Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis

Molecular and Cellular Biochemistry

Volumn 199, Issue 1-2, 1999, Pages 169-178

  Srikanth, Sampathkumar ^a   Franklin, Christopher C ^a,b   Duke, Richard C ^a   Kraft, Andrew S ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Apoptosis; Fas; Fas ligand; MKP 1; Prostate cancer

Indexed keywords

CASPASE; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PROSTATE CANCER; PROTEIN EXPRESSION; TUMOR GROWTH;

APOPTOSIS; CASPASES; CELL CYCLE PROTEINS; ENZYME ACTIVATION; FAS LIGAND PROTEIN; HUMANS; IMMEDIATE-EARLY PROTEINS; MALE; MAP KINASE KINASE KINASE 1; MAP KINASE KINASE KINASE 5; MAP KINASE KINASE KINASES; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; METALLOTHIONEIN; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 10; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASE; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED;

EID: 0032877013     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006980326855     Document Type: Article

References (31)

1. Denmeade R, Liu XS and Isaacs JT: Role of programmed cell death during the progression and therapy of prostate cancer. Prostate 28: 251-265, 1996
2. Suzuki A, Matsuzawa A and Iguchi T: Down regulation of bcl-2 is the first step in Fas-mediated apoptosis of male reproductive tract. Oncogene 13: 31-37, 1996
3. Nagata S: Apoptosis by death factor. Cell 88: 355-365, 1997
4. Yang X, Khosravi-Far R, Chang HY and Baltimore D: Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89: 1067-1076, 1997
5. Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E and Sanchez I: Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci USA 94: 3302-3307, 1997
6. Sun H, Charles CH, Lau LF and Tonks NK: MKP-1 (3CH134), an immediate early gene product is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75: 487-493, 1993
7. Franklin CC and Kraft AS: Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J Biol Chem 272: 16917-16923, 1997
8. Magi-Galluzzi C, Mishra R, Fiorentino M, Montironi R, Yao H, Capodieci P, Whishnow K, Kaplan I, Stork PJ and Loda M: MKP-1 is overexpressed in prostate cancers and is inversely related to apoptosis. Lab Invest 76: 37-54, 1997
9. Loda M, Capodieci P, Mishra R, Yao H, Corless C, Grigoioni W, Wang Y, Magi-Galluzzi C and Stork PJ: Expression of MKP-1 in early phases of human epithelial carcinogenesis. Am J Path 149: 1553-1562, 1996
10. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin K, Krammer PH and Peter ME: Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17: 1675-1687, 1998
11. Hedlund TE, Duke RC, Schleicher MS and Miller GJ: Fas-mediated apoptosis in seven human prostate cancer cell lines: Correlation with tumor stage. Prostate (In Press)
12. Zamzami N, Susin SA, Marchetti P, Hirsch T, Gomez-Monterrey I, Castedo M, Kroemer G: Mitochondrial control of nuclear apoptosis. J Exp Med 183: 1293-1295, 1996
13. Rosette C and Karin M: Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274: 1194-1197, 1996
14. Franklin CC, Srikanth S and Kraft AS: Conditional expression of mitogen-activatec protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis. Proc Natl Acad Sci USA 95: 3014-3019, 1998
15. Thomas DJ and Caffrey TC: LPS induces double-stranded DNA fragmentation in mouse thymus: protective effect of zinc pretreatment. Toxicology 68: 327-337, 1991
16. Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG and Hannun YA: Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem 272: 18530-18533, 1997
17. Xia Z, Dickens M, Raingeaud J, Davis RJ and Greenberg ME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331
18. Cardone MH, Salvesen GS, Weidmann C, Johnson G and Frisch SM: The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90: 315-323, 1997
19. Ichijo H, Nishida E, Irie K, Dijke Pt, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K and Gotoh Y: Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275: 90-94, 1997
20. Chang HY, Nishitoh H, Yang X, Ichijo H and Baltimore D: Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281: 1860-1863, 1998
21. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME and Dixit VM: FLICE, a novel Fadd-homologous ICE/ CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827, 1996
22. Boldin MP, Gancharov TM, Goltsev YV and Wallach D: Involvement of MACH, a novel Mort1/Fadd-Interacting protease in Fas/ APO-1- and TNF receptor-induced cell death. Cell 85: 803-815, 1996
23. Rehemtulla A, Hamilton CA, Chinnaiyan AM and Dixit VM: Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1). J Biol Chem 272: 25783-25786, 1997
24. Guo Y-L, Kang B and Williamson JR: Inhibition of the expression of mitogen-activated protein phosphatase-1 potentiates apoptosis induced by tumor necrosis factor-a in rat mesangial cells. J Biol Chem 273: 10362-10366, 1998
25. Liu Z-g, Hsu H, Boeddel DV and Karin M: Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death. Cell 87: 565-576, 1996
26. Natoli G, Costanze A, Ianni A, Templeton D, Woodgett JR, Balsano C and Levrero M: Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science 275: 200-203, 1997
27. Haldar S, Chintapalli J and Croce CM: Taxol induces bcl-2 phosphorylation and death of prostrate cancer cells. Cancer Res 56: 1253-1255, 1996
28. Chang BS, Minn AJ, Muchmore SW, Fesik SW and Thompson CB: Identification of a novel regulatory domain in Bcl-xL and Bcl-2. EMBO J16: 968-977, 1997
29. Haldar S, Jena N and Croce CM: Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci USA 92: 4507-4511, 1995
30. Maundrell K, Antonsson B, Magnenat E, Camps M, Muda M, Chabert C, Gillieron C, Beschert U, Vial-Knecht E, Marinou J-C and Arkinstall S: Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. J Biol Chem 272: 25238-25242, 1997
31. Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K and Ichijo H: ASK1 is essential for JNK/SAPK activation of TRAF2. Mol Cell 2: 389-395, 1998