Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation

Diabetologia

Volumn 50, Issue 9, 2007, Pages 1997-2007

  Menini, S ^a   Iacobini, C ^a   Ricci, C ^a   Oddi, G ^a   Pesce, C ^b   Pugliese, F ^a   Block, K ^c   Abboud, H E ^c   Giorgio, M ^d   Migliaccio, E ^d   Pelicci, P G ^d   Pugliese, G ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c University of Texas Health Science Center   (United States)

^d EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

AGE receptors; AGEs; Apoptosis; Extracellular matrix; NAD(P)H oxidase; Nephropathy; NOX4; Nuclear factor B; Oxidative stress; p66Shc

Indexed keywords

4 HYDROXYNONENAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSINE DERIVATIVE; PROSTAGLANDIN F2 ALPHA DERIVATIVE; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GLOMERULOPATHY; GLOMERULOSCLEROSIS; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PARENCHYMA; KIDNEY STRUCTURE; KNOCKOUT MOUSE; MALE; MESANGIUM; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; TISSUE INJURY; UPREGULATION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; DNA PRIMERS; GENOTYPE; GLOMERULAR MESANGIUM; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASES; KIDNEY GLOMERULUS; MICE; MICE, INBRED STRAINS; NF-KAPPA B; REACTIVE OXYGEN SPECIES; RECEPTORS, IMMUNOLOGIC;

EID: 34547659642     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0728-7     Document Type: Article

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