Cardiovascular determinants of life span

Pflugers Archiv European Journal of Physiology

Volumn 459, Issue 2, 2010, Pages 315-324

  Shi, Yi ^a   Camici, Giovanni G ^a   Lüscher, Thomas F ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Blood pressure; Diabetes mellitus; Mitochondria; Obesity; Oxidative stress

Indexed keywords

OXYGEN RADICAL; PROTEIN P66; PROTEIN SHC; REACTIVE OXYGEN METABOLITE; SIRTUIN 1;

AGING; ALCOHOL CONSUMPTION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIABETES MELLITUS; DIET; HUMAN; IMMOBILIZATION; LIFESPAN; NONHUMAN; OBESITY; OXIDATIVE STRESS; PREVALENCE; PRIORITY JOURNAL; REVIEW; SMOKING;

AGING; ANIMALS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DIET; HUMANS; LIFE EXPECTANCY; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SHC SIGNALING ADAPTOR PROTEINS; SIRTUIN 1;

EID: 73749088608     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-009-0727-2     Document Type: Review

References (122)

1. P Abete N Ferrara F Cacciatore E Sagnelli M Manzi V Carnovale C Calabrese D de Santis G Testa G Longobardi C Napoli F Rengo 2001 High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients J Am Coll Cardiol 38 1357 1365 Electronic Resource Number (111) 1:STN:280:DC%2BD3MnktVOmug%3D%3D 11691508
2. A Adler E Messina B Sherman Z Wang H Huang A Linke TH Hintze 2003 NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats Am J Physiol Heart Circ Physiol 285 H1015 H1022 Electronic Resource Number (44) 1:CAS:528:DC%2BD3sXnsVGnur4%3D 12915388
3. M Aikawa S Sugiyama CC Hill SJ Voglic E Rabkin Y Fukumoto FJ Schoen JL Witztum P Libby 2002 Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma Circulation 106 1390 1396 Electronic Resource Number (53) 1:CAS:528:DC%2BD38XntVKksLw%3D 12221058
4. RR Alcendor S Gao P Zhai D Zablocki E Holle X Yu B Tian T Wagner SF Vatner J Sadoshima 2007 Sirt1 regulates aging and resistance to oxidative stress in the heart Circ Res 100 1512 1521 Electronic Resource Number (106) 1:CAS:528:DC%2BD2sXltl2nsbY%3D 17446436
5. CS Baker RJ Hall TJ Evans A Pomerance J Maclouf C Creminon MH Yacoub JM Polak 1999 Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages Arterioscler Thromb Vasc Biol 19 646 655 Electronic Resource Number (49) 1:CAS:528:DyaK1MXitFGnsb4%3D 10073969
6. VL Ballard JM Edelberg 2007 Stem cells and the regeneration of the aging cardiovascular system Circ Res 100 1116 1127 Electronic Resource Number (2) 1:CAS:528:DC%2BD2sXktlOhsrs%3D 17463327
7. M Barton CC Haudenschild LV d'Uscio S Shaw K Munter TF Luscher 1998 Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice Proc Natl Acad Sci U S A 95 14367 14372 Electronic Resource Number (13) 1:CAS:528:DyaK1cXns1Gls7g%3D 9826706
8. PM Bath 1993 The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro Eur J Clin Pharmacol 45 53 58 Electronic Resource Number (7) 1:CAS:528:DyaK3sXmtFOjt7s%3D 8405030
9. I Berniakovich M Trinei M Stendardo E Migliaccio S Minucci P Bernardi PG Pelicci M Giorgio 2008 p66Shc-generated oxidative signal promotes fat accumulation J Biol Chem 283 34283 34293 Electronic Resource Number (83) 1:CAS:528:DC%2BD1cXhsVelu7rF 18838380
10. MA Black DJ Green NT Cable 2008 Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels J Physiol 586 3511 3524 Electronic Resource Number (116) 1:CAS:528:DC%2BD1cXptlanur8%3D 18483071
11. JA Blumenthal A Sherwood MA Babyak LL Watkins R Waugh A Georgiades SL Bacon J Hayano RE Coleman A Hinderliter 2005 Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial JAMA 293 1626 1634 Electronic Resource Number (114) 1:CAS:528:DC%2BD2MXjtV2qs7Y%3D 15811982
12. L Bonfini E Migliaccio G Pelicci L Lanfrancone PG Pelicci 1996 Not all Shc's roads lead to Ras Trends Biochem Sci 21 257 261 Electronic Resource Number (75) 1:CAS:528:DyaK28XksVymsbc%3D 8755247
13. L Bordone MC Motta F Picard A Robinson US Jhala J Apfeld T McDonagh M Lemieux M McBurney A Szilvasi EJ Easlon SJ Lin L Guarente 2006 Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells PLoS Biol 4 e31 Electronic Resource Number (99) 16366736
14. L Boring J Gosling M Cleary IF Charo 1998 Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis Nature 394 894 897 Electronic Resource Number (27) 1:CAS:528:DyaK1cXlvVemsLY%3D 9732872
15. A Brunet LB Sweeney JF Sturgill KF Chua PL Greer Y Lin H Tran SE Ross R Mostoslavsky HY Cohen LS Hu HL Cheng MP Jedrychowski SP Gygi DA Sinclair FW Alt ME Greenberg 2004 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2011 2015 Electronic Resource Number (91) 1:CAS:528:DC%2BD2cXisVGlt70%3D 14976264
16. F Cacciapuoti R Marfella G Paolisso 2009 Is the aging heart similar to the diabetic heart? Evaluation of LV function of the aging heart with Tissue Doppler Imaging Aging Clin Exp Res 21 22 26 Electronic Resource Number (37) 19225265
17. H Cai DG Harrison 2000 Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress Circ Res 87 840 844 Electronic Resource Number (33) 1:CAS:528:DC%2BD3cXoslygsrk%3D 11073878
18. GG Camici F Cosentino FC Tanner TF Luscher 2008 The role of p66Shc deletion in age-associated arterial dysfunction and disease states J Appl Physiol 105 1628 1631 Electronic Resource Number (79) 1:CAS:528: DC%2BD1cXhsVOqsrfJ 18772327
19. GG Camici M Schiavoni P Francia M Bachschmid I Martin-Padura M Hersberger FC Tanner P Pelicci M Volpe P Anversa TF Luscher F Cosentino 2007 Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress Proc Natl Acad Sci U S A 104 5217 5222 Electronic Resource Number (58) 1:CAS:528:DC%2BD2sXjvFCgtbk%3D 17360381
20. D Cesselli I Jakoniuk L Barlucchi AP Beltrami TH Hintze B Nadal-Ginard J Kajstura A Leri P Anversa 2001 Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy Circ Res 89 279 286 Electronic Resource Number (1) 1:CAS:528:DC%2BD3MXmt1ClsbY%3D 11485979
21. HY Cohen C Miller KJ Bitterman NR Wall B Hekking B Kessler KT Howitz M Gorospe R de Cabo DA Sinclair 2004 Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science 305 390 392 Electronic Resource Number (95) 1:CAS:528:DC%2BD2cXls1egtrs%3D 15205477
22. T Collins MI Cybulsky 2001 NF-kappaB: pivotal mediator or innocent bystander in atherogenesis? J Clin Invest 107 255 264 Electronic Resource Number (57) 1:CAS:528:DC%2BD3MXhtVGitrc%3D 11160146
23. Cosentino F, Francia P, Camici GG, Pelicci PG, Luscher TF (2007) Final common molecular pathways of aging and cardiovascular disease. Role of the p66Shc Protein. Arterioscler Thromb Vasc Biol Resource Number (78)
24. F Cosentino P Francia GG Camici PG Pelicci TF Luscher M Volpe 2008 Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein Arterioscler Thromb Vasc Biol 28 622 628 Electronic Resource Number (32) 1:CAS:528:DC%2BD1cXjt1Sls7g%3D 18162611
25. A Csiszar K Smith N Labinskyy Z Orosz A Rivera Z Ungvari 2006 Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition Am J Physiol Heart Circ Physiol 291 H1694 H1699 Electronic Resource Number (121) 1:CAS:528:DC%2BD28XhtFegt77L 16973825
26. A Csiszar Z Ungvari JG Edwards P Kaminski MS Wolin A Koller G Kaley 2002 Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function Circ Res 90 1159 1166 Electronic Resource Number (16) 1:CAS:528:DC%2BD38XkvV2gsLs%3D 12065318
27. A Csiszar M Wang EG Lakatta Z Ungvari 2008 Inflammation and endothelial dysfunction during aging: role of NF-kappaB J Appl Physiol 105 1333 1341 Electronic Resource Number (24) 1:CAS:528:DC%2BD1cXht1KqurzK 18599677
28. SD Cushing JA Berliner AJ Valente MC Territo M Navab F Parhami R Gerrity CJ Schwartz AM Fogelman 1990 Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells Proc Natl Acad Sci U S A 87 5134 5138 Electronic Resource Number (30) 1:CAS:528:DyaK3cXkvFGmtLg%3D 1695010
29. MI Cybulsky K Iiyama H Li S Zhu M Chen M Iiyama V Davis JC Gutierrez-Ramos PW Connelly DS Milstone 2001 A major role for VCAM-1, but not ICAM-1, in early atherosclerosis J Clin Invest 107 1255 1262 Electronic Resource Number (26) 1:CAS:528:DC%2BD3MXjsl2ntrs%3D 11375415
30. A de Belder M Radomski V Hancock A Brown S Moncada J Martin 1995 Megakaryocytes from patients with coronary atherosclerosis express the inducible nitric oxide synthase Arterioscler Thromb Vasc Biol 15 637 641 Electronic Resource Number (4) 7538428
31. AS De Vriese TJ Verbeuren J Van de Voorde NH Lameire PM Vanhoutte 2000 Endothelial dysfunction in diabetes Br J Pharmacol 130 963 974 Electronic Resource Number (35) 10882379
32. V Di Stefano C Cencioni G Zaccagnini A Magenta MC Capogrossi F Martelli 2009 p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose Cardiovasc Res 82 3 421 429 19261622
33. C Fernandez-Patron MW Radomski ST Davidge 2000 Role of matrix metalloproteinase-2 in thrombin-induced vasorelaxation of rat mesenteric arteries Am J Physiol Heart Circ Physiol 278 H1473 H1479 Electronic Resource Number (6) 1:CAS:528:DC%2BD3cXjvFahsr8%3D 10775124
34. N Ferrara B Rinaldi G Corbi V Conti P Stiuso S Boccuti G Rengo F Rossi A Filippelli 2008 Exercise training promotes SIRT1 activity in aged rats Rejuvenation Res 11 139 150 Electronic Resource Number (110) 1:CAS:528:DC%2BD1cXitVKmtrw%3D 18069916
35. T Finkel NJ Holbrook 2000 Oxidants, oxidative stress, and the biology of ageing Nature 408 239 247 Electronic Resource Number (42) 1:CAS:528: DC%2BD3cXotFGltb0%3D 11089981
36. I Fleming A Mohamed J Galle L Turchanowa RP Brandes B Fisslthaler R Busse 2005 Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha Cardiovasc Res 65 897 906 Electronic Resource Number (54) 1:CAS:528:DC%2BD2MXhsVOnu7c%3D 15721870
37. P Francia C delli Gatti M Bachschmid I Martin-Padura C Savoia E Migliaccio PG Pelicci M Schiavoni TF Luscher M Volpe F Cosentino 2004 Deletion of p66shc gene protects against age-related endothelial dysfunction Circulation 110 2889 2895 Electronic Resource Number (84) 1:CAS:528:DC%2BD2cXptVejs70%3D 15505103
38. RF Furchgott JV Zawadzki 1980 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 373 376 Electronic Resource Number (5) 1:CAS:528:DyaL3MXhtFCktbY%3D 6253831
39. L Gu Y Okada SK Clinton C Gerard GK Sukhova P Libby BJ Rollins 1998 Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice Mol Cell 2 275 281 Electronic Resource Number (29) 1:CAS:528:DyaK1cXmtVyisrc%3D 9734366
40. ME Haberland D Fong L Cheng 1988 Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits Science 241 215 218 Electronic Resource Number (51) 1:CAS:528:DyaL1cXltVygtb0%3D 2455346
41. B Halliwell 1996 Free radicals, proteins, and DNA: oxidative damage versus redox regulation Biochem Soc Trans 24 1023 1027 Electronic Resource Number (41) 1:CAS:528:DyaK28XnsVOktbg%3D 8968505 (Pubitemid 26417963)
42. D Harman 1956 Aging: a theory based on free radical and radiation chemistry J Gerontol 11 298 300 Electronic Resource Number (38) 1:STN:280:DyaG28%2FosVygsw%3D%3D 13332224
43. C Heymes A Habib D Yang E Mathieu F Marotte J Samuel CM Boulanger 2000 Cyclo-oxygenase-1 and -2 contribution to endothelial dysfunction in ageing Br J Pharmacol 131 804 810 Electronic Resource Number (15) 1:CAS:528: DC%2BD3cXnvVGiu78%3D 11030731
44. KT Howitz KJ Bitterman HY Cohen DW Lamming S Lavu JG Wood RE Zipkin P Chung A Kisielewski LL Zhang B Scherer DA Sinclair 2003 Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature 425 191 196 Electronic Resource Number (117) 1:CAS:528:DC%2BD3sXntFCitr4%3D 12939617
45. C Karasu 1999 Increased activity of H2O2 in aorta isolated from chronically streptozotocin-diabetic rats: effects of antioxidant enzymes and enzymes inhibitors Free Radic Biol Med 27 16 27 Electronic Resource Number (69) 1:CAS:528:DyaK1MXkvVKqs7Y%3D 10443915
46. A Keegan H Walbank MA Cotter NE Cameron 1995 Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta Diabetologia 38 1475 1478 Electronic Resource Number (68) 1:CAS:528: DyaK28XnsVSrtg%3D%3D 8786022
47. BV Khan SS Parthasarathy RW Alexander RM Medford 1995 Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells J Clin Invest 95 1262 1270 Electronic Resource Number (31) 1:CAS:528: DyaK2MXktlKhu78%3D 7533787
48. J Kitayama C Yi FM Faraci DD Heistad 2006 Modulation of dilator responses of cerebral arterioles by extracellular superoxide dismutase Stroke 37 2802 2806 Electronic Resource Number (45) 17008608 (Pubitemid 44922543)
49. MD Knutson C Leeuwenburgh 2008 Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases Nutr Rev 66 591 596 Electronic Resource Number (118) 18826454
50. N Kume MI Cybulsky MA Gimbrone Jr 1992 Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human, and rabbit arterial endothelial cells J Clin Invest 90 1138 1144 Electronic Resource Number (25) 1:CAS:528:DyaK38XmtFSjsLo%3D 1381720
51. S Le TJ Connors AC Maroney 2001 c-Jun N-terminal kinase specifically phosphorylates p66ShcA at serine 36 in response to ultraviolet irradiation J Biol Chem 276 48332 48336 Electronic Resource Number (76) 1:CAS:528: DC%2BD38XltVKk 11602589
52. H Li MI Cybulsky MA Gimbrone Jr P Libby 1993 An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium Arterioscler Thromb 13 197 204 Electronic Resource Number (28) 7678986
53. S Liu IM Lee Y Song M Van Denburgh NR Cook JE Manson JE Buring 2006 Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial Diabetes 55 2856 2862 Electronic Resource Number (107) 1:CAS:528:DC%2BD28XhtVGlsrfJ 17003353
54. J Luo AY Nikolaev S Imai D Chen F Su A Shiloh L Guarente W Gu 2001 Negative control of p53 by Sir2alpha promotes cell survival under stress Cell 107 137 148 Electronic Resource Number (89) 1:CAS:528:DC%2BD3MXotVSntro%3D 11672522
55. TF Luscher FC Tanner Y Dohi 1992 Age, hypertension and hypercholesterolaemia alter endothelium-dependent vascular regulation Pharmacol Toxicol 70 S32 S39 Electronic Resource Number (34) 1:STN:280: DyaK38znsF2htg%3D%3D 1508846
56. TF Luscher ZH Yang D Diederich FR Buhler 1989 Endothelium-derived vasoactive substances: potential role in hypertension, atherosclerosis, and vascular occlusion J Cardiovasc Pharmacol 14 Suppl 6 S63 S69 Electronic Resource Number (9) 2478827
57. LA MacMillan-Crow JP Crow JA Thompson 1998 Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues Biochemistry 37 1613 1622 Electronic Resource Number (21) 1:CAS:528:DyaK1cXlt1agtg%3D%3D 9484232
58. LA Macmillan-Crow DL Cruthirds 2001 Invited review: manganese superoxide dismutase in disease Free Radic Res 34 325 336 Electronic Resource Number (20) 1:CAS:528:DC%2BD3MXjt1WmsrY%3D 11328670
59. S Makimattila A Virkamaki PH Groop J Cockcroft T Utriainen J Fagerudd H Yki-Jarvinen 1996 Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus Circulation 94 1276 1282 Electronic Resource Number (10) 1:STN:280: DyaK28vitVarsw%3D%3D 8822980
60. T Matsumoto M Kakami E Noguchi T Kobayashi K Kamata 2007 Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of Type 2 diabetes Am J Physiol Heart Circ Physiol 293 H1480 H1490 Electronic Resource Number (62) 1:CAS:528:DC%2BD2sXhtVOqtrzO 17513496
61. T Matsumoto E Noguchi K Ishida T Kobayashi N Yamada K Kamata 2008 Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes Am J Physiol Heart Circ Physiol 295 H1165 H1176 Electronic Resource Number (63) 1:CAS:528:DC%2BD1cXhtFCgtL7N 18641273
62. T Matsumoto S Yoshiyama K Wakabayashi T Kobayashi K Kamata 2004 Effects of chronic insulin on endothelial dysfunction of basilar arteries from established streptozotocin-diabetic rats Eur J Pharmacol 504 119 127 Electronic Resource Number (60) 1:CAS:528:DC%2BD2cXovFansLg%3D 15507228
63. I Mattagajasingh CS Kim A Naqvi T Yamamori TA Hoffman SB Jung J DeRicco K Kasuno K Irani 2007 SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase Proc Natl Acad Sci U S A 104 14855 14860 Electronic Resource Number (103) 1:CAS:528:DC%2BD2sXhtVOnsLrL 17785417
64. S Menini L Amadio G Oddi C Ricci C Pesce F Pugliese M Giorgio E Migliaccio P Pelicci C Iacobini G Pugliese 2006 Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress Diabetes 55 1642 1650 Electronic Resource Number (86) 1:CAS:528:DC%2BD28XlsF2rtbg%3D 16731826
65. S Menini C Iacobini C Ricci G Oddi C Pesce F Pugliese K Block HE Abboud M Giorgio E Migliaccio PG Pelicci G Pugliese 2007 Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation Diabetologia 50 1997 2007 Electronic Resource Number (87) 1:CAS:528:DC%2BD2sXos1CjtLw%3D 17611735
66. E Migliaccio M Giorgio S Mele G Pelicci P Reboldi PP Pandolfi L Lanfrancone PG Pelicci 1999 The p66shc adaptor protein controls oxidative stress response and life span in mammals Nature 402 309 313 Electronic Resource Number (74) 1:CAS:528:DyaK1MXnvFSksLc%3D 10580504
67. E Migliaccio S Mele AE Salcini G Pelicci KM Lai G Superti-Furga T Pawson PP Di Fiore L Lanfrancone PG Pelicci 1997 Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway Embo J 16 706 716 Electronic Resource Number (82) 1:CAS:528: DyaK2sXhs1Kht78%3D 9049300
68. JC Milne PD Lambert S Schenk DP Carney JJ Smith DJ Gagne L Jin O Boss RB Perni CB Vu JE Bemis R Xie JS Disch PY Ng JJ Nunes AV Lynch H Yang H Galonek K Israelian W Choy A Iffland S Lavu O Medvedik DA Sinclair JM Olefsky MR Jirousek PJ Elliott CH Westphal 2007 Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes Nature 450 712 716 Electronic Resource Number (102) 1:CAS:528:DC%2BD2sXhtlKmtbrM 18046409
69. S Moncada RM Palmer EA Higgs 1991 Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol Rev 43 109 142 Electronic Resource Number (8) 1:CAS:528:DyaK3MXmt1amtLw%3D 1852778
70. KA Moynihan AA Grimm MM Plueger E Bernal-Mizrachi E Ford C Cras-Meneur MA Permutt S Imai 2005 Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice Cell Metab 2 105 117 Electronic Resource Number (100) 1:CAS:528:DC%2BD2MXps12ht7s%3D 16098828
71. C Napoli I Martin-Padura F de Nigris M Giorgio G Mansueto P Somma M Condorelli G Sica G De Rosa P Pelicci 2003 Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet Proc Natl Acad Sci U S A 100 2112 2116 Electronic Resource Number (85) 1:CAS:528:DC%2BD3sXhsFGrtrk%3D 12571362
72. S Nemoto CA Combs S French BH Ahn MM Fergusson RS Balaban T Finkel 2006 The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism J Biol Chem 281 10555 10560 Electronic Resource Number (77) 1:CAS:528:DC%2BD28Xjt1Knsbk%3D 16481327
73. S Nemoto MM Fergusson T Finkel 2004 Nutrient availability regulates SIRT1 through a forkhead-dependent pathway Science 306 2105 2108 Electronic Resource Number (90) 1:CAS:528:DC%2BD2cXhtVOjsL3P 15604409
74. E Nisoli C Tonello A Cardile V Cozzi R Bracale L Tedesco S Falcone A Valerio O Cantoni E Clementi S Moncada MO Carruba 2005 Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS Science 310 314 317 Electronic Resource Number (98) 1:CAS:528:DC%2BD2MXhtV2hurvO 16224023
75. H Nohl R Kramer 1980 Molecular basis of age-dependent changes in the activity of adenine nucleotide translocase Mech Ageing Dev 14 137 144 Electronic Resource Number (39) 1:CAS:528:DyaL3MXmt1KksQ%3D%3D 6259455
76. M Orimo T Minamino H Miyauchi K Tateno S Okada J Moriya I Komuro 2009 Protective role of SIRT1 in diabetic vascular dysfunction Arterioscler Thromb Vasc Biol 29 889 894 Electronic Resource Number (101) 1:CAS:528: DC%2BD1MXlslCgtbc%3D 19286634
77. H Ota M Eto MR Kano S Ogawa K Iijima M Akishita Y Ouchi 2008 Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells Arterioscler Thromb Vasc Biol 28 1634 1639 Electronic Resource Number (105) 1:CAS:528:DC%2BD1cXpvFKhtrc%3D 18556572
78. E Pagnin G Fadini R de Toni A Tiengo L Calo A Avogaro 2005 Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress J Clin Endocrinol Metab 90 1130 1136 Electronic Resource Number (81) 1:CAS:528:DC%2BD2MXhsVCgtbw%3D 15562031
79. S Pandolfi M Bonafe L Di Tella L Tiberi S Salvioli D Monti S Sorbi C Franceschi 2005 p66(shc) is highly expressed in fibroblasts from centenarians Mech Ageing Dev 126 839 844 Electronic Resource Number (80) 1:CAS:528: DC%2BD2MXlvVWnu7k%3D 15992607
80. UR Pendurthi JT Williams LV Rao 1999 Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells: a possible mechanism for the cardiovascular benefits associated with moderate consumption of wine Arterioscler Thromb Vasc Biol 19 419 426 Electronic Resource Number (119) 1:CAS:528:DyaK1MXhsFSjur4%3D 9974427
81. Z Radak H Naito T Kaneko S Tahara H Nakamoto R Takahashi F Cardozo-Pelaez S Goto 2002 Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle Pflugers Arch 445 273 278 Electronic Resource Number (112) 1:CAS:528: DC%2BD3sXis1agurY%3D 12457248
82. R Radi JS Beckman KM Bush BA Freeman 1991 Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide Arch Biochem Biophys 288 481 487 Electronic Resource Number (19) 1:CAS:528: DyaK3MXksVertrY%3D 1654835
83. L Raij 1991 Hypertension, endothelium, and cardiovascular risk factors Am J Med 90 13S 18S Electronic Resource Number (11) 1:STN:280:DyaK3M7jsFOhtg%3D%3D 1994709
84. C Richter JW Park BN Ames 1988 Normal oxidative damage to mitochondrial and nuclear DNA is extensive Proc Natl Acad Sci U S A 85 6465 6467 Electronic Resource Number (40) 1:CAS:528:DyaL1cXls1Ghs70%3D 3413108
85. B Rinaldi G Corbi S Boccuti W Filippelli G Rengo D Leosco F Rossi A Filippelli N Ferrara 2006 Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart Exp Gerontol 41 764 770 Electronic Resource Number (115) 1:CAS:528:DC%2BD28XotlKjs74%3D 16822632
86. JT Rodgers C Lerin W Haas SP Gygi BM Spiegelman P Puigserver 2005 Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 Nature 434 113 118 Electronic Resource Number (96) 1:CAS:528: DC%2BD2MXhslClsb0%3D 15744310
87. L Rodriguez-Manas J Angulo S Vallejo C Peiro A Sanchez-Ferrer E Cercas P Lopez-Doriga CF Sanchez-Ferrer 2003 Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature Diabetologia 46 556 566 Electronic Resource Number (70) 1:CAS:528:DC%2BD3sXjsFejs70%3D 12739028
88. MJ Romero DH Platt HE Tawfik M Labazi AB El-Remessy M Bartoli RB Caldwell RW Caldwell 2008 Diabetes-induced coronary vascular dysfunction involves increased arginase activity Circ Res 102 95 102 Electronic Resource Number (71) 1:CAS:528:DC%2BD2sXhsVGgtLjE 17967788
89. S Ryoo CA Lemmon KG Soucy G Gupta AR White D Nyhan A Shoukas LH Romer DE Berkowitz 2006 Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling Circ Res 99 951 960 Electronic Resource Number (55) 1:CAS:528:DC%2BD28XhtFSlur7I 17008605
90. HD Sesso JE Buring WG Christen T Kurth C Belanger J MacFadyen V Bubes JE Manson RJ Glynn JM Gaziano 2008 Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial JAMA 300 2123 2133 Electronic Resource Number (109) 1:CAS:528:DC%2BD1cXhtlOrtLvP 18997197
91. Y Shi M Feletou DD Ku RY Man PM Vanhoutte 2007 The calcium ionophore A23187 induces endothelium-dependent contractions in femoral arteries from rats with streptozotocin-induced diabetes Br J Pharmacol 150 624 632 Electronic Resource Number (14) 1:CAS:528:DC%2BD2sXisVeisr0%3D 17245370 (Pubitemid 46355551)
92. Y Shi RY Man PM Vanhoutte 2008 Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats Acta Pharmacol Sin 29 185 192 Electronic Resource Number (17) 1:CAS:528:DC%2BD1cXit1Sitbs%3D 18215347
93. DA Sinclair L Guarente 1997 Extrachromosomal rDNA circles-a cause of aging in yeast Cell 91 1033 1042 Electronic Resource Number (97) 1:CAS:528:DyaK1cXjtVKitQ%3D%3D 9428525
94. AD Sniderman CD Furberg 2008 Age as a modifiable risk factor for cardiovascular disease Lancet 371 1547 1549 Electronic Resource Number (36) 18321568
95. MM Spitaler WF Graier 2002 Vascular targets of redox signalling in diabetes mellitus Diabetologia 45 476 494 Electronic Resource Number (67) 1:CAS:528:DC%2BD38Xjs1yit7g%3D 12032623
96. J Su PA Lucchesi RA Gonzalez-Villalobos DI Palen BM Rezk Y Suzuki HA Boulares K Matrougui 2008 Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice Arterioscler Thromb Vasc Biol 28 1432 1438 Electronic Resource Number (59) 1:CAS:528:DC%2BD1cXosVeru74%3D 18483403
97. C Szabo AL Salzman 1995 Endogenous peroxynitrite is involved in the inhibition of mitochondrial respiration in immuno-stimulated J774.2 macrophages Biochem Biophys Res Commun 209 739 743 Electronic Resource Number (22) 1:CAS:528:DyaK2MXltVGkt7c%3D 7733945
98. C Szabo B Zingarelli M O'Connor AL Salzman 1996 DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite Proc Natl Acad Sci U S A 93 1753 1758 Electronic Resource Number (18) 1:CAS:528:DyaK28XhsFarsLg%3D 8700830
99. N Taniguchi M Takahashi H Sakiyama YS Park M Asahi Y Misonou Y Miyamoto 2005 A common pathway for intracellular reactive oxygen species production by glycoxidative and nitroxidative stress in vascular endothelial cells and smooth muscle cells Ann N Y Acad Sci 1043 521 528 Electronic Resource Number (72) 1:CAS:528:DC%2BD2MXpvVKqtLo%3D 16037274
100. FC Tanner CM Boulanger TF Luscher 1993 Endothelium-derived nitric oxide, endothelin, and platelet vessel wall interaction: alterations in hypercholesterolemia and atherosclerosis Semin Thromb Hemost 19 167 175 Electronic Resource Number (50) 1:STN:280:DyaK3szmtF2rtQ%3D%3D 8356462
101. FC Tanner G Noll CM Boulanger TF Luscher 1991 Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide Circulation 83 2012 2020 Electronic Resource Number (56) 1:CAS:528:DyaK3MXltleju7c%3D 2040054
102. RS Taylor A Brown S Ebrahim J Jolliffe H Noorani K Rees B Skidmore JA Stone DR Thompson N Oldridge 2004 Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials Am J Med 116 682 692 Electronic Resource Number (113) 15121495
103. B Tesfamariam ML Brown D Deykin RA Cohen 1990 Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta J Clin Invest 85 929 932 Electronic Resource Number (64) 1:CAS:528: DyaK3cXhsFansrg%3D 2312734
104. A van der Horst LG Tertoolen LM de Vries-Smits RA Frye RH Medema BM Burgering 2004 FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1) J Biol Chem 279 28873 28879 Electronic Resource Number (92) 15126506
105. B van der Loo R Labugger JN Skepper M Bachschmid J Kilo JM Powell M Palacios-Callender JD Erusalimsky T Quaschning T Malinski D Gygi V Ullrich TF Luscher 2000 Enhanced peroxynitrite formation is associated with vascular aging J Exp Med 192 1731 1744 Electronic Resource Number (43) 11120770
106. A Van der Vliet D Smith CA O'Neill H Kaur V Darley-Usmar CE Cross B Halliwell 1994 Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion Biochem J 303 Pt 1 295 301 Electronic Resource Number (23) 7945255
107. PM Vanhoutte 2009 Endothelial dysfunction: the first step toward coronary arteriosclerosis Circ J 73 595 601 Electronic Resource Number (4) 1:CAS:528:DC%2BD1MXkslWnsrk%3D 19225203
108. PM Vanhoutte EH Tang 2008 Endothelium-dependent contractions: when a good guy turns bad! J Physiol 586 5295 5304 Electronic Resource Number (12) 1:CAS:528:DC%2BD1cXhsVKitbfM 18818246
109. H Vaziri SK Dessain E Ng Eaton SI Imai RA Frye TK Pandita L Guarente RA Weinberg 2001 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase Cell 107 149 159 Electronic Resource Number (88) 1:CAS:528:DC%2BD3MXotVSntrs%3D 11672523
110. NC Ward JH Wu MW Clarke IB Puddey V Burke KD Croft JM Hodgson 2007 The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial J Hypertens 25 227 234 Electronic Resource Number (108) 1:CAS:528:DC%2BD28Xht1OhtrnN 17143195
111. A Warnholtz G Nickenig E Schulz R Macharzina JH Brasen M Skatchkov T Heitzer JP Stasch KK Griendling DG Harrison M Bohm T Meinertz T Munzel 1999 Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system Circulation 99 2027 2033 Electronic Resource Number (48) 1:CAS:528: DyaK1MXivFSrsbk%3D 10209008
112. Y Wei AT Whaley-Connell K Chen J Habibi GM Uptergrove SE Clark CS Stump CM Ferrario JR Sowers 2007 NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat Hypertension 50 384 391 Electronic Resource Number (61) 1:CAS:528:DC%2BD2sXnsFOjsbw%3D 17533199
113. JN Wilcox RR Subramanian CL Sundell WR Tracey JS Pollock DG Harrison PA Marsden 1997 Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels Arterioscler Thromb Vasc Biol 17 2479 2488 Electronic Resource Number (46) 1:CAS:528:DyaK1cXisVyktQ%3D%3D 9409218
114. SB Williams AB Goldfine FK Timimi HH Ting MA Roddy DC Simonson MA Creager 1998 Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo Circulation 97 1695 1701 Electronic Resource Number (73) 1:CAS:528:DyaK1cXjsVSrsb8%3D 9591763
115. L Xia XX Wang XS Hu XG Guo YP Shang HJ Chen CL Zeng FR Zhang JZ Chen 2008 Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms Br J Pharmacol 155 387 394 Electronic Resource Number (122) 1:CAS:528:DC%2BD1cXhtFKkurbF 18587418
116. Y Yang H Hou EM Haller SV Nicosia W Bai 2005 Suppression of FOXO1
117. F Yeung JE Hoberg CS Ramsey MD Keller DR Jones RA Frye MW Mayo 2004 Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase EMBO J 23 2369 2380 Electronic Resource Number (94) 1:CAS:528:DC%2BD2cXkvVeku7Y%3D 15152190
118. S Yla-Herttuala W Palinski ME Rosenfeld S Parthasarathy TE Carew S Butler JL Witztum D Steinberg 1989 Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man J Clin Invest 84 1086 1095 Electronic Resource Number (52) 1:CAS:528:DyaL1MXlvFantb8%3D 2794046
119. T Yu JL Robotham Y Yoon 2006 Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology Proc Natl Acad Sci U S A 103 2653 2658 Electronic Resource Number (65) 1:CAS:528:DC%2BD28XksF2rsbk%3D 16477035
120. HM Zbikowska B Olas B Wachowicz T Krajewski 1999 Response of blood platelets to resveratrol Platelets 10 247 252 Electronic Resource Number (120) 1:CAS:528:DyaK1MXltlKrt7w%3D 16801100
121. Q Zhang RY Zhang JS Zhang J Hu ZK Yang J Ni YH Fang X Zhang WF Shen 2006 One-year clinical outcomes of Chinese sirolimus-eluting stent in the treatment of unselected patients with coronary artery disease Chin Med J (Engl) 119 165 168 Electronic Resource Number (66) (Pubitemid 43796935)
122. QJ Zhang Z Wang HZ Chen S Zhou W Zheng G Liu YS Wei H Cai DP Liu CC Liang 2008 Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice Cardiovasc Res 80 191 199 Electronic Resource Number (104) 1:CAS:528:DC%2BD1cXht1Knt7jI 18689793