Binding of small molecules to an adaptive protein-protein interface

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 4, 2003, Pages 1603-1608

  Arkin, Michelle R ^a   Randal, Mike ^a   DeLano, Warren L ^a   Hyde, Jennifer ^a   Luong, Tinh N ^a   Oslob, Johan D ^a   Raphael, Darren R ^a   Taylor, Lisa ^a   Wang, Jun ^a   McDowell, Robert S ^a   Wells, James A ^a   Braisted, Andrew C ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; CYTOKINE; DISULFIDE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PEPTIDE;

ARTICLE; BINDING SITE; CONFORMATION; ENERGY; MOLECULAR DYNAMICS; MOLECULAR SIZE; MUTATIONAL ANALYSIS; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RIGIDITY; SCREENING; STRUCTURE ANALYSIS; SURFACE PROPERTY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTERLEUKIN-2; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, INTERLEUKIN-2; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

EID: 0037452709     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.252756299     Document Type: Article

References (30)

1. Cochram, A. G. (2001) Curr. Opin. Chem. Biol. 5, 654-659.
2. Toogood, P. L. (2002) J. Med. Chem. 45, 1-16.
3. Lo Conte, L., Chothia, C. & Janin, J. (1999) J. Mol. Biol. 285, 2177-2198.
4. Stites, W. E. (1997) Chem. Rev. 97, 1233-1250.
5. Tilley, J. W., Chen, L., Fry, D. C., Emerson, S. D., Powers, G. D., Biondi, D., Varnell, T., Trilles, R., Guthrie, R., Mennona, F., et al. (1997) J. Am. Chem. Soc. 119, 7589-7590.
6. Erlanson, D. A., Braisted, A. C., Raphael, D. R., Randal, M., Stroud, R. M., Gordon, E. M. & Wells, J. A. (2000) Proc. Natl. Acad. Sci. USA 97, 9367-9372.
7. Taniguchi, T., Matsui, H., Fujita, T., Takaoka, C., Kashima, N., Yoshimoto, R. & Hamuro, J. (1983) Nature 302, 305-310.
8. Devos, R., Plaetinck, G., Cheroutre, H., Simons, G., Degrave, W., Tavernier, J. Remaut, E. & Fiers, W. (1983) Nucleic Acids Res. 11, 4307-4323.
9. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. USA 82, 488-492.
10. Nikaido, T., Shimizu, A., Ishida, N., Sabe, H., Teshigawara, K., Maeda, M., Uchiyama, T., Yodoi, J. & Honjo, T. (1984) Nature 311, 631-635.
11. Taniguchi, T., Hatakeyama, M., Minamoto, S., Kono, T., Doi, T., Tsudo, M., Miyasaka, M. & Miyata, T. (1989) Cold Spring Harbor Symp. Quant. Biol. 54, 689-694.
12. Pflugrath, J. W. (1999) Acta Crystallogr. D 55, 1718-1725.
13. CCP4 (1994) Acta Crystallogr. D 55, 1718-1725.
14. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119.
15. Deinum, J., Gustavsson, L., Gyzander, E., Kullman-Magnusson, M., Edstrom, A. & Karlsson, R. (2002) Anal. Biochem. 300, 152-162.
16. Krieger, M., Kay, L. M. & Stroud, R. M. (1974) J. Mol. Biol. 83, 209-230.
17. Sauve, K., Nachman, M., Spence, C., Bailon, P., Campbell, E., Tsien, W. H., Kondas, J. A., Hakimi, J. & Ju, G. (1991) Proc. Natl. Acad Sci. USA 88, 4636-4640.
18. Zurawski, S. M., Vega, F., Jr., Doyle, E. L., Huyghe, B., Flaherty, K., McKay, D. B. & Zurawski, G. (1993) EMBO J 12, 5113-5119.
19. Weigel, U., Meyer, M. & Sebald, W. (1989) Eur. J. Biochem. 180, 295-300.
20. McKay, D. B. (1992) Science 257, 412-413.
21. Mott, H. R., Baines, B. S., Hall R. M., Cooke, R. M., Driscoll, P. C., Weir, M. P. & Campbell, I. D. (1995) J Mol. Biol. 247, 979-994.
22. Murphy, K. P., Freire, E. & Paterson, Y. (1995) Proteins 21, 83-90.
23. Erlanson, D. A., Lam, J. W., Wiesmann, C., Luong, T. N., Simmons, R. L., DeLano, W. L., Choong, I. C., Burdett, M. T., Flanagan, W. M., Lee, D., et al. (2003) Nat. Biotechnol., in press.
24. DeLano, W. L., Ultsch, M. H., de Vos, A. M. & Wells, J. A. (2000) Science 287, 1279-1283.
25. Atwell, S., Ultsch, M., De Vos, A. M. & Wells, J. A. (1997) Science 278, 1125-1128.
26. Ma, B., Shatsky, M., Wolfson, H. J. & Nussinov, R. (2002) Protein Sci. 11, 184-197.
27. Livnah, O., Stura, E. A., Johnson, D. L., Middleton, S. A., Mulcahy, L. S., Wrighton, N. C., Dower, W. J., Jolliffe, L. K. & Wilson, I. A. (1996) Science 273, 464-471.
28. Pan, B., Li, B., Russell, S. J., Tom, J. Y., Cochran, A. G. & Fairbrother, W. J. (2002) J. Mol. Biol. 316, 769-787.
29. Rockwell, A., Melden, M., Copeland, R. A., Hardman, K., Decicco, C. P., DeGrado, W. F. (1996) J. Am. Chem. Soc. 118, 10337-10338.
30. Bursavich, M. G. & Rich, D. H. (2002) J. Med. Chem. 45, 541-558.