Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCα

Cardiovascular Research

Volumn 65, Issue 4, 2005, Pages 897-906

  Fleming, Ingrid ^a   Mohamed, Annisuddin ^a   Galle, Jan ^b   Turchanowa, Ljudmila ^a   Brandes, Ralf P ^a   Fisslthaler, Beate ^a   Busse, Rudi ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Endothelial function; Lipoproteins; Nitric oxide; Oxygen radicals; Protein kinase C

Indexed keywords

NITRIC OXIDE SYNTHASE; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN KINASE C ALPHA; SUPEROXIDE;

ARTICLE; ATTENUATION; CELL STRAIN COS7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; OXIDATION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 13844255039     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2004.11.003     Document Type: Article

References (36)

1. D. Stuehr, S. Pou, and G.M. Rosen Oxygen reduction by nitric-oxide synthases J. Biol. Chem. 276 2001 14533 14536
2. C.P. Tiefenbacher, W.M. Chilian, M. Mitchell, and D.V. DeFily Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin Circulation 94 1996 1423 1429
3. L.V. d'Uscio, S. Milstien, D. Richardson, L. Smith, and Z.S. Katusic Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity Circ. Res. 92 2003 88 95
4. K.A. Pritchard Jr., A.W. Ackerman, E.R. Gross, D.W. Stepp, Y. Shi, and J.T. Fontana Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase J. Biol. Chem. 276 2001 17621 17624
5. M.I. Lin, D. Fulton, R. Babbitt, I. Fleming, R. Busse, and K.A. Pritchard Jr. Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of l-arginine metabolism to efficient nitric oxide production J. Biol. Chem. 278 2003 44719 44726
6. L. Cominacini, A. Rigoni, A.F. Pasini, U. Garbin, A. Davoli, and M. Campagnola The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide J. Biol. Chem. 276 2001 13750 13755
7. A. Heinloth, K. Heermeier, U. Raff, C. Wanner, and J. Galle Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells J. Am. Soc. Nephrol. 11 2000 1819 1825
8. R. Popp, J. Bauersachs, M. Hecker, I. Fleming, and R. Busse A transferable, β-naphthoflavone-inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells J. Physiol. (Lond.) 497 1996 699 709
9. 2+-independent activation of the endothelial nitric oxide synthase in response to tyrosine phosphatase inhibitors and fluid shear stress Circ. Res. 82 1998 686 695
10. J. Galle, A. Mameghani, S.S. Bolz, S. Gambaryan, M. Gorg, and T. Quaschning Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA J. Am. Soc. Nephrol. 14 2003 1471 1479
11. N. Kuzkaya, N. Weissmann, D.G. Harrison, and S. Dikalov Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase J. Biol. Chem. 278 2003 22546 22554
12. 2+/calmodulin- dependent endothelial nitric oxide synthase activity Circ. Res. 88 2001 e68 e75
13. 495 Cardiovasc. Res. 59 2003 844 853
14. L.R. Vann, S.G. Payne, L.C. Edsall, S. Twitty, S. Spiegel, and S. Milstien Involvement of sphingosine kinase in TNF-α-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells J. Biol. Chem. 277 2002 12649 12656
15. M.D. Davis, S. Kaufman, and S. Milstien Conversion of 6-substituted tetrahydropterins to 7-isomers via phenylalanine hydroxylase-generated intermediates Proc. Natl. Acad. Sci. U. S. A. 88 1991 385 389
16. T.C. He, S. Zhou, L.T. da Costa, J. Yu, K.W. Kinzler, and B. Vogelstein A simplified system for generating recombinant adenoviruses Proc. Natl. Acad. Sci. U. S. A. 95 1998 2509 2514
17. T.J. Mccabe, D. Fulton, L.J. Roman, and W.C. Sessa Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation J. Biol. Chem. 275 2000 6123 6128
18. Y.M. Go, A.L. Levonen, D. Moellering, A. Ramachandran, R.P. Patel, and H. Jo Endothelial NOS-dependent activation of c-Jun NH2-terminal kinase by oxidized low-density lipoprotein Am. J. Physiol, Heart Circ. Physiol. 281 2001 H2705 H2713
19. E. Chavakis, E. Dernbach, C. Hermann, U.F. Mondorf, A.M. Zieher, and S. Dimmeler Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway Circulation 103 2001 2102 2107
20. B.J. Michell, Z. Chen, T. Tiganis, D. Stapleton, F. Katsis, and D.A. Power Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase J. Biol. Chem. 276 2001 17625 17628
21. M.B. Harris, H. Ju, V.J. Venema, H. Liang, R. Zou, and B.J. Michell Reciprocal phosphorylation and regulation of the endothelial nitric oxide synthase in response to bradykinin stimulation J. Biol. Chem. 19 2001 16587 16591
22. 2+ center at the enzyme active site J. Biol. Chem. 277 2002 5962 5969
23. 2+- calmodulin Biochemistry 35 1996 14651 14658
24. R.K. Davda, L.J. Chandler, and N.J. Guzman Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase Eur. J. Pharmacol. 266 1994 237 244
25. K. Hirata, R. Kuroda, T. Sakoda, M. Katayama, N. Inoue, and M. Suematsu Inhibition of endothelial nitric oxide synthase activity by protein kinase C Hypertension 25 1995 180 185
26. S. Mukherjee, S.D. Coaxum, M. Maleque, and S.K. Das Effects of oxidized low density lipoprotein on nitric oxide synthetase and protein kinase C activities in bovine endothelial cells Cell. Mol. Biol. (Noisy-le-grand) 47 2001 1051 1058
27. V.J. Venema, M.B. Marrero, and R.C. Venema Bradykinin-stimulated protein tyrosine phosphorylation promotes endothelial nitric oxide synthase translocation to the cytoskeleton Biochem. Biophys. Res. Commun. 226 1996 703 710
28. J.B. Giardina, D.J. Tanner, and R.A. Khalil Oxidized-LDL enhances coronary vasoconstriction by increasing the activity of protein kinase C isoforms α and ε. Hypertension 37 2001 561 568
29. D. Li, L. Liu, H. Chen, T. Sawamura, and J.L. Mehta LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells Arterioscler. Thromb. Vasc. Biol. 23 2003 816 821
30. A. Blair, P.W. Shaul, I.S. Yuhanna, P.A. Conrad, and E.J. Smart Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation J. Biol. Chem. 274 1999 32512 32519
31. A. Nuszkowski, R. Grabner, G. Marsche, A. Unbehaun, E. Malle, and R. Heller Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase J. Biol. Chem. 276 2001 14212 14221
32. P.W. Shaul Regulation of endothelial nitric oxide synthase: location, location, location Annu. Rev. Physiol. 64 2002 749 774
33. D.W. Stepp Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ Am. J. Physiol, Heart Circ. Physiol. 283 2002 H750 H759
34. S. Milstien, and Z. Katusic Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function Biochem. Biophys. Res. Commun. 263 1999 681 684
35. J. Dulak, M. Polus, I. Guevara, A. Polus, J. Hartwich, and A. Dembinska-Kiec Regulation of inducible nitric oxide synthase (iNOS) and GTP cyclohydrolase I (GTP-CH I) gene expression by ox-LDL in rat vascular smooth muscle cells J. Physiol. Pharmacol. 48 1997 689 697
36. U. Landmesser, S. Dikalov, S.R. Price, L. McCann, T. Fukai, and S.M. Holland Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension J. Clin. Invest. 111 2003 1201 1209