Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 3, 2008, Pages

  Matsumoto, Takayuki ^a   Noguchi, Eri ^a   Ishida, Keiko ^a   Kobayashi, Tsuneo ^a   Yamada, Nobuhiro ^b   Kamata, Katsuo ^a  

^a HOSHI UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Cyclooxygenase; Endothelium derived contracting factor; Endothelium derived hypopolarizing factor

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 6 OXOPROSTAGLANDIN F1 ALPHA; ACETYLCHOLINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INDOMETACIN; METFORMIN; NITRIC OXIDE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTANOID; SUPEROXIDE; THROMBOXANE A2; ANTIDIABETIC AGENT; CHOLESTEROL; FATTY ACID; INSULIN; LEPTIN; PROSTAGLANDIN; TRIACYLGLYCEROL; VASOCONSTRICTOR AGENT;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; MALE; MESENTERIC ARTERY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; BLOOD; BLOOD PRESSURE; DRUG EFFECT; GLUCOSE BLOOD LEVEL; METABOLISM; MUSCLE ISOMETRIC CONTRACTION; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; CHOLESTEROL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; FATTY ACIDS, NONESTERIFIED; HYPOGLYCEMIC AGENTS; INSULIN; ISOMETRIC CONTRACTION; LEPTIN; MESENTERIC ARTERIES; METFORMIN; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; PROSTAGLANDINS; RATS; RATS, INBRED OLETF; SUPEROXIDES; TRIGLYCERIDES; VASOCONSTRICTOR AGENTS;

EID: 54049100065     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00486.2008     Document Type: Article

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