Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3

Journal of Biological Chemistry

Volumn 278, Issue 3, 2003, Pages 1892-1903

  Govaerts, Cédric ^a,d   Bondue, Antoine ^a   Springael, Jean Yves ^a   Olivella, Mireia ^b   Deupi, Xavier ^b   Le Poul, Emmanuel ^c   Wodak, Shoshana J ^a   Parmentier, Marc ^a   Pardo, Leonardo ^b   Blanpain, Cédric ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c Euroscreen SA   (Belgium)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; IMMUNOLOGY; MUTAGENESIS; VIRUSES;

FUNCTIONAL RESPONSE;

PROTEINS;

CHEMOKINE RECEPTOR CCR5; HELICASE; HELICASE 2; HELICASE 3; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 2; RANTES; UNCLASSIFIED DRUG; CHEMOKINE; LIGAND;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; RECEPTOR INTRINSIC ACTIVITY; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMOKINES; LIGANDS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CCR5; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0037449732     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205685200     Document Type: Article

References (54)

1. Baggiolini, M. (1998) Nature 392, 565-568
2. Gerard, C., and Rollins, B. J. (2001) Nat. Immunol. 2, 108-115
3. Berger, E. A., Murphy, P. M., and Farber, J. M. (1999) Annu. Rev. Immunol. 17, 657-700
4. Blanpain, C., Migeotte, I., Lee, B., Vakili, J., Doranz, B. J., Govaerts, C., Vassart, G., Doms, R. W., and Parmentier, M. (1999) Blood 94, 1899-1905
5. Meng, E. C., and Bourne, H. R. (2001) Trends Pharmacol. Sci. 22, 587-593
6. Gether, U. (2000) Endocr. Rev. 21, 90-113
7. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W. L., and Khorana, H. G. (1996) Science 274, 768-770
8. Dunham, T. D., and Farrens, D. L. (1999) J. Biol. Chem. 274, 1683-1690
9. Gether, U., Lin, S., Ghanouni, P., Ballesteros, J. A., Weinstein, H., and Kobilka, B. K. (1997) EMBO J. 16, 6737-6747
10. Marjamaki, A., Frang, H., Pihlavisto, M., Hoffren, A. M., Salminen, T., Johnson, M. S., Kallio, J., Javitch, J. A., and Scheinin, M. (1999) J. Biol. Chem. 274, 21867-21872
11. Abdulaev, N. G., and Ridge, K. D. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 12854-12859
12. Ji, T. H., Grossmann, M., and Ji, I. (1998) J. Biol. Chem. 273, 17299-17302
13. Govaerts, C., Blanpain, C., Deupi, X., Ballet, S., Ballesteros, J. A., Wodak, S. J., Vassart, G., Pardo, L., and Parmentier, M. (2001) J. Biol. Chem. 276, 13217-13225
14. Wess, J., Gdula, D., and Brann, M. R. (1991) EMBO J. 10, 3729-3734
15. Fong, T. M., Cascieri, M. A., Yu, H., Bansal, A., Swain, C., and Strader, C., D. (1993) Nature 362, 350-353
16. Kim, J., Wess, J., van Rhee, A. M., Schoneberg, T., and Jacobson, K. A. (1995) J. Biol. Chem. 270, 13987-13997
17. Cho, W., Taylor, L. P., Mansour, A., and Akil, H. (1995) J. Neurochem. 65, 2105-2115
18. Lee, S. Y., Zhu, S. Z., and el Fakahany, E. E. (1996) Recept. Signal. Transduct. 6, 43-52
19. Roth, B. L., Shoham, M., Choudhary, M. S., and Khan, N. (1997) Mol. Pharmacol. 52, 259-266
20. Javitch, J. A., Ballesteros, J. A., Weinstein, H., and Chen, J. (1998) Biochemistry 37, 998-1006
21. Colson, A. O., Perlman, J. H., Jinsi-Parimoo, A., Nussenzveig, D. R., Osman, R., and Gershengorn, M. C. (1998) Mol. Pharmacol. 54, 968-978
22. Rhee, M. H., Nevo, I., Bayewitch, M. L., Zagoory, O., and Vogel, Z. (2000) J. Neurochem. 75, 2485-2491
23. Simpson, M. M., Ballesteros, J. A., Chiappa, V., Chen, J., Suchiro, M., Hartman, D. S., Godel, T., Snyder, L. A., Sakmar, T. P., and Javitch, J. A. (1999) Mol. Pharmacol. 56, 1116-1126
24. Ballesteros, J. A., and Weinstein, H. (1995) Methods Neurosci. 25, 366-428
25. Lopez-Rodriguez, M. L., Vicente, B., Deupi, X., Barrondo, S., Olivella, M., Morcillo, M. J., Behamu, B., Ballesteros, J. A., Salles, J., and Pardo, L. (2002) Mol. Pharmacol. 62, 15-21
26. Ballesteros, J., Deupi, X., Olivella, M., Haaksma E., and Pardo, L. (2000) Biophys. J. 79, 2754-2760
27. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le, T., I, Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Science 289, 739-745
28. Kelley, L. A., Gardner, S. P., and Sutcliffe, M. J. (1996) Protein Eng. 9, 1063-1065
29. Bower, M. J., Cohen, F. E., and Dunbrack, R. L. (1997) J. Mol. Biol. 267, 1268-1282
30. Tsuzuki, S., Honda, K., Uchimaru, T., Mikami, M., and Tanabe, K. (2000) J. Am. Chem. Soc 122, 3746-3753
31. Olivella, M., Deupi, X., Govaerts, C., and Pardo, L. (2002) Biophys. J. 82, 3207-3213
32. Darden, T., York, D., and Pedersen, L. (1993) J. Chem. Phys. 98, 10089-10092
33. Case, D. A., Pearlman, D. A., Caldwell, J. W, Cheatham, T. E., Ross, W. S., Simmerling, C. L., Darden, T. A., Merz, K. M., Stanton, R. V., Cheng, A. L., Vincent, J., Crowley, M. Ferguson, D. M., Radmer, R. J., Seibel, G. L., Singh, U. C., Weiner, P. K., and Kollman, P. A. (1997) AMBER5, University of California, San Francisco
34. Cornell, W. D., Cieplak, P., Bayly, C. I., Gould, I. R., Merz, K. M., Jr., F., D. M. Spellmeyer, D. C., Fox, T., Caldwell, J. W., and Kollman, P. A. (1995) J. Am. Chem. Soc. 117, 5179-5197
35. Samson, M., LaRosa, G., Libert, F., Paindavoine, P., Detheux, M., Vassart, G., and Parmentier, M. (1997) J. Biol. Chem. 272, 24934-24941
36. Rizzuto, R., Pinton, P., Carrington, W., Fay, F. S., Fogarty, K. E., Lifshitz, L. M., Tuft, R. A., and Pozzan, T. (1998) Science 280, 1763-1766
37. Stables, J., Green, A., Marshall, F., Fraser, N., Knight, E., Sautel, M., Milligan, G., Lee, M., and Rees, S. (1997) Anal. Biochem. 252, 115-126
38. Blanpain, C., Lee, B., Vakili, J., Doranz, B. J., Govaerts, C., Migeotte, I., Sharron, M., Dupriez, V., Vassart, G., Doms, R. W., and Parmentier, M. (1999) J. Biol. Chem. 274, 18902-18908
39. Blanpain, C., Wittamer, V., Vanderwinden, J. M., Boom, A., Renneboog, B., Lee, B., Le Poul, E., El Asmar, L., Govaerts, C., Vassart, G., Doms, R. W., and Parmentier, M. (2001) J. Biol. Chem. 276, 23795-23804
40. Blanpain, C., Vanderwinden, J. M., Cihak, J., Wittamer, V., Le Poul, E., Issafras, H., Stangassinger, M., Vassart, G., Marullo, S., Schlndorff, D., Parmentier, M., and Mack, M. (2002) Mol. Biol. Cell 13, 723-737
41. Schagger, H., and von Jagow, G. (1987) Anal. Biochem. 166, 368-379
42. Lee, B., Sharron, M., Blanpain, C., Doranz, B. J., Vakili, J., Setoh, P., Berg, E., Liu, G., Guy, H. R., Durell, S. R., Parmentier, M., Chang, C. N., Price, K., Tsang, M., and Doms, R. W. (1999) J. Biol. Chem. 274, 9617-9626
43. Steiner, T., and Koellner, G. (2001) J. Mol. Biol. 305, 535-557
44. Dairaghi, D. J., Franz-Bacon, K., Callas, E., Cupp, J., Schall, T. J., Tamraz, S. A., Boehme, S. A., Taylor, N., and Bacon, K. B. (1998) Blood 91, 2905-2913
45. Misse, D., Esteve, P. O., Renneboog, B., Vidal, M., Cerutti, M., St Pierre, Y., Yssel, H., Parmentier, M., and Veas, F. (2001) Blood 98, 541-547
46. Burley, S. K., and Petsko, G. A. (1985) Science 229, 23-28
47. Suzuki, S., Green, P. G., Bumgarner, R. E., Dasgupta, S., Goddard, W. A., III, and Blake, G. A. (1992) Science 257, 942-945
48. Zoffmann, S., Gether, U., and Schwartz, T. W. (1993) FEBS Lett. 336, 506-510
49. Fong, T. M., Yu, H., Cascieri, M. A., Underwood, D., Swain, C. J., and Strader, C. D. (1994) J. Biol. Chem. 269, 2728-2732
50. Kask, K., Berthold, M., Kahl, U., Nordvall, G., and Bartfai, T. (1996) EMBO J. 15, 236-244
51. Turner, C. A., Cooper, S., and Pulakat, L. (1999) Biochem. Biophys. Res. Commun. 257, 704-707
52. Huang, X. P., Nagy, P. I., Williams, F. E., Peseckis, S. M., and Messer, W. S., Jr. (1999) Br. J. Pharmacol. 126, 735-745
53. Granas, C., Nordvall, G., and Larhammar, D. (1998) J. Recept. Signal. Transduct. Res. 18, 225-241
54. Ri, Y., Ballesteros, J. A., Abrams, C. K., Oh, S., Verselis, V. K., Weinstein, H., and Bargiello, T. A. (1999) Biophys. J. 76, 2887-2898