JM, Castedo M, Metivier D, Loeffler M, Susin SA, Ravagnan L, Zamzami N, Garrido C, Kroemer G. Preprocessed caspase-9 contained in mitochondria participates in apoptosis. Cell Death Differ 2002; 9:82-8.
29. Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci USA 1999; 96:5752-7.
30. Wolff JE, Denecke J, Jurgens H. Dexamethasone induces partial resistance to cisplatinum in C6 glioma cells. Anticancer Res 1996; 16:805-9.
31. Moutsatsou P, Psarra AM, Tsiapara A, Paraskevakou H, Davaris P, Sekeris CE. Localization of the glucocorticoid receptor in rat brain mitochondria. Arch Biochem Biophys 2001; 386:69-78.
32. Tsiriyotis C, Spandidos DA, Sekeris CE. The mitochondrion as a primary site of action of glucocorticoids: Mitochondrial nucleotide sequences, showing similarity to hormone response elements, confer dexamethasone inducibility to chimaeric genes transfected in LATK- cells. Biochem Biophys Res Commun 1997; 235:349-54.
33. Pastorino JG, Wilhelm TJ, Glascott Jr PA, Kocsis JJ, Farber JL. Dexamethasone induces resistance to the lethal consequences of electron transport inhibition in cultured hepatocytes. Arch Biochem Biophys 1995; 318:175-81.
34. Sakamoto T, Repasky WT, Chen J, Hirata A, Hirata F. Downregulation of bcl-xs gene expression in rat thymocytes by dexamethasone. Biochem Biophys Res Commun 1995; 215:511-6.
35. Sasson R, Tajima K, Amsterdam A. Glucocorticoids protect against apoptosis induced by serum deprivation, cyclic adenosine 3′,5′- monophosphate and p53 activation in immortalized human granulosa cells: Involvement of Bcl-2. Endocrinology 2001; 142:802-11.