Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells

Cancer Research

Volumn 59, Issue 6, 1999, Pages 1378-1385

  Ramdas, Jyoti ^a   Liu, Wei ^a,b   Harmon, Jeffrey M ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; DNA; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; TETRACYCLINE; TRITIUM;

ARTICLE; CELL DEATH; GENE EXPRESSION REGULATION; GROWTH REGULATION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; CELL DIVISION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOCORTICOIDS; HUMANS; LEUKEMIA, T-CELL; MUTATION; RECEPTORS, GLUCOCORTICOID; T-LYMPHOCYTES; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033559204     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Vanderbilt, J. N., Miesfeld, R., Maler, B. A., and Yamamoto, K. R. Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity. Mol. Endocrinol., 1, 68-74, 1987.
2. Gehring, U., Mugele, K., and Ulrich, J. Cellular receptor levels and glucocorticoid responsiveness of lymphoma cells. Mol. Cell. Endocrinol., 36: 107-113, 1984.
3. Bourgeois, S., and Newby, R. F. Diploid and haploid states of the glucocorticoid receptor gene of mouse lymphoid cell lines. Cell. 11: 423-430, 1977.
4. Chapman, M. S., Askew, D. J., Kuscuoglu, U., and Miesfeld, R. L. Transcriptional control of steroid-regulated apoptosis in murine thymoma cells. Mol. Endocrinol., 10: 967-978, 1996.
5. Weiss, C., Ho, A. D., Hiller, E., Thiel, E., Schlag, R., Lipp, T., Herrmann, R., Musch, E., Termander, B., and Hunstein, W. Prognostic significance of glucocorticoid receptor determination in patients with chronic lymphocytic leukemia and immunocytoma: lack of a positive correlation between receptor levels and clinical responsiveness. Leuk. Res., 14: 327-332, 1990.
6. Kato, G. J., Quddus, F. F., Shuster, J. J., Boyett, J., Pullen, J. D., Borowitz, M. J., Whitehead, V. M., Crist, W. M., and Leventhal, B. G. High glucocorticoid receptor content of leukemic blasts is a favorable prognostic factor in childhood acute lymphoblastic leukemia. Blood, 82: 2304-2309, 1993.
7. Iacobelli, S., Marchetti, P., De Rossi, G., Mandelli, F., and Gentiloni, N. Glucocorticoid receptors predict response to combination chemotherapy in patients with acute lymphoblastic leukemia. Oncology (Basel), 44: 13-16, 1987.
8. Pui, C. H., Dahl, G. V., Rivera, G., Murphy, S. B., and Costlow, M. E. The relationship of blast cell glucocorticoid receptor levels to response to single-agent steroid trial and remission response in children with acute lymphoblastic leukemia. Leuk. Res., 8: 579-585, 1984.
9. Pui, C. H., and Costlow, M. E. Sequential studies of lymphoblast glucocorticoid receptor levels at diagnosis and relapse in childhood leukemia: an update. Leuk. Res., 10: 227-229, 1986.
10. Pui, C. H., Ochs, J., Kalwinsky, D. K., and Costlow, M. E. Impact of treatment efficacy on the prognostic value of glucocorticoid receptor levels in childhood acute lymphoblastic leukemia. Leuk. Res., 8: 345-350, 1984.
11. Pui, C. H., Costlow, M. E., Kalwinsky, D. K., and Dahl, G. V. Glucocorticoid receptors in childhood acute non-lymphocytic leukemia. Leuk. Res., 7: 11-16, 1983.
12. Eisen, L. P., Elsasser, M. S., and Harmon, J. M. Positive regulation of the glucocorticoid receptor in human T-cells sensitive to the cytolytic effects of glucocorticoids. J. Biol. Chem., 263: 12044-12048, 1988.
13. Denton, R. R., Eisen, L. P., Elsasser, M. S., and Harmon, J. M. Differential autoregulation of glucocorticoid receptor expression in human T-cell and B-cell lines. Endocrinology, 133: 248-256, 1993.
14. Ashraf, J., Kunapuli, S., Chilton, D., and Thompson, E. B. Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells. J. Steroid Biochem. Mol. Biol., 38: 561-568, 1991.
15. Antakly, T., Thompson, E. B., and O'Donnell, D. Demonstration of the intracellular localization and up-regulation of glucocorticoid receptor by in situ hybridization and immunocytochemistry. Cancer Res., 49: 2230-2234, 1989.
16. Barrett, T. J., Vig, E., and Vedeckis, W. V. Coordinate regulation of glucocorticoid receptor and c-jun gene expression is cell type-specific and exhibits differential hormonal sensitivity for down-and up-regulation. Biochemistry, 35: 9746-9753, 1996.
17. Gomi, M., Moriwaki, K., Katagiri, S., Kurata, Y., and Thompson, E. B. Glucocorticoid effects on myeloma cells in culture: correlation of growth inhibition with induction of glucocorticoid receptor messenger RNA. Cancer Res., 50: 1873-1878, 1990.
18. Powers, J. H., Hillmann, A. G., Tang, D. C., and Harmon, J. M. Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and glucocorticoid-resistant human leukemic cells. Cancer Res., 53: 4059-4065, 1993.
19. Liu, W., Hillmann, A. G., and Harmon, J. M. Hormone-independent repression of AP-1-inducible collagenase promoter activity by glucocorticoid receptors. Mol. Cell. Biol., 15: 1005-1013, 1995.
20. Ramdas, J., and Harmon, J. M. Glucocorticoid-induced apoptosis and regulation of NF-κB activity in human leukemic T cells. Endocrinology, 139: 3813-3821, 1998.
21. Gossen, M., and Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA, 89: 5547-5551, 1992.
22. 1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol., 14: 1669-1679, 1994.
23. Hollenberg, S. M., Weinberger, C., Ong, E. S., Cerelli, G., Oro, A., Lebo, R., Thompson, E. B., Rosenfeld, M. G., and Evans, R. M. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature (Lond.), 318: 635-641, 1985.
24. Harmon, J. M., and Thompson, E. B. Isolation and characterization of dexamethasone-resistant mutants from human lymphoid cell line CEM-C7. Mol. Cell. Biol., 1: 512-521, 1981.
25. Gorczyca, W., Gong, J., and Darzynkiewicz, Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res., 53: 1945-1951, 1993.
26. Palmer, L. A., Hukku, B., and Harmon, J. M. Human glucocorticoid receptor gene deletion following exposure to cancer chemotherapeutic drugs and chemical mutagens. Cancer Res., 52: 6612-6618, 1992.
27. Harmon, J. M., Eisen, H. J., Brower, S. T., Simons, S. S., Jr., Langley, C. L., and Thompson, E. B. Identification of human leukemic glucocorticoid receptors using affinity labeling and anti-human glucocorticoid receptor antibodies. Cancer Res., 44: 4540-4547, 1984.
28. Palmer, L. A., and Harmon, J. M. Biochemical evidence that glucocorticoid-sensitive cell lines derived from the human leukemic cell line CCRF-CEM express a normal and a mutant glucocorticoid receptor gene. Cancer Res., 51: 5224-5231, 1991.
29. Burnstein, K. L., Bellingham, D. L., Jewell, C. M., Powell-Oliver, F. E., and Cidlowski, J. A. Autoregulation of glucocorticoid receptor gene expression. Steroids, 56: 52-58, 1991.
30. Schmidt, T. J., and Meyer, A. S. Autoregulation of corticosteroid receptors: how, when, where, and why? Receptor, 4: 229-257, 1994.
31. Vig, E., Barren, T. J., and Vedeckis, W. V. Coordinate regulation of glucocorticoid receptor and c-jun mRNA levels: evidence for cross-talk between two signaling pathways at the transcriptional level. Mol. Endocrinol., 8: 1336-1346, 1994.
32. Hollenberg, S. M., and Evans, R. M. Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. Cell, 55: 899-906, 1988.
33. Dahlman-Wright, K., Almlöf, T., McEwan, I. J., Gustafsson, J. Å., and Wright, A. P. H. Delineation of a small region within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression. Proc. Natl. Acad. Sci. USA, 91: 1619-1623, 1994.
34. Sheppard, K. E., Roberts, J. L., and Blum, M. Differential regulation of type II corticosteroid receptor messenger ribonucleic acid expression in the rat anterior pituitary and hippocampus. Endocrinology, 127: 431-439, 1990.
35. Zong, J., Ashraf, J., and Thompson, E. B. The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor clement sites. Mol. Cell. Biol., 10: 5580-5585, 1990.
36. Encio, I. J., and Detera-Wadleigh, S. D. The genomic structure of the human glucocorticoid receptor. J. Biol. Chem., 266: 7182-7188, 1991.
37. Govindan, M. V., Pothier, F., Leclerc, S., Palaniswami, R., and Xie, B. Human glucocorticoid receptor gene promotor: homologous down-regulation. J. Steroid Biochem. Mol. Biol., 40: 317-323, 1991.
38. Nobukuni, Y., Smith, C. L., Hager, G. L., and Detera-Wadleigh, S. D. Characterization of the human glucocorticoid receptor promoter. Biochemistry, 34: 8207-8214, 1995.
39. Warriar, N., Page, N., and Govindan, M. V. Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element. J. Biol. Chem., 271: 18662-18671, 1996.
40. Castren, M., Trapp, T., Berninger, B., Castren, E., and Holsboer, F. Transcriptional induction of rat mineralocorticoid receptor gene in neurones by corticosteroids. J. Mol. Endocrinol., 14: 285-293, 1995.
41. Dai, J. L., Maiorino, C. A., Gkonos, P. J., and Burnstein, K. L. Androgenic up-regulation of androgen receptor cDNA expression in androgen-independent prostate cancer cells. Steroids, 61: 531-539, 1996.
42. Ledai, J., and Bumstein, K. L. Two androgen response elements in the androgen receptor coding region are required for cell-specific up-regulation of receptor messenger RNA. Mol. Endocrinol., 10: 1582-1594, 1996.
43. Geley, S., Hartmann, B. L., Hala, M., Strasser-Wozak, E. M. C., Kapelari, K., and Kofler, R. Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression. Cancer Res., 56: 5033-5038, 1996.
44. Thompson, E. B., Smith, J. R., Bourgeois, S., and Harmon, J. M. Glucocorticoid receptors in human leukemias and related diseases. Klin. Wochenschr., 63: 689-698, 1985.
45. Gasson, J. C., and Bourgeois, S. A new determinant of glucocorticoid sensitivity in lymphoid cell lines. J. Cell Biol., 96: 409-415, 1983.
46. Howe, J. R., Skryabin, B. V., Belcher, S. M., Zerillo, C. A., and Schmauss, C. The responsiveness of a tetracycline-sensitive expression system differs in different cell lines. J. Biol. Chem., 270: 14168-14174, 1995.
47. Compton, M. M., and Cidlowski, J. A. Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid. Endocrinology, 118: 38-45, 1986.
48. Bansal, N., Houle, A., and Melnykovych, G. Apoptosis: mode of cell death induced in T-cell leukemia lines by dexamethasone and other agents. FASEB J., 5: 211-216, 1991.
49. Wyllie, A. H., Morris, R. G., Smith, A. L., and Dunlop, D. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol., 142: 67-77, 1984.