FOXP3: Required but not sufficient. the role of GARP (LRRC32) as a safeguard of the regulatory phenotype

Current Molecular Medicine

Volumn 10, Issue 6, 2010, Pages 533-539

  Probst Kepper, M ^a,b   Balling, R ^c   Buer, J ^d  

^a KLINIKUM BRAUNSCHWEIG   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^d UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

FOXP3; GARP; LAP; Positive feedback; Regulatory T cells; TGF

Indexed keywords

CD28 ANTIGEN; CELL SURFACE RECEPTOR; GLYCOPROTEIN A REPETITION PREDOMINANTLY; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; LEGUMAIN; LYMPHOCYTE RECEPTOR; MICRORNA; PROTEIN LRRC32; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; LRRC32 PROTEIN, HUMAN; MEMBRANE PROTEIN;

ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CELL STIMULATION; CROSS LINKING; ENDOSOME; EPIGENETICS; HUMAN; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; LYSOSOME; NONHUMAN; PHENOTYPE; POSITIVE FEEDBACK; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; ANIMAL; BIOLOGICAL MODEL; GENETICS; METABOLISM;

ANIMALS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 77249105101     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/1566524011009060533     Document Type: Article

References (70)

1. Hori, S. (2008) Eur. J. Immunol., 38, 928-930.
2. Ziegler, S.F. (2006) Annu. Rev. Immunol., 24, 209-226.
3. Gambineri, E., Torgerson, T.R. and Ochs, H.D. (2003) Curr. Opin. Rheumatol., 15, 430-435.
4. Fontenot, J.D., Rasmussen, J.P., Williams, L.M., Dooley, J.L., Farr, A.G. and Rudensky, A.Y. (2005) Immunity, 22, 329-341.
5. Lin, W., Haribhai, D., Relland, L., Truong, N., Carlson, M., Williams, C. and Chatila, T. (2007) Nat. Immunol., 8, 359-368.
6. Hori, S., Nomura, T. and Sakaguchi, S. (2003) Science, 299, 1057-1061.
7. Fontenot, J.D., Gavin, M.A. and Rudensky, A.Y. (2003) Nat. Immunol., 4, 330-336.
8. Khattri, R., Cox, T., Yasayko, S.A. and Ramsdell, F. (2003) Nat. Immunol., 4, 337-342.
9. Ocklenburg, F., Moharregh-Khiabani, D., Geffers, R., Janke, V., Pfoertner, S., Garritsen, H., Groebe, L., Klempnauer, J., Dittmar, K.E., Weiss, S., Buer, J. and Probst-Kepper, M. (2006) Lab. Invest., 86, 724-737.
10. Allan, S.E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P.C., Ziegler, S.F., Roncarolo, M.G. and Levings, M.K. (2005) J. Clin. Invest., 115, 3276-3284.
11. Fontenot, J.D., Dooley, J.L., Farr, A.G. and Rudensky, A.Y. (2005) J. Exp. Med., 202, 901-906.
12. Roncarolo, M.G. and Gregori, S. (2008) Eur. J. Immunol., 38, 925-927.
13. Walker, M.R., Kasprowicz, D.J., Gersuk, V.H., Benard, A., Van Landeghen, M., Buckner, J.H. and Ziegler, S.F. (2003) J. Clin. Invest., 112, 1437-1443.
14. Gavin, M.A., Torgerson, T.R., Houston, E., deRoos, P., Ho, W.Y., Stray-Pedersen, A., Ocheltree, E.L., Greenberg, P.D., Ochs, H.D. and Rudensky, A.Y. (2006) Proc. Natl. Acad. Sci. USA, 103, 6659-6664.
15. Allan, S.E., Crome, S.Q., Crellin, N.K., Passerini, L., Steiner, T.S., Bacchetta, R., Roncarolo, M.G. and Levings, M.K. (2007) Int. Immunol., 19, 345-354.
16. Tran, D.Q., Ramsey, H. and Shevach, E.M. (2007) Blood, 110, 2983-2990.
17. Wang, F., Ioan-Facsinay, A., van der Voort, E.I.H., Huizinga, T.W. and Toes, R.E. (2007) Eur. J. Immunol., 37, 129-138.
18. François, V., Ottaviani, S., Renkvist, N., Stockis, J., Schuler, G., Thielemans, K., Colau, D., Marchand, M., Boon, T., Lucas, S. and van der Bruggen, P. (2009) Cancer Res., 69, 4335-4345.
19. Probst-Kepper, M., Geffers, R., Kröger, A., Viegas, N., Erck, C., Hecht, H.J., Lünsdorf, H., Roubin, R., Moharregh-Khiabani, D., Wagner, K., Ocklenburg, F., Jeron, A., Garritsen, H., Arstila, T.P., Kekäläinen, E., Balling, R., Hauser, H., Buer, J., and Weiss, S. (2009) J. Cell. Mol. Med., 13 (9B), 3343-3357.
20. Takaki, H., Ichiyama, K., Koga, K., Chinen, T., Takaesu, G., Sugiyama, Y., Kato, S., Yoshimura, A. and Kobayashi, T. (2008) J. Biol. Chem., 283, 14955-14962.
21. Tran, D.Q., Andersson, J., Wang, R., Ramsey, H., Unutmaz, D. and Shevach, E.M. (2009) Proc. Natl. Acad. Sci. USA, 106, 13445-13450.
22. Gavin, M.A., Rasmussen, J.P., Fontenot, J.D., Vasta, V., Manganiello, V.C., Beavo, J.A. and Rudensky, A.Y. (2007) Nature, 445, 771-775.
23. Hill, J.A., Feuerer, M., Tash, K., Haxhinasto, S., Perez, J., Melamed, R., Mathis, D. and Benoist, C. (2007) Immunity, 27, 786-800.
24. Apostolou, I., Sarukhan, A., Klein, L. and von Boehmer, H. (2002) Nat. Immunol., 3, 756-763.
25. Jordan, M.S., Boesteanu, A., Reed, A.J., Petrone, A.L., Holenbeck, A.E., Lerman, M.A., Naji, A. and Caton, A.J. (2001) Nat. Immunol., 2, 301-306.
26. Koonpaew, S., Shen, S., Flowers, L. and Zhang, W. (2005) J. Exp. Med., 203, 119-129.
27. Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z.A., Cobb, B.S., Cantrell, D., O'Connor, E., Shokat, K.M., Fisher, A.G. and Merkenschlager, M. (2008) Proc. Natl. Acad. Sci. USA, 105, 7797-7802.
28. Haxhinasto, S., Mathis, D. and Benoist, C. (2008) J. Exp. Med., 205, 565-574.
29. Salomon, B., Lenschow, D.J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A. and Bluestone, J.A. (2000) Immunity, 12, 431-440.
30. Tai, X., Cowan, M., Feigenbaum, L. and Singer, A. (2005) Nat. Immunol., 6, 152-162.
31. Mantel, P.Y., Ouaked, N., Ruckert, B., Karagiannidis, C., Welz, R., Blaser, K. and Schmidt-Weber, C.B. (2006) J. Immunol., 176, 3593-3602.
32. Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M.L., Greene, M.I. and Tone, M. (2008) Nat. Immunol., 9, 194-202.
33. Kim, H.P. and Leonard, W.J. (2007) J. Exp. Med., 204, 1543-1551.
34. Bruno, L., Mazzarella, L., Hoogenkamp, M., Hertweck, A., Cobb, B.S., Sauer, S., Hadjur, S., Leleu, M., Naoe, Y., Telfer, J.C., Bonifer, C., Taniuchi, I., Fisher, A.G. and Merkenschlager, M. (2009) J. Exp. Med., 206, 2329-2337.
35. Klunker, S., Chong, M.M.W., Mantel, P.Y., Palomares, O., Bassin, C., Ziegler, M., Rückert, B., Meiler, F., Akdis, M., Littman, D.R. and Akdis, C.A. (2009) J. Exp. Med., 206, 2701-2715.
36. Sadlack, B., Löhler, J., Schorle, H., Klebb, G., Haber, H., Sickel, E., Noelle, R.J. and Horak, I. (1995) Eur. J. Immunol., 25, 3053-3059.
37. Setoguchi, R., Hori, S., Takahashi, T. and Sakaguchi, S. (2005) J. Exp. Med., 201, 723-735.
38. Malek, T.R., Yu, A., Vincek, V., Scibelli, P. and Kong, L. (2002) Immunity, 17, 167-178.
39. Burchill, M.A., Yang, J., Vogtenhuber, C., Blazar, B.R. and Farrar, M.A. (2007) J. Immunol., 178, 280-290.
40. Zorn, E., Nelson, E.A., Mohseni, M., Porcheray, F., Kim, H., Litsa, D., Bellucci, R., Raderschall, E., Canning, C., Soiffer, R.J., Frank, D.A. and Ritz, J. (2006) Blood, 108, 1571-1579.
41. Mayack, S.R. and Berg, L.J. (2006) J. Immunol., 176, 2059-2063.
42. Yao, Z., Kanno, Y., Kerenyi, M., Stephens, G., Durant, L., Watford, W.T., Laurence, A., Robinson, G.W., Shevach, E.M., Moriggl, R., Hennighausen, L., Wu, C. and O'Shea, J.J. (2007) Blood, 109, 4368-4375.
43. Fontenot, J.D., Rasmussen, J.P., Gavin, M.A. and Rudensky, A.Y. (2005) Nat. Immunol., 6, 1142-1151.
44. Fantini, M.C., Becker, C., Monteleone, G., Pallone, F., Galle, P.R. and Neurath, M.F. (2004) J. Immunol., 172, 5149-5153.
45. Stockis, J., Fink, W., François, V., Connerotte, T., de Smet, C., Knoops, L., van der Bruggen, P., Coulie, P.G. and Lucas, S. (2009) Eur. J. Immunol., 39, 869-882.
46. Nakamura, K., Kitani, A., Fuss, I., Pedersen, A., Harada, N., Nawata, H. and Strober, W. (2004) J. Immunol., 172, 834-842.
47. Venuprasad, K., Huang, H., Harada, Y., Elly, C., Subramaniam, M., Spelsberg, T., Su, J. and Liu, Y.C. (2008) Nat. Immunol., 9, 245-253.
48. Jonuleit, H., Schmitt, E., Kakirman, H., Stassen, M., Knop, J. and Enk, A.H. (2002) J. Exp. Med., 196, 255-260.
49. Stockis, J., Colau, D., Coulie, P.G. and Lucas, S. (2009) Eur. J. Immunol., 39, 3315-3322.
50. Reinwald, S., Wiethe, C., Westendorf, A.M., Breloer, M., Probst-Kepper, M., Fleischer, B., Steinkasserer, A., Buer, J. and Hansen, W. (2008) J. Immunol., 180, 5890-5897.
51. Hansen, W., Loser, K., Westendorf, A.M., Bruder, D., Pfoertner, S., Siewert, C., Huehn, J., Beissert, S. and Buer, J. (2006) J. Immunol., 177, 209-215.
52. Yang, Z.Z., Novak, A.J., Ziesmer, S.C., Witzig, T.E. and Ansell, S.M. (2008) Blood, 110, 2537-2544.
53. Wang, R., Wan, Q., Kozhaya, L., Fujii, H. and Unutmaz, D. (2008) PLoS. One, 3, e27705.
54. Probst-Kepper, M., Kröger, A., Garritsen, H.S.P. and Buer, J. (2009) Transfus. Med. Hemother., 36, 302-308.
55. Wang, R., Kozhaya, L., Mercer, F., Khaitan, A., Fujii, H. and Unutmaz, D. (2009) Proc. Natl. Acad. Sci. USA, 106, 13439-13444.
56. Zhou, X., Jeker, L.T., Fife, B.T., Zhu, S., Anderson, M.S., McManus, M.T. and Bluestone, J.A. (2008) J. Exp. Med., 205, 1983-1991.
57. Liston, A., Lu, L.-F., O'Carroll, D., Tarakhovsky, A. and Rudensky, A.Y. (2008) J. Exp. Med., 205, 1993-2004.
58. Chong, M.M., Rasmussen, J.P., Rudensky, A.Y. and Littman, D.R. (2008) J. Exp. Med., 205, 2005-2017.
59. Rouas, R., Fayyad-Kazan, H., El Zein, N., Lewalle, P., Rothe, F., Simion, A., Akl, H., Mourtada, M., El Rifai, M., Burny, A., Romero, P., Martiat, P. and Badran, B. (2009) Eur. J. Immunol., 39, 1608-1618.
60. Marson, A., Kretschmer, K., Frampton, G.M., Jacobsen, E.S., Polansky, J.K., MacIsaac, K.D., Levine, S.S., Fraenkel, E., von Boehmer, H. and Young, R.A. (2007) Nature, 445, 931-935.
61. Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J., Schlawe, K., Chang, H.D., Bopp, T., Schmitt, E., Klein-Hessling, S., Serfling, E., Hamann, A. and Huehn, J. (2007) PLoS Biol., 5, e38.
62. Schmidl, C., Klug, M., Boeld, T.J., Andreesen, R., Hoffmann, P., Edinger, M. and Rehli, M. (2009) Genome Res., 19, 1165-1174.
63. Martinez-Llordella, M., Lozano, J.J., Puig-Pey, I., Orlando, G., Tisone, G., Lerut, J., Benitez, C., Pons, J.A., Parilla, P., Ramirez, P., Bruguera, M., Rimola, A. and Sanchez-Fueyo, A. (2008) J. Clin. Invest., 118, 2845-2857.
64. Demotte, N., Stroobant, V., Van Der Smissen, P., Colau, D., Luescher, E.F., Hivroz, C., Nicaise, C., Squifflet, J., Mourad, M., Godelaine, D., Boon, T. and van der Bruggen, P. (2008) Immunity, 28, 414-424.
65. Watts, C., Matthews, S.P., Mazzeo, D., Manoury, B. and Moss, C.X. (2005) Immunol. Rev., 207, 218-228.
66. MacKenzie, D.A., Schartner, J., Lin, J., Timmel, A., Jennens-Clough, M., Fathman, C.G. and Seroogy, C.M. (2007) J. Biol. Chem., 282, 9696-9702.
67. Wei, J., Duramad, J.O., Perng, O.A., Reiner, S.L., Liu, Y.J. and Qin, F.X. (2007) Proc. Natl. Acad. Sci. USA, 104, 18169-18174.
68. Hadjur, S.B.L., Hertweck, A., Cobb, B.S., Taylor, B., Fisher, A.G., and Merkenschlager, M. (2009) Immunol. Lett., 122, 37-43.
69. Macaulay, I.C., Tijssen, M.R., Thijssen-Timmer, D.C., Gusnanto, A., Steward, M., Burns, P., Langford, C.F., Ellis, P., Dudbridge, F., Zwaginga, J.J., Watkins, N.A., van der Schoot, C.E. and Ouwehand, W.H. (2007) Blood, 109, 3260-3269.
70. Bernard, J.J., Seweryniak, K.E., Koniski, A.D., Spinelli, S.L., Blumberg, N., Francis, C.W., Taubman, M.B., Palis, J. and Phipps, R.P. (2009) Arterioscler. Thromb. Vasc. Biol., 29, 1874-1882.