Exploring novel target space: A need to partner high throughput docking and ligand-based similarity searches?

Combinatorial Chemistry and High Throughput Screening

Volumn 12, Issue 10, 2009, Pages 984-999

  Shanmugasundaram, Kumaran ^a   Rigby, Alan C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chemical genetics; High throughput screening (HTS); Ligand based virtual screening (LBVS); Structure based virtual screening (SBVS)

Indexed keywords

ANDROGEN RECEPTOR DOWN REGULATING AGENT; ANTINEOPLASTIC AGENT; CHECKPOINT KINASE 1 INHIBITOR; CHORISMATE MUTASE INHIBITOR; ISOMERASE INHIBITOR; PROTEIN INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TRANSCRIPTION FACTOR AP 1 INHIBITOR; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

AFFINITY LABELING; CHEMICAL COMPOSITION; COMPUTER ANALYSIS; COMPUTER PROGRAM; CRYSTAL STRUCTURE; DRUG DETERMINATION; DRUG DNA BINDING; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; IMAGING SYSTEM; LIGAND BINDING; MOLECULAR DOCKING; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

ANIMALS; COMPUTER-AIDED DESIGN; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; PROTEIN BINDING;

EID: 71249158576     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620709789824709     Document Type: Review

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