Small-molecule aggregates inhibit amyloid polymerization

Nature Chemical Biology

Volumn 4, Issue 3, 2008, Pages 197-199

  Feng, Brian Y ^a   Toyama, Brandon H ^b   Wille, Holger ^a   Colby, David W ^a   Collins, Sean R ^b   May, Barnaby C H ^a   Prusiner, Stanley B ^a   Weissman, Jonathan ^b   Shoichet, Brian K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; BETA LACTAMASE;

ARTICLE; ENZYME INHIBITION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEIN POLYMERIZATION; YEAST CELL;

EID: 39349094523     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.65     Document Type: Article

References (14)

1. Nelson, R. et al. Nature 435, 773-778 (2005).
2. Blanchard, B.J. et al. Proc. Natl. Acad. Sci. USA 101, 14326-14332 (2004).
3. Lorenzo, A. & Yankner, B.A. Proc. Natl. Acad. Sci. USA 91, 12243-12247 (1994).
4. Ritchie, C.W. et al. Arch. Neurol. 60, 1685-1691 (2003).
5. Yang, F. et al. J. Biol. Chem. 280, 5892-5901 (2005).
6. Zhu, M. et al. J. Biol. Chem. 279, 26846-26857 (2004).
7. Heiser, V. et al. Proc. Natl. Acad. Sci. USA 97, 6739-6744 (2000).
8. McGovern, S.L., Caselli, E., Grigorieff, N. & Shoichet, B.K. J. Med. Chem. 45, 1712-1722 (2002).
9. McGovern, S.L., Helfand, B.T., Feng, B. & Shoichet, B.K. J. Med. Chem. 46, 4265-4272 (2003).
10. True, H.L. & Lindquist, S.L. Nature 407, 477-483 (2000).
11. Abid, K. & Soto, C. Cell. Mol. Life Sci. 63, 2342-2351 (2006).
12. Coan, K.E.D. & Shoichet, B.K. Mol. Biosyst. 3, 208-213 (2007).
13. Feng, B.Y., Shelat, A., Doman, T.N., Guy, R.K. & Shoichet, B.K. Nat. Chem. Biol. 1, 146-148 (2005).
14. Tanaka, M. & Weissman, J.S. Methods Enzymol. 412, 185-200 (2006).